Article
Biochemistry & Molecular Biology
Shadi Jafari, Johan Henriksson, Hua Yan, Mattias Alenius
Summary: The regulation of Drosophila odorant receptor expression during the pupal stage is permissive and imprecise, with an OR feedback mechanism directing and refining OR expression. dLsd1 and Su(var)3-9 balance heterochromatin formation to direct OR expression, linking OR level and possibly function to OR expression. OR expression refinement has a restricted duration, ending olfactory sensory neuron differentiation through a gene regulatory critical period.
Article
Entomology
Yu Zhang, Kai Feng, Ruolan Mei, Wei Li, Fang Tang
Summary: This study used transcriptome sequencing to investigate the expression of antennal genes in Micromelalopha troglodyta and identified olfactory-related genes. The results showed that these genes are abundantly expressed in the antennae and head, laying the foundation for future research on the olfactory system in M. troglodyta and providing a theoretical basis for biological control.
JOURNAL OF INSECT SCIENCE
(2022)
Article
Entomology
Eric Wiesel, Sabine Kaltofen, Bill S. Hansson, Dieter Wicher
Summary: Flying insects have developed a sensitive olfactory system to detect faint odor traces, which is enhanced through the regulation of mitochondrial calcium ions.
Article
Chemistry, Multidisciplinary
Xiaojing Cong, Wenwen Ren, Jody Pacalon, Rui Xu, Lun Xu, Xuewen Li, Claire A. de March, Hiroaki Matsunami, Hongmeng Yu, Yiqun Yu, Jerome Golebiowski
Summary: This study investigated how the amino-acid sequences of olfactory receptors (ORs) encode diversified responses to various ligands. Using a proteochemometric model, the researchers were able to predict OR responses to odorants and discover new OR-ligand pairs. This approach will contribute to the mapping of OR-odorant interactions and the identification of orphan receptors.
ACS CENTRAL SCIENCE
(2022)
Article
Immunology
Zhenjie Ma, Weihao Li, Liujing Zhuang, Tieqiao Wen, Ping Wang, Hongmeng Yu, Yongliang Liu, Yiqun Yu
Summary: In this study, TMEM59 is identified as a critical regulator in maintaining and regenerating the olfactory epithelium. TMEM59 deletion leads to transcriptional changes, affecting genes associated with olfactory transduction and inflammatory/immune response. Loss of TMEM59 impairs olfactory functions, decreases proliferation, and promotes infiltration of inflammatory cells. TMEM59 also plays a role in the regeneration of the olfactory epithelium, with reduced proliferative cells and sensory neurons. Anti-inflammatory treatment can recover neuronal generation and olfactory functions, suggesting a potential therapy for olfactory dysfunction associated with inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Ying-Jie Peng, Jayasri Nanduri, Ning Wang, Ganesh K. K. Kumar, Vytautas Bindokas, Bindu D. D. Paul, Xuanmao Chen, Aaron P. P. Fox, Thibaut Vignane, Milos R. R. Filipovic, Nanduri R. R. Prabhakar
Summary: This study shows that hydrogen sulfide (H2S) signaling plays a role in the activation of the carotid body during low oxygen conditions. The persulfidation of olfactory receptor 78 (Olfr78) by H2S is found to be essential for this activation. Mutations in Olfr78, adenylate cyclase 3 (Adcy3), or cyclic nucleotide-gated channel alpha 2 (Cnga2) impair the carotid body and glomus cell responses to H2S and hypoxia.
Article
Entomology
Sina Cassau, Doreen Sander, Thomas Karcher, Michael Laue, Gerd Hause, Heinz Breer, Juergen Krieger
Summary: Research has found that two SNMP proteins in the desert locust play a vital role in the olfactory system. SNMP1 functions in both olfactory sensory neurons and associated support cells, participating in odor detection and maintaining the sensillum lymph. SNMP2 is only present in support cells and is involved in the recovery process of sensillum lymph.
Article
Multidisciplinary Sciences
Kevin W. Zhu, Shawn D. Burton, Maira H. Nagai, Justin D. Silverman, Claire A. de March, Matt Wachowiak, Hiroaki Matsunami
Summary: This study utilized targeted spatial transcriptomics to map the distribution of olfactory receptors in the murine olfactory bulb and generated a 3D model. The findings revealed a relationship between receptors and odorants, providing significant insights into olfaction.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Aimei Fei, Wanqing Wu, Longzhi Tan, Cheng Tang, Zhengrong Xu, Xiaona Huo, Hongqiang Bao, Yalei Kong, Mark Johnson, Griffin Hartmann, Mustafa Talay, Cheng Yang, Clemens Riegler, Kristian J. Herrera, Florian Engert, X. Sunney Xie, Gilad Barnea, Stephen D. Liberles, Hui Yang, Qian Li
Summary: In this study, the researchers identified two conserved enhancers across placental mammals named TAAR enhancer 1 and 2 that coordinately regulate expression of the entire Taar gene repertoire in olfactory sensory neurons (OSNs). This finding reveals a coordinated control of Taar gene choice in OSNs by two remote enhancers, providing an excellent model to study molecular mechanisms underlying formation of an olfactory subsystem.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Dieter Wicher, Fabio Miazzi
Summary: The majority of insect olfactory receptors belong to two distinct protein families - ionotropic receptors (IRs) related to the ionotropic glutamate receptor family, and odorant receptors (ORs) evolved from the gustatory receptor family. Both types assemble into heteromeric ligand-gated cation channels, addressing environmental and ecological challenges insects face.
CELL AND TISSUE RESEARCH
(2021)
Article
Energy & Fuels
Chan-Soo Lee, Ayodeji Matthew Monebi, Dansran Bayarsaikhan, Songyuan Xu, Bierng-Chearl Ahn, In-Sung Lee
Summary: This paper presents a design for a charge pump DC-DC boost regulator with an integrated low-voltage control circuit. The design utilizes 0.35μm CMOS technology to implement the charge pump and feedback circuits, providing an efficient solution for low-power applications. The control circuit incorporates an error amplifier, oscillator, and comparator, operating at a supply voltage of 1.8-3.5V and a frequency of 2MHz. The stability of the system is achieved through pole-zero compensation in the feedback circuit. The performance of the regulator circuit, which includes four pump stages, is analyzed using the Cadence simulation tool. Measurement results of the fabricated 0.35μm CMOS regulator demonstrate that the error amplifier maintains a controlled transient time within 1.0μsec and accurately regulates the output voltage from 7.8V to 9.4V, with a ripple of 27-38mV and a maximum current of 4.5mA.
Article
Optics
Jueming Bao, Zhaorong Fu, Tanumoy Pramanik, Jun Mao, Yulin Chi, Yingkang Cao, Chonghao Zhai, Yifei Mao, Tianxiang Dai, Xiaojiong Chen, Xinyu Jia, Leshi Zhao, Yun Zheng, Bo Tang, Zhihua Li, Jun Luo, Wenwu Wang, Yan Yang, Yingying Peng, Dajian Liu, Daoxin Dai, Qiongyi He, Alif Laila Muthali, Leif K. Oxenlowe, Caterina Vigliar, Stefano Paesani, Huili Hou, Raffaele Santagati, Joshua W. Silverstone, Anthony Laing, Mark G. Thompson, Jeremy L. O'Brien, Yunhong Ding, Qihuang Gong, Jianwei Wang
Summary: Researchers have successfully manufactured a quantum photonic device based on graph theory, which can be used to perform complex quantum computing tasks with high design flexibility and scalability.
Article
Biology
Kaitlin Ching, Jennifer T. Wang, Tim Stearns, Danelle Devenport
Summary: This study discovered that centrioles migrate together during dendrite outgrowth in olfactory sensory neurons (OSNs) and form cilia during maturation. They are associated with microtubule nucleation factors and the parental centriole forms a cilium before other centrioles.
Article
Medicine, General & Internal
Shu Kikuta, Bing Han, Tatsuya Yamasoba
Summary: The objective of this study was to determine if olfactory sensory neurons are uniformly damaged in PVOD. Comparing PVOD patients with CRS and PTOD patients, it was found that a response to a single odor is characteristic of PVOD, while there were no significant abnormalities in the response to five different odors. In mouse experiments, it was found that a single odor selectively activated one type of sensory neurons, while five different odors activated both types of sensory neurons simultaneously.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Haichao Li, Weizheng Li, Changjian Miao, Gaoping Wang, Man Zhao, Guohui Yuan, Xianru Guo
Summary: By analyzing the whole transcriptome sequence of adult Helicoverpa assulta, the study revealed significant differences in the expression of olfaction-related genes between males and females, which may contribute to the differences in how they identify odorant substances, especially sex pheromones. This study enhances our understanding of mate search and host differentiation in H. assulta.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemical Research Methods
Todd J. Levy, Umair Ahmed, Tea Tsaava, Yao-Chuan Chang, Peter J. Lorraine, Jacquelyn N. Tomaio, Marina Cracchiolo, Maria Lopez, Loren Rieth, Kevin J. Tracey, Stavros Zanos, Theodoros P. Zanos
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Neurosciences
Pablo S. Villar, Ruilong Hu, Ricardo C. Araneda
Summary: This study reveals that GABAergic inputs from the basal forebrain play a crucial role in modulating local circuitry and influencing the activity of mitral/tufted cells in the olfactory bulb. These inputs lead to rapid disinhibition of mitral/tufted cells, impacting their response precision to stimuli and local oscillations in a layer-specific manner.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Umair Ahmed, Yao-Chuan Chang, Maria F. Lopez, Jason Wong, Timir Datta-Chaudhuri, Loren Rieth, Yousef Al-Abed, Stavros Zanos
Summary: The study found that the threshold for eliciting discernable neural responses with VNS is significantly lower than that for causing a drop in heart rate. Additionally, factors such as implant age, electrode impedance, and type of anesthesia were shown to affect VNS thresholds.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
P. Ordenes, P. S. Villar, E. Tarifeno-Saldivia, M. Salgado, R. Elizondo-Vega, Ricardo C. Araneda, Maria A. Garcia-Robles
Summary: The study investigated the impact of lactate receptor HCAR1 on POMC neurons, revealing that lactate can modulate neuronal excitability through both intracellular and intercellular actions, with HCAR1 mainly located in astrocytes rather than POMC neurons.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Magdiel Salgado, Roberto Elizondo-Vega, Pablo S. Villar, Macarena Konar, Scarlet Gallegos, Estefania Tarifeno-Saldivia, Patricia Luz-Crawford, Luis G. Aguayo, Ricardo C. Araneda, Elena Uribe, Maria Angeles Garcia-Robles
Summary: This study investigates the role of glucokinase regulatory protein (GKRP) in metabolic regulation and feeding behavior. The results suggest that GKRP can modulate tanycyte-neuron metabolic communication to regulate feeding behavior, and it may serve as a therapeutic target for enhancing satiety in patients with obesity.
Article
Engineering, Multidisciplinary
Elisabeth Smela
Summary: This study investigates the use of bipolar current injection and voltage measurement patterns in electrical impedance tomography (EIT) for tactile sensing. The performance of 36 unique combinations for a 16-electrode system is evaluated through simulations. The choice of pattern should be based on the specific application's needs, with performance influenced by electrode placement symmetry and sensitivity at the center of the sensor. Patterns with high spatial symmetry and adjacent electrode positions should be avoided, while a 3-3 pattern may be a good strategy for overall performance. The use of 13 electrodes instead of 16 is also examined for greater flexibility in pattern selection and potential reduction in data collection time. Decreasing noise on the signal is more important than selecting from among the remaining patterns.
ENGINEERING RESEARCH EXPRESS
(2022)
Article
Immunology
Ibrahim T. Mughrabi, Michael Gerber, Naveen Jayaprakash, Santhoshi P. Palandira, Yousef Al-Abed, Timir Datta-Chaudhuri, Corey Smith, Valentin A. Pavlov, Stavros Zanos
Summary: The noradrenergic innervation of the spleen plays a role in the regulation of inflammation, but there is currently no real-time marker to monitor its activation. This study provides a method to monitor the anti-inflammatory effects of splenic nerve stimulation in real-time.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Engineering, Multidisciplinary
Elisabeth Smela
Summary: This article investigates the application of electrical impedance tomography (EIT) in tactile sensing. The study finds that noise destabilizes EIT images and introduces artefacts. To manage the destabilization, the authors propose an efficient criterion based on the onset of artefacts to evaluate tactile sensor image quality. The study also evaluates different methods for determining optimal hyperparameters.
ENGINEERING RESEARCH EXPRESS
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Kang Choi, Kasun Pathirage, Salman Azam, Pamela Abshire, Roy Anderson, Elisabeth Smela
Summary: This paper presents a handheld fluorometer that can detect blue/green fluorescence from small Stokes shift fluorophores. It introduces two novel techniques to emulate far-field operation while operating in the near field. The detection of Alexa Fluor 488 achieved a sensitivity of 26 (seconds per decade of dilution) and a resolution of 0.01 (concentration units).
2022 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS (ISCAS 22)
(2022)
Article
Urology & Nephrology
Christine B. Sethna, Kumail Merchant, Stavros Zanos, Clifford S. Deutschman, Timir Datta-Chaudhuri, Sangeeta Chavan, Kevin J. Tracey
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Proceedings Paper
Automation & Control Systems
Lasitha Weerakoon, Zepeng Ye, Rahul Subramonian Bama, Elisabeth Smela, Miao Yu, Nikhil Chopra
Summary: This paper explores integrated estimation and control of soft robots, introducing a new method of estimating curvature using stretchable sensing skin. The study includes uni-directional and bi-directional bending of soft robots, and demonstrates successful curvature tracking control through integrated soft sensing skin.
2021 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA 2021)
(2021)
Article
Chemistry, Analytical
Christiana Oh, Bumjun Park, Chunyan Li, Charles Maldarelli, Jennifer L. L. Schaefer, Timir Datta-Chaudhuri, Paul W. W. Bohn
Summary: The label-free electrochemical immunosensor developed in this work showed high sensitivity and selectivity for detecting IL-6 in human cerebrospinal fluid and serum. Its performance in quantifying IL-6 and distinguishing it from other common cytokines makes it a promising tool for rapid diagnostics and monitoring of cytokine-related illnesses.
ACS MEASUREMENT SCIENCE AU
(2021)
Proceedings Paper
Engineering, Biomedical
Yao-Chuan Chang, Umair Ahmed, Jacquelyn N. Tomaio, Loren Rieth, Timir Datta-Chaudhuri, Stavros Zanos
2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2019)
Article
Engineering, Biomedical
Ahmed Ramadan, Anindo Roy, Elisabeth Smela
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Bathiya Senevirathna, Sheung Lu, Nathan Renegar, Marc Dandin, Elisabeth Smela, Pamela Abshire
2019 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS (ISCAS)
(2019)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)