Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 222, Issue -, Pages 588-597Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2015.08.101
Keywords
Hemoglobin; Carboxyl graphene; Electrochemistry; Oxygen-carrying ability
Funding
- National Natural Science Foundation of China [21475070, 21175075, 81202249]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Province Natural Science Foundation [BK2011047]
- Postgraduate Technology Innovation Project of Nantong University [YKC13043]
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Hemoglobin (Hb) was successfully combined with carboxyl graphene (CG) through condensation reaction to form novel bio-nanocomposite hemoglobin-carboxyl graphene bio-nanocomposites (CG-Hb). Scanning electron microscope (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR) and Raman spectra indicated that the morphology and structure of CG-Hb. Cyclic voltammograms of CG-Hb modified on the gold nanoparticles (Au-NPs) electro-deposited on glassy carbon electrode (GCE) exhibited a pair of redox peaks (-0.235 V and 0.122 V vs. SCE) and showed excellent biosensor for hydrogen peroxide, which realized the direct electron transfer between CG-Hb and GCE. The electrochemistry properties and the ability of oxygen-carrying were investigated by electrochemical methods. It was found this kind of bio-nanocomposite maintained the natural biological activity of Hb and was explored to be no observable denaturation, which can be considered as a novel effective oxygen carrier in electrochemical aspect for further research. (C) 2015 Elsevier B.V. All rights reserved.
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