Article
Chemistry, Analytical
Guolin Hong, Canping Su, Zhongnan Huang, Quanquan Zhuang, Chaoguo Wei, Haohua Deng, Wei Chen, Huaping Peng
Summary: The study introduced a dual-function ECL probe IgG-AuNCs for the development of a high-performance ECLIA platform. It was successfully applied for IgG detection, demonstrating features such as easy preparation, rapid detection, sample saving, and high selectivity.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zihui Zeng, Ping Huang, Yi Kong, Lianpeng Tong, Baohua Zhang, Yelin Luo, Lijuan Chen, Yuwei Zhang, Dongxue Han, Li Niu
Summary: A nanoencapsulation strategy was used to prepare air-stable, water-soluble TADF nanoparticles of 4CzIPN with efficient TADF property. The electrochemiluminescence of TADF emitters in aqueous media was reported for the first time in this study.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Jingjing Zhang, Lin Hao, Jie Chao, Lianhui Wang, Shao Su
Summary: In this study, an ECL imaging technique for single cell membrane protein based on Co3O4 nanozyme catalytic enhancement strategy was developed. The highly efficient catalytic performance of Co3O4 nanozymes allows efficient decomposition of H2O2 into reactive oxygen radicals, leading to enhanced reaction with the luminescence reagent L012 and stronger ECL emission. The optimized design of Co3O4 nanozymes coupled with anti-CEA enables specific recognition of overexpressed CEA on the MCF-7 cell membrane, enabling rapid ECL imaging of single cell membrane protein.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Zhuanzhuan Wang, Haijing Guo, Zewei Luo, Yixiang Duan, Yaqiang Feng
Summary: In recent years, semiconducting polymer dots (Pdots) have attracted intense attention in ECL biosensing and imaging as environmentally friendly and high-brightness nanoemitters. However, the high ECL excitation potential of most available Pdots in the aqueous phase leads to poor selectivity in sample detection. This work demonstrates a simple and universal strategy to lower the trigger potential of Pdots based on electrochemiluminescence resonance energy transfer (ERET). The low potential Pdots showed excellent performance in glucose imaging detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhenqiang Ning, Erli Yang, Yongjun Zheng, Mengyuan Chen, Guoqiu Wu, Yuanjian Zhang, Yanfei Shen
Summary: This study proposed a facile synthesis strategy to prepare a self-enhanced ECL emitter DEAMTES@RuSiO2, which exhibited improved ECL properties and film-forming ability critical for ECL biosensors. By combining catalytic hairpin assembly and signal amplification, a label-free ECL biosensor was constructed for highly sensitive detection of miRNA-21 with a detection limit of 8.19 fM, showing superior reliability in detecting miRNA-21 in human serum samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Guolin Hong, Canping Su, Mingchun Lai, Zhongnan Huang, Zhimin Weng, Yaling Chen, Haohua Deng, Wei Chen, Huaping Peng
Summary: In this study, a novel co-reactant-mediated high-performance low-potential Au nano-cluster (AuNC)-based ECL system was successfully developed for the detection of SARS-CoV-2 N protein. The ECL system exhibited higher energy efficiency and quantum yield, with a wide linear range and low detection limit. It showed good reproducibility and stability, making it suitable for the detection of actual serum samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Ziyu Wang, Meiyun Xu, Nan Zhang, Jian-Bin Pan, Xinqi Wu, Peng Liu, Jing-Juan Xu, Daoben Hua
Summary: The global use of nuclear power has brought potential risks of nuclear accidents, requiring highly sensitive and selective I-2 sensors for early warnings and treatments. An innovative conjugated polymer modified with a co-reactive group was developed for ultra-low limit of detection (LOD), showing aggregation-induced electrochemiluminescence (AIECL) and high selectivity in detecting I-2 vapor.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Chemistry, Analytical
Xuemei Ma, Qi Kang, Mengmeng Li, Li Fu, Guizheng Zou, Dazhong Shen
Summary: In this study, a modulating strategy involving a band-pass filter is proposed to determine the electrochemiluminescence (ECL) spectrum. The strategy allows for the upgrade of a conventional ECL analyzer to a highly sensitive ECL spectrometer without changing the hardware. The strategy enables the determination of ultra-weak emission spectra and the demonstration of the interaction between co-existing emitters.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiaofei Wang, Huiwen Liu, Jiaxing Jiang, Manping Qian, Honglan Qi, Qiang Gao, Chengxiao Zhang
Summary: This study reports on a cyanophenyl-functionalized tetraphenylethene material with highly efficient aggregation-induced enhanced electrochemiluminescence (ECL), which has potential applications in biothiol analysis. The material exhibits high ECL efficiency and stability, achieved through the suppression of nonradiative transition, decrease in energy gap, and increase in anionic radical stability. Additionally, the material can be used to develop biothiol assays with low detection limits.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Jing Liu, Ruke Wang, Hong Zhou, Motilal Mathesh, Mukul Dubey, Wengan Zhang, Bo Wang, Wenrong Yang
Summary: This article provides an overview of the recent developments in nucleic acid isothermal amplification strategies based on soft nanoarchitectonics in the field of electrochemical techniques. It discusses the design and fabrication of new electrochemical biosensors for efficient biomolecular detection, as well as the current challenges and prospects in this area.
Article
Chemistry, Analytical
Li Fu, Bin Zhang, Xuwen Gao, Shuangtian Dong, Dongyang Wang, Guizheng Zou
Summary: This study proposes a general approach to trigger chemiluminescence using charge transfer between oxidants and n-type nanocrystals. The chemiluminescent system developed through this method can be used for ultrasensitive immunoassays.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Arun Ashokan, Paul Mulvaney
Summary: Solution-phase spectroelectrochemistry was used to study electron injection into colloidal CdSe quantum dots in THF. The results showed reversible optical changes on a time-scale of minutes, with the injection of electrons leading to quenching of photoluminescence. The number of electrons injected into the QDs depended on the electrode potential and QD size, with most injection occurring below the band edge.
CHEMISTRY OF MATERIALS
(2021)
Article
Multidisciplinary Sciences
Shijun Wang, Shu Zhu, Ziili Kang, Xiangxiu Wang, Zixin Deng, Kun Hu, Jianjun Hu, Xiancheng Liu, Guixue Wang, Guangchao Zang, Yuchan Zhang
Summary: In this study, gold nanoparticles/reduced graphene oxide (Au/rGO) composites were synthesized to promote and modulate the luminescence of tris(2,2 ' -bipyridine) ruthenium(II) (Ru(bpy)32+). The size of the gold nanoparticles affected the luminescence of Ru(bpy)32+. This method achieved a good linear range and a low limit of detection for detecting carcinoembryonic antigen.
Article
Chemistry, Analytical
Zihui Liang, Yixin Nie, Xin Zhang, Peilin Wang, Qiang Ma
Summary: A novel multiplex electrochemiluminescence polarization assay was developed to detect breast cancer-related genes BRCA1 and BRCA2 simultaneously. The study revealed the relation between the structure of metal nanomaterials and SPC-ECL, and a high polarization-resolved sensing system was designed to detect multitarget DNA. Polarization-based multiple ECL analysis has broad prospects in related cancer diagnosis and treatment evaluation.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Hongying Jia, Jingshuai Li, Lei Yang, Dawei Fan, Xuan Kuang, Xu Sun, Qin Wei, Huangxian Ju
Summary: The utilization of HDS-CuCo2O4@Cu2O heterostructures as coreaction accelerators greatly enhances the NIR ECL performance of AuNCs. The use of L-methionine templated AuNCs allows for nondestructive detection with improved susceptibility and circumambient adaptability. The introduction of a well site-oriented fixation strategy preserves the bioactivity of antibodies and enhances the incubation performance. The NIR immunosensor achieved ultrasensitive analysis of CYFRA21-1 with a wide linear range and low limit of detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)