Review
Clinical Neurology
Giovanni D'Andrea, Antonina Gucciardi, Alberta Leon
Summary: The pathogenesis of primary headaches, such as migraine and cluster headache, is still debated. This review discusses the possible role of tyrosine and tryptophan metabolism in these conditions, emphasizing neurotransmitter and neuromodulator abnormalities. The study finds important abnormalities in tyrosine-related metabolites in chronic migraine patients, and significantly lower plasma tryptamine levels in both chronic migraine and chronic tension-type headache patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Iris Hardege, Julia Morud, Amy Courtney, William R. Schafer
Summary: This study identifies multiple new inhibitory ion channels with diverse ligand activation properties in Caenorhabditis elegans. These channels have inhibitory effects on acetylcholine and also show both excitatory and inhibitory effects on other major neurotransmitters. The findings shed light on the important role of diverse ligand-gated ion channels in generating complexity in a compact anatomical nervous system.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Du Won Jeong, Kyuhyoung Kim, Geonhee Lee, Minsoung Kang, Hyunju Chang, A-Rang Jang, Jeong-O Lee
Summary: In this study, we demonstrated that the direct intercalation of alkali-metal cations is not necessary for the redox reaction of Prussian blue. Passivation of Prussian blue thin films with monolayer graphene preserved its electrochemical activity and enhanced its stability. We also showed the potential of a transparent graphene electrode as an efficient hydrogen peroxide transducer.
Review
Entomology
Francesca Barbero, Giuseppe Mannino, Luca Pietro Casacci
Summary: Insects with highly structured societies rely on the coordination of individuals and the regulation of biogenic amines to achieve social behavior. This study reviews the potential role of biogenic amines in modulating insect social behavior, particularly in ants. It also provides an analysis of research trends and interests related to biogenic amines in social insects.
Article
Medicine, Research & Experimental
Andy Hsien Wei Koh, Russ Chess-Williams, Anna Elizabeth Lohning
Summary: The study found that the trace amines p-tyramine, p-synephrine, and p-octopamine induced similar vasoconstrictor responses in porcine renal arteries, but their mechanisms of action appeared to differ. Tyramine seemed to mainly mediate constriction of the renal artery via an indirect sympathomimetic mechanism, while synephrine and octopamine exerted additional direct effects on a1-adrenoceptors.
Review
Entomology
Luca Finetti, Thomas Roeder, Girolamo Calo, Giovanni Bernacchia
Summary: This review comprehensively describes the molecular, structural characteristics, and functions of type 1 tyramine receptors (TAR1s) in insects, with a special focus on the important roles of TAR1 in physiology, behavior, and pharmacology. In addition, it explores the design of insecticides based on TAR1 and the development of pest management strategies for insect control.
Review
Biochemical Research Methods
Mandana Amiri, Khadijeh Nekoueian, Reyhaneh Sadat Saberi
Summary: Research on graphene-based carbon nanocomposites has significantly increased in recent years, with functionalized graphene structures like graphene oxide and reduced graphene oxide showing great potential in novel electrochemical sensors. Aptamers-based electrochemical sensors have gained attention for their high sensitivity, selectivity, simplicity, and low cost.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Parag P. Chavan, Vijay S. Sapner, Bhaskar R. Sathe
Summary: This study demonstrates the electrochemical oxidation of nitrite using a metal-free, highly stable, and selective biomolecule - tyramine functionalized graphene oxide (GT) as an electrocatalyst. The successful functionalization of biomolecule on graphene was achieved through a simple chemical method, and the surface features were characterized using various spectroscopic and microscopic techniques. The biomolecule functionalized graphene oxide showed enhanced electrochemical activity and stability for nitrite oxidation, highlighting its potential as an effective electrocatalyst for environmental remediation.
Article
Fisheries
Hsin-Wei Kuo
Summary: Stress has an impact on the immune systems, growth, and reproduction of aquatic organisms, which is related to the synthesis pathway of octopamine (OA). This study reveals the changes in the expression of tyramine beta hydroxylase (TBH), and its correlation with OA levels, in Litopenaeus vannamei under various stress conditions.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biophysics
Wenxi Lu, Xixiang Xie, Xianli Lan, Pan Wu, Hongmei Peng, Jian He, Liping Zhong, Xiyu Liu, Zhiming Deng, Zhenkai Tan, Aiqun Wu, Liang Shi, Yong Huang
Summary: An ultrasensitive electrochemical immunosensor was developed for the detection of Glypican-3 (GPC3), a liver cancer marker. This sensor utilized the signal amplification of electro-active ferrocene-tyramine (Fc-Tyr) molecule deposition, catalyzed by horseradish peroxidase (HRP). The sensor demonstrated high selectivity and sensitivity to GPC3, and was validated through simultaneous testing with ELISA in clinical liver cancer patients.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Sherry J. Cheriyamkunnel, Saloni Rose, Pedro F. Jacob, Lauren A. Blackburn, Shaleen Glasgow, Jacob Moorse, Mike Winstanley, Patrick J. Moynihan, Scott Waddell, Carolina Rezaval
Summary: This study describes how fruit flies make decisions between feeding and courtship behaviors, with nutritional status playing a key role in prioritizing these actions. The tyramine signaling pathway is identified as essential for mediating this decision-making process, with tyramine levels modulating the activity of neurons controlling food-seeking and courtship behaviors.
Article
Biochemistry & Molecular Biology
Viknasvarri Ayerdurai, Maciej Cieplak, Krzysztof R. Noworyta, Marianna Gajda, Agnieszka Ziminska, Marta Sosnowska, Joanna Piechowska, Pawel Borowicz, Wojciech Lisowski, Shuai Shao, Francis D'Souza, Wlodzimierz Kutner
Summary: The electrochemical sensor with MIP film was developed for selective determination of tyramine, with a detection limit of 159 and 168 μM. The sensor showed a linear dynamic range from 290 μM to 2.64 mM, high selectivity, and an apparent imprinting factor of 5.6.
BIOELECTROCHEMISTRY
(2021)
Article
Neurosciences
Hui Liu, Jing-Jing Wu, Rong Li, Ping-Zhou Wang, Jia-Hao Huang, Yu Xu, Jia-Lu Zhao, Piao-Ping Wu, Si-Jia Li, Zheng-Xing Wu
Summary: In this study, the researchers found that the interaction between ASH and ADL neurons enhances Caenorhabditis elegans' avoidance behavior towards mild and medium hyperosmolality. This interaction is mediated through a negative feedback circuit involving ASH, ADL, and RIM interneurons. Additionally, multiple sensory neurons, including ASH and ADL, are involved in hyperosmotic sensation and avoidance behavior.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Microbiology
Patrick Vudriko, Rika Umemiya-Shirafuji, Dickson Stuart Tayebwa, Joseph Byaruhanga, Benedicto Byamukama, Maria Tumwebaze, Xuenan Xuan, Hiroshi Suzuki
Summary: This study characterized the OCT/Tyr receptor gene of amitraz-resistant and -susceptible R. (B.) decoloratus ticks from Uganda, revealing four novel amino acid mutations associated with amitraz resistance. However, the absence of mutations in the OCT/Tyr gene fragment for some resistant ticks suggests the presence of other resistance mechanisms.
Article
Chemistry, Analytical
Md Faruk Hossain, Stephanie McCracken, Gymama Slaughter
Summary: A fully integrated dissolved oxygen sensor was fabricated using laser induced graphene, demonstrating excellent catalytic activity towards the reduction of oxygen with high sensitivity and fast response time. The sensor showed good performance in detecting oxygen levels in cell culture systems, offering great promise for biomedical and environmental applications.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Junji Li, Zi-Xuan Liu, Yi-Xuan Li, Guofang Shu, Xue-Ji Zhang, Robert S. Marks, Dan Shan
Summary: In this study, a tailored metal-organic framework transducer material Cu BDC(NH2)@2-MI was synthesized using 2-methylimidazole as a competitive ligand, which allowed for the modulation of its morphology and catalytic activity. The 2-MI-doped MOF exhibited well-tuned morphology and showed efficient performance in electrochemical H2O2 reduction. This novel design could potentially enable the utilization of proprietary MOFs materials beyond the laboratory.
Article
Chemistry, Analytical
Haobo Sun, Jingliang Liu, Yunliang Qiu, Jinming Kong, Xueji Zhang
Summary: A highly sensitive and selective biosensor for methamphetamine detection was designed using aptamer recognition probe and ATRP signal amplification. The sensor could detect METH as low as 17 fM, with a recovery rate of 93% in serum and urine. This approach shows promising potential for sensitive detection of low concentration toxicants.
Article
Chemistry, Analytical
Jingyu Xiao, Chuan Fan, Tailin Xu, Lei Su, Xueji Zhang
Summary: In this study, a simple, wearable, noninvasive, and portable metal-organic framework (MOF)-based electrochemical sensor was developed for monitoring the concentration of levodopa in sweat, which can serve as a proxy for the levels of L-dopa in the body. The sensor showed a wide linear response range, low detection limit, good selectivity, high sensitivity, and stability.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Chemistry, Analytical
Chenyu Ren, Tong Shu, Xin Du, Linzhi Yang, Lei Su, Xueji Zhang
Summary: This article reviews the mechanisms, structures and properties of nanoclusters formed by coinage metals, such as Cu, Ag and Au, and focuses on the assembly and analysis processes of nanocluster sensor platforms and provides examples of applications.
Article
Environmental Sciences
Jeyaraj Jeyavani, Ashokkumar Sibiya, Narayanan Gopi, Shahid Mahboob, Khalid A. Al-Ghanim, Fahad Al-Misned, Zubair Ahmed, Mian Nadeem Riaz, Balasubramanian Palaniappan, Marimuthu Govindarajan, Baskaralingam Vaseeharan
Summary: Polypropylene microplastics are the main contaminant in aquatic environments, but research on their toxicity is limited. This study demonstrates that acute exposure to polypropylene microplastics causes immobility in Daphnia similis and enhances the generation of reactive oxygen species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Analytical
Yan Huang, Yiyi Zhang, Wenbin Hao, Huiting Lu, Haifeng Dong, Xueji Zhang
Summary: To achieve fast, convenient, and highly sensitive detection of microRNA (miRNA), palladium-gold (Pd-Au) bimetallic nanoplates with high photothermal effect were synthesized and combined with locked nucleic acid (LNA) detection probe to develop a photothermal lateral flow locked nucleic acid biosensor (P-LFLNAB) for miRNA detection. The P-LFLNAB enables sensitive and selective miRNA-21 detection with detection limit down to 0.094 pM using a smartphone with external thermal imager, which is 639.5 times lower than that of the conventional gold nanoparticles based colorimetric lateral flow biosensor and the most sensitive enzyme-free lateral flow biosensor for miRNA detection. Besides, the P-LFLNAB achieved single-base mismatch discrimination and can quantify signals in various cell lysates. This highly sensitive, selective and portable P-LFLNAB with smartphone readout has great potential in point-of-care test of miRNAs-related biomedical application.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Xiangdan Meng, Sirong Sun, Chenchen Gong, Junyan Yang, Zhou Yang, Xueji Zhang, Haifeng Dong
Summary: In this study, we report the design of a Ti-based metal-organic framework (MIL) and silver nanoparticles (Ag NPs) heterostructure, MIL@Ag. It is found that the introduction of Ag NPs significantly improves the electron transfer efficiency and O2 adsorption capacity of MIL, leading to enhanced reactive oxygen species (ROS) generation for sonodynamic therapy (SDT). Under ultrasound irradiation, the activated electrons and holes from MIL and Ag NPs produce superoxide radicals and hydroxyl radicals, respectively, improving the therapeutic efficiency of SDT. MIL@Ag-PEG-mediated SDT demonstrates effective cancer cell killing and bacterial infection eradication. Thus, MIL@Ag-PEG provides a promising strategy for enhancing SDT performance through rational heterostructure design of sonosensitizers.
Article
Chemistry, Analytical
Shuangshuang Yang, Jinya Du, Menglian Wei, Yan Huang, Yufan Zhang, Yeyu Wang, Jinze Li, Wei Wei, Yuchun Qiao, Haifeng Dong, Xueji Zhang
Summary: Rapid, simple, sensitive and reliable approaches for quantifying biogenic amines in food samples are essential for food safety. Here, the authors reported a Fe3O4@Au nanoparticles based multimodal readout LFIA for rapid quantification of putrescine and histamine. The assay showed high sensitivity and could be easily expanded to detect other biogenic amines.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biophysics
Mengyun Zhou, Yong Luo, Lirong Wang, Chuan Fan, Tailin Xu, Xueji Zhang
Summary: The outbreak of COVID-19 has posed a great challenge to global health systems. A rapid and sensitive POCT diagnostic platform for SARS-CoV-2 that can be deployed on-site is crucial in containing the epidemic. A portable microdroplet detection platform with temperature control and micro-stirring has been developed, enabling high-throughput and ultrafast COVID-19 diagnosis. The platform, utilizing a PN junction as the temperature controller and incorporating an ultrasonic micro-stirring unit, shows good linearity and low LOD, providing results in a short time. This integrated platform offers a promising tool for point-of-care diagnosis of COVID-19 in resource-limited settings.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Kun Yu, Mengjie Li, Huining Chai, Qian Liu, Xin Hai, Mingwei Tian, Lijun Qu, Tailin Xu, Guangyao Zhang, Xueji Zhang
Summary: This study presents a portable colorimetric and electrochemical dual-mode sensor based on MOF-818 nanozyme for the detection of cellular secreted H2O2 and H2S. The sensor enables accurate detection of H2O2 and H2S through colorimetric and electrochemical methods. By combining with a smartphone and miniature electrochemical analyzer, it allows for in situ detection of H2O2 and H2S released from live cells, showcasing potential applications in various fields.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Tingyi Yan, Guangyao Zhang, Kun Yu, Huining Chai, Mingwei Tian, Lijun Qu, Haifeng Dong, Xueji Zhang
Summary: Maintaining normal levels of vitamin C is crucial for a healthy immune system. The development of real-time non-invasive wearable sensors for monitoring vitamin C in sweat shows promise in personalized health management. In this study, a smartphone light-driven enzyme-free wearable photoelectrochemical sensor was presented for precise monitoring of sweat vitamin C.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Xiaofeng Jin, Lin Zha, Fan Wang, Yongzhong Wang, Xueji Zhang
Summary: Respiration monitoring is a promising alternative to medical diagnosis, but current techniques have limitations due to expensive and cumbersome devices. This study presents a fully integrated wearable device consisting of a flexible LCP-copper interdigital electrode, a sensing layer, and a wireless electrochemical analysis system. The developed humidity sensor shows high sensitivity and rapid response/recover time, with long-term stability under different humidity levels. By integrating with a miniaturized electrochemical analysis system, the response current related to respiration can be wirelessly transmitted to a smartphone for real-time monitoring, and it can also monitor skin moisture in a touchless way.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Arsh E. Noor, Zaib Un Nisa, Salma Sultana, Khalid A. Al-Ghanim, F. Al-Misned, Mian Nadeem Riaz, Z. Ahmed, Shahid Mahboob
Summary: Heavy metal contamination is a serious global environmental issue that harms soil and plant growth. Wastewater has become an essential source of irrigation in developing countries and rural areas due to the scarcity of canal water. This study found that spinach irrigated with sanitary wastewater exceeded the permissible limits of heavy metal concentration, posing potential health risks to humans.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Chemistry, Analytical
Yaodong Hu, Shuaibing Yu, Nan Ma, Jinming Kong, Xueji Zhang
Summary: In this study, a Rose Bengal-Mediated photoinduced atom transfer radical polymerization (photo-ATRP) method was used to achieve highly sensitive detection of target DNA (tDNA), which is of great significance in the field of early disease screening.
Review
Materials Science, Multidisciplinary
Xuhua Liu, Jinlei Miao, Qiang Fan, Wenxiao Zhang, Xingwei Zuo, Mingwei Tian, Shifeng Zhu, Xueji Zhang, Lijun Qu
Summary: With the rapid development of smart products, flexible and stretchable smart wearable electronic devices are considered as pioneers in the new generation of flexible electronic devices. Flexible strain sensors, known for their good flexibility, high sensitivity, high repeatability, and potential in personal healthcare and motion detection, have been widely studied. Unlike traditional bulky sensors, these lightweight portable devices with excellent mechanical and electrical performance meet personalized needs and are becoming more popular.
ADVANCED FIBER MATERIALS
(2022)
