Article
Gastroenterology & Hepatology
Daniel Bushyhead, Eamonn M. M. Quigley
Summary: The concept of small intestinal bacterial overgrowth (SIBO) explains the cause of maldigestion and malabsorption. With the development of diagnostic testing, the methods for diagnosing SIBO have evolved from small bowel culture to breath tests and culture-independent microbial analytics. The availability of breath tests has led to an expansion in the diagnosis of SIBO and the associated clinical symptoms. However, issues with the specificity of breath tests have raised doubts about the role of SIBO in certain clinical scenarios. The hope is to use modern molecular microbiology to study the human small intestinal microbiome in order to provide an objective basis for diagnosing SIBO.
Review
Infectious Diseases
Yorinobu Maeda, Teruo Murakami
Summary: Small intestinal bacterial overgrowth (SIBO) is characterized by an increase in the number and/or alteration in the type of bacteria in the upper gastrointestinal tract, causing various bowel symptoms. SIBO can be diagnosed using microbial culture or breath tests after carbohydrate ingestion. However, these methods have limitations and risks. Urinary excretion tests using bile acid conjugates have shown potential as diagnostic substrates for SIBO. PABA-UDCA disulfate offers a simple and rapid method for evaluating SIBO. Treatments for SIBO include antibiotics, probiotics, therapeutic diets, herbal medicines, and fecal microbiota transplantation.
Article
Microbiology
Irina Efremova, Roman Maslennikov, Aliya Alieva, Elena Poluektova, Vladimir Ivashkin
Summary: The aim of this study was to determine whether the presence of small intestinal bacterial overgrowth (SIBO) affects the prognosis in cirrhosis. A total of 50 patients were included in this prospective cohort study and underwent lactulose hydrogen breath test for SIBO. The results showed that SIBO is associated with poor prognosis in cirrhosis.
Review
Nutrition & Dietetics
Anna Gudan, Dominika Jamiol-Milc, Victoria Hawrylkowicz, Karolina Skonieczna-Zydecka, Ewa Stachowska
Summary: Bacterial overgrowth in the small intestine (SIBO) is associated with non-alcoholic fatty liver disease (NAFLD). This systematic review and meta-analysis found that the prevalence of SIBO in patients with chronic non-alcoholic liver diseases can be as high as 35%, and it increases with the percentage of men in the population. However, further research is needed due to the moderate to low quality of included studies and high heterogeneity.
Article
Gastroenterology & Hepatology
Daanish A. Siddique, Claire L. Jansson-Knodell, Anita Gupta, Gage Howard, Matthew E. Bohm, Robert M. Siwiec, David E. Nelson, Andrea S. Shin, John M. Wo
Summary: This study investigated whether different types of small intestinal bacterial overgrowth (SIBO) lead to different symptoms. The study found that overgrowth of bacteria in the oropharyngeal and respiratory tract was more associated with abdominal distention, while overgrowth of bacteria in the distal small bowel and colon was more associated with iron deficiency.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Huaizhu Guo, Siqi Lu, Jindong Zhang, Chen Chen, Yanlin Du, Kun Wang, Liping Duan
Summary: This study aims to evaluate the effects of berberine compared to rifaximin in SIBO patients. 180 patients will be recruited and divided into two groups for treatment, with the effectiveness and safety assessed. The findings of this study may have implications for the management of SIBO, increasing awareness among physicians and patients about long-term abdominal discomfort and excessive examination.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Daniel Bushyhead, Eamonn M. Quigley
Summary: The concept of SIBO has undergone significant changes and challenges, with uncertainty and controversy surrounding its diagnosis. This review aims to discuss the current pathophysiology of SIBO.
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2021)
Article
Gastroenterology & Hepatology
Roman Maslennikov, Vladimir Ivashkin, Irina Efremova, Elena Poluektova, Anna Kudryavtseva, George Krasnov
Summary: This study found a relationship between small intestinal bacterial overgrowth (SIBO) and gut dysbiosis in patients with cirrhosis. Patients with SIBO had higher levels of Firmicutes and Fusobacteria, and lower levels of Bacteroidetes compared to patients without SIBO. However, gut dysbiosis and SIBO are likely independent disorders in cirrhosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Microbiology
Jia Li, Ru Zhang, Jinxia Ma, Shuai Tang, Yuan Li, Yi Li, Jun Wan
Summary: This study thoroughly investigated the gut microbial profile of patients with SIBO, finding significant differences in bacterial compositions between fecal and mucosal samples, as well as potential microbial biomarkers in the mucosa-associated gut microbiome. Further research is needed to explore the mechanisms and roles of these mucosa-associated taxa in SIBO.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Juan Wei, Jing Feng, Liya Chen, Zhao Yang, Hui Tao, Liuying Li, Ji Xuan, Fangyu Wang
Summary: This study revealed a high prevalence of SIBO in patients with CD and its independent association with clinical relapse in patients in remission, with SIBO and penetrating disease behavior being the main risk factors for relapse in individuals with quiescent CD.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Neha Durgam, Ankur A. Dashputre, Olga Moshkovich, Ali Rezaie, Nicholas Martinez, Pedram Enayati, James Stansbury, George Joseph
Summary: The purpose of this study was to develop and validate a new PRO instrument, the SIBO Symptom Measure (SSM) daily diary. The SSM assesses symptom severity in SIBO patients, aiming to provide a PRO tool for endpoint measurement.
QUALITY OF LIFE RESEARCH
(2023)
Article
Nutrition & Dietetics
Raymond J. Playford, Naheed Choudhry, Paul Kelly, Tania Marchbank
Summary: The study examined the effects of bovine colostrum (BC), chicken eggs, or their combination on bacterial-induced damage associated with SIBO and infectious diarrhea. Results showed that BC and eggs could reduce these effects and enhance mucosal integrity against a variety of relevant bacteria.
Review
Biochemistry & Molecular Biology
Adela Danau, Laura Dumitrescu, Antonia Lefter, Delia Tulba, Bogdan Ovidiu Popescu
Summary: There is a close connection between the gut microbiota and the brain via the gut-brain axis, with Small Intestinal Bacterial Overgrowth (SIBO) potentially playing a role in the progression of Parkinson's disease (PD). SIBO can be eradicated with antibiotics, but may reappear if predisposing factors persist, highlighting its potential impact on the development of PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Xin Feng, Xiao-Qing Li
Summary: This systematic review and meta-analysis found that the prevalence of SIBO in diabetic patients was 29%, and the risk of SIBO in diabetic patients was 2.91 times higher than that in patients without diabetes. The prevalence of SIBO in diabetes was higher in studies using jejunal aspirate culture for diagnosis and in studies conducted in Western countries.
Article
Pharmacology & Pharmacy
Kaifan Bao, Meiling Wang, Li Liu, Dongya Zhang, Cuiyuan Jin, Junfeng Zhang, Liyun Shi
Summary: This study demonstrates that Jinhong Decoction can significantly improve the survival rate of septic mice and alleviate infection-related lung inflammation and injury. The protective role of JHD is mediated through the regulation of gut microbiota and restoration of intestinal barrier function. This research reveals the mechanism of gut bacteria migration leading to sepsis-associated acute lung injury and highlights the potential of JHD as an effective treatment strategy.
FRONTIERS IN PHARMACOLOGY
(2023)