Review
Pharmacology & Pharmacy
Arnela Saljic, Thomas Jespersen, Rikke Buhl
Summary: Atrial fibrillation is becoming a serious health problem in the aging population. Animal models, particularly large animals like pigs, goats, dogs, and horses, are important tools in understanding the mechanisms of AF and testing new pharmacological interventions. This review focuses on anti-arrhythmic investigations in large animals, discussing commonly used methods for inducing AF and exploring potential new AF medication candidates.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Environmental Sciences
Qiuxia Song, Xianwei Guo, Chenyu Sun, Wanying Su, Ning Li, Hao Wang, Qiwei Liang, Mingming Liang, Xiuxiu Ding, Yehuan Sun
Summary: Exposure to noise is associated with a higher risk of atrial fibrillation (AF).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Loryn J. Bohne, Hailey J. Jansen, Tristan W. Dorey, Irene M. Daniel, K. Lockhart Jamieson, Darrell D. Belke, Megan D. Mcrae, Robert A. Rose
Summary: This study demonstrates that GLP-1 and its analogues can reduce the incidence of atrial fibrillation and prevent atrial remodeling in patients with type 2 diabetes.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Physiology
Hailey. J. J. Jansen, Megan. D. D. McRae, Martin Mackasey, Robert. A. A. Rose
Summary: The study revealed that Ang II mediated atrial electrical and structural remodeling develop earlier and more extensively in the left atrium compared to the right atrium, leading to enhanced AF susceptibility.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tim De Coster
Summary: A new study has revealed a fully biological, shock-free method for cardioversion of atrial fibrillation, which may provide a new treatment approach for patients with AF.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Physiology
Wenli Dai, Sneha Kesaraju, Christopher R. Weber
Summary: Healthy cardiac conduction relies on coordinated electrical activity of distinct populations of cardiomyocytes. Disruption of cell-cell conduction can lead to cardiac arrhythmias, with genetic factors potentially playing a major role in the development of atrial fibrillation by disrupting calcium handling mechanisms. Further research into how genetic alterations can trigger arrhythmias provides insights into the pathogenesis of atrial fibrillation.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jordi Heijman, Stefan H. Hohnloser, A. John Camm
Summary: This review summarizes important milestones in AAD research that have shaped their current role in AF management, including awareness of the proarrhythmic potential of AADs, increasing understanding of the pleiotropic effects of AADs, the development of dronedarone, and the search for AF-specific AADs. Potential short- and long-term opportunities for better AF management through advances in AAD therapy, including personalization of AAD therapy based on individual AF mechanisms, are also discussed.
Article
Genetics & Heredity
Oliver Bundgaard Vad, Yannan Yan, Federico Denti, Gustav Ahlberg, Lena Refsgaard, Sofia Hammami Bomholtz, Joana Larupa Santos, Simon Rasmussen, Stig Haunso, Jesper Hastrup Svendsen, Ingrid Elizabeth Christophersen, Nicole Schmitt, Morten Salling Olesen, Bo Hjorth Bentzen
Summary: AF is a common sustained cardiac arrhythmia with complex pathogenesis, and rare genetic variants in the CACNA1A gene have been identified in patients with familial AF, suggesting a potential novel link between ion channel dysfunction and increased risk of AF.
FRONTIERS IN GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Dorothee Jakob, Alexander Klesen, Benoit Allegrini, Elisa Darkow, Diana Aria, Ramona Emig, Ana Simon Chica, Eva A. Rog-Zielinska, Tim Guth, Friedhelm Beyersdorf, Fabian A. Kari, Susanne Proksch, Stephane N. Hatem, Matthias Karck, Stephan R. Kunzel, Helene Guizouarn, Constanze Schmidt, Peter Kohl, Ursula Ravens, Remi Peyronnet
Summary: The study found that human atrial fibroblasts contain at least two types of ion channels activated during stretch: Piezol and BKca. Sustained atrial fibrillation is associated with increased Piezol and decreased BKca activity, indicating differential regulation of these channels.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Review
Computer Science, Artificial Intelligence
Lei Li, Veronika A. Zimmer, Julia A. Schnabel, Xiahai Zhuang
Summary: This paper provides a systematic review of computing methods for the segmentation and quantification of left atrial (LA) cavity, wall, scar, and ablation gap from late gadolinium enhancement magnetic resonance imaging (LGE MRI), as well as the related literature for atrial fibrillation (AF) studies. The review suggests that there is still a large scope for further algorithmic developments in this field due to performance issues related to the high variability of enhancement appearance and differences in image acquisition.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Health Care Sciences & Services
Lulu Yang, Hongliang Feng, Sizhi Ai, Yue Liu, Binbin Lei, Jie Chen, Xiao Tan, Christian Benedict, Ningjian Wang, Yun Kwok Wing, Lu Qi, Jihui Zhang
Summary: Evidence suggests a potential relationship between circadian rhythm and atrial fibrillation (AF), however, it is largely unknown whether circadian disruption can predict the onset of AF in the general population. This study aimed to investigate the association between accelerometer-measured circadian rest-activity rhythm (CRAR) and the risk of AF, as well as examine the joint associations and potential interactions of CRAR and genetic susceptibility with AF incidence. The results indicate that low amplitude, delayed acrophase, and low mesor are significantly associated with a higher risk of AF.
NPJ DIGITAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yusuke Ebana, Lian Liu, Kensuke Ihara, Keiko Abe, Chikashi Terao, Yoichiro Kamatani, Tetsuo Sasano, Tetsushi Furukawa
Summary: This study aimed to explore novel ischemic stroke risk variants in patients with a history of atrial fibrillation (AF), and to investigate their associations with CHADS2 and CHA2DS2-VASc scores. By conducting an association study on 8181 AF cases, we identified eight genetic loci that were potentially associated with the risk of ischemic stroke. Further analysis showed that these associations were independent of CHADS2 or CHA2DS2-VASc scores.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Plant Sciences
Hongyan Yin, Yu Yan, Wei Hu, Guoyin Liu, Hongqiu Zeng, Yunxie Wei, Haitao Shi
Summary: This study identified specific SNPs affecting ionomic variation in cassava through genome-wide association studies, with some SNPs associated with both calcium and magnesium. Many loci for different ionomic traits appear to be clustered on specific chromosome regions. The study also found peak SNPs in promoter regions of genes related to nitrogen and phosphorus accumulation, positively modulating nutrient levels in cassava.
Article
Physiology
Rebecca Belletti, Lucia Romero, Laura Martinez-Mateu, Elizabeth M. Cherry, Flavio H. Fenton, Javier Saiz
Summary: Three gain-of-function mutations related to atrial fibrillation have been found to increase arrhythmogenicity at both single-cell and tissue levels, with effects including higher current density, shortened action potential duration, and sustained rotor initiation. Different tissue types show varied susceptibilities to rotor initiation and maintenance, with pulmonary vein tissues being more prone to rotor initiation.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Yalin Cao, Xiao Liu, Zhengbiao Xue, Kang Yin, Jianyong Ma, Wengen Zhu, Fuwei Liu, Jun Luo, Junyi Sun
Summary: This meta-analysis suggests that coffee consumption is associated with a trend towards reducing the risk of atrial fibrillation in a dose-response manner, although the results were not statistically significant. An increase in daily coffee consumption of one cup was associated with a 2% reduced risk of atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yuki Sahashi, Toshiki Kuno, Yoshihiro Tanaka, Rod Passman, Alexandros Briasoulis, Aaqib H. Malik
Summary: This study aimed to evaluate the all-cause readmission rates within 30-days among patients receiving catheter ablation for atrial fibrillation with a same-day discharge protocol compared with a conventional overnight stay. The results showed no significant difference in the 30-day all-cause readmission following same-day discharge for catheter ablation compared with overnight stay.
Article
Pathology
Yumiko Fukuda, Yoshihiro Tanaka, Ken Eto, Natsuko Ukai, Shoko Sonobe, Hiroyuki Takahashi, Masahiro Ikegami, Masayuki Shimoda
Summary: Perineural invasion (PNI) is a poor prognostic factor in colorectal cancer (CRC), particularly in stage I/II, and may be associated with immunosuppression in the tumor microenvironment.
PATHOLOGY INTERNATIONAL
(2022)
Article
Neurosciences
Yusuke Tomita, Yosuke Shimazu, Agila Somasundaram, Yoshihiro Tanaka, Nozomu Takata, Yukitomo Ishi, Samantha Gadd, Rintaro Hashizume, Angelo Angione, Gonzalo Pinero, Dolores Hambardzumyan, Daniel J. Brat, Christine M. Hoeman, Oren J. Becher
Summary: The tumorigenic effects of H3.3K27M are found to be cell-of-origin dependent, with this mutation being more oncogenic in Nestin+ cells than Olig2+ cells. Additionally, the requirement for H3.3K27M is reduced when tumorigenesis is initiated in Olig2+ cells.
Article
Cardiac & Cardiovascular Systems
Takuya Nakahashi, Hayato Tada, Kenji Sakata, Taiji Yoshida, Yoshihiro Tanaka, Akihiro Nomura, Hidenobu Terai, Yuki Horita, Masatoshi Ikeda, Masanobu Namura, Masayuki Takamura, Masa-aki Kawashiri
Summary: This study aims to explore the association between uric acid (UA) and long-term outcomes in patients with acute coronary syndrome (ACS). The results show a "J-shaped" association between UA levels upon admission and all-cause mortality in ACS patients who underwent PCI.
INTERNATIONAL HEART JOURNAL
(2022)
Article
Genetics & Heredity
Jianjun Huang, Li Liu, Lingling Qin, Hehua Huang, Xue Li
Summary: This study utilized single-cell transcriptomics to reveal cellular heterogeneity and identified the importance of endothelial cells in Parkinson's disease (PD). Five upregulated marker genes of endothelial cells were identified as potential therapeutic targets for PD.
FRONTIERS IN GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Iwanari Kawamura, Toshiki Kuno, Yuki Sahashi, Yoshihiro Tanaka, Rod Passman, Alexandros Briasoulis, Aaqib H. Malik
Article
Cardiac & Cardiovascular Systems
Kenshi Hayashi, Yoshihiro Tanaka, Toyonobu Tsuda, Akihiro Nomura, Noboru Fujino, Hiroshi Furusho, Norihiko Sakai, Yasunori Iwata, Soichiro Usui, Kenji Sakata, Takeshi Kato, Hayato Tada, Takashi Kusayama, Keisuke Usuda, Masa-Aki Kawashiri, Rod S. Passman, Takashi Wada, Masakazu Yamagishi, Masayuki Takamura
Summary: This study aimed to identify factors associated with the development of worsening kidney function (WKF) in patients with non-valvular atrial fibrillation (NVAF). The study found that age ≥ 75 years, heart failure, diabetes mellitus, and anemia were independently associated with incident WKF. For patients with these risk factors, monitoring kidney function and appropriate interventions may be important.
Article
Cardiac & Cardiovascular Systems
Jessica M. Duke, Lutfiyya N. Muhammad, Jing Song, Yoshihiro Tanaka, Celeste Witting, Sadiya S. Khan, Rod S. Passman
Summary: Black patients are less likely to undergo AFCA compared with White patients, despite similar referral rates.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Immunology
Bin He, Ya Zhan, Chunyu Cai, Dianyou Yu, Qinjiang Wei, Liping Quan, Da Huang, Yan Liu, Zhile Li, Li Liu, Xingshou Pan
Summary: CX3CR1 and HBB genes can be used as common biomarkers in both TAA and AAA, and they are associated with a high infiltration of innate and adaptive immune cells in aortic aneurysms. Furthermore, CX3CR1 and HBB are highly correlated with immune cell infiltration and may serve as potential targets for immunotherapeutic drugs. Gene mutation research holds promise for the treatment of aortic disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bin He, Li-Ping Quan, Chun-Yu Cai, Dian-You Yu, Wei Yan, Qin-Jiang Wei, Zhen Zhang, Xian-Nan Huang, Li Liu
Summary: This study identified key genes and immune-related pathways involved in the progression of cardiomyopathy from various etiologies. CD14, CCL2, and SERPINA3 were revealed as promising biomarkers for distinguishing cardiomyopathy from non-cardiomyopathy individuals, with SERPINA3 showing the best diagnostic performance. T cell immunity and innate immune responses play crucial roles in cardiomyopathy progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Yutaka Umemura, Kazuma Yamakawa, Yoshihiro Tanaka, Jumpei Yoshimura, Hiroshi Ogura, Satoshi Fujimi
Summary: This study aimed to evaluate the survival effect associated with carbapenems as initial therapy for sepsis compared with other antibiotics. The study found that carbapenems did not significantly reduce mortality compared to noncarbapenem broad-spectrum beta-lactam antibiotics.
CRITICAL CARE MEDICINE
(2023)
Article
Health Care Sciences & Services
Sarah Chuzi, Yoshihiro Tanaka, Avni Bavishi, Matthew Bruce, Lisa B. Van Wagner, Jane E. Wilcox, Faraz S. Ahmad, Daniela P. Ladner, Tara Lagu, Sadiya S. Khan
Summary: This study aimed to evaluate the association between end-stage liver disease (ESLD) and incident heart failure (HF) in a real-world clinical cohort. The study found that patients with ESLD had a higher risk of developing HF, especially HF with preserved ejection fraction.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Keisuke Usuda, Kenshi Hayashi, Tadashi Nakajima, Yasutaka Kurata, Shihe Cui, Takashi Kusayama, Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Kenji Sakata, Soichiro Usui, Noboru Fujino, Yoshihiro Tanaka, Yoshiaki Kaneko, Masahiko Kurabayashi, Shoichi Tange, Takekatsu Saito, Kunio Ohta, Masakazu Yamagishi, Masayuki Takamura
Summary: This study aimed to determine the mechanism by which KCNH2 mutations cause fever-induced QT prolongation and torsades de pointes (TdP). The results showed that the mutations in KCNH2 gene, including G584S, D609G, and T613M, reduced the temperature-dependent increase in current densities and caused prolonged action potential durations and early afterdepolarization formation. These findings indicate that KCNH2 mutations affect the temperature-related current densities, resulting in QT prolongation and TdP in patients with LQT2 during fever.
Article
Medicine, Research & Experimental
Yusuke Tomita, Elizabeth A. Hibler, Yasuki Suruga, Joji Ishida, Kentaro Fujii, Kaishi Satomi, Koichi Ichimura, Nobuyuki Hirotsune, Isao Date, Yoshihiro Tanaka, Yoshihiro Otani
Summary: This study provides a thorough characterization of the incidence and mortality rates of pilocytic astrocytomas (PAs) in the US. The study reveals that the trends in age-adjusted incidence rates and mortality rates of PAs remained constant over the years. It also highlights that older populations, especially those over 60 years old, have a higher risk of death from PAs.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Letter
Cardiac & Cardiovascular Systems
Zachary H. Hughes, Nilay S. Shah, Yoshihiro Tanaka, Michael M. Hammond, Rod Passman, Sadiya S. Khan
Summary: This study on cardiac death was contributed equally by Dr. Lador and Dr. Giudicessi. The study did not involve any participation from Abbott, AliveCor, or Anumana, despite Dr. Ackerman's consulting and equity/royalty relationships with these companies. The authors have disclosed no relevant relationships, and confirm compliance with ethical and regulatory requirements.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)