Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 56, Issue -, Pages 111-116Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.01.024
Keywords
Dosage compensation; Evolutionary tinkering; Paternal imprints; Long non-coding RNA; CpG methylation and escape genes
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X inactivation, a developmental process that takes place in early stages of mammalian embryogenesis, balances the sex difference in dosage of X-linked genes. Although all mammals use this form of dosage compensation, the details differ from one species to another because of variations in the staging of embryogenesis and evolutionary tinkering with the DNA blueprint for development. Such differences provide a broader view of the process than that afforded by a single species. My overview of X inactivation is based on these species variations. (C) 2016 Elsevier Ltd. All rights reserved.
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