Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 54, Issue -, Pages 117-125Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.01.008
Keywords
Meiosis; Double-strand break; Crossover; Sumoylation; Ubiquitination
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Funding
- Stowers Institute for Medical Research
- American Cancer Society Research Professor [RP-05-086-06DDC]
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The proper execution of meiotic recombination (or crossing over) is essential for chromosome segregation during the first meiotic division, and thus this process is regulated by multiple, and often elaborate, mechanisms. Meiotic recombination begins with the programmed induction of DNA double-strand breaks (DSBs), of which only a subset are selected to be repaired into crossovers. This crossover selection process is carried out by a number of pro-crossover proteins that regulate the fashion in which DSBs are repaired. Here, we highlight recent studies regarding the process of DSB fate selection by a family of pro-crossover proteins known as the Zip-3 homologs. (C) 2016 Elsevier Ltd. All rights reserved.
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