Article
Public, Environmental & Occupational Health
Stephen W. Farrell, Kristen J. Meyer, David Leonard, Kerem Shuval, Carolyn E. Barlow, Andjelka Pavlovic, Laura DeFina, William L. Haskell
Summary: This study found that levels of physical activity are positively associated with 25(OH)D levels and negatively associated with measures of adiposity. Higher levels of physical activity attenuate the association between adiposity and 25(OH)D.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Medicine, General & Internal
Maria Reyes Beltran-Valls, Rute Santos, Jorge Mota, Carla Moreira, Luis Lopes, Cesar Agostinis-Sobrinho
Summary: This prospective cohort study found that adiposity mediated the association between cardiorespiratory fitness (CRF) and blood pressure in adolescents, particularly affecting the relationships between CRF and systolic BP, pulse pressure, and rate product pressure.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Ahmad H. Alghadir, Masood Khan
Summary: Knee pain and physical functions in patients with KOA were significantly associated with age, BMI, and K/L grade. K/L grade was the most significant predictor. Age, BMI, and K/L grade explained a significant portion of knee pain and physical functions.
Article
Cardiac & Cardiovascular Systems
Hong Lin, Liping Xuan, Jiali Xiang, Yanan Hou, Huajie Dai, Tiange Wang, Zhiyun Zhao, Shuangyuan Wang, Jieli Lu, Yu Xu, Yuhong Chen, Weiqing Wang, Guang Ning, Yufang Bi, Mian Li, Min Xu
Summary: Changes in BMI significantly modulate the effect of the APOA5 rs662799 genetic variant on dyslipidemia and long-term lipid profile.
Article
Endocrinology & Metabolism
Sarah LeMay-Russell, Natasha A. Schvey, Nichole R. Kelly, Megan N. Parker, Eliana Ramirez, Lisa M. Shank, Meghan E. Byrne, Taylor N. Swanson, Esther A. Kwarteng, Loie M. Faulkner, Kweku G. Djan, Anna Zenno, Sheila M. Brady, Shanna B. Yang, Susan Z. Yanovski, Marian Tanofsky-Kraff, Jack A. Yanovski
Summary: This study found that earlier wake times and sleep midpoints were associated with greater gains in fat mass among youth. Additional research is needed to determine whether adjusting sleep timing could help prevent pediatric obesity.
Article
Pediatrics
David S. Freedman, Jessica G. Woo, Stephen R. Daniels
Summary: This study examined the ability of different BMI metrics to assess adiposity changes in children and found that expressing BMI changes as a percentage of the 50th or 95th percentiles was more strongly associated with changes in body fatness compared to BMIz. Choosing the best BMI metric can help pediatricians better assess a child's change in body fatness over time.
Article
Nutrition & Dietetics
Jamee Guerra Valencia, Willy Ramos, Liliana Cruz-Ausejo, Jenny Raquel Torres-Malca, Joan A. Loayza-Castro, Gianella Zulema Zenas-Trujillo, Norka Rocio Guillen Ponce, Fiorella E. Zuzunaga-Montoya, Mario J. Valladares-Garrido, Victor Juan Vera-Ponce, Jhony A. De La Cruz-Vargas
Summary: The study analyzed the association between fruit intake and body mass index (BMI) and waist circumference (WC) in a representative sample of Peruvians. Fruit intake per serving was found to be negatively related to general body adiposity and central fat distribution. However, the consumption of fruit in the form of juices was positively associated with a significant increase in BMI and WC.
Review
Multidisciplinary Sciences
Waruna L. Peiris, Flavia M. Cicuttini, Sultana Monira Hussain, Mahnuma M. Estee, Lorena Romero, Tom A. Ranger, Jessica L. Fairley, Emily C. McLean, Donna M. Urquhart
Summary: This systematic review found evidence of a relationship between body fat and its central distribution with low back and knee pain, as well as a longitudinal relationship between adiposity and back, knee and foot pain. These results highlight the potential for developing novel treatments at these sites.
Article
Cardiac & Cardiovascular Systems
Ashwinkumar Modi, Rajendra Gadhavi, Cynthia M. Perez, Kaumudi Joshipura
Summary: This study found that lower baseline adiposity and higher reduction in adiposity were associated with regression of prediabetes/diabetes among individuals with overweight/obesity.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Yanhui Li, Tao Ma, Ying Ma, Di Gao, Li Chen, Manman Chen, Jieyu Liu, Bin Dong, Yanhui Dong, Jun Ma
Summary: This study found that childhood adiposity is associated with earlier puberty onset, and body composition has a higher sensitivity than BMI and WC in predicting early puberty. Boys and girls with a high body fat percentage are more likely to experience early puberty compared to those with a low body fat percentage. However, boys and girls with a high fat-free mass/fat mass ratio have a decreased risk of early puberty. Additionally, high-level trajectories of rapid increase in body measurements are also significantly associated with a higher risk of early puberty.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Hannah Oh, So-Young Kwak, Garam Jo, Juhee Lee, Dahyun Park, Dong Hoon Lee, NaNa Keum, Jong-Tae Lee, Edward L. Giovannucci, Min-Jeong Shin
Summary: The study examined the relationships between BMI, waist circumference, predicted body fat mass, and mortality in a Korean population. The results showed a J-shaped association between BMI and all-cause and cardiovascular mortality, with the lowest point at BMI = 25.0-29.9. It was also found that higher waist circumference and predicted body fat mass were positively associated with mortality, suggesting a need for re-evaluation of current overweight criteria for Asians.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Jian Huang, Ying Gui, Hongping Qin, Yubo Xie
Summary: This study evaluated the causal effects of adiposity traits including BMI, body fat percentage, waist circumference, and waist-to-hip ratio on hemorrhoids using Mendelian randomization. The results indicated a positive impact of these adiposity traits on hemorrhoids, supporting the importance of adiposity prevention in reducing the risk of hemorrhoids. The findings were robust and there was evidence against reverse causation, highlighting the potential significance of controlling adiposity for hemorrhoid prevention.
FRONTIERS IN MEDICINE
(2023)
Article
Nutrition & Dietetics
Tsung Yu, Yacong Bo, Ly-Yun Chang, Xudong Liu, Tony Tam, Xiang Qian Lao
Summary: This study found that BMI remains the primary marker for screening excessive adiposity in assessing the risk of mortality. However, waist circumference, waist-to-height ratio, and body fat percentage can also be valuable additional indicators in the evaluation of mortality risk.
CLINICAL NUTRITION
(2021)
Article
Pediatrics
Dan Lin, Didi Chen, Jun Huang, Yun Li, Xiaosa Wen, Ling Wang, Huijing Shi
Summary: The study identified modifiable pre-birth or early-life factors associated with the timing of adiposity peak (AP) and adiposity rebound (AR) in children. Boys were less likely to have a late AP, but preterm born children had a higher risk of a late AP. Children breastfed for longer than 4 months were less likely to have an early AR, while children born to advanced-age mothers and who were born small for gestational age had a higher risk of early AR.
FRONTIERS IN PEDIATRICS
(2021)
Article
Health Care Sciences & Services
Maulik D. Majmudar, Siddhartha Chandra, Kiran Yakkala, Samantha Kennedy, Amit Agrawal, Mark Sippel, Prakash Ramu, Apoorv Chaudhri, Brooke Smith, Antonio Criminisi, Steven B. Heymsfield, Fatima Cody Stanford
Summary: This study evaluated the performance of a novel automated computer vision method, VBC, for estimating percentage total body fat using photos captured with a smartphone camera. The results showed that VBC was more accurate and had minimal bias compared to DXA, indicating great potential for widespread use in assessing body fat levels.
NPJ DIGITAL MEDICINE
(2022)
Article
Rheumatology
Xingzhong Jin, Ilana N. Ackerman, Zanfina Ademi
Summary: Productivity-adjusted life-years (PALYs) provide a novel approach to quantify the productivity burden of chronic conditions in the working population. This study estimated the productivity burden of knee osteoarthritis (KOA) among working-age Australians, resulting in significant productivity loss and an economic impact of 424 billion Australian dollars in lost GDP. Public health funding and scalable population-level strategies are needed for effective KOA prevention and support.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Jason Rogers, Graeme Jones, Jill L. L. Cook, Kathryn Squibb, Andrew Halliday, Karen Wills, Aroub Lahham, Tania Winzenberg
Summary: This study found that certain imaging biomarkers derived from MRI and ultrasonography are associated with chronic plantar heel pain. These biomarkers include calcaneal bone marrow lesions, plantar fascia signal and thickness, spurs, and echogenicity. Combining these imaging biomarkers, calcaneal bone marrow lesions and plantar fascia imaging biomarkers were independently associated with chronic plantar heel pain.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Yuanyuan Wang, Ega Wirayoda Pontoh, Sultana Monira Hussain, Yuan Z. Lim, Graeme Jones, Catherine L. Hill, Anita E. Wluka, Andrew Tonkin, Changhai Ding, Flavia M. Cicuttini
Summary: This study found evidence for the involvement of vascular pathology in the progression of knee osteoarthritis and suggested that targeting atherosclerosis could improve outcomes in knee osteoarthritis.
Article
Health Care Sciences & Services
Julie A. Campbell, Hasnat Ahmad, Gang Chen, Ingrid van der Mei, Bruce Taylor, Suzi Claflin, Glen J. Henson, Steve Simpson-Yap, Laura L. Laslett, Kirsty Hawkes, Carol Hurst, Hilary Waugh, Andrew J. Palmer
Summary: This study aimed to externally validate the EQ-5D-5L-Psychosocial in a large cohort of people with multiple sclerosis (pwMS) and explore the discriminatory power of the new instrument with EQ-5D-5L/AQoL-8D. The results showed that the EQ-5D-5L-Psychosocial is more sensitive than the EQ-5D-5L in pwMS whose health state utilities approach those reflecting full health.
QUALITY OF LIFE RESEARCH
(2023)
Article
Rheumatology
Laura Sutton, Kim Jose, Emily Hansen, Laura Laslett, Jennifer Makin, Tania Winzenberg, Saliu Balogun, Dawn Aitken
Summary: The study aimed to explore the experience of individuals living with osteoarthritis (OA), how they navigate the healthcare system, and their opinions on exercise and joint replacement surgery for OA management. Findings suggest that OA patients may not consistently choose high-value care, and emphasize the importance of evidence-based multi-disciplinary approaches to guide self-management and support navigation of the health system.
MUSCULOSKELETAL CARE
(2023)
Article
Rheumatology
S. J. J. Drummen, S. Balogun, A. Lahham, K. Bennell, R. S. Hinman, M. Callisaya, G. Cai, P. Otahal, T. Winzenberg, Z. Wang, B. Antony, I. P. Munugoda, J. Martel-Pelletier, J. P. Pelletier, F. Abram, G. Jones, D. Aitken
Summary: This study aimed to determine the feasibility of a randomized controlled trial (RCT) examining the effects of outdoor walking on knee osteoarthritis (KOA) clinical outcomes and MRI structural changes. The study found that a full-scale RCT is feasible based on acceptable adherence, retention, randomization, and safety, although recruitment challenges were identified. The significant symptomatic benefits demonstrate the clinical usefulness of a subsequent trial.
CLINICAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Jing Tian, Graeme Jones, Xin Lin, Yuan Zhou, Anna King, James Vickers, Feng Pan
Summary: This study investigates the association between the number of chronic pain sites and the risk of dementia and its subtypes. The findings suggest that a greater number of chronic pain sites is associated with an increased risk of all-cause dementia and Alzheimer's disease, but not vascular and frontotemporal dementia.
Article
Rheumatology
Hylton B. B. Menz, Jamie J. J. Allan, Andrew K. K. Buldt, Karl B. B. Landorf, Flavia M. M. Cicuttini, Edward Roddy, Shannon E. E. Munteanu
Summary: This study aimed to determine whether neuropathic pain is a feature of first metatarsophalangeal (MTP) joint osteoarthritis (OA). By comparing pain questionnaire results and related factors, the study found that a significant proportion of individuals with first MTP joint OA experience neuropathic pain, which may partly explain the suboptimal responses to commonly used treatments. Screening for neuropathic pain may be useful in selecting targeted interventions and improving clinical outcomes.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Medicine, General & Internal
Nicholas Woodland, Antony Takla, Mahnuma Mahfuz Estee, Angus Franks, Mansi Bhurani, Susan Liew, Flavia M. Cicuttini, Yuanyuan Wang
Summary: This systematic review evaluated the patient-reported outcomes following total knee replacement in individuals aged 65 years and older. The study found that TKR can reduce pain, improve function, and increase the quality of life for older individuals. Patients generally reported overall satisfaction with the results of the surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Ziyuan Shen, Yining Wang, Xing Xing, Graeme Jones, Guoqi Cai
Summary: Our findings from two independent cohorts consistently showed that smoking was not associated with knee cartilage loss in older adults.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Rheumatology
Zhiqiang Wang, Graeme Jones, Leigh Blizzard, Dawn Aitken, Zhen Zhou, Mengmeng Wang, Saliu Balogun, Flavia Cicuttini, Benny Antony
Summary: This study aimed to describe the prevalence and correlates of the use of complementary and alternative medicines (CAMs) among community-dwelling older adults. The results showed that 35% of the participants reported CAM use, with vitamins/minerals being the most commonly used. CAM users were more likely to be female, be better educated, have more joints with osteoarthritis, and have healthier lifestyles.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Clinical Neurology
Julie A. Campbell, Ingrid van der Mei, Bruce Taylor, Andrew J. Palmer, Glen J. Henson, Laura Louise Laslett, Steve Simpson-Yap, Suzi B. Claflin
Summary: This study investigated the lived experience of a large cohort of Australians living with different levels of multiple sclerosis (MS)-related disability during the COVID-19 pandemic. The study found negative impacts of multitasking and social isolation for PwMS, while working from home was identified as beneficial for some.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
J. A. Kanis, H. Johansson, E. McCloskey, E. Liu, K. E. Akesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyere, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da Silva, B. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C. -c. Glueer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W. -p. Koh, F. Koromani, M. A. Kotowicz, H. Kroger, T. Kwok, O. Lamy, A. Langhammer, B. Larijani, K. Lippuner, D. Mellstrom, T. Merlijn, A. Nordstrom, P. Nordstrom, T. W. O'Neill, B. Obermayer-Pietsch, C. Ohlsson, E. S. Orwoll, J. A. Pasco, F. Rivadeneira, A. -M. Schott, E. J. Shiroma, K. Siggeirsdottir, E. M. Simonsick, E. Sornay-Rendu, R. Sund, K. M. A. Swart, P. Szulc, J. Tamaki, D. J. Torgerson, N. M. van Schoor, T. P. van Staa, J. Vila, N. J. Wareham, N. C. Wright, N. Yoshimura, M. C. Zillikens, M. Zwart, L. Vandenput, N. C. Harvey, M. Lorentzon, W. D. Leslie
Summary: A large international meta-analysis finds that a previous history of fracture is associated with an increased risk of future fractures, regardless of age, sex, and bone mineral density. The study highlights the importance of considering previous fracture history as a risk factor for fracture prevention strategies.
OSTEOPOROSIS INTERNATIONAL
(2023)
Meeting Abstract
Medicine, General & Internal
Jason Rogers, Graeme Jones, Jill Cook, Kathryn Squibb, Andrew Halliday, Aroub Lahham, Tania Winzenberg
INTERNAL MEDICINE JOURNAL
(2023)
Letter
Clinical Neurology
J. Tian, G. Jones, X. Lin, Y. Zhou, A. King, J. Vickers, Feng Pan
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
