Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy

Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet

(2016) Anna Rocchi et al.   ACTA NEUROPATHOLOGICA

MiR-298 Counteracts Mutant Androgen Receptor Toxicity in Spinal and Bulbar Muscular Atrophy

(2016) Naemeh Pourshafie et al.   MOLECULAR THERAPY

Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing

(2016) Elisa Giorgetti et al.   Cell Reports

Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells

(2015) Julia Lindqvist et al.   MOLECULAR BIOLOGY OF THE CELL

Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy

(2015) Chiara Scaramuzzino et al.   NEURON

Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA

(2015) Lori Zboray et al.   Cell Reports

Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases

(2014) Eun Hye Lee et al.   BMB Reports

Androgen receptor phosphorylation: biological context and functional consequences

(2014) Yulia Koryakina et al.   ENDOCRINE-RELATED CANCER

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

(2014) Diane Moujalled et al.   HUMAN MOLECULAR GENETICS

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA

(2014) Constanza J Cortes et al.   NATURE NEUROSCIENCE

Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients

(2014) Christopher Grunseich et al.   NEUROBIOLOGY OF DISEASE

Peripheral Androgen Receptor Gene Suppression Rescues Disease in Mouse Models of Spinal and Bulbar Muscular Atrophy

(2014) Andrew P. Lieberman et al.   Cell Reports

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

(2013) Davide Pozzi et al.   EMBO JOURNAL

Non-hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1

(2013) Guillaume Bony et al.   Nature Communications

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

(2012) Holly B. Kordasiewicz et al.   NEURON

Increasing MuSK Activity Delays Denervation and Improves Motor Function in ALS Mice

(2012) María J. Pérez-García et al.   Cell Reports

Review on the Protective Effects of PACAP in Models of Neurodegenerative Diseases In Vitro and In Vivo

(2011) D. Reglodi et al.   CURRENT PHARMACEUTICAL DESIGN

Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice

(2011) Dorothea Rat et al.   FASEB JOURNAL

Regulation of Androgen Receptor and Prostate Cancer Growth by Cyclin-dependent Kinase 5

(2011) Fu-Ning Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial

(2011) Lindsay E Fernández-Rhodes et al.   LANCET NEUROLOGY

Functional Interaction between Trace Amine-Associated Receptor 1 and Dopamine D2 Receptor

(2011) S. Espinoza et al.   MOLECULAR PHARMACOLOGY

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

(2011) Kerry J. Ressler et al.   NATURE

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

(2011) Mardo Kõivomägi et al.   NATURE

Cell-autonomous and non-cell-autonomous toxicity in polyglutamine diseases

(2011) Fabio Sambataro et al.   PROGRESS IN NEUROBIOLOGY

Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects

(2010) Ngoc-Duc Doan et al.   BIOCHEMICAL PHARMACOLOGY

Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial

(2010) Masahisa Katsuno et al.   LANCET NEUROLOGY

Phosphorylation of ATXN1 at Ser776 in the cerebellum

(2009) Nathan D. Jorgensen et al.   JOURNAL OF NEUROCHEMISTRY

CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors

(2009) Brian Yee Hong Lam et al.   JOURNAL OF NEUROCHEMISTRY

p21 Expression Is Induced by Activation of Nuclear Nerve Growth Factor-Induced B  (Nur77) in Pancreatic Cancer Cells

(2009) S.-O. Lee et al.   MOLECULAR CANCER RESEARCH

Overexpression of IGF-1 in Muscle Attenuates Disease in a Mouse Model of Spinal and Bulbar Muscular Atrophy

(2009) Isabella Palazzolo et al.   NEURON

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

(2009) D. Vaudry et al.   PHARMACOLOGICAL REVIEWS

Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP Biosensor

(2008) L. S. Barak et al.   MOLECULAR PHARMACOLOGY

Novel stable PACAP analogs with potent activity towards the PAC1 receptor

(2008) Steve Bourgault et al.   PEPTIDES