Article
Cardiac & Cardiovascular Systems
Rohit K. Kharbanda, Jeremy P. Moore, Michael S. Lloyd, Robert Galotti, Ad J. J. C. Bogers, Yannick J. H. J. Taverne, Malini Madhavan, Christopher J. McLeod, Anne M. Dubin, Douglas Y. Mah, Philip M. Chang, Anna N. Kamp, Jens C. Nielsen, Alper Aydin, Ronn E. Tanel, Maully J. Shah, Thomas Pilcher, Reinder Evertz, Paul Khairy, Reina B. Tan, Richard J. Czosek, Kalyanam Shivkumar, Natasja M. S. de Groot
Summary: This international multicenter study investigated the outcomes of cardiac resynchronization therapy (CRT) in patients with a systemic right ventricle (SRV) and identified predictors for congestive heart failure readmissions and mortality. The study found that CRT significantly improved functional class and QRS duration in patients with pre-CRT ventricular pacing who underwent an upgrade to a CRT device. However, no beneficial change was observed in patients who underwent de novo CRT. A quarter of all patients were readmitted for heart failure and the mortality rate was 21.3%.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Etienne Jacquemart, Nicolas Combes, Guillaume Duthoit, Francis Bessiere, Magalie Ladouceur, Laurence Iserin, Mikael Laredo, Charlene Bredy, Alice Maltret, Sylvie Di Filippo, Sebastien Hascoet, Jean-Luc Pasquie, Eloi Marijon, Victor Waldmann
Summary: This multicenter cohort study found that one-third of patients with CHD implanted with a CRT device had SRV. Patients with SRV showed similar rates of response to CRT compared to patients with systemic left ventricle.
Article
Cardiac & Cardiovascular Systems
Matthew J. Lewis, Alexandra Van Dissel, Jonathan Kochav, Michael P. DiLorenzo, Jonathan Ginns, Noa Zemer-Wassercug, Maarten Groenink, Barbara Mulder, Marlon Rosenbaum
Summary: Cardiac MRI is a valuable tool for predicting death, heart transplantation, or need for a ventricular assist device in individuals with a systemic right ventricle.
Review
Medicine, General & Internal
Frans A. van Nieuwenhoven, Blanche Schroen, Lucio Barile, Lars van Middendorp, Frits W. Prinzen, Angelo Auricchio
Summary: Cardiac resynchronization therapy (CRT) is a valuable addition to heart failure treatment options, especially for patients with electrical conduction disturbances causing regional contraction patterns (dyssynchrony). Experimental studies have shown extensive molecular and cellular remodeling in dyssynchronous hearts. Increasing evidence suggests that several miRNAs are involved in this remodeling process. Measurement of myocardium-derived miRNAs in extracellular vesicles (EVs) in peripheral blood may provide new insights into investigating and monitoring (reverse) remodeling in dyssynchronous and resynchronized hearts of patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Henry Chubb, Anica Bulic, Douglas Mah, Jeremy P. Moore, Jan Janousek, Jennifer Fumanelli, S. Yukiko Asaki, Andreas Pflaumer, Allison C. Hill, Carolina Escudero, Sit Yee Kwok, Jasveer Mangat, Luis A. Ochoa Nunez, Seshadri Balaji, Eric Rosenthal, William Regan, Michaela Horndasch, Hiroko Asakai, Ronn Tanel, Richard J. Czosek, Ming-Lon Young, David J. Bradley, Thomas Paul, Peter Fischbach, Lindsey Malloy-Walton, Doff B. McElhinney, Anne M. Dubin
Summary: This study aimed to quantify the risk of permanent ventricular pacing (PPMv) in patients with single ventricle (SV) and identify modifiable risk factors. The results showed that PPMv was associated with an increased risk of heart transplantation and death. Higher ventricular pacing percentage (Vp), higher QRS z-score, and nonapical ventricular lead position were all associated with a higher risk of adverse outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Monal Yu-Hsuan Chang, Yan-De Liou, Jou-Hsuan Huang, Chia-Hung Su, Shu-Chien Huang, Ming-Tai Lin, Shyh-Jye Chen
Summary: This study aims to introduce the image characteristics of double-chambered right ventricle on cardiac computed tomography and establish a diagnostic criterion. The right ventricular constrictive ratio was found to be a valuable asset for the preoperative diagnosis of double-chambered right ventricle.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Maria Paz Ocaranza, Jorge E. Jalil, Rodrigo Altamirano, Ana de Leon, Jackeline Moya, Alejandra Lonis, Luigi Gabrielli, Paul Mac Nab, Samuel Cordova, Alejandro Paredes, Ismael Vergara, Alex Bittner, Karime Sabat, Karla Pastorini
Summary: In patients with heart failure, effective cardiac resynchronization therapy induced reverse myocardial remodeling over three months, with significantly decreased ROCK activation in circulating leukocytes. This suggests that reduced ROCK activation in circulating leukocytes may reflect reverse cardiac remodeling in heart failure patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biophysics
Pim J. A. Oomen, Thien-Khoi N. Phung, Seth H. Weinberg, Kenneth C. Bilchick, Jeffrey W. Holmes
Summary: Cardiac resynchronization therapy (CRT) is effective for heart failure patients, but response rate is limited. Computational models can predict remodeling outcomes to help clinicians tailor personalized treatment strategies.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Engineering, Biomedical
Ze-Wei Tao, Dillon K. Jarrell, Andrew Robinson, Elizabeth M. Cosgriff-Hernandez, Jeffrey G. Jacot
Summary: The study improved the acellular fibrin patch material, prevascularized it, and used stem cells to develop a new treatment that effectively promotes heart defect repair and improves heart function.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Agriculture, Dairy & Animal Science
Domenico Caivano, Maria Chiara Marchesi, Piero Boni, Noemi Venanzi, Giovanni Angeli, Francesco Porciello, Elvio Lepri
Summary: This case report describes a rare congenital heart malformation in a Chianina calf, including a double-outlet right ventricle and interventricular and interatrial septal defects. Clinical signs included tachypnea, tachycardia, cyanotic mucous membranes, and a right apical systolic murmur.
Article
Cardiac & Cardiovascular Systems
Marieke Nederend, Monique R. M. Jongbloed, Philippine Kies, Hubert W. Vliegen, Berto J. Bouma, Madelien V. Regeer, Dave R. Koolbergen, Mark G. Hazekamp, Martin J. Schalij, Anastasia D. Egorova
Summary: The study revealed that 41% of patients with high degree AV-block requiring chronic ventricular pacing after TV surgery, with 56% developing this condition within 24 months postoperatively (including 3 before hospital discharge). Patients with heart failure showed a significant increase in QRS duration and higher levels of NT-pro-BNP compared to those with native AV-conduction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Elena Galli, Virginie Le Rolle, Otto A. Smiseth, Jurgen Duchenne, John M. Aalen, Camilla K. Larsen, Elif A. Sade, Arnaud Hubert, Smitha Anilkumar, Martin Penicka, Cecilia Linde, Christophe Leclercq, Alfredo Hernandez, Jens-Uwe Voigt, Erwan Donal
Summary: This study evaluated the impact of clinical, electrocardiographic, and echocardiographic data on left ventricular remodeling and prognosis of CRT candidates. Machine learning techniques identified features predictive of CRT response and prognosis, highlighting the importance of evaluating right ventricular size and function in risk stratification of CRT candidates.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Cardiac & Cardiovascular Systems
Elena Surkova, Attila Kovacs, Balint Karoly Lakatos, Marton Tokodi, Alexandra Fabian, Cathy West, Roxy Senior, Wei Li
Summary: The contraction patterns of the systemic right ventricle differ between patients with transposition of great arteries post-atrial switch operation and those with congenitally corrected transposition of great arteries. In patients with TGA, the anteroposterior component is dominant in compensating for impaired longitudinal and radial components, while in patients with ccTGA, all components contribute equally to the total ejection fraction. Strong correlations are observed between SRV EF and longitudinal strain with B-type natriuretic peptide levels, indicating the importance of routine echocardiographic assessment of the SRV.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Syed Shahyan Bakhtiyar, Sara Sakowitz, Konmal Ali, Nikhil L. Chervu, Arjun Verma, Ming-Sing Si, David D'Alessandro, Peyman Benharash
Summary: The study evaluates the survival rate after heart transplantation in adults with single and biventricular CHD and compares it to that of non-CHD transplant recipients. Single-ventricle physiology is associated with higher short-term mortality, but 10-year conditional survival is similar for biventricular CHD patients and most single-ventricle CHD patients, and notably better for biventricular CHD patients compared to non-CHD heart transplant recipients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremy Layec, Marie Decroocq, Francois Delelis, Ludovic Appert, Yves Guyomar, Clemence Riolet, Helene Dumortier, Amandine Mailliet, Christophe Tribouilloy, Sylvestre Marechaux, Aymeric Menet
Summary: This study evaluated the relationship between preprocedural echocardiographic parameters of electromechanical dyssynchrony (EMD) and outcome following cardiac resynchronization therapy (CRT) in heart failure patients. The results showed that certain echocardiographic parameters were associated with treatment response and patient prognosis. Therefore, echocardiographic assessment can help select patients who will benefit from CRT.
JACC-CARDIOVASCULAR IMAGING
(2023)