Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 545, Issue -, Pages 127-136Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2015.12.097
Keywords
Obesogen; Lipid disruptor; Nuclear receptor; Arthropod; Reproduction; Juvenile receptor
Categories
Funding
- Spanish Ministry of Science and Innovation project [CTM2011-30471-C02-01]
- European Research Foundation [ERC-2012-AdG-320737]
- Portuguese Foundation for Science and Technology (FCT)
- doctoral fellowship of Rita Jordao [SFRH/BD/79453/2011]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/79453/2011] Funding Source: FCT
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The analysis of lipid disruptive effects in invertebrates is limited by our poor knowledge of the lipid metabolic pathways. A recent study showed that tributyltin activated the ecdysteroid, juvenile hormone and retinoic X receptor signaling pathways, and disrupted the dynamics of neutral lipids in the crustacean Daphnia magna impairing the transfer of triacylglycerols to eggs and hence promoting their accumulation in post-spawning females. Tributyltin disruptive effects correlated with lower fitness for offspring and adults. The present study aims to addresses effects of existing compounds on storage lipids in post-spawning females and their health effects. D. magna individuals were exposed 12 chemicals that included vertebrate obesogens (tributyltin, triphenyltin, bisphenol A, nonylphenol, di-2-ethylhexyl phthalate), other contaminants known to affect arthropods (pyriproxyfen, fenarimol, methoprene, emamectin benzoate and fluoxetine), as well as the natural hormones methyl farnesoate and 20-hydroxyecdysone. Reproductive effects were also assessed. Quantitative changes in storage lipids accumulated in lipid droplets were studied using Nile red staining, which showed a close relationship with whole organism levels of triacylglycerols. Ten compounds altered storage lipids in a concentration related manner enhancing (tributyltin, bisphenol A, methyl farnesoate, pyriproxyfen and 20-hydroxyecdysone) or decreasing (nonylphenol, fenarimol, emamectin benzoate, methoprene and fluoxetine) their levels in post-spawning females. Eight compounds that altered lipid levels also had detrimental effects on growth and/or reproduction. (C) 2015 Elsevier B.V. All rights reserved.
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