Article
Chemistry, Medicinal
Zeineb Marzougui, Sylvie Huet, Anne-Louise Blier, Ludovic Le Hegarat, Haifa Tounsi-Kettiti, Riadh Kharrat, Riadh Marrouchi, Valerie Fessard
Summary: In this study, the in vivo genotoxic effects of C17-sphinganine analog mycotoxin (C17-SAMT) were evaluated using comet assays and micronucleus assay. The results showed that C17-SAMT induced DNA damage in the duodenum and spleen, but had no significant effect on chromosome and genome damage in the bone marrow. Microscopic observations of the liver revealed increased mitosis and hepatocytes' cytoplasm clarification.
Article
Environmental Sciences
Ronan Adler Tavella, Caroline Lopes Feijo Fernandes, Lucia Emanueli Schimith, Lisiane Martins Volcao, Marina dos Santos, Flavio Manoel Rodrigues da Silva Junior
Summary: Socioeconomic and demographic factors, lifestyle, and cultural characteristics may have an important impact on genetic damage. This study analyzed the association between a set of factors and genetic damage by studying populations in southern Brazil. The results showed that age had a weak association with genetic damage, while factors such as skin color, occupational exposure, drug use, exposure to radiation, and the cultural habit of consuming chimarrao were found to be associated with genetic damage. Yerba mate consumption was identified as a confounding factor in cytogenetic studies in the southern region of South America.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Concepcion Medrano-Padial, Maria Puerto, Ana Isabel Prieto, Nahum Ayala, Pauline Beaumont, Caroline Rouger, Stephanie Krisa, Silvia Pichardo
Summary: This study investigated the in vivo genotoxic effects of rats orally exposed to different doses of ST-99 and found no genotoxicity in the cells isolated from stomach, liver, and blood. Analytical studies confirmed the presence of stilbenes and their metabolites in plasma and tissues, supporting the safety profile of ST-99 for potential application as a preservative in the wine industry.
Article
Food Science & Technology
Antonio Cascajosa-Lira, Maria Puerto, Ana I. Prieto, Silvia Pichardo, Leticia Diez-Quijada Jimenez, Alberto Banos, Enrique Guillamon, Rosario Moyano, Veronica Molina-Hernandez, Angeles Jos, Ana M. Camean
Summary: This study confirmed the lack of in vivo genotoxicity of PTS at the doses tested, indicating that it is a promising natural alternative in animal feed without adverse effects on genetic material.
Article
Environmental Sciences
Claudia Galeano-Paez, Pedro Espitia-Perez, Luisa Jimenez-Vidal, Karina Pastor-Sierra, Shirley Salcedo-Arteaga, Luz Stella Hoyos-Giraldo, Adriana Gioda, Tatiana Dillenburg Saint'Pierre, Solange Cristina Garcia, Hugo Brango, Lyda Espitia-Perez
Summary: The study found that residents of La Mojana region showed significant increase in cytogenetic damage and total Hg levels in hair, which were related to high fish consumption. High fish consumption and T-Hg contents were also correlated with necrotic and apoptotic cell frequencies. Additionally, exposure to Hg induced genetic instability and increased micronuclei frequencies in individuals who consumed certain fish species with carnivorous habits.
Article
Environmental Sciences
Sardar Khan, Zahir Qamar, Ajmal Khan, Muhammad Waqas, Javed Nawab, Muhmmmad Khisroon, Ajmal Khan
Summary: This study investigated the genotoxic effects of polycyclic aromatic hydrocarbons (PAHs) present in vehicle-wash wastewater (VWW) on fish and freshwater mussels. The results showed that the genotoxicity of VWW on both fish and mussels increased with the duration of exposure, indicating the high genotoxicity of VWW and the need for treatment before discharge into aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2023)
Article
Plant Sciences
Hussin Muhammad, Maizatul Hasyima Omar, Elda Nurafnie Ibnu Rasid, Shazlan Noor Suhaimi, Shazlan Noor Suhaimi Farah Huda Mohkiar, Lau Mei Siu, Norizah Awang
Summary: The present study evaluated the genotoxicity potential of Ficus deltoidea var. kunstleri aqueous extract (FDAE) using standard in vitro assays. The results showed that FDAE at certain concentrations could cause DNA damage, but did not significantly affect micronucleus formation or revertant colonies in bacteria. Further investigation in animal models is necessary to confirm the non-genotoxicity activities of FDAE.
Article
Pharmacology & Pharmacy
Raffaella di Vito, Mattia Acito, Cristina Fatigoni, Carl H. Schiesser, Michael J. Davies, Francesca Mangiavacchi, Milena Villarini, Claudio Santi, Massimo Moretti
Summary: This study evaluated the cytotoxic and genotoxic potential of SeTal in liver cells through in vitro experiments. The results showed that SeTal had minimal impact on cell viability and did not cause clastogenic or aneugenic activity. These findings suggest that SeTal may be a potential active pharmaceutical ingredient.
Article
Biodiversity Conservation
Claudio Barberini Camargo Filho, Alexandre Rosa dos Santos, Jeferson Luiz Ferrari, Bruno de Lima Preto, Sustanis Horn Kunz, Adriano Posse Senhorelo, Diego Lang Burak, Joao Luiz Rossi Junior
Summary: This study assessed the environmental quality of a lagoon in southeastern Brazil that receives industrial effluents from a large iron ore company. The study found poor environmental quality in the lagoon, with high levels of chromium and nickel and genotoxic damage in fish. The presence of trace elements, even at low concentrations or low bioavailability, can cause genotoxic damage.
Article
Chemistry, Multidisciplinary
Adriana Rodriguez-Garraus, Maria Alonso-Jauregui, Ana-Gloria Gil, Inigo Navarro-Blasco, Adela Lopez de Cerain, Amaya Azqueta
Summary: A new material composed of kaolin base with silver nanoparticles was developed as an alternative to antibiotics in animal feed. In an in vivo geno-toxicological evaluation in rats, the material showed no adverse effects when administered orally at a dose of 2000 mg/kg b.w. for 28 days. The material did not induce micronuclei or DNA damage in various tissues, and silver content in target organs confirmed the negative results.
Article
Toxicology
Edvannia dos Santos Silva, Maria Joao Matos, Edson Luis Maistro
Summary: This study evaluated the cytotoxic and genotoxic potential of a coumarin derivative on human peripheral blood mononuclear cells (PBMC) and hepatocellular carcinoma cells (HepG2/C3A). The compound showed no significant genotoxic or cytotoxic effects at concentrations below 10 μg/mL, but had a slight genotoxic effect on PBMC cells at the highest tested concentration.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hossam El Din H. Abdelhafez, Amr A. Abdallah, Asmaa A. El-Dahshan, Yasser A. Abd El-Baset, Osama M. Morsy, Mohamed Bedair M. Ahmed
Summary: The study found that fipronil induces various health risks in vivo, while date extract can alleviate the toxic effects of fipronil but failed to reduce genotoxicity.
Article
Toxicology
Franz Oesch, Daniela Fruth, Jan G. Hengstler, Eric Fabian, Franz Ingo Berger, Robert Landsiedel
Summary: N-vinyl pyrrolidone (NVP) is produced in large quantities annually for the production of polymers used in pharmaceuticals, cosmetics, and food technology. Inhalation of NVP can lead to liver tumor formation in rats, but it is considered a non-genotoxic carcinogen with potential threshold approaches for assessment. The mechanism underlying the carcinogenicity of NVP in rats remains unclear despite extensive studies.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Toxicology
Xia Zhu, Yiyi Chen, Xinyao Tang, Dongxia Wang, Yeqiu Miao, Jing Zhang, Ruirui Li, Lishi Zhang, Jinyao Chen
Summary: The mycotoxin altertoxin I (ATX-I) can cause damage to the liver, kidney, and spleen, but may not have direct genotoxicity at relatively low doses.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Environmental Sciences
Claudia Castro, Ana Carvalho, Isabel Gaivao, Jose Lima-Brito
Summary: The study evaluated the tolerance of four wine-producing varieties to different concentrations of Cu by treating V. vinifera cuttings with Cu-rich hydroponic solutions. It was found that 50μM Cu treatment increased DNA damage, with 'Tinto Cao' being the most sensitive variety. Comet-FISH analysis revealed partial damage on rDNA and telomeric DNA in response to Cu treatment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
S. L. Kober, P. Schaefer, H. Hollert, M. Frohme
Summary: The investigation of large contaminated sites is limited due to the cost of traditional analysis methods. The authors propose a new high-throughput screening system that combines GPS data collection, quantitative analysis of explosives, and visualization of heatmaps. This system allows for fast characterization of contaminated areas.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Genetics & Heredity
Stoimir Kolarevic, Margareta Kracun-Kolarevic, Jovana Jovanovic Maric, Jelena Djordjevic, Branka Vukovic-Gacic, Danijela Joksimovic, Rajko Martinovic, Oliver Bajt, Andreja Ramsak
Summary: This study investigated the possible 'vector effect' within the exposure of Mediterranean mussels to polystyrene microplastics with adsorbed fluoranthene. It found that exposure to polystyrene increased DNA damage but did not have a clear pattern in affecting acetylcholinesterase or glutathione S-transferase activity. The study also found that changes in heart rate patterns supported the concept of the Trojan horse effect within the exposure to polystyrene particles with adsorbed fluoranthene.
Article
Environmental Sciences
E. Ransome, F. Hobbs, S. Jones, C. M. Coleman, N. D. Harris, G. Woodward, T. Bell, J. Trew, S. Kolarevic, M. Kracun-Kolarevic, V. Savolainen
Summary: No evidence of SARS-CoV-2 RNA or infectious virus was found in untreated sewage from the River Thames in the UK, in contrast to samples from Serbia. The study also found that infectious SARS-CoV-2 inoculum is stable in Thames water and sediment for <3 days, while SARS-CoV-2 RNA is detectable for at least seven days. This suggests that dilution of wastewater likely limits environmental transmission, and that detection of viral RNA alone is not an indication of pathogen spillover.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Anne Kreutzer, Mathias Reininghaus, Julia Meyer, Ingrid Kroencke, Thomas-Benjamin Seiler, Henner Hollert, Gesine Witt
Summary: The pollution state in the German Bight was investigated by determining pollutant concentrations in sediment samples. Polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAH) were measured in the pore water of North Sea sediment. The results showed relatively low contamination levels, but higher contamination near the sediment-dumping site.
ENVIRONMENTAL POLLUTION
(2023)
Article
Genetics & Heredity
Jovana Jovanovic Maric, Stoimir Kolarevic, Jelena Dordevic, Karolina Sunjog, Ivan Nikolic, Ana Maric, Marija Ilic, Predrag Simonovic, Nikiforos Alygizakis, Kelsey Ng, Peter Oswald, Jaroslav Slobodnik, Bojana Zegura, Branka Vukovic-Gacic, Momir Paunovic, Margareta Kracun-Kolarevic
Summary: This study demonstrates the importance of employing a complex weight-of-evidence approach in environmental studies to accurately assess the impact of pollution on ecological systems. The use of multiple lines of evidence ensures that the full extent of pollution effects is considered.
Review
Environmental Sciences
Oliver Machate, Dirk S. Schmeller, Tobias Schulze, Werner Brack
Summary: This article critically reviews the current knowledge on the exposure and risk of chemical pollution for mountain lakes. It suggests that mountain lakes, despite their remote locations, are likely to suffer from pollution-induced toxicity. The vulnerability of mountain lakes to toxic effects is expected to be particularly high due to harsh environmental conditions, the traits of organisms, the insular position of mountain lakes, and lower species richness with increasing altitudes.
ENVIRONMENTAL SCIENCES EUROPE
(2023)
Article
Agronomy
Carina Lackmann, Antonio Simic, Sandra Ecimovic, Alma Mikuska, Thomas-Benjamin Seiler, Henner Hollert, Mirna Velki
Summary: The aim of this study was to assess the effects of pesticides on earthworms. The results showed that commercial pesticide formulations had higher toxicity and affected earthworm behavior, biomarkers, and oxidative stress. These findings highlight the potential hazards of pesticide usage on the environment.
Article
Biodiversity Conservation
Boris Liptak, Antonin Kouba, Jiri Patoka, Momir Paunovic, Pavol Prokop
Summary: Public knowledge and comprehension of biological invasions play a crucial role in management strategies. A survey revealed that increased awareness positively affects the willingness to protect native species and decrease support for invasive species.
HUMAN DIMENSIONS OF WILDLIFE
(2023)
Article
Anthropology
Boris Liptak, Antonin Kouba, Katarina Zoric, Lazaros Salvaras, Pavol Prokop, Momir Paunovic
Summary: The attractiveness of a species affects people's willingness to protect it, and endangered species receive higher protection willingness than invasive species. Using attractive species can promote the conservation and restoration of freshwater ecosystems.
Article
Environmental Sciences
Liza-Marie Beckers, Rolf Altenburger, Werner Brack, Beate I. Escher, Jorg Hackermueller, Enken Hassold, Gianina Illing, Martin Krauss, Janet Krueger, Paul Michaelis, Andreas Schuettler, Sarah Stevens, Wibke Busch
Summary: Aquatic environments are polluted with a wide range of organic micropollutants, posing challenges for risk assessment due to the complexity and diversity of pollutant mixtures. This study suggests that investigating source-specific background pollution in aquatic environments could be a way to approach mixture risk assessment. By preparing a representative mixture of organic micropollutants and comparing it with predicted mixture effects, the study demonstrates that this approach can help identify substances that should be considered in future monitoring efforts and provide measures to estimate wastewater background concentrations and assess mixture risks. The study highlights data gaps that should be addressed for prioritization of effect testing, and offers the approach and mixture for further investigations by authorities and scientists.
ENVIRONMENT INTERNATIONAL
(2023)
Editorial Material
Ecology
Francisco Sylvester, Fabian G. Weichert, Veronica L. Lozano, Ksenia J. Groh, Miklos Balint, Lisa Baumann, Claus Baessler, Werner Brack, Barbara Brandl, Joachim Curtius, Paul Dierkes, Petra Doell, Ingo Ebersberger, Sotirios Fragkostefanakis, Eric J. N. Helfrich, Thomas Hickler, Sarah Johann, Jonas Jourdan, Sven Klimpel, Helge Kminek, Florencia Liquin, Darrel Moellendorf, Thomas Mueller, Joerg Oehlmann, Richard Ottermanns, Steffen U. Pauls, Meike Piepenbring, Jakob Pfefferle, Gerrit Jasper Schenk, J. F. Scheepens, Martin Scheringer, Sabrina Schiwy, Antje Schlottmann, Flurina Schneider, Lisa M. Schulte, Maria Schulze-Sylvester, Ernst Stelzer, Frederic Strobl, Andrea Sundermann, Klement Tockner, Tobias Troeger, Andreas Vilcinskas, Carolin Voelker, Ricarda Winkelmann, Henner Hollert
Summary: Chemical pollution research needs to be integrated with other factors contributing to biodiversity loss and the assessment of human impacts on ecosystems in order to provide more effective guidance for biodiversity loss mitigation.
NATURE ECOLOGY & EVOLUTION
(2023)
Article
Biology
Boris Liptak, Katarina Zoric, Jiri Patoka, Antonin Kouba, Momir Paunovic
Summary: The aquarium pet trade is a source of potentially invasive crayfish species that can be introduced into new environments, posing a threat to native biodiversity and freshwater ecosystem functioning. Europe, particularly Serbia, is experiencing an increase in invasive crayfish species, such as the marbled crayfish and the red swamp crayfish, traded as ornamentals. The presence of these species in the pet trade could lead to their occurrence in the wild.
Article
Environmental Sciences
Ana Atanackovic, Natasa Popovic, Nikola Marinkovic, Jelena Tomovic, Jelena Duknic, Jelena Stankovic, Momir Paunovic
Summary: The aim of this study was to analyze the distribution and ecological differentiation of oligochaete species with respect to environmental factors. The results revealed differences in oligochaete communities based on waterbody type and altitude. Total beta diversity was found to decrease with decreasing waterbody size, increasing substrate particle size, river flow velocity, and altitude. The study also identified specific preferences of certain families of Oligochaeta based on waterbody type.
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
