Article
Cell Biology
Abdellatif Benraiss, John N. Mariani, Ashley Tate, Pernille M. Madsen, Kathleen M. Clark, Kevin A. Welle, Renee Solly, Laetitia Capellano, Karen Bentley, Devin Chandler-Militello, Steven A. Goldman
Summary: Huntington's disease (HD) is characterized by defective oligodendroglial differentiation and white matter disease. This study reveals a link between oligodendrocyte progenitor cell (OPC) dysfunction and impaired myelin maintenance in adult HD patients. The downregulation of genes associated with oligodendrocyte differentiation and myelinogenesis is identified as a major driver of this dysfunction, and Tcf7l2 signaling is found to be a potential therapeutic target.
Article
Cell Biology
Masahiro Otsu, Zubair Ahmed, Daniel Fulton
Summary: A simple method was developed to generate immature oligodendrocyte lineage cells from mouse ESC-derived neural stem cells, which showed potential for differentiation into mature OPC under specific conditions. Interestingly, these cells retained multipotentiality and could differentiate into neurons or astrocytes. However, their efficiency in myelinating axons was lower compared to primary OPC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elisabeth Traiffort, Severine Morisset-Lopez, Mireille Moussaed, Amina Zahaf
Summary: Motor neurons and their axons reaching the skeletal muscle have long been considered the primary targets of degeneration in ALS, but recent research suggests that glial cells, particularly oligodendrocytes, also play a significant role. Oligodendrocytes are now recognized to be critically involved in axonal injury and are affected by toxic effects of degenerative neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Tomohiro Torii, Tomohiro Miyasaka, Hiroaki Misonou
Summary: This review article discusses the presence of tau in oligodendrocytes and its potential impact on oligodendrocyte function. The study shows that the expression levels of tau significantly change in hypomyelination models and in demyelination regions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Shuang-Ling Wu, Bin Yu, Yong-Jie Cheng, Shu-Yu Ren, Fei Wang, Lan Xiao, Jing-Fei Chen, Feng Mei
Summary: Alzheimer's disease (AD) is characterized by the presence of aggregated amyloid beta-protein (Aβ). Recent evidence suggests that inadequate myelinogenesis plays a role in AD-related functional deficits. The relationship between Aβ and myelinogenesis in AD brains, however, remains unclear.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feifei Yang, Han Wen, Siqi Ma, Qi Chang, Ruile Pan, Xinmin Liu, Yonghong Liao
Summary: Myelin repair, critical to neurodegenerative diseases treatment, relies on the differentiation and proliferation of oligodendrocyte precursor cells. Traditional Chinese medicine (TCM), particularly kidney-tonifying herbs, has shown effectiveness in improving the symptoms of degenerative patients. Icaritin, an active component of Yin-Yang-Huo, has demonstrated multiple effects on remyelination therapy, including enhancing cell proliferation, facilitating differentiation, and promoting maturation of oligodendrocytes.
Article
Neurosciences
Tomohiro Torii, Yuki Miyamoto, Rinaho Nakata, Yuto Higashi, Yohei Shinmyo, Hiroshi Kawasaki, Tomohiro Miyasaka, Hiroaki Misonou
Summary: In this study, the expression pattern of Tau protein in oligodendrocyte lineage was investigated. Tau was found to be expressed in mature oligodendrocytes, but not in oligodendrocyte progenitors and immature pre-oligodendrocytes. Moreover, Tau expression occurred after the peak of myelination, suggesting its role in oligodendrocyte maturation and demyelination.
Article
Cell Biology
Laurent Vergnes, Bernard Foucaud, Carlos Cepeda, Araceli Espinosa-Jeffrey
Summary: This study investigates the impact of space microgravity on the metabolomics profile of oligodendrocyte progenitors (OLPs) and reveals increased glutamate and energy metabolism during the OLPs' stay in space. The study also shows significantly increased mitochondrial respiration and glycolysis in OLPs after space flight. These findings provide valuable information about the energetic state of OLPs in space and suggest potential therapeutic targets for long-term space missions.
Article
Cell Biology
Michelle L. Wegscheid, Corina Anastasaki, Kelly A. Hartigan, Olivia M. Cobb, Jason B. Papke, Jennifer N. Traber, Stephanie M. Morris, David H. Gutmann
Summary: Neurodevelopmental disorders can be caused by chromosomal microdeletions involving numerous genes. This study identified abnormalities in neural stem cell proliferation and neuronal maturation in NF1-TGD patients, with reduced CRLF3 gene expression potentially contributing to these issues. Additionally, a deleterious germline mutation in the CRLF3 gene may lead to a higher autistic trait burden in NF1 patients.
Article
Multidisciplinary Sciences
Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco, Ajai Tripathi, R. Ross Welliver, Suyog U. Pol, Richard A. Seidman, Jacqueline E. Broome, Melanie A. O'Bara, Toin H. van Kuppervelt, Joanna J. Phillips, Ranjan Dutta, Fraser J. Sim
Summary: Chronic demyelination in the CNS leads to inhibitory microenvironment impairing oligodendrocyte progenitor cell recruitment. Sulfatase 1/2 modulates myelination by editing the sulfation pattern on heparan sulfate proteoglycans. Pharmacological sulfatase inhibition using PI-88 accelerates oligodendrocyte recruitment and remyelination by blocking OPC-expressed sulfatases.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Darpan Saraswat, R. Ross Welliver, Roopa Ravichandar, Ajai Tripathi, Jessie J. Polanco, Jacqueline Broome, Edward Hurley, Ranjan Dutta, M. Laura Feltri, Fraser J. Sim
Summary: IFN-gamma, a proinflammatory cytokine elevated in multiple sclerosis, induces pathologic quiescence in human oligodendrocyte progenitor cells via upregulation of the transcription factor PRRX1. Heparan sulfate proteoglycans play a key role in modulating IFN-gamma signaling following demyelination, and its modulation can mitigate the negative effects of proinflammatory signaling in the inflamed and demyelinated human brain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Sitong Yang, Jingjing Ma, Han Zhang, Laiqiang Chen, Yuxuan Li, Mingtian Pan, Hongcheng Zhu, Jun Liang, Dajian He, Shihua Li, Xiao-Jiang Li, Xiangyu Guo
Summary: Huntington's disease (HD) is characterized by late-onset neurodegeneration caused by expanded CAG repeats in the huntingtin gene (HTT). This study investigated whether mutant HTT affects the development of glial cells during early brain development. The results showed that the numbers of astrocytes and oligodendrocytes in postnatal HD KI mice were not significantly altered compared to wild type (WT) mice, but myelin protein expression was reduced at 3 months of age. These findings suggest that cytoplasmic mutant HTT mediates myelination defects in the early stages of HD without impacting glial cell differentiation and maturation.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Cell Biology
Kristina G. Maxwell, Jeffrey R. Millman
Summary: Improved stem cell-derived pancreatic islet differentiation protocols can robustly generate insulin-secreting beta cells from patient iPSCs, enabling in vitro disease modeling and the development of autologous diabetes cell replacement therapy. Combining disease modeling with gene editing and sequencing reveals the impact of diabetes-causing mutations on various islet cell types.
CELL REPORTS MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Feng-Yi Yang, Li-Hsin Huang, Meng-Ting Wu, Zih-Yun Pan
Summary: This study explored the effects of low-intensity pulsed ultrasound (LIPUS) on remyelination and resident cells in a demyelination model. The results showed that LIPUS can significantly increase myelin basic protein (MBP) expression, inhibit glial cell activation, enhance mature oligodendrocyte density, and promote brain-derived neurotrophic factor (BDNF) expression at the lesion site. In addition, LIPUS treatment resulted in the presence of a heterogeneous population of microglia with various morphologies in the demyelination lesion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Irene L. Llorente, Yuan Xie, Jose A. Mazzitelli, Emily A. Hatanaka, Jessica Cinkornpumin, David R. Miller, Ying Lin, William E. Lowry, S. Thomas Carmichael
Summary: Research shows that hiPSC-GEPs cells, derived from hiPSC-neural progenitor cells, have the potential to differentiate into astrocytes and promote brain repair when transplanted after WMS in mice.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Mo Li, Ying Wang, Jidi Zhang, Zheng Cao, Shuo Wang, Wei Zheng, Qian Li, Tianqi Zheng, Xiumei Wang, Qunyuan Xu, Zhiguo Chen
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2018)
Article
Multidisciplinary Sciences
Weiqi Zhang, Haifeng Wan, Guihai Feng, Jing Qu, Jiaqiang Wang, Yaobin Jing, Ruotong Ren, Zunpeng Liu, Linlin Zhang, Zhiguo Chen, Shuyan Wang, Yong Zhao, Zhaoxia Wang, Yun Yuan, Qi Zhou, Wei Li, Guang-Hui Liu, Baoyang Hu
Article
Critical Care Medicine
Yingli Jing, Degang Yang, Fan Bai, Chao Zhang, Chuan Qin, Di Li, Limiao Wang, Mingliang Yang, Zhiguo Chen, Jianjun Li
JOURNAL OF NEUROTRAUMA
(2019)
Review
Cell & Tissue Engineering
Sumei Liu, Zhiguo Chen
STEM CELLS INTERNATIONAL
(2019)
Article
Oncology
Yu Zhao, Zhongfeng Liu, Xuan Wang, Huantong Wu, Jianping Zhang, Junfang Yang, Fayou Zhang, Lining Liu, Jiafu Long, Peihua Lu, Zhiguo Chen
CLINICAL CANCER RESEARCH
(2019)
Article
Multidisciplinary Sciences
Wei Zheng, Zhiguo Chen
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Medicine, Research & Experimental
Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunming Ji, Michael J. Welsh, Lei Li
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Cell & Tissue Engineering
Heng Chi, Yunqian Guan, Fengyan Li, Zhiguo Chen
CELL TRANSPLANTATION
(2019)
Review
Neurosciences
Deqiang Han, Wei Zheng, Xueyao Wang, Zhiguo Chen
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Review
Cell & Tissue Engineering
Deqiang Han, Xin Zheng, Xueyao Wang, Tao Jin, Li Cui, Zhiguo Chen
STEM CELLS INTERNATIONAL
(2020)
Article
Cell & Tissue Engineering
Xiaobo Li, Wenxiu Yu, Yunqian Guan, Haiqiang Zou, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Zhenhua Ren, Zhiguo Chen
STEM CELLS INTERNATIONAL
(2020)
Article
Microbiology
Yingli Jing, Fan Bai, Limiao Wang, Degang Yang, Yitong Yan, Qiuying Wang, Yanbing Zhu, Yan Yu, Zhiguo Chen
Summary: FMT treatment has a significant impact on the microenvironment of spinal cord injury, involving microcirculation, blood-spinal cord-barrier, activation of immune cells, and secretion of neurotrophic factors. Metabolic profiling analysis reveals around 22 differentially detected metabolites between the groups, and beta-alanine was further chosen for functional validation experiments. Supplementation of beta-alanine significantly improves neuronal survival and the integrity of the blood-spinal cord-barrier at the lesion site, suggesting beta-alanine may be one of the mediators following FMT that contributes to the recovery.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Liping Zhou, Deqiang Han, Xingzhe Wang, Zhiguo Chen
Summary: This study provides evidence for the neuroprotective activities of human umbilical cord MSCs through anti-inflammatory actions. The study also suggests the potential of probiotic formulation VSL#3 as an adjuvant therapy in Parkinson's disease treatment, as it interacts with hMSCs to suppress inflammation and exert neuroprotective actions without altering the effects of hMSCs.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Huantong Wu, Yajie Yu, Yu Zhao, Weihua Liu, Zhongfeng Liu, Guangji Zhang, Zhiguo Chen
Summary: In this study, CD5-specific CAR-T cells were designed with different molecular structures and their anti-tumor efficacy against T cell acute lymphoblastic leukemia (T-ALL) was investigated in vitro and in vivo. The results showed that by optimizing the structure of CARs, the anti-tumor activity of CAR-T cells against T-ALL cells was enhanced. Specifically, CD5 CAR-T cells with a CD28 co-stimulation domain and C(H)2C(H)3 hinge region exhibited superior anti-tumor activity compared to other CAR designs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Zhongfeng Liu, Xuan Wang, Kewen Jiang, Xunming Ji, Y. Alex Zhang, Zhiguo Chen