Review
Plant Sciences
Adam Zeiner, Francisco J. Colina, Matteo Citterico, Michael Wrzaczek
Summary: CYSTEINE-RICH RLKs (CRKs), a subgroup of plant-specific receptor-like protein kinases (RLKs), play important regulatory roles in developmental and stress-related signaling pathways. Recent studies have revealed the interactions of CRKs with various proteins and their localization within the plasma membrane. The exact activation post-translational modification or ligands perceived by CRKs are still unknown.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Nikita Sharma, Paramjit Khurana
Summary: Somatic embryogenesis (SE) is a vital process in plant development, and SERKs play a crucial role in this process. This study identified 18 members of the SERK/SERL gene family in the annotated wheat genome and analyzed their gene and protein structures, phylogenetic relationships, and expression patterns. The results revealed the functional diversity and overlapping expression of SERKs/SERLs in plant growth and development.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Review
Biochemistry & Molecular Biology
Ana Marcia Escocard de Azevedo Manhaes, Fausto Andres Ortiz-Morea, Ping He, Libo Shan
Summary: Plants, as sessile organisms, have evolved plasma membrane-resident receptors like RLKs and RLPs to sense endogenous and exogenous signals and regulate growth, development, and immunity. These receptors interact with co-regulatory receptors and kinases like RLCKs, bifurcating signals to key signaling hubs like MAPK cascades to regulate diverse biological processes. Recent advancements have shed light on the roles of these receptors in activating intracellular signaling pathways in plants.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)
Article
Plant Sciences
Jawahar Singh, Praveen Kumar Verma
Summary: In this study, we identified and characterized CaLysM-RLK genes in chickpea and found that CaNFP and CaLYK3 could be candidate genes for NF perception. Down-regulation of these genes significantly reduced nodule numbers in chickpea. This study is of importance for improving root nodule symbiosis in chickpea.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Review
Plant Sciences
Jawahar Singh, Praveen Kumar Verma
Summary: Lysin motif (LysM)-receptor-like kinase (RLK) and leucine-rich repeat (LRR)-RLK mediated signaling play important roles in the development and regulation of root nodule symbiosis in legumes.
Article
Plant Sciences
Meizhen Li, Minghui Lv, Xiaojuan Wang, Zeping Cai, Hongrui Yao, Dongyang Zhang, Huiqiang Li, Mingsong Zhu, Wenbin Du, Ruoshi Wang, Zhe Wang, Hong Kui, Suiwen Hou, Jia Li, Jing Yi, Xiaoping Gou
Summary: In Arabidopsis thaliana, SERKs and ERf genes are shown to play essential roles in integument development. The interaction between SERKs and ERf depends on EPFL family peptides. The findings suggest that the ERf-SERK-mediated EPFL signaling controls the development of both the female gametophyte and the surrounding sporophytic integuments.
Article
Multidisciplinary Sciences
Mary Jo Cantoria, Elaheh Alizadeh, Janani Ravi, Reeba P. Varghese, Nawat Bunnag, Kelvin W. Pond, Arminja N. Kettenbach, Yashi Ahmed, Andrew L. Paek, John J. Tyson, Konstantin Doubrovinski, Ethan Lee, Curtis A. Thorne
Summary: In this study, it was found that the cellular response to Wnt ligands is proportional to their concentration. Positive feedback between the scaffold protein Axin and the kinase GSK3 resulted in bistable behavior of the destruction complex. Experimental evidence showed that the cellular concentration of beta-catenin exhibited an all-or-none response with sustained memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Anna Grochmal, Ben Woods, Lilia Milanesi, Manuel Perez-Soto, Salvador Tomas
Summary: Research on mimicking biological systems reveals that minimal environmental changes can trigger high avidity membrane receptor assembly, which can be modulated by weakly binding divalent ligands. Mathematical models and equations can predict the modulation intensity of the ligand-messenger on the ligand-receptor ON signal, providing valuable tools for studying membrane receptors in biological and biomimetic systems.
Review
Cell Biology
Vanessa M. Ruscetta, Taj J. J. Seaton, Aleen Shakeel, Stanley N. S. Vasconcelos, Russell D. D. Viirre, Marc J. J. Adler, Michael F. F. Olson
Summary: Cytoskeleton organization and dynamics are regulated by post-translational modifications of key target proteins, including the phosphorylation of myosin light chain proteins by MRCK kinases. Compared to ROCK kinases, the contributions of MRCK kinases are less characterized due to the late discovery of selective inhibitors. The recent development of selective MRCK inhibitors has expanded the tools to study MRCK function and shown therapeutic benefits in cancer studies.
Article
Biochemistry & Molecular Biology
Zhenwei Yan, Ke Li, Yanli Li, Wenli Wang, Bingying Leng, Guoqi Yao, Fajun Zhang, Chunhua Mu, Xia Liu
Summary: The study uncovers a novel mechanism of salt tolerance in maize mediated by the ZmbHLH32-ZmIAA9-ZmARF1 module, which can be exploited for breeding salt-tolerant maize varieties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Farnaz Razmkhah, Sena Kim, Sora Lim, Abdul-Jalil Dania, Jaebok Choi
Summary: S100A8 and S100A9 can initiate various signaling pathways and modulate cell function both inside and outside immune cells. They have been reported as dysregulated genes and proteins in various cancers, including hematologic malignancies. In this review, we discuss their critical roles in forming and promoting the malignant bone marrow microenvironment, as well as their potential as biomarkers and therapeutic targets in hematologic malignancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Anam Arif, Ameer A. Alameri, Umer Bin Tariq, Shakeel Ahmed Ansari, Hader Ibrahim Sakr, Maytham T. Qasim, Fadhil F. M. Aljoborae, Andres Alexis Ramirez-Coronel, Hijran Sanaan Jabbar, Gamal A. Gabr, Rasoul Mirzaei, Sajad Karampoor
Summary: Currently, cancer is the second leading cause of death worldwide, and the burden of cancer continues to increase. Understanding the molecular pathways involved in cancer initiation and development may lead to new treatments. Recent research suggests that TRIB3 plays a significant role in oncogenesis in various types of cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Margaux Richter, Enzo Lalli, Carmen Ruggiero
Summary: The secreted protein augurin, derived from the tumor suppressor gene Ecrg4, was identified as a peptide hormone in the human proteome in 2007. Since then, numerous studies have been conducted to understand its structure, processing, and potential roles in various physiological and pathological processes. However, the molecular mechanisms and signaling pathways of augurin's biological effects remain poorly understood. This article provides a comprehensive overview of augurin-dependent signal transduction pathways, emphasizing the potential for therapeutic targeting of augurin and its derived peptides.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Chemistry, Multidisciplinary
Hui Chen, Wanyu Xu, Hui Shi, Yan Qiao, Xiaoxiao He, Jing Zheng, Shaohong Zhou, Xiaohai Yang, Kemin Wang, Jianbo Liu
Summary: In this study, an artificial transmembrane signal transduction system using DNA-based artificial membrane receptors is described. Through low pH-mediated formation of the i-motif and dimerization of the receptors, fluorescence resonance energy transfer and G-quadruplex/hemin-mediated fluorescence amplification are activated within giant unilamellar vesicles. The study also establishes an intercellular signal communication model using coacervate microdroplets, which activate the dimerization of artificial receptors and subsequent fluorescence production or polymerization in giant unilamellar vesicles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Momoko Akiyama, Ryosuke Ueki, Masataka Yanagawa, Mitsuhiro Abe, Michio Hiroshima, Yasushi Sako, Shinsuke Sando
Summary: In this study, a synthetic receptor agonist was designed using a DNA aptamer as a building block to fine-tune agonism. The developed synthetic partial agonist can regulate therapeutically relevant cellular activities by eliciting finely-tuned receptor signaling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Plant Sciences
Zhenhua Liu, Juan Li, Long Wang, Qiang Li, Qing Lu, Yanchong Yu, Shuo Li, Ming-Yi Bai, Yuxin Hu, Fengning Xiang
Article
Multidisciplinary Sciences
Yanchen Tian, Min Fan, Zhaoxia Qin, Hongjun Lv, Minmin Wang, Zhe Zhang, Wenying Zhou, Na Zhao, Xiaohui Li, Chao Han, Zhaojun Ding, Wenfei Wang, Zhi-Yong Wang, Ming-Yi Bai
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Min Fan, Ming-Yi Bai, Jung-Gun Kim, Tina Wang, Eunkyoo Oh, Lawrence Chen, Chan Ho Park, Seung-Hyun Son, Seong-Ki Kim, Mary Beth Mudgett, Zhi-Yong Wang
Review
Plant Sciences
Cui Zhang, Ming-yi Bai, Kang Chong
PLANT CELL REPORTS
(2014)
Article
Plant Sciences
Li Song, Wei Chen, Biao Wang, Qiu-Ming Yao, Babu Valliyodan, Ming-Yi Bai, Ming-Zhe Zhao, Heng Ye, Zhi-Yong Wang, Henry T. Nguyen
Article
Biochemistry & Molecular Biology
Qi-Qi Zhang, Jia-Gang Wang, Ling-Yan Wang, Jun-Fang Wang, Qun Wang, Ping Yu, Ming-Yi Bai, Min Fan
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2020)
Article
Plant Sciences
Ke Liao, Yu-Jun Peng, Li-Bing Yuan, Yang-Shuo Dai, Qin-Fang Chen, Lu-Jun Yu, Ming-Yi Bai, Wen-Qing Zhang, Li-Juan Xie, Shi Xiao
Article
Biochemistry & Molecular Biology
Jin-Ge Li, Min Fan, Wenbo Hua, Yanchen Tian, Lian-Ge Chen, Yu Sun, Ming-Yi Bai
Article
Biochemistry & Molecular Biology
Lingyan Wang, Yanchen Tian, Wen Shi, Ping Yu, Yanfei Hu, Jinyang Lv, Chunxiang Fu, Min Fan, Ming-Yi Bai
Article
Plant Sciences
Na Zhao, Min Zhao, Yanchen Tian, Yichuan Wang, Chao Han, Min Fan, Hongwei Guo, Ming-Yi Bai
Summary: The study revealed that plant growth and development are coordinated by the crosstalk between brassinosteroid (BR) and ethylene (ET) signaling pathways, with the transcription factors BZR1 and EIN3 interdependently promoting apical hook development and cell elongation. Additionally, BR signaling is facilitated by gibberellin (GA) and ET enhances the growth-promoting effects of BR.
Article
Plant Sciences
Chao Han, Yan Qiao, Lianmei Yao, Wei Hao, Yue Liu, Wen Shi, Min Fan, Ming-Yi Bai
Summary: This study reveals the crucial roles of SnRK1 and TOR in regulating stomatal development under different sugar availability. SnRK1 promotes stomatal development by stabilizing SPCH under low sucrose conditions, while high accumulation of Tre6P inhibits SnRK1 activity, leading to degradation of SPCH and inhibition of stomatal development under high sucrose conditions.
Article
Plant Sciences
Guohua Chai, Guang Qi, Dian Wang, Yamei Zhuang, Hua Xu, Zetao Bai, Ming-Yi Bai, Ruibo Hu, Zeng-Yu Wang, Gongke Zhou, Yingzhen Kong
Summary: This study reveals the negative regulatory mechanism of the Arabidopsis CCCH protein C3H15 in cell elongation through inhibiting brassinosteroid signaling. C3H15 functions downstream of the BRI1 receptor as a negative regulator in the BR pathway. It is phosphorylated by the kinase BIN2 and its dephosphorylation leads to its accumulation in the nucleus, where it regulates transcription of G-rich elements. C3H15 and the transcriptional regulators BZR1 and BES1 antagonize each other and share common BR-responsive target genes.
Article
Multidisciplinary Sciences
Wen Shi, Lingyan Wang, Lianmei Yao, Wei Hao, Chao Han, Min Fan, Wenfei Wang, Ming-Yi Bai
Summary: In this study, the authors reveal that spatially patterned hydrogen peroxide plays a critical role in stomatal development in Arabidopsis. It activates the energy sensor SnRK1 to stabilize the SPCH transcription factor and optimize stomatal development.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Chao Han, Lingyan Wang, Jinyang Lyu, Wen Shi, Lianmei Yao, Min Fan, Ming-Yi Bai
Summary: Plants have evolved sophisticated mechanisms to optimize growth and development in response to fluctuating nutrient levels. Brassinosteroids (BRs) play critical roles in plant growth, development, and responses to the environment, and are integrated with different nutrient signaling processes to coordinate gene expression, metabolism, growth, and survival.
JOURNAL OF GENETICS AND GENOMICS
(2023)