Article
Biochemistry & Molecular Biology
Eduardo Larriba, Ana Belen Sanchez-Garcia, Maria Salud Justamante, Cristina Martinez-Andujar, Alfonso Albacete, Jose Manuel Perez-Perez
Summary: Plants have the ability to regenerate damaged tissues after stress, and in this study, tomato 'Micro-Tom' explants were used to investigate organ formation post-injury. The research found that high levels of auxin-to-cytokinin accumulation were required in the basal region for adventitious root formation, while minimal levels were established in the apical region shortly after wounding. This process involved dynamic changes in endogenous hormone levels and a complex regulation of auxin transport and degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Sorrel Tran, Yun-Fan Stephanie Chen, Dawei Xu, Madalene Ison, Li Yang
Summary: This study found that bacteria inhibit the regeneration of roots by activating pathogen-associated molecular pattern (PAMP)-triggered immunity, and the bacteria-derived flagellin 22 peptide (flg22) inhibits root regeneration by interfering with the formation of an auxin maximum at the wound site.
Article
Developmental Biology
Taiichi Tsuyama, Yusaku Hayashi, Hanae Komai, Kohei Shimono, Tadashi Uemura
Summary: This study investigated the developmental processes of the adult-type fat body (AFB) in Drosophila. It identified precursor cells that give rise to the AFB and described the dynamic cellular behaviors underlying AFB formation. The study also examined the roles of ecdysone signaling and the transcription factor Serpent in adult fat body organogenesis.
Editorial Material
Endocrinology & Metabolism
S. Rodriguez-Fdez, A. Vidal-Puig
Summary: Recent research explores the concept of thermogenic memory and identifies a subset of adipocytes that enhance the response to repeated stimulation events through de novo lipogenesis.
Article
Endocrinology & Metabolism
Yuwei Deng, Nan Luo, Ming Xie, Ling He, Ruixue Jiang, Nan Hu, Jin Wen, Xinquan Jiang
Summary: This study compared periodontal tissues from different stages of mice and found that tissue development, energy metabolism, and immune response were critical processes in periodontal remodeling. The developmental and adult stages showed different gene expression patterns. These findings contribute to a deeper understanding of periodontal development and remodeling, and may provide references for periodontal regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Plant Sciences
Jan Smeringai, Petra Prochazkova Schrumpfova, Marketa Pernisova
Summary: Plants have a unique developmental plasticity that allows them to adapt to changing environmental conditions by triggering specific spatiotemporal changes in developmental programs. The phytohormone cytokinin is known as a principal regulator of plant development and plays an important role in de novo shoot organogenesis and shoot regeneration.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Engineering, Biomedical
Shengran Wang, Changlai Zhu, Bin Zhang, Junxia Hu, Jinghui Xu, Chengbin Xue, Shuangxi Bao, Xiaokun Gu, Fei Ding, Yumin Yang, Xiaosong Gu, Yun Gu
Summary: A favorable microenvironment is crucial for nerve regeneration. This study investigates the components and spatial organization of extracellular matrix (ECM) secreted by different cells and finds that ECM derived from bone marrow mesenchymal cells (BMSCs) is more similar to acellular nerves. ECM-modified nerve grafts (ECM-NGs) co-cultivated with BMSCs exhibit the most promising nerve repair properties and create a superior microenvironment for nerve regeneration, indicating a potential alternative for clinical repair of peripheral nerve defects.
Review
Biotechnology & Applied Microbiology
Rebecca Powell, Despoina Eleftheriadou, Simon Kellaway, James B. Phillips
Summary: This review discusses the physical processes by which natural biomaterials mimic the function of the extracellular matrix and regulate cellular behavior, as well as highlights representative cases of controllable cell microenvironments developed through the combination of cell biology and tissue engineering principles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Plant Sciences
Kyounghee Lee, Jong Hee Kim, Ok-Sun Park, Yu Jin Jung, Pil Joon Seo
Summary: The overexpression of WOX5 promotes cytokinin signaling and shoot regeneration, enhancing the plant's capacity for tissue culture regeneration.
PLANT CELL REPORTS
(2022)
Article
Pharmacology & Pharmacy
Rossella Dorati, Silvia Pisani, Enrica Chiesa, Ida Genta, Giovanna Bruni, Tiziana Modena, Bice Conti
Summary: Polymeric tubular vascular grafts manufactured using electrospinning technique have the potential to serve as an alternative to autologous vascular grafts for treating peripheral artery occlusive disease. By combining different biocompatible and biodegradable polymers in various design approaches, researchers were able to produce prototypes with optimal mechanical behavior and cell interaction for tissue regeneration purposes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Cell & Tissue Engineering
Jiaxi Liu, Jinfang Gao, Zixie Liang, Chong Gao, Qing Niu, Fengping Wu, Liyun Zhang
Summary: This review discusses the characteristics of MSCs, their interaction with the microenvironment, and the importance of the microenvironment in maintaining cell function and disease progression.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Genetics & Heredity
Katarzyna Hnatuszko-Konka, Aneta Gerszberg, Izabela Weremczuk-Jezyna, Izabela Grzegorczyk-Karolak
Summary: Plant organisms have the remarkable ability to restore or replace injured tissues, with one pathway being organogenesis triggered by phytohormones. Cytokinins, a class of phytohormones, play a key role in this process by demonstrating pleiotropic effects and a powerful network of molecular interactions. The study reviews the molecular and genetic events underlying de novo shoot organogenesis initiated by cytokinins, aiming to collect reactions encompassing cytokinin primary responses and other control mechanisms like epigenetic reprogramming.
Review
Cardiac & Cardiovascular Systems
Syed Baseeruddin Alvi, Salmman Ahmed, Divya Sridharan, Zahra Naseer, Nooruddin Pracha, Henry Wang, Konstantinos Dean Boudoulas, Wuqiang Zhu, Nazish Sayed, Mahmood Khan
Summary: Cardiovascular disease is a leading cause of death globally, with acute myocardial infarctions being a major contributor. Advances in nanomedicine and nanotechnology have opened new possibilities for treating damaged hearts by improving drug delivery methods, targeting injured areas with innovative therapies such as growth factors, stem cells, and exosomes. This review focuses on three major drug delivery modalities: nanoparticles, microspheres, and hydrogels, and their potential in treating damaged hearts following a myocardial infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Shuichi Ogino, Atsushi Yamada, Takashi Nakano, Sunghee Lee, Hiroki Yamanaka, Itaru Tsuge, Yoshihiro Sowa, Michiharu Sakamoto, Fukazawa Kyoko, Yusuke Kambe, Yuki Kato, Jun Arata, Koji Yamauchi, Tetsuji Yamaoka, Naoki Morimoto
Summary: In this study, we evaluated the adipose tissue regeneration ability of implant aggregates in a porcine model. The results showed that the implant aggregates could induce autologous adipose tissue regeneration after long-term implantation, without the use of any growth factor or cell treatment, presenting a potential novel method for breast reconstruction.
REGENERATIVE THERAPY
(2023)
Article
Plant Sciences
Federico Marangelli, Vera Pavese, Giuseppe Vaia, Michela Lupo, Muhammad Ajmal Bashir, Valerio Cristofori, Cristian Silvestri
Summary: Polyploid induction is important for the development of new varieties in horticultural plants. In this study, a protocol for in vitro polyploid induction of highbush blueberry leaf tissues was studied. Different concentrations of colchicine and oryzalin were used, and it was found that colchicine can induce polyploidization. The resulting polyploids showed morphological differences compared to diploids.