Article
Hematology
Pierre-Nicolas Bris, Philippe Gauchez, Raynier Devillier, Lionel Galicier, Aude Collignon, Gilles Piana, Flora Poizat, Marion Faucher, Marie-Anne Hospital, Norbert Vey, Frederic Gonzalez, Luca Servan, Laurent Chow-Chine, Antoine Sannini, Djamel Mokart, Colombe Saillard, Magali Bisbal
Summary: Liver biopsy is valuable in patients with haematological malignancies and hepatic dysfunction, especially in cases where the cause is unclear. Hepatic haemophagocytosis is common in these patients and is associated with a poor prognosis. The HScore, combined with liver biopsy, may be helpful in diagnosing haemophagocytic syndrome.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Immunology
Kristina E. N. Clark, William D. Nevin, Tabitha Mahungu, Helen Lachmann, Animesh Singh
Summary: This study found similarities in the clinical manifestations and molecular inflammatory responses between COVID-19 patients and HLH patients, but did not support the use of HLH risk-scoring methodology for risk stratification in COVID-19 patients.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Rheumatology
Roberto Caricchio, Marcello Gallucci, Chandra Dass, Xinyan Zhang, Stefania Gallucci, David Fleece, Michael Bromberg, Gerard J. Criner
Summary: Researchers developed predictive criteria for COVID-19-associated cytokine storm (CS) and proposed new early predictive criteria to identify CS occurring in patients with COVID-19, which can determine the need for early therapeutic regimen and potentially reduce mortality.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Sinem Nihal Esatoglu, Koray Tascilar, Hakan Babaoglu, Cemal Bes, Berna Yurttas, Servet Akar, Ozlem Pehlivan, Cansu Akleylek, Duygu Tecer, Emire Seyahi, Tuba Yuce-Inel, Nilufer Alpay-Kanitez, Erdal Bodakci, Emre Tekgoz, Seda Colak, Ertugrul Cagri Bolek, Suleyman Serdar Koca, Umut Kalyoncu, Ozan Cemal Icacan, Serdal Ugurlu, Hande Ece Oz, Vedat Hamuryudan, Gulen Hatemi
Summary: This study found that among patients with inflammatory rheumatic diseases (IRDs) and COVID-19, factors such as glucocorticoid use, chronic kidney disease, pulmonary disease, and obesity were associated with worse outcomes, while biologic disease-modifying antirheumatic drugs did not seem to be associated with worse outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Marc H. A. Jansen, Christien Rondaan, Geertje E. Legger, Kirsten Minden, Yosef Uziel, Natasa Toplak, Despoina Maritsi, Lotte van den Berg, Guy A. M. Berbers, Patricia Bruijning, Yona Egert, Christophe Normand, Marc Bijl, Helen E. Foster, Isabelle Kone-Paut, Carine Wouters, Angelo Ravelli, Ori Elkayam, Nicolaas M. Wulffraat, Marloes W. Heijstek
Summary: This article updates the EULAR recommendations on vaccination for pedAIIRD patients, providing guidelines on vaccination principles, special circumstances, and the safety for immunosuppressed patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Andrea Di Matteo, Erica Moscioni, Maria Giovanna Lommano, Edoardo Cipolletta, Gianluca Smerilli, Sonia Farah, Carla Airoldi, Sibel Zehra Aydin, Andrea Becciolini, Karina Bonfiglioli, Marina Carotti, Greta Carrara, Tomas Cazenave, Davide Corradini, Micaela Ana Cosatti, Juan Jose de Agustin, Giulia Maria Destro Castaniti, Marco Di Carlo, Eleonora Di Donato, Luca Di Geso, Ashley Elliott, Daniela Fodor, Francesca Francioso, Alessandra Gabba, Cristina Hernandez-Diaz, Rudolf Horvath, Jana Hurnakova, Diogo Jesus, Josefina Marin, Maria Victoria Martire, Riccardo Mashadi Mirza, Marco Massarotti, Alice Andreea Musca, Jagdish Nair, Tadashi Okano, Ioannis Papalopoulos, Javier Rosa, Marcos Rosemffet, Joao Rovisco, Davide Rozza, Fausto Salaffi, Crescenzio Scioscia, Carlo Alberto Scire, Maria-Magdalena Tamas, Shun Tanimura, Lucio Ventura-Rios, Catalina Villota-Eraso, Orlando Villota, Paraskevi V. Voulgari, Florentin Ananu Vreju, Gentiana Vukatana, Johana Zacariaz Hereter, Anna Zanetti, Walter Grassi, Emilio Filippucci
Summary: This study investigated the reliability of ultrasound (US) muscle echogenicity in patients with rheumatic diseases. The results showed moderate reliability for the semi-quantitative scale and high reliability for the continuous quantitative measurement. There was also a strong correlation between the visual scales and the analysis by the software. Overall, the US assessment of muscle echogenicity demonstrated good reliability in patients with different rheumatic diseases.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Livia Roseti, Brunella Grigolo
Summary: Joint pain and arthralgia can be symptoms of COVID-19, and there is evidence suggesting a possible relationship between the virus and the development of inflammatory arthritis. Viral infections and rheumatic diseases have documented associations, and they share genetic and environmental risk factors. The interaction between viruses and the immune system plays a role in the development of rheumatic diseases, and infections may contribute to autoimmune rheumatic diseases and patient mortality. Therefore, understanding the interaction between viral infections and rheumatic diseases is crucial.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Hee Jung Ryu, Jin-Ok Han, Sang Ah Lee, Mi Ryoung Seo, Hyo Jin Choi, Kwang-Pil Ko, Han Joo Baek
Summary: A study in Korea found that female sex, comorbidities, and specific medication use increased the risk of herpes zoster in patients with rheumatic diseases. Systemic lupus erythematosus and Behcet's syndrome were identified as stronger risk factors for herpes zoster compared to rheumatoid arthritis.
Article
Immunology
Zixi Yi, Zhongqiang Yao, Dan Xu, Chuanhui Xu, Wenqiang Fang, Zhanfei Guo, Yong Wang, Jianlin Huang, Qin Li, Hong Zhang, Anbin Huang, Lijun Wu, Zhenbiao Wu, Huifang Guo, Fengxiao Zhang, Jing Lu, Zhenchun Zhang, Zhongming Yu, Zhanyun Da, Li Luo, Bin Wu, Henglian Wu, Lin Zeng, Rong Mu
Summary: The study highlights the intentions and actual vaccination rates among patients with rheumatic diseases in China. The majority of patients intended to get vaccinated, but the actual vaccination rate was low. Male, employed, high-income patients and those with inactive disease showed a more positive attitude towards vaccination. Concerns about adverse events and disease flare were the main factors affecting vaccination willingness. Furthermore, a significant portion of patients felt that they did not receive enough information about the COVID-19 vaccine from their doctors.
Article
Medicine, General & Internal
Michael R. Ardern-Jones, Matt Stammers, Hang T. T. Phan, Florina Borca, Anastasia Koutalopoulou, Ying Teo, James Batchelor, Trevor Smith, Andrew S. Duncombe
Summary: A study on 567 COVID-19 inpatients found that the modified %HScore does not effectively predict the risk of sHLH, and its application in elderly patients is less effective.
Article
Immunology
Haralampos M. Moutsopoulos
Summary: Patients with autoimmune and autoinflammatory rheumatic disorders may have limited effectiveness in vaccination against SARS-CoV-2, especially under immunosuppressive regimens. Recommendations are proposed to guide the vaccination of immune suppressed patients to achieve optimal vaccine benefit.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Rheumatology
George C. Drosos, Daisy Vedder, Eline Houben, Laura Boekel, Fabiola Atzeni, Sara Badreh, Dimitrios T. Boumpas, Nina Brodin, Ian N. Bruce, Miguel Angel Gonzalez-Gay, Soren Jacobsen, Gyorgy Kerekes, Francesca Marchiori, Chetan Mukhtyar, Manuel Ramos-Casals, Naveed Sattar, Karen Schreiber, Savino Sciascia, Elisabet Svenungsson, Zoltan Szekanecz, Anne-Kathrin Tausche, Alan Tyndall, Vokko van Halm, Alexandre Voskuyl, Gary J. Macfarlane, Michael M. Ward, Michael T. Nurmohamed, Maria G. Tektonidou
Summary: This study developed recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, emphasizing the importance of regular screening and management of modifiable CVR factors as well as patient education. The recommendations covered CVR prediction tools, interventions on traditional CVR factors, and interventions on disease-related CVR factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Paola Ghanem, Joseph C. Murray, Kristen A. Marrone, Susan C. Scott, Josephine L. Feliciano, Vincent K. Lam, Christine L. Hann, David S. Ettinger, Benjamin P. Levy, Patrick M. Forde, Ami A. Shah, Christopher Mecoli, Julie Brahmer, Laura C. Cappelli
Summary: Lung cancer patients with concomitant autoimmune rheumatic diseases (ARD) have different tumor characteristics and clinical outcomes compared to those without ARD. Patients with ARD are more likely to be diagnosed with early-stage lung cancer and have a longer overall survival (OS).
Article
Respiratory System
Mohammadreza Bordbar, Anahita Sanaei Dashti, Ali Amanati, Eslam Shorafa, Yasaman Mansoori, Seyed Javad Dehghani, Hossein Molavi Vardanjani
Summary: In patients with COVID-19, a higher HScore is associated with a higher likelihood of needing ICU care, longer hospital stays, and a higher mortality rate. Compared to sHLH, COVID-19 patients have significantly lower HScores. A modified HScore with new cut-offs may be more practical in predicting disease severity in severe COVID-19 patients.
BMC PULMONARY MEDICINE
(2021)
Article
Medicine, General & Internal
Marta Rorat, Dorota Zarebska-Michaluk, Justyna Kowalska, Krzysztof Kujawa, Magdalena Rogalska, Dorota Kozielewicz, Beata Lorenc, Katarzyna Sikorska, Piotr Czupryna, Beata Bolewska, Jadwiga Maciukajc, Tomasz Piekos, Regina Podlasin, Anna Dworzanska, Wlodzimierz Mazur, Michal Brzdek, Anna Szymanek-Pasternak, Robert Flisiak
Summary: Patients with systemic autoimmune rheumatic disease (SARD) are more susceptible to SARS-CoV-2 infection. This study compared the characteristics, severity, course, and outcomes of COVID-19 in SARD patients with the non-SARD group. Factors associated with prognosis, including remdesivir therapy efficacy, were also examined. The study found that SARD patients had longer hospital stays, higher mortality rates, and a greater need for oxygen therapy compared to the non-SARD group. Age, the presence of cardiovascular disease, severity of condition on admission, and higher inflammatory marker values were identified as risk factors for death in the SARD group. Remdesivir treatment showed a trend towards improved mortality in SARD patients but was not statistically significant. Overall, SARD patients had worse outcomes and were more likely to have other chronic diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Ezgi D. Batu, Seher Sener, Gulcan Ozomay Baykal, Elif Arslanoglu Aydin, Semanur Ozdel, Alenka Gagro, Esra Esen, Merav Heshin-Bekenstein, Niluefer Akpinar Tekgoz, Fatma G. Demirkan, Kubra Ozturk, Olga Vougiouka, H. Emine Sonmez, Maria Cristina Maggio, Ummusen Kaya Akca, Marija Jelusic, Aysenur Pac Kisaarslan, Banu Acar, Nuray Aktay Ayaz, Betul Sozeri, Seza Ozen
Summary: This study analyzed the characteristics, treatment, and outcomes of COVID-19-associated pediatric vasculitis (excluding KD-like vasculitis in MIS-C). The results showed that COVID-19-associated pediatric IgA vasculitis/Henoch-Schönlein purpura had more severe clinical manifestations and poorer treatment outcomes compared to pre-pandemic cases.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Bernhard Hellmich, Beatriz Sanchez-Alamo, Jan H. Schirmer, Alvise Berti, Daniel Blockmans, Maria C. Cid, Julia U. Holle, Nicole Hollinger, Omer Karadag, Andreas Kronbichler, Mark A. Little, Raashid A. Luqmani, Alfred Mahr, Peter A. Merkel, Aladdin J. Mohammad, Sara Monti, Chetan B. Mukhtyar, Jacek Musial, Fiona Price-Kuehne, Marten Segelmark, Y. K. Onno Teng, Benjamin Terrier, Gunnar Tomasson, Augusto Vaglio, Dimitrios Vassilopoulos, Peter Verhoeven, David Jayne
Summary: Since the publication of the EULAR recommendations for the management of AAV in 2016, several clinical trials have been conducted that have the potential to change clinical care. A systematic literature review and expert opinions were used to modify existing recommendations and create new ones. The recommendations provide updated guidance on AAV management.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Obstetrics & Gynecology
Arzu Taghiyeva, Levent Kilic, Murat Cagan, Ertugrul Cagri Bolek, Gozde Kubra Yardimci, Ozgur Ozyuncu, Sule Apras Bilgen, Omer Karadag
Summary: This study aimed to evaluate fertility, early menopause, and pregnancy outcomes of patients with Takayasu's arteritis (TA) before and after diagnosis. The results showed that TA patients had a higher infertility rate compared to the general population in Turkey (12.5% vs 8.6%) and a lower rate of early menopause (16.7% vs 36.1%). Pregnancy following a TA diagnosis had more maternal complications, and fetal complications were common both before and after diagnosis. Chronic inflammation may contribute to increased infertility and fetal complications.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Review
Immunology
Pinar Akyuez Dagli, Abdulsamet Erden, Serdar Can Gueven, Berkan Armagan, oeykue Tayfur Yuerekli, Yasemin oezderin oezin, Ahmet Omma, Orhan Kuecueksahin
Summary: This study evaluated the effectiveness of tofacitinib in the treatment of enteropathic arthritis. The results showed that after tofacitinib treatment, clinical and laboratory symptoms of both inflammatory bowel disease and arthritis improved in three patients.
Article
Medicine, General & Internal
Melda Bahap-Kara, Emine Duran, Aygin Bayraktar-Ekincioglu, Omer Karadag
Summary: CT-P10 is the first biosimilar of rituximab approved in Europe for all indications of originator rituximab. This study provides real-life data on treatment changes and adverse events in patients who received oRTX or CT-P10. The results show that CT-P10 is a safe alternative for rituximab therapy.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Rheumatology
Mohamed-Yacine Khitri, Alessandra Bartoli, Georgina Maalouf, Alban Deroux, Carlo Salvarani, Giacomo Emmi, Omer Karadag, Gerard Espinosa, Mathilde Leclercq, Gabriele Simonini, Mathieu Vautier, Patrice Cacoub, David Saadoun
Summary: This study evaluated the efficacy of tocilizumab in patients with refractory Behcet disease. The results showed that 83% of patients responded to tocilizumab, with 60% achieving complete response and 23% achieving partial response. Tocilizumab also significantly reduced steroid dosage and the need for concomitant disease-modifying antirheumatic drugs. However, a small number of patients experienced mild to moderate side effects and serious adverse events.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Julien Culerrier, Yann Nguyen, Omer Karadag, Sule Yasar Bilge, Tuba Demirci Yildrim, Tahir Saygin Ogut, Veli Yazisiz, Cemal Bes, Ayse Celfe, Ayten Yazici, Oznur Sadioglu Cagdas, Andreas Kronbichler, David Jayne, Philipp Gauckler, Alexis Regent, Vitor Teixeira, Sylvain Marchand-Adam, Pierre Duffau, Saskia Ingen- Housz-Oro, Celine Droumaguet, Baptiste Andre, Luminita Luca, Sarah Lechtman, Achille Aouba, Celine Lebas, Amelie Servettaz, Amandine Dernoncourt, Marc Ruivard, Anne-Marie Milesi, Vincent Poindron, Patrick Jego, Roberto Padoan, Paolo Delvino, Frederic Vandergheynst, Christian Pagnoux, Elaine Yacyshyn, Peter Lamprecht, Oliver Flossmann, Xavier Puechal, Benjamin Terrier
Summary: This retrospective multicentre study aimed to investigate the characteristics and outcome of ANCA-associated vasculitis (AAV) induced by anti-thyroid drugs (ATD) compared to primary AAV. The results showed that ATD-induced AAV mainly presented as microscopic polyangiitis (MPA), with the most common manifestations being skin involvement, arthralgia, and glomerulonephritis. However, ATD-induced MPA was less severe and had a lower risk of relapse compared to primary MPA.
Article
Pediatrics
Ozge Basaran, Ezgi Deniz Batu, Ummusen Kaya Akca, Erdal Atalay, Muserref Kasap Cuceoglu, Seher Sener, Zeynep Balik, Erdem Karabulut, Selman Kesici, Tevfik Karagoz, Yasemin Ozsurekci, Yelda Bilginer, Ali Bulent Cengiz, Seza Ozen
Summary: This study compared the clinical and laboratory outcomes of MIS-C patients treated with IVIG plus corticosteroids (CS) to those treated with IVIG plus CS and an additional biologic drug. The results showed that the primary outcome was favorable in patients treated with IVIG plus CS, while it was unfavorable in patients treated with IVIG plus CS and a biologic drug.
Article
Rheumatology
Gozde Kubra Yardimci, Doruk Arslan, Berrin Babaoglu, Ertugrul Cagri Bolek, Levent Kilic, Arzu Saglam, Asli Tuncer, Figen Soylemezoglu, Rahsan Gocmen, Kader K. Oguz, Ersin Tan, Omer Karadag
Summary: In this study, the HUVAC database was used to evaluate cases of pachymeningitis in patients with IgG4-related disease. It was found that most of these patients had normal serum IgG4 levels, therefore not useful for diagnosis. Typical radiology and tentorial thickening should raise suspicion of IgG4-related disease and prompt early biopsy. With steroids+ rituximab treatment, there was no long-term relapse related to meningeal involvement.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Ezgi D. Batu, Seher Sener, Seza Ozen
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Ezgi Deniz Batu, Aybuke Gunalp, Sezgin Sahin, Semanur Ozdel, Zehra Kizildag, Aysenur Pac Kisaarslan, Ilknur Bagrul, Muserref Kasap Cuceoglu, Ayse Tanatar, Hafize Emine Sonmez, Erdal Sag, Selcan Demir, Elif Celikel, Sengul Caglayan, Banu Celikel Acar, Betul Sozeri, Nuray Aktay Ayaz, Yelda Bilginer, M. Hakan Poyrazoglu, Erbil Unsal, Oezgur Kasapcopur, Seza Ozen
Summary: This study compared the characteristics and outcomes of pediatric MCTD and other overlap syndromes, finding differences in disease phenotype and prognosis. MCTD may be considered a more severe disease. Analyzing these patients could pave the way for early and effective treatment.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Berkan Armagan, Metin Oksul, Yusuf Ziya Sener, Alper Sari, Abdulsamet Erden, Goezde Kuebra Yardimci, Kadir Mutlu Hayran, Levent Kilic, Oemer Karadag, Ergun Baris Kaya, Sadberk Lale Tokgozoglu, Ali Ihsan Ertenli, Ali Akdogan
Summary: This study aimed to investigate the prevalence and causes of pulmonary hypertension (PH) in Behcet's disease (BD). The study found that PH is not rare in BD patients and is mainly due to left heart disease or pulmonary arterial involvement. BD patients with vascular involvement are at a higher risk of developing PH.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Hatice Ecem Konak, Abdulsamet Erden, Berkan Armagan, Serdar Can Guven, Hakan Apaydin, Pinar Akyuez Dagli, Yagnur Uzun, Merve Kaygisiz, Orhan Kucuksahin, Ahmet Omma
Summary: Breastfeeding may have positive effects on the course of Behcet's disease, as breastfed patients had a lower need for TNF-i and a lower incidence of sacroiliitis. Additionally, patients who were breastfed were diagnosed with the disease at a later age compared to those who were not breastfed.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Esra Firat Senturk, Abdulsamet Erden, Alper Sari, Berkan Armagan, Levent Kilic, Umut Kalyoncu, Oemer Karadag, Sule Apras Bilgen, Sedat Kiraz, Ihsan Ertenli, Ali Akdogan
Summary: This study examines the significance of antiphospholipid antibodies (aPL) in Takayasu arteritis (TA). The results indicate that aPL positivity is not rare in TA patients, but its association with disease-related complications is unclear.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Rheumatology
Ezgi Deniz Batu, Seher Sener, Zeynep Balik, Yagmur Bayindir, Veysel Cam, Muserref Kasap Cuceoglu, Ozan Uysal, Emil Aliyev, Ozge Basaran, Yelda Bilginer, Seza Ozen
Summary: This study compared the characteristics of patients with systemic juvenile idiopathic arthritis (SJIA) who developed macrophage activation syndrome (MAS) during the course of the disease to those who never experienced MAS. It was found that patients with MAS had younger age, longer duration of fever, higher frequency of rash, hepatomegaly, and splenomegaly, and lower frequency of arthralgia/arthritis at the time of SJIA diagnosis compared to patients without MAS.
CLINICAL RHEUMATOLOGY
(2023)