Role of Eosinophil Granulocytes in Allergic Airway Inflammation Endotypes

A randomized trial of benralizumab, an antiinterleukin 5 receptor α monoclonal antibody, after acute asthma

(2015) Richard M. Nowak et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia

(2015) J. Ho et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Comorbidity has no impact on eosinophil inflammation in the upper airways or on severity of the sinonasal disease in patients with nasal polyps

(2015) B. Uhliarova et al.   CLINICAL OTOLARYNGOLOGY

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma

(2015) Russell S. Traister et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of novel immune phenotypes for allergic and nonallergic childhood asthma

(2015) Diana Raedler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function

(2015) Laurence E. Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells

(2015) Rafael Carretero et al.   NATURE IMMUNOLOGY

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

(2015) Polina L. Yarova et al.   Science Translational Medicine

Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies

(2015) Nicola A Hanania et al.   THORAX

Association between Group 2 Innate Lymphoid Cells enrichment, nasal polyps and allergy in Chronic Rhinosinusitis

(2014) D. Miljkovic et al.   ALLERGY

Gene Expression in Relation to Exhaled Nitric Oxide Identifies Novel Asthma Phenotypes with Unique Biomolecular Pathways

(2014) Brian D. Modena et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Eosinophils Promote Generation and Maintenance of Immunoglobulin-A-Expressing Plasma Cells and Contribute to Gut Immune Homeostasis

(2014) Van Trung Chu et al.   IMMUNITY

Enhanced innate type 2 immune response in peripheral blood from patients with asthma

(2014) Kathleen R. Bartemes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 Induces Antigen-Specific IL-5+ T Cells and Promotes Allergic-Induced Airway Inflammation Independent of IL-4

(2014) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations

(2014) Rakesh K. Kumar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

(2014) Mario Castro et al.   Lancet Respiratory Medicine

Anti-IL5 therapy for asthma and beyond

(2014) Manali Mukherjee et al.   World Allergy Organization Journal

The consequences of not having eosinophils

(2013) G. J. Gleich et al.   ALLERGY

Elevated Sputum Interleukin-5 and Submucosal Eosinophilia in Obese Individuals with Severe Asthma

(2013) Dhananjay Desai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

(2013) S. Ueki et al.   BLOOD

The Role of Interleukin-33 in Rhinitis

(2013) Barbara Rogala et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Type 2 Innate Lymphocytes in Allergic Airway Inflammation

(2013) Roel G. J. Klein Wolterink et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Innate lymphoid cells and allergic inflammation

(2013) Brian S Kim et al.   CURRENT OPINION IN IMMUNOLOGY

Asthma: The importance of dysregulated barrier immunity

(2013) Bart N. Lambrecht et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

What is an “eosinophilic phenotype” of asthma?

(2013) Parameswaran Nair   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lysis of primed eosinophils in severe asthma

(2013) Carl Persson   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

(2013) Andrei Malinovschi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction

(2013) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease

(2013) Derek E. Byers et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eosinophils secrete IL-4 to facilitate liver regeneration

(2013) Y. P. S. Goh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

(2013) B. S. Kim et al.   Science Translational Medicine

New treatments for severe treatment-resistant asthma: targeting the right patient

(2013) Kian Fan Chung   Lancet Respiratory Medicine

Anti-inflammatory Treatment of Atopic Asthma Guided by Exhaled Nitric Oxide: A Randomized, Controlled Trial

(2013) Jörgen Syk et al.   Journal of Allergy and Clinical Immunology-In Practice

Local allergic rhinitis: Concept, pathophysiology, and management

(2012) Carmen Rondón et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

(2012) Guiquan Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

(2012) Adaikalavan Ramasamy et al.   PLoS One

Asthma in adults and its association with chronic rhinosinusitis: The GA2LEN survey in Europe

(2011) D. Jarvis et al.   ALLERGY

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Eosinophil extracellular DNA traps in skin diseases

(2011) Dagmar Simon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways

(2011) Ryszard Dworski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis

(2011) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophils are required for the maintenance of plasma cells in the bone marrow

(2011) Van Trung Chu et al.   NATURE IMMUNOLOGY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of mast cells in allergic inflammation

(2011) Kawa Amin   RESPIRATORY MEDICINE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Local proliferation and mobilization of CCR3+ CD34+ eosinophil-lineage-committed cells in the lung

(2010) Madeleine Rådinger et al.   IMMUNOLOGY

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients

(2009) A. Fuentes-Beltrán et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Functional extracellular eosinophil granules: novel implications in eosinophil immunobiology

(2009) Josiane S Neves et al.   CURRENT OPINION IN IMMUNOLOGY

Hypereosinophilic syndrome: A multicenter, retrospective analysis of clinical characteristics and response to therapy

(2009) Princess U. Ogbogu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Presence of Rhinovirus in Lower Airways of Patients with Bronchial Asthma

(2008) Monika Woś et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early-life environment, developmental immunotoxicology, and the risk of pediatric allergic disease including asthma

(2008) Rodney R. Dietert et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Eosinophils: Biological Properties and Role in Health and Disease

(2008) SIMON P. HOGAN et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

(2008) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET

Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane

(2008) Jamel El-Benna et al.   Seminars in Immunopathology