Article
Medicine, General & Internal
Maria Chaparro, Ana Garre, Andrea Nunez Ortiz, Maria Teresa Diz-Lois Palomares, Cristina Rodriguez, Sabino Riestra, Milagros Vela, Jose Manuel Benitez, Estela Fernandez Salgado, Eugenia Sanchez Rodriguez, Vicent Hernandez, Rocio Ferreiro-Iglesias, Angel Ponferrada Diaz, Jesus Barrio, Jose Maria Huguet, Beatriz Sicilia, Maria Dolores Martin-Arranz, Xavier Calvet, Daniel Ginard, Inmaculada Alonso-Abreu, Luis Fernandez-Salazar, Pilar Varela Trastoy, Montserrat Rivero, Isabel Vera-Mendoza, Pablo Vega, Pablo Navarro, Monica Sierra, Jose Luis Cabriada, Mariam Aguas, Raquel Vicente, Merce Navarro-Llavat, Ana Echarri, Fernando Gomollon, Elena Guerra del Rio, Concepcion Pinero, Maria Jose Casanova, Katerina Spicakova, Jone Ortiz de Zarate, Emilio Torrella Cortes, Ana Gutierrez, Horacio Alonso-Galan, Alvaro Hernandez-Martinez, Jose Miguel Marrero, Rufo Lorente Poyatos, Margalida Calafat, Lidia Marti Romero, Pilar Robledo, Orencio Bosch, Nuria Jimenez, Maria Esteve Comas, Jose Maria Duque, Ana Maria Fuentes Coronel, Manuela Josefa Sampedro, Eva Sese Abizanda, Belen Herreros Martinez, Liliana Pozzati, Hipolito Fernandez Rosaenz, Belen Crespo Suarez, Pilar Lopez Serrano, Alfredo J. Lucendo, Margarita Munoz Vicente, Fernando Bermejo, Jose Joaquin Ramirez Palanca, Margarita Menacho, Amalia Carmona, Raquel Camargo, Sandra Torra Alsina, Nuria Maroto, Juan Nerin de la Puerta, Elena Castro, Ignacio Marin-Jimenez, Belen Botella, Amparo Sapina, Noelia Cruz, Jose Luis F. Forcelledo, Abdel Bouhmidi, Carlos Castano-Milla, Veronica Opio, Isabel Nicolas, Marcos Kutz, Alfredo Abraldes Bechiarelli, Jordi Gordillo, Yolanda Ber, Yolanda Torres Dominguez, Maria Teresa Novella Duran, Silvia Rodriguez Mondejar, Francisco J. Martinez-Cerezo, Lilyan Kolle, Miriam Sabat, Cesar Ledezma, Eduardo Iyo, Oscar Roncero, Rebeca Irisarri, Laia Lluis, Isabel Blazquez Gomez, Eva Maria Zapata, Maria Jose Alcala, Cristina Martinez Pascual, Maria Montealegre, Laura Mata, Ana Monrobel, Alejandro Hernandez Camba, Luis Hernandez, Maria Tejada, Alberto Mir, Maria Luisa Galve, Marta Soler, Daniel Hervias, Jose Antonio Gomez-Valero, Manuel Barreiro-de Acosta, Fernando Rodriguez-Artalejo, Esther Garcia-Esquinas, Javier P. Gisbert
Summary: The study found a high incidence of inflammatory bowel disease (IBD) in Spain, similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, especially in cases of Crohn's disease (CD) and in hospitals with high resources, which are much higher than previously reported.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
James D. Lewis, Lauren E. Parlett, Michele L. Jonsson Funk, Colleen Brensinger, Virginia Pate, Qufei Wu, Ghadeer K. Dawwas, Alexandra Weiss, Brad D. Constant, Maureen Mccauley, Kevin Haynes, Jeff Yufeng Yang, Douglas E. Schaubel, Andres Hurtado-Lorenzo, Michael David Kappelman
Summary: This study aimed to estimate the incidence, prevalence, and racial-ethnic distribution of physician-diagnosed inflammatory bowel disease (IBD) in the United States. Four administrative claims data sets were used, and corresponding estimates were obtained. The incidence of IBD remained relatively stable between the ages of 20 and 80, with variations in diagnosis rates among different races and ethnicities.
Article
Gastroenterology & Hepatology
Emir Tulumovic, Nermin Salkic, Denijal Tulumovic
Summary: A study was conducted to review the epidemiology of inflammatory bowel disease (IBD) in the Tuzla Canton of Bosnia-Herzegovina over a 10-year period. The findings showed that trends in the incidence and prevalence of IBD in the region were similar to Eastern European averages, although there were significant epidemiological differences within geographically close and demographically similar areas.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Rahma Elmahdi, Camilla E. Lemser, Sandra B. Thomsen, Kristine H. Allin, Manasi Agrawal, Tine Jess
Summary: This meta-analysis revealed that patients with pediatric-onset IBD have a more than 2-fold increased rate of cancer compared to the general pediatric population, primarily due to an increased rate of gastrointestinal cancers.
Article
Gastroenterology & Hepatology
Emily W. Lopes, Simon S. M. Chan, Mingyang Song, Jonas F. Ludvigsson, Niclas Hakansson, Paul Lochhead, Allan Clark, Kristin E. Burke, Ashwin N. Ananthakrishnan, Amanda J. Cross, Domenico Palli, Manuela M. Bergmann, James M. Richter, Andrew T. Chan, Ola Olen, Alicja Wolk, Hamed Khalili
Summary: This study aimed to estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. Using several cohorts in the US and Europe, the researchers created modifiable risk scores and healthy lifestyle scores, and found that a significant number of CD and UC cases could be prevented through lifestyle modification.
Article
Gastroenterology & Hepatology
Edward L. Barnes, William B. Nowell, Shilpa Venkatachalam, Angela Dobes, Michael D. Kappelman
Summary: A study found that the prevalence of Crohn's disease and ulcerative colitis is lower among minority populations in the United States.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Anders Forss, Mark Clements, David Bergman, Bjorn Roelstraete, Gilaad G. Kaplan, Par Myrelid, Jonas Halfvarson, Ola Olen, Jonas F. Ludvigsson
Summary: The study in Sweden revealed that the incidence of IBD in all subtypes increased from 1990 to 2001, followed by a gradual decline. Incidence rates for IBD, UC, and IBD-U were higher in males, while CD had a higher incidence rate in females. The lifetime risk of being diagnosed with IBD was approximately 2.5% for both sexes.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Manasi Agrawal, Tine Jess
Summary: The epidemiology of inflammatory bowel disease is undergoing changes, with rising incidence and burden of disease. Understanding the causes and preparing healthcare systems are crucial for improving outcomes and health.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Paul Lochhead, Hamed Khalili, Ashwin N. Ananthakrishnan, Kristin E. Burke, James M. Richter, Qi Sun, Philippe Grandjean, Andrew T. Chan
Summary: The study found inverse associations between certain PFAS concentrations and the risk of Crohn's disease, but no associations with ulcerative colitis risk. This suggests that elevated PFAS exposure may not be associated with higher risk of ulcerative colitis, and some PFAS concentrations may be inversely related to the development of Crohn's disease.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Jasbir Dhaliwal, Meltem Tuna, Baiju R. Shah, Sanjay Murthy, Emily Herrett, Anne M. Griffiths, Eric Benchimol
Summary: A study on South Asian and Chinese populations in Ontario, Canada, found that South Asians have a comparable risk of IBD to the general population, but a higher risk of UC, while Chinese people have much lower rates of IBD, CD, and UC. These findings highlight the differences in risk factors for IBD among different Asian ethnic groups living in the Western world.
CLINICAL EPIDEMIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Gastroenterology & Hepatology
Sonia Friedman, Floor Dijkstra Zegers, Line Riis Jolving, Jan Nielsen, Bente Mertz Norgard
Summary: Women with inflammatory bowel disease (IBD) who undergo caesarean section or vaginal delivery have an increased risk of infection within the first 30 days after childbirth. Physicians should be aware of this increased risk and take measures to minimize infectious complications.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Bente Mertz Norgard, Floor Dijkstra Zegers, Torben Knudsen, Jens Kjeldsen, Ken Lund, Jacob Broder Brodersen, Jan Nielsen
Summary: This study investigated the initiation of medications, drug persistency, and surgeries in elderly patients with inflammatory bowel disease (IBD). The results showed a significantly lower chance of medication initiation in elderly patients, but comparable drug persistency to adult patients. Clinicians should carefully consider the use of IBD-specific medications in elderly patients and timely discontinuation of corticosteroids.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Line Riis Jolving, Jan Nielsen, Mette Louise Andersen, Sonia Friedman, Bente Mertz Norgard
Summary: This nationwide cohort study aimed to investigate the effect of in utero exposure to corticosteroids on the risk of adverse birth outcomes and early-life infections in offspring of women with IBD. The results showed that in utero exposure to corticosteroids increased the risk of preterm birth in the offspring by almost 2.5 times, but there was no significant increase in other examined birth and early-life outcomes.
Article
Gastroenterology & Hepatology
Bente Mertz Norgard, Floor Dijkstra Zegers, Jan Nielsen, Torben Knudsen, Jens Kjeldsen
Summary: This study examined the association between COVID-19 infection and corticosteroid prescriptions in patients with inflammatory bowel diseases (IBD). The results showed that COVID-19 infection did not result in a higher rate of corticosteroid prescriptions, which is reassuring for patients with IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Public, Environmental & Occupational Health
Mette Louise Andersen, Line Riis Jolving, Egon Stenager, Torben Knudsen, Bente Mertz Norgard
Summary: This systematic review examined the literature on in utero exposure to maternal multiple sclerosis (MS) and its influence on offspring health outcomes. The findings suggest that women with MS have an increased risk of preterm birth and small for gestational age. However, no clear conclusions could be drawn for women with MS treated with disease-modifying therapy (DMT) during pregnancy. Additionally, the limited studies on long-term child outcomes showed inconsistent results, particularly in neurodevelopment and psychiatric impairment.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Julie Rasmussen, Bente Mertz Norgard, Rasmus Gaardskaer Nielsen, Henrik Boggild, Niels Qvist, Rene Borge Korsgaard Brund, Niels Henrik Bruun, Kirsten Fonager
Summary: This study aimed to examine the effect of being diagnosed with IBD on the achievement of upper secondary education, as well as the influence of disease severity and psychiatric comorbidity. The study found that being diagnosed with IBD at an early age increased the chance of achieving upper secondary education, but patients with more severe disease or psychiatric comorbidity were at higher risk of not achieving it.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Ken Lund, Floor D. Zegers, Sonia Friedman, Jessica R. Allegretti, Bente Mertz Norgard
Summary: The use of tramadol in patients with inflammatory bowel diseases (IBDs) was associated with lower odds of infection, bowel obstruction/ileus, and mortality compared to traditional opioids (TOs). These findings suggest that tramadol may be a safer option for pain management in IBD patients.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Ken Lund, Floor Dijkstra Zegers, Jan Nielsen, Jacob Broder Brodersen, Torben Knudsen, Jens Kjeldsen, Michael Due Larsen, Bente Mertz Norgard
Summary: This study investigated the effect of inflammatory bowel disease (IBD) onset on the prescription pattern of non-IBD medication and the risk of becoming a new user. The results showed that the prescription of non-IBD medication significantly increased after IBD onset in patients of different age groups. Elderly patients had an increased risk of becoming new users of non-IBD medication.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Anders Mark-Christensen, Line Riis Jolving, Pavithra Laxsen Anru, Joseph A. Murray, Rasmus Gaardskaer Nielsen, Niels Qvist, Soren Laurberg, Henriette Engberg, Jens Kjeldsen, Bente Mertz Norgard
Summary: In this nationwide Danish cohort study, it was found that patients with ulcerative colitis who underwent total colectomy had a higher risk of being diagnosed with inflammatory and autoimmune disease (IAD) compared to those who did not.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)