Journal
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B
Volume 10, Issue 6, Pages 1007-1013Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1990793116060257
Keywords
antidepressant drug; surface tension; critical micelle concentration (CMC); inorganic salt; thermodynamic parameters
Categories
Ask authors/readers for more resources
Herein, the micellization phenomena of an amphiphilic antidepressant drug nortriptyline hydrochloride (NOT) have been studied using tensiometric technique in the absence and presence of different concentration of inorganic salts (NaCl, NaBr and KCl) at 298.15 K. NOT is employed for the relief of symptoms of depression. In presence of inorganic salt the CMC value decreases which is explained on the basis of nature and ion size. Various parameters, i.e., the maximum surface excess concentration at the air/solution interface (Gamma(max)), minimum area per head group at the air/solution interface (A(min)), free energy of micellization (Delta G(m)degrees), minimum energy of surface (G(min)) and standard Gibbs energy of adsorption (Delta G(ads)degrees) were evaluated and discussed in detail.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available