Synthesis of conjugates of polyhedral boron hydrides with nucleosides

Methods of synthesis of the conjugates of polyhedral boron hydrides with natural and non-natural nucleosides are overviewed. These conjugates are of interest for their potential pharmaceutical use. Main synthetic approaches toward nucleosides based on 12-vertex closo-carboranes (C2B10H12), 11-vertex nido-carboranes ([C2B9H11](-)), metallacarboranes [cobalt and iron bis(1,2-dicarbollides)] or closo-dodecaborates ([B12H12](2-)) are described including modifications of nucleoside at nucleobase and sugar units.