Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

A Small-Molecule Inhibitor of Lin28

(2016) Martina Roos et al.   ACS Chemical Biology

Identification of factors involved in target RNA-directed microRNA degradation

(2016) Gabrielle Haas et al.   NUCLEIC ACIDS RESEARCH

Surprises in the 3′-end: ‘U’ can decide too!

(2015) Sandra C. Viegas et al.   FEBS Journal

LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans

(2015) Ho-Chou Tu et al.   GENES & DEVELOPMENT

The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea

(2015) Erin J. Golden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression

(2015) Robinson Triboulet et al.   Cell Reports

Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors

(2014) Alexandre Desjardins et al.   NUCLEIC ACIDS RESEARCH

The Heterochronic Genes lin-28a and lin-28b Play an Essential and Evolutionarily Conserved Role in Early Zebrafish Development

(2014) Yasuo Ouchi et al.   PLoS One

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

(2014) Xiaoyu Ma et al.   Nature Communications

Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation

(2014) Nila Roy Choudhury et al.   Cell Reports

Lin28: Primal Regulator of Growth and Metabolism in Stem Cells

(2013) Ng Shyh-Chang et al.   Cell Stem Cell

Exonuclease hDIS3L2 specifies an exosome-independent 3′-5′ degradation pathway of human cytoplasmic mRNA

(2013) Michal Lubas et al.   EMBO JOURNAL

The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway

(2013) Michal Malecki et al.   EMBO JOURNAL

LIN28/LIN28B: An emerging oncogenic driver in cancer stem cells

(2013) Jianbiao Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway

(2013) Hao-Ming Chang et al.   NATURE

A compendium of RNA-binding motifs for decoding gene regulation

(2013) Debashish Ray et al.   NATURE

Conserved microRNA pathway regulates developmental timing of retinal neurogenesis

(2013) A. La Torre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs

(2013) D. Ustianenko et al.   RNA

Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition

(2013) M. Hafner et al.   RNA

The RNase II/RNB family of exoribonucleases: putting the ‘Dis’ in disease

(2013) Filipa P. Reis et al.   Wiley Interdisciplinary Reviews-RNA

LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells

(2012) Jun Cho et al.   CELL

Lin28 regulates HER2 and promotes malignancy through multiple mechanisms

(2012) Chen Feng et al.   CELL CYCLE

miR-9 Controls the Timing of Neurogenesis through the Direct Inhibition of Antagonistic Factors

(2012) Marion Coolen et al.   DEVELOPMENTAL CELL

LIN28 Binds Messenger RNAs at GGAGA Motifs and Regulates Splicing Factor Abundance

(2012) Melissa L. Wilbert et al.   MOLECULAR CELL

Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility

(2012) Dewi Astuti et al.   NATURE GENETICS

Systematic screens of proteins binding to synthetic microRNA precursors

(2012) Harry Towbin et al.   NUCLEIC ACIDS RESEARCH

The Lin28 cold-shock domain remodels pre-let-7 microRNA

(2012) Florian Mayr et al.   NUCLEIC ACIDS RESEARCH

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7)

(2012) J. E. Thornton et al.   RNA

How does Lin28 let-7 control development and disease?

(2012) James E. Thornton et al.   TRENDS IN CELL BIOLOGY

A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing

(2011) Helen L. Lightfoot et al.   BIOCHEMISTRY

Molecular Basis for Interaction of let-7 MicroRNAs with Lin28

(2011) Yunsun Nam et al.   CELL

Single-molecule approach to immunoprecipitated protein complexes: insights into miRNA uridylation

(2011) Kyu-Hyeon Yeom et al.   EMBO REPORTS

LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans

(2011) Priscilla M Van Wynsberghe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28

(2011) Fionna E Loughlin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Importance of the NCp7-like domain in the recognition of pre-let-7g by the pluripotency factor Lin28

(2011) Alexandre Desjardins et al.   NUCLEIC ACIDS RESEARCH

LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro

(2010) E. Balzer et al.   DEVELOPMENT

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis

(2010) Gracjan Michlewski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation

(2010) Pietro Laneve et al.   NUCLEIC ACIDS RESEARCH

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

The deep evolution of metazoan microRNAs

(2009) Benjamin M. Wheeler et al.   EVOLUTION & DEVELOPMENT

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

(2009) John P Hagan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SOAP: short oligonucleotide alignment program

(2008) R. Li et al.   BIOINFORMATICS

Expression of microRNAs during embryonic development of Xenopus tropicalis

(2008) James C. Walker et al.   GENE EXPRESSION PATTERNS

Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28

(2008) Elena Piskounova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranscriptional Regulation of miRNAs Harboring Conserved Terminal Loops

(2008) Gracjan Michlewski et al.   MOLECULAR CELL

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

(2008) Agnieszka Rybak et al.   NATURE CELL BIOLOGY

MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary

(2008) Christoph Leucht et al.   NATURE NEUROSCIENCE

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA

Genetic Analysis of the Role of the Reprogramming GeneLIN-28in Human Embryonic Stem Cells

(2008) Henia Darr et al.   STEM CELLS