Journal
RNA BIOLOGY
Volume 13, Issue 12, Pages 1175-1181Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2016.1236171
Keywords
Gene expression; growth rate; mRNA stability; Saccharomyces cerevisiae; transcription; yeast
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Funding
- Spanish MiNECO
- European Union funds (FEDER) [BFU2013-48643-C3-3-P, BFU2013-48643-C3-1-P]
- Regional Valencian Government [PROMETEO II 2015/006]
- Regional Andalusian Government [P12-BIO1938MO]
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Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases or decreases with growth rate. Our recently published results have unveiled that these changes in mRNA concentration with growth depend on the relative alteration of mRNA synthesis and decay, and that, in addition to this gene-specific transcriptomic signature of growth, global mRNA turnover increases with growth rate. We discuss here these results in relation with other previous and concurrent publications, and we add new evidence which indicates that growth rate controls mRNA turnover even under non-steady-state conditions.
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