Article
Immunology
Chaojun Hu, Siting Li, Zhijuan Xie, Hanxiao You, Hui Jiang, Yu Shi, Wanting Qi, Jiuliang Zhao, Qian Wang, Xinping Tian, Mengtao Li, Yan Zhao, Xiaofeng Zeng
Summary: This study found that detecting aCL IgA, aβ2GPI IgA, aAnxV IgG/M, and aPS/PT IgG/M as biomarkers provides additive value in APS diagnosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Riccardo Tomasello, Giulio Giordano, Francesco Romano, Federica Vaccarino, Sergio Siragusa, Alessandro Lucchesi, Mariasanta Napolitano
Summary: Antiphospholipid syndrome (APS) is often linked with mild thrombocytopenia, while some patients may develop secondary immune thrombocytopenia (ITP) leading to severe thrombocytopenia with risks of major bleeding. It is important to assess the presence of antiphospholipid antibodies (aPL) in patients with ITP to stratify the risk of thrombosis and to define appropriate treatment strategies.
Article
Rheumatology
Ronen Weiss, Doron Bushi, Ekaterina Mindel, Almog Bitton, Yael Diesendruck, Orna Gera, Tali Drori, Ofir Zmira, Shay Anat Aharoni, Nancy Agmon-Levin, Oren Kashi, Itai Benhar, Valery Golderman, David Orion, Joab Chapman, Efrat Shavit-Stein
Summary: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thromboembolic events, and antibodies to ANXA2 have been found to play a pathological role in thrombosis. The study demonstrates that antibodies to ANXA2 result in more severe strokes, supporting the hypothesis that these auto-antibodies are an independent risk factor for cerebral thrombosis.
Article
Biochemistry & Molecular Biology
Javier Pagan-Escribano, Javier Corral, Antonia Minano, Jose Padilla, Vanessa Roldan, Maria Julia Hernandez-Vidal, Jesus Lozano, Isabel de la Morena-barrio, Vicente Vicente, Maria Luisa Lozano, Maria Teresa Herranz, Maria Eugenia de la Morena-barrio
Summary: This study aims to evaluate the role of the emerging hemostatic molecule FXI in the thrombotic risk of patients with circulating antiphospholipid autoantibodies (aPL). Results showed a significant association between high FXI levels and symptomatic patients with aPL (APS), suggesting a causal role of FXI in the prothrombotic state induced by aPL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Daniele Roselli, Maria Addolorata Bonifacio, Giovanna Barbuti, Maria Rosaria Rossiello, Prudenza Ranieri, Maria Addolorata Mariggio
Summary: This real life study aimed to explore the connections between laboratory criteria and the prevalence of non-criteria antiphospholipid antibodies (aPL) in antiphospholipid syndrome (APS). The study found a significant association between aPS and aCL as well as aβ(2)GPI, while the association with LA was less significant. Therefore, measuring aPT and aA5 autoantibodies may be useful, particularly in aCL/aβ(2)GPI-negative patients or in cases of isolated LA positivity.
Article
Rheumatology
Laure Ricard, Charlotte Laurent, Matthias Papo, Sophie Deriaz, Jennifer Catano, Sonia Alamowitch, Gilles Kayem, Francois Chasset, Claire De Moreuil, Jean Jacques Boffa, Grigorios Gerotziafas, Ismail Elalamy, Marie Bornes, Francois Maillot, Alexandra Audemard-Verger, Virginie Planche, Eric Ballot, Olivier Fain, Arsene Mekinian
Summary: In this study, the clinical and biological data of 195 APS patients were retrospectively analyzed, revealing that APS patients with antinuclear antibodies (ANA-positive APS) may have a more severe clinical phenotype and prognosis, without increasing the risk of developing SLE. Prospective studies with longer follow-up are needed to evaluate the effects of additional therapies in this subset of APS.
Article
Immunology
Gustavo Guimaraes Moreira Balbi, Flavio Signorelli, Ana Paula Gandara, Indira Azam, Silvana de Barros, Dilson Marreiros, Pedro Rodrigues Genta, Paulo Andrade Lotufo, Isabela M. Bensenor, Luciano F. Drager, Danieli Andrade
Summary: This study aimed to evaluate the frequency of obstructive sleep apnea (OSA) in patients with thrombotic primary antiphospholipid syndrome (tPAPS), investigate the performance of screening tools for OSA in this scenario, and compare clinical/laboratory differences in tPAPS patients with and without OSA. The results showed that OSA is common in tPAPS patients, with rates comparable to a non-referred population. Both NoSAS and STOP-Bang scores seem to be useful for screening OSA in these patients.
CLINICAL IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ariela Hoxha, Daniela Tormene, Elena Campello, Paolo Simioni
Summary: This study conducted a systematic review on the additional treatments used in refractory and high-risk antiphospholipid antibody syndrome (APS) pregnancies. The results showed that combination therapy with IVIG and PEX achieved a 100% live birth rate in refractory APS pregnancies, while Pravastatin, IA, and PEX showed higher live birth rates in high-risk APS pregnancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, Michael H. Belmont, Maria Laura Bertolaccini, D. Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesus, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M. Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-Garcia, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K. Leaf, Nina Kello, Jason S. Knight, Carl Laskin, Alfred I. Lee, Kimberly Legault, Steve R. Levine, Roger A. Levy, Maarten Limper, Michael D. Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L. Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A. Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V. Seshan, Savino Sciascia, Maria G. Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cecile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
Summary: This study developed new APS classification criteria with high specificity, including clinical and laboratory domains, and improved classification accuracy through weighting and stratification.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Xue Peng, Xi Tan, Aiyun Xing
Summary: Antiphospholipid syndrome (APS) is an acquired autoimmune disorder characterized by recurrent thrombosis and pregnancy complications. Obstetrical APS (OAPS) specifically refers to APS in pregnant women. The classification criteria for OAPS have generated discussion due to the possibility of excluding certain patients. This article presents two cases of non-criteria OAPS with severe complications and discusses the diagnosis, treatment, and prognosis of this unusual antenatal event. It also provides an overview of the pathogenetic mechanisms and clinical features of OAPS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katja Perdan-Pirkmajer, Polona Zigon, Anja Boc, Eva Podovsovnik, Sasa Cucnik, Alenka Mavri, Ziga Rotar, Ales Ambrozic
Summary: This study suggests that negative aCL and/or anti-beta 2GPI at the time of acute DVT may not require further aPL testing, while LA should be checked after discontinuation of anticoagulant therapy. Positive aCL and/or anti-beta 2GPI at the time of acute DVT have a strong positive predictive value for APS and may impact therapeutic decisions.
Article
Hematology
Yajing Zhao, Pengcheng Xu, Li Guo, Haoyi Wang, Yanan Min, Qi Feng, Yu Hou, Tao Sun, Guosheng Li, Xuebin Ji, Jihua Qiu, Jun Peng, Xinguang Liu, Ming Hou
Summary: The study found increased proinflammatory CD16(+) monocytes in peripheral blood of ITP patients and elevated TNF-alpha-expressing macrophages in the spleen. TNF-alpha blockade reduced the number and function of proinflammatory subsets of monocytes and macrophages, leading to remarkable attenuation of antibody-mediated platelet destruction.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Immunology
Kleio-Maria Verrou, Petros P. Sfikakis, Maria G. Tektonidou
Summary: In this study, gene signatures associated with thrombotic primary antiphospholipid syndrome (thrPAPS) were identified using whole blood RNA-sequencing. The differentially expressed genes, including those related to interferon and interferon signaling pathway, showed high accuracy in discriminating thrPAPS patients from healthy controls. Moreover, these genes were found to be highly expressed in subgroups with venous thrombosis, triple antiphospholipid antibody positivity, and recurrent thrombosis, providing potential treatment implications.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Immunology
Giuseppe Barilaro, Emmanuel Coloma-Bazan, Alejandro Chacur, Carlo Della Rocca, Albert Perez-Isidro, Estibaliz Ruiz-Ortiz, Odette Vinas, Dolors Tassies Penella, Joan Carles Reverter, Alicia Molina Andujar, Ricard Cervera, Gerard Espinosa
Summary: The purpose of this study was to analyze the persistence of antiphospholipid antibodies (aPL) over time in patients with antiphospholipid syndrome (APS) and its association with clinical recurrence. The results showed that more than half of the patients maintained persistent positive aPLs over a long-term follow-up, and these patients were more prone to experience recurrence of clinical manifestations.
AUTOIMMUNITY REVIEWS
(2022)
Article
Medicine, Research & Experimental
Tam D. Quach, Weiqing Huang, Ranjit Sahu, Catherine M. M. Diadhiou, Chirag Raparia, Roshawn Johnson, Tung Ming Leung, Susan Malkiel, Peta Gay Ricketts, Stefania Gallucci, Cagla Tukel, Chaim O. Jacob, Martin L. Lesser, Yong-Rui Zou, Anne Davidson
Summary: TNF inhibitors used for treating inflammatory diseases may cause the development of new autoantibodies and secondary autoimmune diseases. TNF deficiency can induce the production of TH17 T cells and enhance the production of germline encoded, T-dependent IgG anti-cardiolipin antibodies. However, it does not induce germinal center formation or precipitate clinical disease. Additional immune stimuli can restore germinal center formation and induce pathogenic autoimmunity in TNF-deficient mice via extrafollicular pathways or atypical germinal center-like pathways.
Article
Hematology
Mirjana Becarevic, Velibor Cabarkapa, Mirjana Deric, Svetlana Ignjatovic
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2017)
Article
Rheumatology
Mirjana Becarevic, Duko Mirkovic, Svetlana Ignjatovic
CLINICAL RHEUMATOLOGY
(2016)
Article
Rheumatology
Mirjana Becarevic, Ljudmila Stojanovic, Svetlana Ignjatovic, Violeta Dopsaj
CLINICAL RHEUMATOLOGY
(2016)
Article
Rheumatology
Mirjana Becarevic, Svetlana Ignjatovic
CLINICAL RHEUMATOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Mirjana Becarevic
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2016)
Article
Medicine, General & Internal
Bozana Nikolic, Jovan Popovic, Mirjana Becarevic, Dusica Rakic
VOJNOSANITETSKI PREGLED
(2018)
Review
Cardiac & Cardiovascular Systems
Mirjana Becarevic
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2017)
Article
Biochemistry & Molecular Biology
Mihalj Posa, Ana Pilipovic, Mirjana Becarevic, Zita Farkas
Article
Rheumatology
Mirjana Becarevic
CURRENT RHEUMATOLOGY REPORTS
(2017)
Article
Rheumatology
Mirjana Becarevic, Marija Saric, Ljudmila Stojanovich, Dusko Mirkovic, Violeta Dopsaj, Svetlana Ignjatovic
CLINICAL RHEUMATOLOGY
(2018)
Article
Medical Laboratory Technology
Mirjana Becarevic, Svetlana Ignjatovic, Nada Majkic-Singh
CLINICAL LABORATORY
(2012)
Article
Biochemistry & Molecular Biology
Mirjana Becarevic, Svetlana Ignjatovic, Nada Majkic-Singh
JOURNAL OF MEDICAL BIOCHEMISTRY
(2013)
Review
Rheumatology
Mirjana B. Becarevic, Bozana S. Nikolic, Svetlana D. Ignjatovic
RHEUMATOLOGY INTERNATIONAL
(2019)
Article
Endocrinology & Metabolism
Mirjana B. Becarevic, Marija Saric Matutinovic, Milos Zarkovic, Biljana Nedeljkovic Beleslin, Jasmina Ciric, Svetlana D. Ignjatovic
Summary: This study is the first report of the presence of aPL Abs in GO patients. The anti-thyroid Abs were linked to aPL, suggesting larger studies are necessary to confirm potential cause-effect relations.