Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Cardiac & Cardiovascular Systems
Xujie Zhang, Yumin Jiang, Fuyou Liang, Jianping Lu
Summary: The study aims to establish the threshold values of AVI and API for screening increased arterial stiffness in the general population. The results indicate that with appropriate threshold values, AVI and API can be used for preliminary screening, but the values should be adjusted to improve diagnostic accuracy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mandi Luo, Dan Yan, Xiaolu Liang, Yi Huang, Pengcheng Luo, Zhen Yang, Yucong Zhang, Ting Xu, Shangbang Gao, Le Zhang, Yiwu Zhou, Qing Shi, Cuntai Zhang, Lei Ruan
Summary: Arterial stiffness is the basis for cardiovascular diseases and its early detection and intervention are crucial for improving global burden of CVD. In this study, the researchers used quantitative proteomics to analyze plasma samples and found that fibulin-1 was significantly upregulated in individuals with high arterial stiffness, and it was positively correlated with arterial stiffness.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Summary: The study found a significant association between plasma lipoprotein(a) (Lp(a)) levels and markers of vascular stiffening in hypertensive patients. This association may help predict cardiovascular risk and suggests that reducing Lp(a) levels could be beneficial for cardiovascular protection in hypertensive patients.
Article
Health Care Sciences & Services
Kyi Mar Wai, Sawada Kaori, Ken Itoh, Okuyama Shinya, Yuka Uchikawa, Sakura Hayashi, Akiko Shiraki, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara
Summary: Telomere length is inversely associated with arterial stiffness as reflected by baPWV, suggesting that shorter telomeres may increase the risk of developing cardiovascular diseases. Individuals with longer telomeres may have a lower risk of arterial stiffness and related cardiovascular risks.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Ivan Cavero-Redondo, Alicia Saz-Lara, Cristina Lugones-Sanchez, Diana P. Pozuelo-Carrascosa, Leticia Gomez-Sanchez, Jose Francisco Lopez-Gil, Luis Garcia-Ortiz, Rosa Maria Bruno, Manuel Angel Gomez-Marcos
Summary: This study synthesized and evaluated scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension. The findings suggest that thiazide diuretics, ACE inhibitors, ARBs, and their combinations can effectively reduce pulse wave velocity, while ACE inhibitors and ARBs can reduce augmentation index.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anhang Zhang, Yupeng Liu, Shouyuan Ma, Qiligeer Bao, Jin Sun, Yongkang Su, Shuang Cai, Bokai Cheng, Man Li, Yan Zhang, Tianqi Tao, Jiaojiao Qiu, Jing Dong, Ge Song, Ping Zhu, Shuxia Wang
Summary: This study evaluated the relationship between ABI and baPWV in a Chinese community-based elderly population and found that baPWV is an independent predictor of all-cause mortality in the elderly community population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Fabio Anastasio, Marzia Testa, Cinzia Ferreri, Arianna Rossi, Gaetano Ruocco, Mauro Feola
Summary: This study aimed to evaluate the prognostic role of arterial stiffness in heart failure patients. The results showed that arterial stiffness was inversely correlated with patient survival and could serve as a prognostic predictor. This study is important for understanding the pathogenesis and clinical outcome of heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Xuan Deng, Yongjian Song, Xu Han, Xueyu Chen, Wenyi Yang, Shouling Wu, Yong Zhou
Summary: This study aimed to identify multiple brachial-ankle Pulse Wave Velocity (baPWV) trajectory phenotypes and assess their determinants. Four distinct baPWV trajectories were identified, mainly determined by mean arterial pressure and age. Additionally, several biochemical markers and body mass index were associated with the trajectory.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Qian Wang, Xinxin Xu, Xue Geng, Haijuan Hu, Wei Cui
Summary: This study found an association between heart rate and brachial-ankle pulse wave velocity, with an increase in heart rate leading to higher pulse wave velocity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Masahiro Nakamori, Hayato Matsushima, Keisuke Tachiyama, Yuki Hayashi, Eiji Imamura, Tatsuya Mizoue, Shinichi Wakabayashi
Summary: Through analyzing records of stroke patients, it was found that a lower ABI, rather than a higher baPWV, was associated with cognitive decline in patients with lacunar infarction.
Article
Urology & Nephrology
Mohamed Mamdouh Elsayed, Elhassan Mohamed Ayman
Summary: Atorvastatin may have a potential role in delaying arterial stiffness progression in hemodialysis patients, as it can help maintain stable arterial stiffness parameters while the placebo treatment group showed a significant increase. This suggests that atorvastatin may have a potential role in delaying arterial stiffness progression in hemodialysis patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Pharmacology & Pharmacy
A. Colak, M. E. Ozpelit, M. Birlik, E. Ozpelit
Summary: The prognostic value of arterial stiffness (AS) parameters in predicting all-cause mortality in systemic sclerosis (SSc) patients was investigated. The results showed that AS parameters were not associated with all-cause mortality. Large-scale studies are needed to determine the exact mechanisms of cardiovascular mortality in SSc patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Zhenyu Chu, Yao Wei, Yan Hao, Jun Wang, Fang Huang, Miao Hou
Summary: This meta-analysis showed that fish oil supplementation has a beneficial effect on pulse wave velocity, especially in low dosage, short time, low DHA to EPA ratio, and among young participants.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Rheumatology
Konstantinos Tselios, Dafna D. Gladman, Haifa Al-Sheikh, Jiandong Su, Murray B. Urowitz
Summary: This study compares the complete renal response rates of lupus nephritis patients treated with low-dose (<= 30 mg/day) or high-dose (>= 40 mg/day) prednisone. The results show that high-dose prednisone achieved better rates of complete response at 12 months and higher rates of complete remission at 2 and 3 years after diagnosis. Cumulative glucocorticoid dose and damage accrual were similar in both groups.
ARTHRITIS CARE & RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Christina Tontikidou, Evangelia S. Makri, Kleo Evripidou, Dimitrios G. Goulis, Antonis Goulas, Stergios A. Polyzos
Summary: Overall, there was no significant difference in total adiponectin concentrations between NAFLD patients with and without liver fibrosis. However, after excluding specific populations and methods, it was found that adiponectin concentrations were lower in NAFLD patients with fibrosis among adult patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Health Care Sciences & Services
Evangelia S. Makri, Eleftheria Makri, Stergios A. Polyzos
Summary: Nonalcoholic fatty liver disease (NAFLD) is a prevalent disease associated with various comorbidities, leading to a socioeconomic burden. Despite the lack of approved pharmacological treatment for NAFLD, combination therapies may be a rational alternative due to the multifaceted pathophysiology of the disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Areti Sofogianni, Nikolaos Stalikas, Christina Antza, Konstantinos Tziomalos
Summary: Cardiovascular disease is the leading cause of death worldwide, and managing cardiovascular risk factors such as hypertension and dyslipidemia is crucial for reducing cardiovascular morbidity and mortality. However, there is currently no definitive optimal cardiovascular risk prediction equation, so country-specific risk scores should be preferred for cardiovascular risk stratification.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Danai-Thomais Kostourou, Dimitrios Milonas, Georgios Polychronopoulos, Areti Sofogianni, Konstantinos Tziomalos
Summary: This article discusses the role and mechanisms of angiotensin receptor blockers (ARBs) in the prevention of diabetic neuropathy. The findings suggest that ARBs may be helpful in delaying and preventing the progression of diabetic neuropathy, but further research is needed to clarify their role in the management of this complication of diabetes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Christodoula Kourtidou, Vasileios Rafailidis, Garyfallia Varouktsi, Efthimios Kanakis, Vassilios Liakopoulos, Timoleon-Achilleas Vyzantiadis, Maria Stangou, Smaragdi Marinaki, Konstantinos Tziomalos
Summary: Patients with diabetic kidney disease (DKD) have a higher risk of cardiovascular events, which may be related to subclinical vascular disease that is not fully explained by traditional risk factors. Evaluating the presence of subclinical vascular disease could improve risk stratification and management of these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Peripheral Vascular Disease
Georgios Polychronopoulos, Dimitrios Milonas, Konstantinos Tziomalos
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Medicine, General & Internal
Eleftheria Ztriva, Adonis Protopapas, Pavlos Mentizis, Anastasios Papadopoulos, Christiana Gogou, Maria Kiosi, Maria Kyziroglou, Ioanna Minopoulou, Anastasia Gkounta, Erofili Papathanasiou, Evangelos Cholongitas, Christos Savopoulos, Konstantinos Tziomalos
Summary: This study aimed to evaluate the relationship between hepatic fibrosis and the severity and outcome of acute ischemic stroke. The study found that hepatic fibrosis, assessed by the FIB-4 index, is associated with more severe ischemic stroke and may also be an independent risk factor for in-hospital mortality in patients admitted with acute ischemic stroke.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Efterpi Mougakou, Elpida Mastrogianni, Maria Kyziroglou, Konstantinos Tziomalos
Summary: Diabetic foot infection is a frequent and potentially life-threatening complication of diabetes mellitus. Antibiotic resistance has become a problem, leading to increasing rates of treatment failure. This review summarizes the safety and efficacy of novel antibiotics in treating diabetic foot infection, although more robust data and randomized controlled studies are needed. Cefiderocol and dalbavancin, which have been extensively studied in patients with bone infections, may be viable options for carefully selected patients with severe diabetic foot infection.
Article
Chemistry, Medicinal
Chrysoula Boutari, Christos V. V. Rizos, Michalis Doumas, George Liamis, Ioannis Skoumas, Loukianos Rallidis, Anastasia Garoufi, Genovefa Kolovou, Konstantinos Tziomalos, Emmanouil Skalidis, Vasileios Kotsis, George Sfikas, Vaia Lambadiari, Panagiotis Anagnostis, Eleni Bilianou, Georgia Anastasiou, Iosif Koutagiar, Estela Kiouri, Achilleas Attilakos, Vana Kolovou, Evangelos Zacharis, Christina Antza, Evangelos Liberopoulos
Summary: Familial hypercholesterolemia (FH) and type 2 diabetes mellitus (T2DM) are both associated with a high risk of atherosclerotic cardiovascular disease (ASCVD). A study found that FH patients with T2DM had a higher prevalence of ASCVD, coronary artery disease (CAD), and stroke compared to those without T2DM. T2DM was significantly associated with prevalent ASCVD even after adjusting for various factors. FH patients with T2DM were also more likely to undergo coronary revascularization procedures. These findings highlight the importance of risk stratification and treatment intensity in FH patients.
Article
Biochemistry & Molecular Biology
Christodoula Kourtidou, Konstantinos Tziomalos
Summary: Diabetic kidney disease (DKD) is the main cause of chronic kidney disease, with a multifactorial pathogenesis involving multiple molecular pathways. Recent studies have shown that histone modification plays a crucial role in the development and progression of DKD. Histone modification is believed to induce oxidative stress, inflammation, and fibrosis in the diabetic kidney. This review provides a summary of the current understanding of the association between histone modification and DKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Dimitrios Kotsos, Konstantinos Tziomalos
Summary: Nonalcoholic fatty liver disease (NAFLD) is common in the general population and even more prevalent in obese and diabetic patients. NAFLD, especially nonalcoholic steatohepatitis (NASH), increases the risk for liver-related and cardiovascular morbidity. The development and progression of NAFLD involve complex and multifactorial pathogenesis, with potential involvement of microsomal prostaglandin E synthase-1 and -2. Targeting these enzymes may offer a novel therapeutic approach for NAFLD. This review discusses the association between microsomal prostaglandin E synthase-1 and -2 and NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Christodoula Kourtidou, Konstantinos Tziomalos
Summary: Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women of reproductive age, and excess body weight worsens its symptoms. Recent studies have evaluated various pharmacological agents for managing obesity in PCOS patients, with glucagon-like peptide-1 receptor agonists showing promising results in reducing body weight. Limited data suggest that sodium-glucose cotransporter-2 inhibitors and phosphodiesterase-4 inhibitors may also be effective. This review discusses the current evidence on the safety and efficacy of these agents in overweight and obese patients with PCOS.
Article
Health Care Sciences & Services
Christodoula Kourtidou, Vasileios Rafailidis, Garyfallia Varouktsi, Efthimios Kanakis, Vassilios Liakopoulos, Timoleon-Achilleas Vyzantiadis, Christos Savopoulos, Smaragdi Marinaki, Maria Stangou, Konstantinos Tziomalos
Summary: SGLT2 inhibitors reduce arterial stiffness and have potential cardiovascular benefits for both high-risk and low-risk patients with type 2 diabetes mellitus.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
Alexandra Tsankof, Konstantinos Tziomalos
Summary: Dyslipidemia is a major modifiable risk factor for ischemic stroke. Treatment with statins is important for secondary prevention of ischemic stroke. If LDL-C targets cannot be achieved with statins, ezetimibe can be added to the treatment. PCSK9 inhibitors can be considered for patients who do not reach LDL-C targets with statin/ezetimibe combination. Adding icosapent ethyl may reduce cardiovascular morbidity in patients with persistently elevated triglyceride levels despite achieving LDL-C targets.