Article
Endocrinology & Metabolism
Zhi-Ju Li, Hao-Yue Hu, Zi-Ling Ding, Zi-Wei Bian, Ying-Hua Xu, Hui-Ting Wen, Ya-Li Qu, Jin-Dong Wang, Xiao-Li Huang, Dong Li, Jing Li, Gui-Fang Hu
Summary: This study found that women with cSLE have more aggressive disease activity during pregnancy compared to those with aSLE, with higher risks of active SLE and LN. However, after adjusting for pre-pregnancy characteristics and pregnancy factors, no significant association was found between cSLE and adverse pregnancy outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Editorial Material
Critical Care Medicine
Brendan Burke, William Tierney, Rachel Georgopoulos, Samir Q. Latifi, Hemant S. Agarwal
Summary: Involvement of the upper airway in the systemic lupus erythematosus (SLE) disease process is uncommon, but can lead to severe complications such as acute tracheal necrosis. Prompt airway evaluation and treatment are crucial for the recovery of SLE patients with rare upper airway involvement.
Article
Pediatrics
Wei Quan, Jingnan An, Gang Li, Guanghui Qian, Meifang Jin, Chenxi Feng, Si Li, Xiaozhong Li, Yunyun Xu, Xiaohan Hu
Summary: This study identified significantly elevated levels of IL-2, IL-10, and IL-21 in cSLE patients compared to healthy controls, with a positive correlation to disease activity. This suggests potential new approaches for regulating T lymphocyte subsets in cSLE diagnosis.
Article
Rheumatology
Kensuke Irino, Yojiro Arinobu, Masahiro Ayano, Shotaro Kawano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: The study retrospectively analyzed 64 pregnancies in 39 cases of lupus patients at Kyushu University Hospital from October 2002 to July 2018. The results showed that 29.7% of patients experienced lupus flare during pregnancy, with discontinuation of immunosuppressants being a significant risk factor. Additionally, fetal stillbirth rates were significantly higher in cases with lower C3 levels at 12 weeks of gestation compared to before conception.
Article
Obstetrics & Gynecology
Robert Silver, Sabrina Craigo, Flint Porter, Sarah S. Osmundson, Jeffrey A. Kuller, Mary E. Norton
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by relapses and remission. It can affect various organs, with the kidneys, joints, and skin being commonly affected. Immunologic abnormalities, such as the production of antinuclear antibodies, are also characteristic of the disease. This document provides recommendations for the treatment and management of SLE during pregnancy, including the use of medications and the prevention of complications.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pediatrics
Pondtip Jongvilaikasem, Pornpimol Rianthavorn
Summary: Patients with childhood-onset systemic lupus erythematosus are at risk of becoming short adults, with independent risk factors including male sex, short stature at diagnosis, low body weight at final height, and cumulative corticosteroid dose. Adequate nutrition and corticosteroid minimization should be emphasized in patients at high risk for short final height.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Chemistry, Medicinal
Noel Zahr, Saik Urien, Christian Funck-Brentano, Helene Vantomme, Nicolas Garcelon, Isabelle Melki, Margaux Boistault, Olivia Boyer, Brigitte Bader-Meunier
Summary: This study investigated the pharmacokinetics of hydroxychloroquine (HCQ) in pediatric patients with systemic lupus erythematosus (SLE). The results showed that HCQ blood concentration was associated with disease activity and could serve as a significant predictor of disease status.
Review
Immunology
Lu Pan, Jinxiang Liu, Congcong Liu, Lishuang Guo, Marilynn Punaro, Sirui Yang
Summary: Childhood-onset systemic lupus erythematosus (cSLE) is a challenging autoimmune disease that requires aggressive treatment due to its genetic background and prevalent elevated type I Interferon expression. High dose oral glucocorticoid (GC) is the standard treatment for moderate to severe cSLE, although its side effects and toxicities cannot be ignored. Recent studies have shown that GC pulse therapy can quickly achieve disease remission and reduce GC-related side effects. This article reviews the characteristics and manifestations of cSLE, and summarizes the evidence on GC therapy, particularly GC pulse therapy, in cSLE.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Lingxiao Xu, Jian Zhao, Qing Sun, Xue Xu, Lei Wang, Ting Liu, Yunjuan Wu, Jingfeng Zhu, Linyu Geng, Yun Deng, Alexander Awgulewitsch, Diane L. Kamen, Jim C. Oates, Prithvi Raj, Edward K. Wakeland, R. Hal Scofield, Joel M. Guthridge, Judith A. James, Bevra H. Hahn, Deborah K. McCurdy, Fang Wang, Miaojia Zhang, Wenfeng Tan, Gary S. Gilkeson, Betty P. Tsao
Summary: This research found two novel SAT1 LOF variants through whole exome sequencing in families with multiple siblings affected by systemic lupus erythematosus (SLE), demonstrating their association with SLE. The study highlights the pathogenic role of dysregulated polyamine catabolism in lupus.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Pediatrics
Shobashenee Sritharan, Peter Sie-Teck Lau, Kamilah Manan, Anand Mohan
Summary: The presence of occult splenic abscesses in children diagnosed with childhood-onset SLE, without evidence of concomitant infection, is an unusual finding. Treatment with corticosteroids and immunosuppressive therapy resulted in rapid recovery of symptoms and complete resolution of the abscesses.
FRONTIERS IN PEDIATRICS
(2023)
Article
Rheumatology
Maya Gerstein, R. Ezequiel Borgia, Daniela Dominguez, Brian M. Feldman, Fangming Liao, Deborah M. Levy, Lawrence Ng, Mohamed Abdelhaleem, Earl D. Silverman, Linda T. Hiraki
Summary: The study aimed to differentiate macrophage activation syndrome (MAS) from active childhood-onset systemic lupus erythematosus (cSLE) and generated decision rules based on clinical and laboratory features. Recursive partitioning identified serum ferritin as the best discriminator between MAS and non-MAS patients. Validation in independent cohorts is needed to confirm the findings.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Gabriela Medina, Francisco R. Gonzalez-Cortes, Antonio Sanchez-Gonzalez, Juan G. Vazquez-Rodriguez, Irvin Ordonez-Gonzalez, Maria P. Jimenez-Arellano, Grettel Garcia-Collinot, Susana Morales-Montalvo, Oscar Florez-Durante, Maria P. Cruz-Dominguez, Maria F. Colorado-Cruz, Miguel A. Zurita-Munoz, Gilberto Cruz-Arteaga, Carolina Sanchez-Enriquez, Luis J. Jara, Miguel A. Saavedra
Summary: The prognostic value of NLR and serum chemerin in predicting maternal-fetal complications in pregnant SLE patients was investigated. NLR was found to be a potential marker of subclinical inflammation and chemerin levels may be associated with preeclampsia.
Article
Rheumatology
Hiba Khogali, Ghada S. M. Al-Bluwi, Virgie Guy Pedo, Ali M. Al Dhanhani
Summary: This study aimed to evaluate adverse pregnancy outcomes in patients with SLE, compare their maternal and fetal outcomes with those of age-matched pregnant women without SLE, and identify factors associated with increased risks of adverse outcomes. The results showed that pregnant women with SLE had a higher risk of adverse maternal and fetal outcomes compared to age-matched pregnant women without SLE, emphasizing the importance of close monitoring and clinical management of SLE pregnancies.
Article
Rheumatology
Ana C. Ulloa, Fangming Liao, Raffaella L. Carlomagno, Talia Diaz, Daniela Dominguez, Deborah M. Levy, Lawrence Ng, Andrea M. Knight, Linda T. Hiraki
Summary: The association between schizophrenia genetic susceptibility loci and NPSLE features in multiethnic childhood-onset SLE patients was examined. The results suggested that there was no significant association between schizophrenia risk loci and NPSLE in this cohort.
JOURNAL OF RHEUMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mario Sestan, Nastasia Kifer, Todor Arsov, Matthew Cook, Julia Ellyard, Carola G. Vinuesa, Marija Jelusic
Summary: The pathogenesis of childhood-onset systemic lupus erythematosus (cSLE) involves genetic risk factors, epigenetic mechanisms, and environmental triggers. While cSLE is typically considered a polygenic disease, rare cases with a single gene mutation provide valuable insights into the disease mechanism and aid in targeted treatment strategies. This review aims to provide an overview of monogenic and polygenic SLE, emphasizing the implications of specific genes in disease pathogenesis. Understanding the genetic factors involved in SLE may improve our understanding of disease mechanisms, identify biomarkers, and guide appropriate therapies.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Beatriz A. Fernandez-Campos, Joaquin Vargas-Penafiel, Maria P. Cruz-Dominguez, Janet Mijangos-Chavez, Edgar Mendoza-Reyes, Ilze J. Huerta-L, Sara Morales-Hernandez, Nelly Berenice Gonzalez Tovar
Summary: This study retrospectively analyzed clinical data from pregnant women with heart disease at two referral centers in Mexico City, finding that the risks of MACEs and preterm birth were associated with the severity of heart disease, while the association with obstetric events was not significant.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Olga Vera-Lastra, Alberto Ordinola Navarro, Maria Pilar Cruz Domiguez, Gabriela Medina, Tania Ivonne Sanchez Valadez, Luis J. Jara
Summary: Two female health care workers developed clinical manifestations of thyroid hyperactivity, increased thyroid hormone levels, suppressed thyroid-stimulating hormone, and elevated antithyroid antibodies three days after receiving a SARS-CoV-2 vaccine. This indicates a potential link between SARS-CoV-2 vaccination and the onset of autoimmune thyroid diseases like Graves' disease.
Review
Immunology
Luis J. Jara, Berenice Lopez-Zamora, Irvin Ordonez-Gonzalez, Maria F. Galaviz-Sanchez, Caroline Gutierrez-Melgarejo, Miguel Angel Saavedra, Olga Vera-Lastra, Maria Pilar Cruz-Dominguez, Gabriela Medina
Summary: The COVID-19 infection induces stress and triggers the immune-neuroendocrine system, which can lead to an inflammatory hyper response in older adults and patients with rheumatic diseases. These vulnerable populations are at a higher risk of complications due to inadequate reactions of the immune-neuroendocrine system.
AUTOIMMUNITY REVIEWS
(2021)
Article
Medicine, General & Internal
Rosa Camacho-Sandoval, Alejandro Nieto-Patlan, Gregorio Carballo-Uicab, Alejandra Montes-Luna, Maria C. Jimenez-Martinez, Luis Vallejo-Castillo, Edith Gonzalez-Gonzalez, Hugo Ivan Arrieta-Oliva, Keyla Gomez-Castellano, Omar U. Guzman-Bringas, Maria Pilar Cruz-Dominguez, Gabriela Medina, Laura A. Montiel-Cervantes, Maricela Gordillo-Marin, Roberto Vazquez-Campuzano, Belem Torres-Longoria, Irma Lopez-Martinez, Sonia M. Perez-Tapia, Juan Carlos Almagro
Summary: This paper reports the implementation and validation of anti-SARS-CoV-2 IgG serological assays using S1 and RBD proteins coated ELISA plates, showing high sensitivity and specificity. The study validated the assays with RT-PCR positive COVID-19 sera and further confirmed their robustness with a large sample of serum collected at different time points.
Article
Neurosciences
Luis Enrique Molina-Carrion, Josehp Lira-Tecpa, Maria Pilar Jimenez-Arellano, Maria Pilar Cruz-Dominguez, Gabriela Medina
Summary: This study provides long-term follow-up data on patients with chronic relapsing inflammatory optic neuropathy (CRION), highlighting the challenging diagnosis and the importance of prompt diagnosis, adequate treatment, and close follow-up to prevent disabling sequelae in these patients.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2022)
Article
Rheumatology
Gabriela Medina, Erik Cime-Ake, Raquel Bonilla-Vazquez, Olga Vera-Lastra, Miguel Angel Saavedra, Maria Pilar Cruz-Dominguez, Luis J. Jara
Summary: The study suggests that cognitive impairment (CI) occurs at a high frequency in primary antiphospholipid syndrome (PAPS), and is correlated with disability and perceived stress. Disability was found in various domains in PAPS patients according to the WHODAS 2.0, and the stress level was normal with a high prevalence of CI. Disability and CI are interdependent in PAPS patients.
Article
Rheumatology
Gabriela Medina, Francisco R. Gonzalez-Cortes, Antonio Sanchez-Gonzalez, Juan G. Vazquez-Rodriguez, Irvin Ordonez-Gonzalez, Maria P. Jimenez-Arellano, Grettel Garcia-Collinot, Susana Morales-Montalvo, Oscar Florez-Durante, Maria P. Cruz-Dominguez, Maria F. Colorado-Cruz, Miguel A. Zurita-Munoz, Gilberto Cruz-Arteaga, Carolina Sanchez-Enriquez, Luis J. Jara, Miguel A. Saavedra
Summary: The prognostic value of NLR and serum chemerin in predicting maternal-fetal complications in pregnant SLE patients was investigated. NLR was found to be a potential marker of subclinical inflammation and chemerin levels may be associated with preeclampsia.
Article
Biochemistry & Molecular Biology
Olga Vera-Lastra, Gabriela Mora, Abihai Lucas-Hernandez, Alberto Ordinola-Navarro, Emmanuel Rodriguez-Chavez, Ana Lilia Peralta-Amaro, Gabriela Medina, Maria Pilar Cruz-Dominguez, Luis J. Jara, Yehuda Shoenfeld
Summary: This study aims to report on autoimmune disease manifestations that occurred following COVID-19 Sputnik vaccination. The study evaluated patients who received the Sputnik vaccine and developed recent-onset autoimmune diseases. Results showed that 28 patients developed recent-onset autoimmune diseases after Sputnik vaccine.
Article
Rheumatology
Michelle Arrucha-Cozaya, Nuria Cecilia Zamora-Zuniga, Dafhne Miranda-Hernandez, Reyna Bustamante-Gonzalez, Gabriela Martinez-Diaz, Drusila Tovar-Rodriguez, Berenice Lopez-Zamora, Maria Del Pilar Cruz-Dominguez, Abraham Edgar Gracia-Ramos, Miguel Angel Saavedra
Summary: Systemic lupus erythematosus (SLE) patients admitted to hospitals have a high mortality rate, with SLE activity and infections, particularly nosocomial infections, being the main causes of death. Hematological manifestations are also associated with in-hospital mortality for these patients.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Gabriela Martinez-Diaz, Maria Pilar Cruz-Dominguez, Berenice Lopez Zamora, Jordan Ramirez-Facio, Gabriela Medina, Ricardo Xavier Munguia-Cruz, Miguel Angel Saavedra-Salinas, Michelle Arrucha-Cozaya, Olga Lidia Vera-Lastra, Ana Lilia Peralta-Amaro, Oscar Ivan Florez-Durante, Kybana Aurora Gil-Galindo
Summary: This study evaluated the impact of body composition and anthropometrics on cardiovascular risk in patients with systemic sclerosis (SSc) compared to healthy controls (HC). The results showed that SSc patients had higher total cholesterol levels, lower muscle mass, and lower total fat compared to HC. Additionally, the increase in BMI in SSc patients with a BMI over 25 was associated with a significant increase in cardiovascular risk.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Olga Vera-Lastra, Erik Cime-Ake, Alberto Ordinola Navarro, Joel Eduardo Morales-Gutierrez, Orestes de Jesus Cobos-Quevedo, Jorge Hurtado-Diaz, Maria Lucero Espinoza-Sanchez, Ana Lilia Peralta-Amaro, Maria Pilar Cruz-Dominguez, Gabriela Medina, Antonio Fraga-Mouret, Jesus Sepulveda-Delgado, Luis J. Jara
Summary: Patients with autoimmune diseases (AID) and COVID-19 have better outcomes compared to the control group. Anticoagulant therapy is associated with lower mortality in patients with AID.
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2022)
Article
Medicine, General & Internal
Laura A. Montiel-Cervantes, Gabriela Medina, Maria Pilar Cruz-Dominguez, Sonia-Mayra Perez-Tapia, Maria C. Jimenez-Martinez, Hugo-Ivan Arrieta-Oliva, Gregorio Carballo-Uicab, Laura Lopez-Pelcastre, Rosa Camacho-Sandoval
Summary: This study demonstrates that levels of lymphocyte subpopulations can serve as biomarkers of survival or mortality in severe COVID-19 cases. Survivors show higher concentrations of lymphocyte subtypes compared to deceased individuals, and lymphocyte levels commonly return to normal in convalescents.
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2021)