Review
Medicine, General & Internal
Ami Schattner
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse and atypical presentations. Early diagnosis is crucial for better outcomes, but the nonspecific symptoms and unusual organ involvement often lead to diagnostic delays.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Immunology
Marten Trendelenburg
Summary: This review discusses the mechanisms and importance of anti-C1q in the development of SLE, highlighting the potential role of C1q in the inflammatory process and exploring its clinical application as a biomarker.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Manuel F. Ugarte-Gil, Yurilis Fuentes-Silva, Victor R. Pimentel-Quiroz, Guillermo J. Pons-Estel, Rosana Quintana, Bernardo A. Pons-Estel, Graciela S. Alarcon
Summary: Systemic lupus erythematosus (SLE) has a more severe impact on non-White populations due to their genetic background and sociodemographic characteristics. Studies on Latin American SLE patients have provided insights into their genetic and clinical characteristics as well as prognostic factors, guiding treatment guidelines and supporting regional and global projects. Educational activities in Spanish and Portuguese have also been initiated to improve patients' health literacy. Despite lower research output, studies from the region and the networks developed have the potential to serve as a model for other rare autoimmune diseases.
FRONTIERS IN MEDICINE
(2023)
Article
Rheumatology
Cesar Magro-Checa, Sofia Ramiro, Inigo Rua-Figueroa, Norman Jimenez, Victor del Campo-Perez, Julia Martinez-Barrio, Maria Galindo-Izquierdo, Jaime Calvo-Alen, Esther Uriarte-Isacelaya, Eva Tomero-Muriel, Mercedes Freire-Gonzalez, Victor Martinez-Taboada, Eva Salgado, Paloma Vela, Natalia Mena-Vazquez, Alejandro Olive, Javier Narvaez, Raul Menor-Almagro, Gregorio Santos-Soler, Jose A. Hernandez-Beriain, Javier Manero-Ruiz, Elena Aurrecoechea-Aguinaga, Oihane Ibarguengoitia, Carlos Montilla-Morales, Gema Bonilla-Hernan, Vicente Torrente-Segarra, Tarek Salman-Monte, Inmaculada Ros-Vilamajo, Maria Jesus Garcia-Villanueva, Clara Moriano-Morales, Concepcion Fito-Manteca, Nuria Lozano-Rivas, Cristina Bohorquez, Jose M. Pego-Reigosa
Summary: This study analyzed the prevalence, incidence, survival, and contribution on mortality of major central nervous system (CNS) involvement in systemic lupus erythematosus (SLE). The results showed that 11.5% of SLE patients developed a total of 522 major CNS neuropsychiatric (NP)-SLE manifestations, and 12% of them died. It was found that cerebrovascular disease (CVD) and organic brain syndrome were associated with the highest mortality rates. The study concluded that major CNS NP-SLE could be an independent prognostic factor for poor survival.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Biochemistry & Molecular Biology
Masahiro Ayano, Takahiko Horiuchi
Summary: Systemic lupus erythematosus (SLE) is a disease where complement is crucial in its pathogenesis. Complement levels in blood and histological tests are used for SLE management, and the evaluation of complement status is useful for diagnosis, disease activity assessment, treatment response prediction, and prognosis. Novel complement biomarkers are more sensitive than traditional markers and have wider application. This review summarizes the utility of complement testing in SLE management over the last decade.
Review
Biochemistry & Molecular Biology
Helena Idborg, Vilija Oke
Summary: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by activation and dysregulation of the immune system. Disturbances in immune pathways and genetic susceptibility are key factors in the development of SLE. Dysregulation of cytokines, particularly interferons, has been extensively studied as potential biomarkers and treatment targets in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Carl Petrus Linge, Andreas Jern, Helena Tyden, Birgitta Gullstrand, Hong Yan, Charlotte Welinder, Robin Kahn, Andreas Jonsen, John W. Semple, Anders A. Bengtsson
Summary: This study found that platelets in patients with SLE have a decreased size and a specific protein profile, including immunoglobulins, complement proteins, and autoantigens. The presence of these proteins may contribute to the pathogenesis of SLE.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Biochemistry & Molecular Biology
Konstantinos Parperis, Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Pulmonary hypertension is commonly seen in patients with systemic lupus erythematosus, presenting with non-specific symptoms and negatively affecting survival. It can result from immune system dysregulation, as well as various other conditions. Early diagnosis and identification of underlying pathogenetic mechanisms are crucial for introducing targeted therapy and preventing irreversible pulmonary vascular damage. The management of pulmonary hypertension in SLE patients is similar to that of idiopathic PAH, but specific diagnostic tools for early diagnosis seem to be unavailable yet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Wen Ma, Yu-Lung Lau, Wanling Yang, Yong-Fei Wang
Summary: The study aimed to improve SLE prediction accuracy using machine-learning algorithms, and the results showed that the random forest (RF) model performed well in SLE classification.
FRONTIERS IN GENETICS
(2022)
Review
Immunology
Amirhossein Azari Jafari, Mojtaba Keikha, Seyyedmohammadsadeq Mirmoeeni, Mohammad Taghi Rahimi, Reza Jafari
Summary: The study systematically reviewed the use of live parasites or parasitic products in treating mouse models of SLE, demonstrating potential immunomodulating effects on improving immunologic cells and pathological changes.
AUTOIMMUNITY REVIEWS
(2021)
Article
Immunology
Tomohiro Koga, Kunihiro Ichinose, George C. Tsokos
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs. Immune abnormalities contribute to the expression of the disease, with elements of the immune system instigating cellular damage. Correcting immune aberrations and preventing organ damage are both important.
CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tao Ming Sim, Siying Jane Ong, Anselm Mak, Sen Hee Tay
Summary: This review discusses the bench to bedside translation of the type I IFN pathway and explores some unresolved issues when selecting SLE patients for treatment with biologics targeting type I IFNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jijuan Yang, Chun Li, Shuhong Chi, Hongliang Wei, Wenqing Du, Qikuan Hu
Summary: This study identified the upregulation of miRNA miR-762 in both SLE and NPSLE samples, which can suppress the expression of GIPC3 and may be involved in the development of SLE and NPSLE.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Immunology
Maria Garcia-Gonzalez, Fuensanta Gomez-Bernal, Juan C. C. Quevedo-Abeledo, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Inigo de la Rua-figueroa, Raquel Lopez-Mejias, Federico Diaz-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study assessed the function of the three complement pathways in SLE patients and found that AL and LE pathways had lower functional values compared to the CL pathway. Clinical activity was not related to functional values of the C pathways, but increased DNA binding was negatively associated. Disease damage was positively correlated with C pathways and components. Anti-ribosomes and anti-nucleosomes antibodies showed a higher relationship with C activation, mainly through the LE and CL pathways. IgG anti-beta 2GP antibodies were most closely related to C activation, predominantly involving the AL pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Telma Miyuki Oshiro, Lais Teodoro da Silva, Marina Mazzilli Ortega, Sandro Felix Perazzio, Alberto Jose da Silva Duarte, Magda Carneiro-Sampaio
Review
Pediatrics
Magda Carneiro-Sampaio, Adriana Almeida de Jesus, Silvia Yumi Bando, Carlos Alberto Moreira-Filho
Summary: This article reviews the literature on Inborn Errors of Immunity (IEI), focusing on diseases with intrauterine or perinatal manifestations. The main finding is that these early manifestations are mainly concentrated in the group of primary immune regulatory disorders and autoinflammatory diseases.
FRONTIERS IN PEDIATRICS
(2022)
Correction
Medical Laboratory Technology
Edward K. L. Chan, Carlos A. von Muhlen, Marvin J. Fritzler, Jan Damoiseaux, Maria Infantino, Werner Klotz, Minoru Satoh, Lucile Musset, Ignacio Garcia-De La Torre, Orlando Gabriel Carballo, Manfred Herold, Wilson de Melo Cruvinel, Tsuneyo Mimori, Karsten Conrad, Luis E. C. Andrade
JOURNAL OF APPLIED LABORATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Marina Mazzilli Ortega, Lais Teodoro da Silva, Erika Donizetti Candido, Yingying Zheng, Bruna Tiaki Tiyo, Arthur Eduardo Fernandes Ferreira, Simone Correa-Silva, Guilherme Pereira Scagion, Fabyano Bruno Leal, Vanessa Nascimento Chalup, Camila Araujo Valerio, Gabriela Justamante Handel Schmitz, Carina Ceneviva, Aline Pivetta Cora, Alexandre de Almeida, Edison Luiz Durigon, Danielle Bruna Leal Oliveira, Patricia Palmeira, Alberto Jose da Silva Duarte, Magda Carneiro-Sampaio, Telma Miyuki Oshiro
Summary: We investigated the immune response to the SARS-CoV-2 vaccine (CoronaVac) in healthcare workers who had received two doses of the inactivated virus-based vaccine. Our study analyzed serum and salivary antibodies, serum antibody neutralizing activity, and cellular immune response. The results showed that CoronaVac induced the production of specific serum and saliva antibodies, as well as IFN-gamma producing T cells, in most individuals who had recovered from COVID-19 and/or were vaccinated. The vaccine demonstrated neutralizing activity against the ancestral strain, but a reduced response against the variants. Vaccinated individuals with previous COVID-19 infection exhibited higher immune responses compared to those without previous infection.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Marilia Moreira Montenegro, Debora Camilotti, Caio Robledo D'Anglioli Costa Quaio, Yanca Gasparini, Evelin Aline Zanardo, Andreia Rangel-Santos, Gil Monteiro Novo-Filho, Gleyson Francisco, Lucas Liro, Amom Nascimento, Samar Nasser Chehimi, Diogo Cordeiro Queiroz Soares, Ana C. V. Krepischi, Marcilia Sierro Grassi, Rachel Sayuri Honjo, Patricia Palmeira, Chong Ae Kim, Magda Maria Sales Carneiro-Sampaio, Carla Rosenberg, Leslie Domenici Kulikowski
Summary: Early molecular diagnosis is effective in the clinical management of rare diseases. This study confirmed the presence of 8p23.1 deletion syndrome in 8 patients using molecular diagnosis. Cytogenomic screening is helpful for differential diagnosis and early detection of microdeletion syndromes.
JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Clovis A. Silva, Ana C. Medeiros-Ribeiro, Leonard V. K. Kupa, Emily F. N. Yuki, Sandra G. Pasoto, Carla G. S. Saad, Solange R. G. Fusco, Rosa M. R. Pereira, Samuel K. Shinjo, Ari S. R. Halpern, Eduardo F. Borba, Fernando H. C. Souza, Lissiane K. N. Guedes, Renata Miossi, Karina R. Bonfiglioli, Diogo S. Domiciano, Andrea Y. Shimabuco, Danieli C. O. Andrade, Luciana P. C. Seguro, Ricardo Fuller, Percival D. Sampaio-Barros, Ana P. L. Assad, Julio C. B. Moraes, Claudia Goldenstein-Schainberg, Henrique A. M. Giardini, Henrique C. Silva, Victor A. O. Martins, Lorena E. B. Villamarin, Renata S. Novellino, Lucas P. Sales, Carlo S. R. Araujo, Matheus S. R. Silva, Dilson M. N. Filho, Marta H. Lopes, Alberto J. S. Duarte, Esper G. Kallas, Nadia E. Aikawa, Eloisa Bonfa
Summary: In autoimmune rheumatic disease patients, a phase 4 clinical trial showed a marked reduction in antibodies 6 months after the second dose of Sinovac-CoronaVac vaccine, especially in males or those under immune targeting therapies. However, there was no increase in COVID-19 cases.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Guilherme S. Goncalves, Simone Correa-Silva, Yingying Zheng, Isabela Avelar, Marilia M. Montenegro, Arthur E. F. Ferreira, Vera Bain, Thais T. Fink, Priscila Suguita, Camilla Astley, Livia Lindoso, Fernanda Martins, Olivia M. Matsuo, Juliana C. O. A. Ferreira, Isabela Firigato, Fernanda de Toledo Goncalves, Maria Fernanda B. Pereira, Clovis Artur A. da Silva, Magda Carneiro-Sampaio, Heloisa H. S. Marques, Patricia Palmeira
Summary: The exacerbation of the inflammatory response caused by SARS-CoV-2 in adults promotes the production of soluble mediators that could act as diagnostic and prognostic biomarkers for COVID-19. Among these potential biomarkers, sTREM-1 has been identified as a predictor of inflammation severity. This study evaluated the concentrations of sTREM-1 and cytokines in pediatric patients with COVID-19 and found that sTREM-1 levels were higher in MIS-C patients, making it a potential early screening tool for MIS-C cases.
Article
Rheumatology
Carla G. S. Saad, Matheus S. R. Silva, Percival D. Sampaio-Barros, Julio C. B. Moraes, Claudia G. Schainberg, Celio R. Goncalves, Andrea Y. Shimabuco, Nadia E. Aikawa, Emily F. N. Yuki, Sandra G. Pasoto, Leonard V. K. Kupa, Renato K. Aoyama, Carlo S. R. Araujo, Clovis A. Silva, Ana C. Medeiros-Ribeiro, Eloisa Bonfa
Summary: This study evaluated the humoral responses to the SARS-CoV-2 vaccine in patients with spondyloarthritis and found that therapy had an impact on the immune response. TNF inhibitors attenuated the immune response, while sulfasalazine had a positive impact on vaccine antibody production.
Editorial Material
Medicine, General & Internal
Braian Lucas Aguiar, Magda Maria Sales Carneiro-Sampaio
Article
Public, Environmental & Occupational Health
Bruno Gualano, Sofia M. Sieczkowska, Italo Ribeiro Lemes, Rafael Pires da Silva, Ana J. Pinto, Bruna C. Mazzolani, Fabiana I. Smaira, Nadia E. Aikawa, Leonard V. K. Kupa, Sandra G. Pasoto, Ana C. Medeiros-Ribeiro, Carla G. S. Saad, Emily F. N. Yuk, Clovis A. Silva, Paul Swinton, Pedro C. Hallal, Hamilton Roschel, Eloisa Bonfa
Summary: Physical activity is associated with improved immunogenicity after vaccination in patients with autoimmune rheumatic diseases (ARD). A study found that physically active patients had higher odds of better antibody responses to CoronaVac booster dose compared to inactive patients. These results support the recommendation of physical activity to enhance vaccination responses in immunocompromised individuals.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Medicine, General & Internal
Maira P. Ribeiro, Amaro N. Duarte-Neto, Marisa Dolhnikoff, Livia Lindoso, Benito Lourenco, Heloisa H. Marques, Maria F. B. Pereira, Lilian M. Cristofani, Vicente Odone-Filho, Lucia M. A. Campos, Adriana M. E. Sallum, Magda Carneiro-Sampaio, Artur F. Delgado, Werther B. Carvalho, Thais Mauad, Clovis A. Silva
Summary: This study aimed to evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases. The results showed that there were major discrepancies between clinical diagnosis of death and autopsy findings in 30% of adolescents with chronic diseases. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.
Meeting Abstract
Rheumatology
Juliana R. Simon, Adriana M. Elias, Maria F. B. Pereira, Heloisa H. Marques, Bianca P. Ihara, Claudia A. A. Strabelli, Reinan T. Campos, Katia T. Kozu, Nadia E. Aikawa, Neusa K. Sakita, Sandra J. F. E. Grisi, Ana Paula S. Ferrer, Vera A. Santos, Vera Bain, Clovis A. Silva, Lucia M. A. Campos
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Camila Pugliese, Katia T. Kozu, Lucia M. A. Campos, Nadia E. Aikawa, Clovis A. A. Silva, Adriana M. Elias
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Immunology
Luis Eduardo C. Andrade, Jan Damoiseaux, Diego Vergani, Marvin J. Fritzler
Summary: The classification and diagnosis of systemic autoimmune diseases rely on a set of criteria that include clinical, laboratory, imaging, and pathology factors. Autoantibodies play a crucial role in the classification criteria of many autoimmune diseases. HEp-2 indirect immunofluorescence assay is capable of detecting a wide range of autoantibodies. A positive HEp-2 IFA test can indicate the most likely autoantibody specificities in the sample. This paper suggests that the classification and diagnostic criteria for certain autoimmune diseases could be improved by modifying the accepted staining patterns for each disease based on relevant autoantibody specificities.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2022)
Article
Rheumatology
Natalia Regine de Franca, Henri Andre Menard, Maximilien Lora, Zhijie Zhou, Joyce Rauch, Carol Hitchon, Luis Eduardo Coelho Andrade, Ines Colmegna
Summary: In this study, ECV304 cells were found to have self-citrullination capacity and novel cit-target proteins were identified in the autocitrullinated products immunoprecipitated by sera from RA patients. The auto-cit-prot-ECV304 ELISA showed high sensitivity and specificity for RA diagnosis.
ARTHRITIS RESEARCH & THERAPY
(2022)