Journal
REVISTA BRASILEIRA DE PSIQUIATRIA
Volume 38, Issue 1, Pages 58-60Publisher
ASSOC BRASILEIRA PSIQUIATRIA
DOI: 10.1590/1516-4446-2015-1708
Keywords
Working memory; crack cocaine; aging; substance use-related disorders; cognition
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Funding
- Conselho Nacional de Desenvolvimento Tecnico Cientifico (CNPq)
- Coordenagao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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Objective: To compare the working memory (WM) performance of young adult crack-cocaine dependent users, healthy older adults, and a control group of healthy young adults. Methods: A total of 77 female participants took part in this study: 26 young adult crack-cocaine dependent users (CRK), 19 healthy older adults (HO), and 32 healthy younger adults (HC). All participants completed the N-back verbal task. Results: A multivariate analysis of covariance was performed. The model included education, income, and medication use as covariates. A group effect (F-6,F-140 = 7.192, p < 0.001) was found. Post-hoc analyses showed that the performance of the CRK and HO groups was reduced compared to the HC group in two N-back conditions. No differences between the HO and CRK groups on WM performance were found. Conclusions: CRK participants perform similar to HO participants on a WM task, despite the well-known effects of age on WM and the young age of CRK. These data point to a possible parallel between cognitive declines associated with crack use and developmental aging.
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