Journal
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Volume 36, Issue 12, Pages S83-S92Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0000000000001338
Keywords
optical coherence tomography; optical coherence tomography angiography; neovascular age-related macular degeneration
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Funding
- Macula Vision Research Foundation, New York
- CAPES Foundation, Ministry of Education of Brazil, Brasilia, DF, Brazil
- Carl Zeiss Meditec
- Optovue
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Purpose: To describe qualitative and quantitative optical coherence tomography (OCT) angiography (OCTA) parameters for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and their applicability as potential clinical trial endpoints. Methods: A review of current literature related to the topic of OCTA and AMD. Results: There are a number of promising OCTA parameters that can be used to diagnose the presence of CNV and to monitor the activity and progression of the lesion, pre- and post-treatment morphological characteristics, CNV dimensions, and automated quantitative parameters such as vessel density. Conclusion: The OCTA parameters described in this review have promise for the future development of clinical trial endpoints, but require further validation before they can be widely used.
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