Review
Critical Care Medicine
Denise Battaglini, Paolo Pelosi, Chiara Robba
Summary: Cardiac arrest is a leading cause of death and disability, often accompanied by neurological and systemic complications. Supportive therapies such as mechanical ventilation, hemodynamic management, and temperature control have been used in post-cardiac arrest patients to protect the brain and lungs and prevent systemic complications. Lung-protective ventilation is now the standard of care for critically ill patients.
Article
Medicine, General & Internal
Arthur Salome, Annabelle Stoclin, Cyrus Motamed, Philippe Sitbon, Jean-Louis Bourgain
Summary: The study showed that measuring end-tidal PCO2 after prolonging inspiratory time reduced the PaCO2-PetCO2 gradient, obtaining values close to PaCO2. This method can better identify hypercapnic patients in both intensive care and during anesthesia.
Article
Multidisciplinary Sciences
Shunsuke Amagasa, Masahiro Kashiura, Hideto Yasuda, Mineji Hayakawa, Kazuma Yamakawa, Akira Endo, Takayuki Ogura, Atsushi Hirayama, Hideo Yasunaga, Takashi Tagami
Summary: This study aimed to evaluate the association between ICU patient volume prior to COVID-19 pandemic and outcomes of ventilated COVID-19 patients. The results showed that institutional intensive care patient volume was not significantly associated with in-hospital death in ventilated COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Review
Multidisciplinary Sciences
Lichen Ouyang, Muqing Yu, Yan Zhu, Jie Gong
Summary: A systematic review of 40 studies involving 15320 COVID-19 patients revealed varying rates of IMV application in different continents, with higher mortality in patients treated with IMV compared to non-IMV respiratory support.
Article
Critical Care Medicine
Jacob C. Jentzer, Carlos L. Alviar, P. Elliott Miller, Thomas Metkus, Courtney E. Bennett, David A. Morrow, Gregory W. Barsness, Kianoush B. Kashani, Ognjen Gajic
Summary: The prevalence of respiratory failure in the CICU more than doubled during the last decade, with overall mortality declining over time. Different types of respiratory support have different impacts on mortality, and cardiac arrest and shock were the main factors contributing to deaths. Further research is needed to improve outcomes for high-risk CICU patients with respiratory failure.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Chung-Yeh Chuang, Han-Shui Hsu, Guan-Jhou Chen, Tzu-Yi Chuang, Ming-Han Tsai
Summary: This study investigated the association between underweight and post-extubation failure in mechanically ventilated patients. The results showed that underweight and lower maximal inspiratory airway pressure were significantly associated with extubation failure.
Article
Medicine, General & Internal
Nobunaga Okada, Tasuku Matsuyama, Yohei Okada, Asami Okada, Kenji Kandori, Satoshi Nakajima, Tetsuhisa Kitamura, Bon Ohta
Summary: The study found that maintaining normocapnia and mild hypercapnia during the 24 hours after ROSC was associated with better neurological outcomes, while severe hypocapnia, mild hypocapnia, severe hypercapnia, and exposure to both hypocapnia and hypercapnia were linked to a higher risk of 1-month poor neurological outcome. There was no significant difference between patients with normocapnia and mild hypercapnia in terms of outcome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Giuseppe Aiello, Micol Cuocina, Luigi La Via, Simone Messina, Giuseppe A. Attaguile, Giuseppina Cantarella, Filippo Sanfilippo, Renato Bernardini
Summary: In this systematic review and meta-analysis, we found that melatonin and ramelteon do not seem to reduce delirium incidence in ICU patients, although there was a potential trend towards reducing the duration of mechanical ventilation. More studies are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Bartholomew Grabman, Natalie E. Bulger, Brenna M. Harrington, Robert G. Walker, Andrew J. Latimer, Bonnie D. Snyder, Michael R. Sayre, Charles Maynard, Nicholas J. Johnson, Molly Van Dyke, Catherine R. Counts
Summary: This study investigated the relationship between end-tidal carbon dioxide (ETCO2) and return of spontaneous circulation (ROSC) after defibrillation in intubated non-traumatic out-of-hospital cardiac arrest (OHCA) patients. The results showed that ETCO2 increased after defibrillation in most patients, and those with sustained ROSC experienced the largest increase.
Article
Cardiac & Cardiovascular Systems
Shiva Nandiwada, Sunjidatul Islam, Jacob C. Jentzer, P. Elliott Miller, Christopher B. Fordyce, Patrick Lawler, Carlos L. Alviar, Louise Y. Sun, Douglas C. Dover, Renato D. Lopes, Padma Kaul, Sean van Diepen
Summary: This study found that higher mechanical ventilation volumes in cardiac intensive care units were associated with lower in-hospital mortality, shorter duration of mechanical ventilation, and shorter length of stay.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Article
Physiology
Ryan J. Sprenger, William K. Milsom
Summary: At the onset of hibernation, there is a transient decrease in CO2 sensitivity allowing for CO2 retention, followed by an increase in CO2 sensitivity in steady-state hibernation. Changes in ventilation, O2 consumption rates, and CO2 chemo-sensitivity are associated with the transition into and out of hibernation in 13-lined ground squirrels.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Pei Shang, Jiachun Feng, Wei Wu, Hong-Liang Zhang
Summary: Guillain-Barre syndrome (GBS) is an acute polyneuropathy characterized by acute flaccid paralysis, with current treatment options including immunotherapies and mechanical ventilation in the ICU setting which are largely empirical. This review emphasizes the importance of ICU care and treatment for severe GBS patients, summarizing the latest knowledge on pharmacological therapies and ICU management.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Loes Mandigers, Fabian Termorshuizen, Nicolette F. de Keizer, Wim Rietdijk, Diederik Gommers, Dinis dos Reis Miranda, Corstiaan A. den Uil
Summary: Sex differences in 1-year mortality of out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA) patients admitted to the intensive care unit (ICU) were studied, showing that women have higher mortality rates than men. This difference was found to persist for OHCA even after left truncation, while for IHCA, the effect of sex was mainly present in the initial phase after the cardiac arrest.
JOURNAL OF CRITICAL CARE
(2021)
Article
Emergency Medicine
Michael E. Winters, Kami Hu, Joseph P. Martinez, Haney Mallemat, William J. Brady
Summary: This review article summarizes important studies published in 2020 regarding resuscitation and care of select critically ill patients, highlighting key findings such as the use of dexamethasone for COVID-19 patients, lower levels of positive end-expiratory pressure for patients without acute respiratory distress syndrome, and early initiation of extracorporeal membrane oxygenation for out-of-hospital cardiac arrest patients with refractory ventricular fibrillation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Sindhaghatta Venkatram, Arundhati Dileep, Ked Fortuzi, Nishant Allena, Gilda Diaz-Fuentes
Summary: This retrospective study compared COVID-19 outcomes in ICU patients during three waves of infection in Bronx, NY. The study found that patients in the first wave had shorter mechanical ventilation and hospital stays, with more patients discharged directly home. The second and third waves showed higher rates of patients being discharged home and decreased mortality. Predictors of mortality included age, gender, COPD, shock, AKI, dialysis requirement, and mechanical ventilation.
Article
Emergency Medicine
Kartik Kishore, George Braitberg, Natasha E. Holmes, Rinaldo Bellomo
Summary: This study aimed to develop a predictive model for hospital admission using available electronic data. By analyzing data from nearly 600,000 ED patients, the machine learning model achieved an 86% accuracy in predicting hospital admission within 30 minutes of ED presentation. The predictive performance of this model is important for improving patient flow.
EMERGENCY MEDICINE AUSTRALASIA
(2023)
Article
Cardiac & Cardiovascular Systems
Eric K. W. Poon, Vassili Kitsios, David Pilcher, Rinaldo Bellomo, Jai Raman
Summary: A model was developed to predict the impact of future climate on ICU demand, based on the relationship between Australian ICU demand and long-lived large-scale climate measures. The results showed a strong correlation between Australian ICU demand and temperature and humidity indicators, and projected changes in demand based on future climate scenarios.
HEART LUNG AND CIRCULATION
(2023)
Article
Anesthesiology
Johnny Vogiatjis, Khin M. Noe, Andrea Don, Andrew D. Cochrane, Michael Z. L. Zhu, Julian A. Smith, Jennifer P. Ngo, Andrew Martin, Amanda G. Thrift, Rinaldo Bellomo, Roger G. Evans
Summary: In patients recovering from on-pump cardiac surgery, changes in norepinephrine dose are associated with reciprocal changes in urinary oxygen tension (PO2), potentially reflecting an effect of norepinephrine on renal medullary oxygenation.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Editorial Material
Orthopedics
Lingjia Wei, Carol Hodgson
JOURNAL OF PHYSIOTHERAPY
(2023)
Article
Clinical Neurology
Tom Balfroid, Aaron E. L. Warren, Linda J. Dalic, Alec Aeby, Salvatore U. Berlangieri, John S. Archer
Summary: In this study, the key networks involved in the epileptic process of LGS were identified using PET scan. The results showed hypometabolism in frontal and parietal cortex of LGS patients, which is consistent with previous studies. It was also found that the metabolic abnormalities in individual patients vary.
Article
Clinical Neurology
Ildefonso Rodriguez-Leyva, Karla Cantu-Flores, Arturo Dominguez-Frausto, Anna Elisabetta Vaudano, John Archer, Boris Bernhardt, Lorenzo Caciagli, Fernando Cendes, Yotin Chinvarun, Paolo Federico, William D. Gaillard, Eliane Kobayashi, Godwin Ogbole, Stefan Rampp, Irene Wang, Shuang Wang, Luis Concha
Summary: The ILAE Neuroimaging Task Force published educational case reports on neuroimaging in epilepsy. Neurocysticercosis is highly endemic in resource-limited countries and is increasingly seen in non-endemic regions due to migration. This article presents two cases with different clinical features to illustrate the varying severity of symptoms caused by this parasitic infestation, as well as examples of imaging characteristics that emphasize the central role of neuroimaging in diagnosing neurocysticercosis.
EPILEPTIC DISORDERS
(2023)
Article
Medicine, General & Internal
Glenn Eastwood, Alistair D. Nichol, Carol Hodgson, Rachael L. Parke, Shay McGuinness, Niklas Nielsen, Stephen Bernard, Markus B. Skrifvars, Dion Stub, Fabio S. Taccone, John Archer, Demetrios Kutsogiannis, Josef Dankiewicz, Gisela Lilja, Tobias Cronberg, Hans Kirkegaard, Gilles Capellier, Giovanni Landoni, Janneke Horn, Theresa Olasveengen, Yaseen Arabi, Yew Woon Chia, Andrej Markota, Matthias Haenggi, Matt P. Wise, Anders M. Grejs, Steffen Christensen, Heidi Munk-Andersen, Asger Granfeldt, Geir O. Andersen, Eirik Qvigstad, Arnljot Flaa, Matthew Thomas, Katie Sweet, Jeremy Bewley, Minna Backlund, Marjaana Tiainen, Manuela Iten, Anja Levis, Leah Peck, James Walsham, Adam Deane, Angajendra Ghosh, Filippo Annoni, Yan Chen, David Knight, Eden Lesona, Haytham Tlayjeh, Franc Svensek, Peter J. McGuigan, Jade Cole, David Pogson, Matthias P. Hilty, Joachim P. During, Michael J. Bailey, Eldho Paul, Bridget Ady, Kate Ainscough, Anna Hunt, Sinead Monahan, Tony Trapani, Ciara Fahey, Rinaldo Bellomo
Summary: This study found that mild hypercapnia did not lead to better neurological outcomes at 6 months than normocapnia in adults with coma who were resuscitated after out-of-hospital cardiac arrest.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Critical Care Medicine
Thomas C. Rollinson, Joleen Rose, Luke A. McDonald, Cara Green, Michelle Topple, Stephen Warrillow, Lucy Modra, Rahul Costa-Pinto, Sue Berney
Summary: This study investigated the feasibility and implementation of a physiotherapy-led intensive proning (PhLIP) team to support the critical care team during the COVID-19 pandemic. The use of prone positioning in the ICU improved oxygenation, and the involvement of the PhLIP team allowed critical care staff to focus on other duties.
AUSTRALIAN CRITICAL CARE
(2023)
Article
Health Care Sciences & Services
Aileen Collier, Deborah Balmer, Eileen Gilder, Rachael Parke
Summary: This research investigated the experiences of families and clinicians in Aotearoa New Zealand during COVID-19 visiting restrictions for people with palliative and end-of-life care needs. The results highlighted the need for greater protection of visitor rights and policies at the end of life during a pandemic, as well as the importance of transparent and evidence-based guidelines.
BMJ QUALITY & SAFETY
(2023)
Article
Medicine, General & Internal
Thilo von Groote, Melanie Meersch, Stefano Romagnoli, Marlies Ostermann, Javier Ripolles-Melchor, Antoine Guillaume Schneider, Wim Vandenberghe, Celine Monard, Silvia De Rosa, Lucia Cattin, Tim Rahmel, Michael Adamzik, Diego Parise, Angel Candela-Toha, Jan Gerrit Haaker, Ulrich Goebel, Alice Bernard, Nuttha Lumlertgul, Paula Fernandez-Valdes-Bango, Irene Romero Bhathal, A. Suarez-de-la-Rica, Jan Larmann, Gianluca Villa, Savino Spadaro, Hinnerk Wulf, Christian Arndt, Christian Putensen, Raquel Garcia-Alvarez, Timo Brandenburger, Antonio Siniscalchi, Richard Ellerkmann, Florian Espeter, Christian Porschen, Mahan Sadjadi, Khaschayar Saadat-Gilani, Raphael Weiss, Joachim Gerss, John Kellum, Alexander Zarbock
Summary: The BigpAK-2 trial aims to verify the effectiveness of the KDIGO guideline-based bundle in reducing the incidence and severity of AKI after surgery. It will recruit 1302 high-risk patients undergoing major surgery and randomize them into either a standard of care or the KDIGO-based AKI care bundle. The primary endpoint is the incidence of moderate or severe AKI within 72 hours after surgery.
Article
Behavioral Sciences
Ewan S. Nurse, Linda J. Dalic, Shannon Clarke, Mark Cook, John Archer
Summary: This study investigates a deep learning model for the detection of generalized paroxysmal fast activity (GPFA) events and estimation of their overall burden from scalp EEG. The model achieved a high correlation coefficient with manual estimates and showed good detection sensitivity. There was no significant difference found in patients with different treatments.
EPILEPSY & BEHAVIOR
(2023)
Review
Health Care Sciences & Services
Sheraya De Silva, Nicholas Chan, Katherine Esposito, Alisa M. Higgins, Carol L. Hodgson
Summary: This study conducted a systematic review on the psychometric properties of health-related quality of life (HRQoL) instruments used in adult survivors following critical illness. The results showed limited evidence for the psychometric properties of the included instruments, with a few demonstrating sufficient reliability, hypothesis testing, and responsiveness.
QUALITY OF LIFE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Livia Whiting, Nathan Bianchi, Mohamed Faouzi, Antoine Schneider
Summary: This study aimed to evaluate the dynamics and factors associated with decreased membrane performance in continuous kidney replacement therapy (CKRT). Mixed-effects logistic regression model analyses showed that time significantly affected these values and identified independent predictors of decreased membrane performance. Additionally, COVID-19 infection was not associated with an increased risk of decreased membrane performance.
SCIENTIFIC REPORTS
(2023)
Article
Medical Laboratory Technology
Annemarie Albert, Sebastian Radtke, Louisa Blume, Rinaldo Bellomo, Michael Haase, Philipp Stieger, Ulrich Paul Hinkel, Ruediger C. Braun-Dullaeus, Christian Albert
Summary: This study investigated the impact of neutrophil gelatinase-associated lipocalin (NGAL) cutoff value selection and the acute kidney injury (AKI) classification system on the allocation of clinical AKI phenotypes and associated outcomes.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
G. Eastwood, A. D. Nichol, C. Hodgson, R. L. Parke, S. McGuinness, N. Nielsen, S. Bernard, M. B. Skrifvars, D. Stub, F. S. Taccone, J. Archer, D. Kutsogiannis, J. Dankiewicz, G. Lilja, T. Cronberg, H. Kirkegaard, G. Capellier, G. Landoni, J. Horn, T. Olasveengen, Y. Arabi, Y. W. Chia, A. Markota, M. Haenggi, M. P. Wise, A. M. Grejs, S. Christensen, H. Munk-Andersen, A. Granfeldt, G. O. Andersen, E. Qvigstad, A. Flaa, M. Thomas, K. Sweet, J. Bewley, M. Backlund, M. Tiainen, M. Iten, A. Levis, L. Peck, J. Walsham, A. Deane, A. Ghosh, F. Annoni, Y. Chen, D. Knight, E. Lesona, H. Tlayjeh, F. Svensek, P. J. McGuigan, J. Cole, D. Pogson, M. P. Hilty, J. P. During, M. J. Bailey, E. Paul, B. Ady, K. Ainscough, A. Hunt, S. Monahan, T. Trapani, C. Fahey, R. Bellomo
Summary: In patients with coma who were resuscitated after out-of-hospital cardiac arrest, targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months than targeted normocapnia. There were no significant differences in the incidence of death or adverse events between the two groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)