Journal
REPRODUCTIVE TOXICOLOGY
Volume 62, Issue -, Pages 9-17Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2016.04.013
Keywords
Air pollution; Personal monitoring; Fetal ultrasound; Doppler; In utero growth; Placental function; Pregnancy
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Funding
- Sao Paulo Research Foundation (FAPESP) [2008/57717-6]
- National Council for Technological and Scientific Development (CNPq)
- National Institute of Integrated Analysis of Environmental Risk (INAIRA)
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We determined the influence of maternal air pollution exposure during each trimester of pregnancy on fetal and birth weight and fetoplacental hemodynamics. In total, 366 women with singleton pregnancies were prospectively followed in the city of Sao Paulo, Brazil. Nitrogen dioxide (NO2) and ozone (O-3) were measured during each trimester using passive personal samplers. We evaluated fetal weight and Doppler velocimetry data from the umbilical, middle cerebral, and uterine arteries in the 3rd trimester, and birth weight. Multivariate analysis was performed, controlling for known determinants of fetal weight. Exposure to higher levels of O-3 during the 2nd trimester was associated with higher umbilical artery pulsatility indices (PIs) [p = 0.013; beta = 0.017: standard error (SE) = 0.007]. Exposure to higher levels of O-3 during the 3rd trimester was associated with lower umbilical artery PIs (p = 0.011; beta = 0.021; SE = 0.008). Our results suggest that in the environment of Sao Paulo, 03 may affects placental vascular resistance. (C) 2016 Elsevier Inc. All rights reserved.
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