Article
Medicine, General & Internal
Raquel Silveira da Cunha Araujo, Sabina Bastos Maia, Juliane Dornelas Lucio, Moises Diogo de Lima, Helizabet Salomao Abdalla Ayroza Ribeiro, Paulo Augusto Ayroza Galvao Ribeiro
Summary: In patients with unilateral ovarian endometriomas, the lateral compartment was the most affected, with dense adhesions around the left ovarian fossa being common. Left-sided ovarian endometriomas were more prevalent, and the posterior and anterior compartments also showed frequent lesions.
Article
Obstetrics & Gynecology
Caroline M. Da Luz, Michele G. Da Broi, Jessica R. Placa, Wilson A. Silva Jr, Juliana Meola, Paula A. Navarro
Summary: The transcriptome of cumulus cells is altered in infertile women with advanced endometriosis, regardless of the presence of endometrioma. Differentially expressed genes in cumulus cells of endometriosis patients are involved in important pathways for oocyte competence acquisition, such as oxidative phosphorylation, metabolism, mitochondrial function, acetylation, and steroid biosynthesis. Comparing cumulus cells from women with advanced endometriosis with and without endometrioma did not show any differentially expressed genes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Oncology
Jacek R. Wilczynski, Maria Szubert, Edyta Paradowska, Milosz Wilczynski
Summary: Endometriosis is a risk factor for endometriosis-associated ovarian cancers (EAOC), and the role of endometriosis stem cells (ESCs) in the development of EAOC is discussed in this article.
Article
Endocrinology & Metabolism
Kaitlyn E. Collins, Xiyin Wang, Yuliya Klymenko, Noah B. Davis, Maria C. Martinez, Chi Zhang, Kaman So, Aaron Buechlein, Douglas B. Rusch, Chad J. Creighton, Shannon M. Hawkins
Summary: Endometriosis is a risk factor for endometriosis-associated ovarian cancers. Analysis of OCCC samples with concurrent endometriosis revealed upregulation of cell cycle regulation and DNA replication pathways, and downregulation of cytokine receptor signaling and matrisome pathways. MiR-10a-5p was identified as a potentially oncogenic molecule with significant impact.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Shai E. Elizur, Adva Aizer, Michal Yonish, Tal Shavit, Raoul Orvieto, Roy Mashiach, Shlomo B. Cohen, Elad Berkowitz
Summary: This retrospective cohort study aimed to evaluate the outcome of fertility-preservation treatments in women with endometrioma, particularly those with endometrioma larger than 4 cm. The results showed that women who underwent surgery for endometrioma before fertility-preservation treatment had a significant reduction in the number of MII oocytes. However, among those who did not undergo surgery, the size of endometrioma did not affect the outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Acoustics
E. Bean, J. Knez, T. Setty, A. Tetteh, D. Casagrandi, J. Naftalin, D. Jurkovic
Summary: In pregnancy, ovarian endometrioma and deep endometriotic nodules regress, but the morphological changes of endometriosis in pregnancy are difficult to differentiate from malignant lesions. Understanding the appearance of endometriosis in pregnancy is crucial for minimizing intervention and counseling women about their condition.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Pietro Santulli, Mathilde Bourdon, Sonia Koutchinsky, Chloe Maignien, Louis Marcellin, Lorraine Maitrot-Mantelet, Khaled Pocate Cheriet, Catherine Patrat, Charles Chapron
Summary: In women with endometriosis undergoing fertility preservation, factors such as previous surgery for ovarian endometriosis, age, and total dose of gonadotrophin used significantly affect the oocyte yield after ovarian stimulation. Additionally, anti-Mullerian hormone levels and gravidity are positively correlated with an increase in the number of retrieved oocytes after the first stimulation cycle.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Laura Buggio, Edgardo Somigliana, Greta Sergenti, Federica Ottolini, Dhouha Dridi, Paolo Vercellini
Summary: Our study failed to find an association between AGD and the presence of endometriosis. Therefore, AGD does not seem to be a reliable indicator of the presence of endometriosis in clinical practice.
REPRODUCTIVE SCIENCES
(2022)
Review
Obstetrics & Gynecology
Jose Manuel Garcia Garcia, Valentina Vannuzzi, Chiara Donati, Caterina Bernacchioni, Paola Bruni, Felice Petraglia
Summary: Endometriosis, a chronic inflammation in women of reproductive age, is characterized by the presence of fibrotic tissue inside and around lesions. The development of fibrosis is influenced by various cell types and molecular mechanisms, such as platelets, myofibroblasts, macrophages, and sensory nerve fibers, as well as the involvement of transforming growth factor-beta, Notch receptor, and sphingosine 1-phosphate (S1P). Understanding these molecular mechanisms is important for identifying new drug targets and developing novel therapeutic approaches for endometriosis patients.
REPRODUCTIVE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jae Chul Lee, Sung Hoon Kim, Young Sang Oh, Ju Hee Kim, Sa Ra Lee, Hee Dong Chae
Summary: RBP4 plays a crucial role in the pathogenesis of endometriosis by increasing the viability, proliferation, and invasion of endometrial cells. High levels of RBP4 in peritoneal fluid and ovarian endometriomas of women with endometriosis suggest its potential as a biomarker for the disease. In vitro studies show that RBP4 enhances the aggressive behavior of endometrial stromal cells, indicating its involvement in the progression of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Elvin Piriyev, Sven Schiermeier, Thomas Romer
Summary: The study aimed to demonstrate the coexistence of endometriomas with peritoneal and deep infiltrating endometriosis, as well as with adhesions. It was a randomized retrospective study including 1054 patients treated for endometrioma at Academic Hospital Cologne Weyertal from January 2014 to October 2019. The results showed a high prevalence of peritoneal and deep infiltrating endometriosis in patients with endometriomas, with the need for surgical treatment to be cautious due to the potential presence of adhesions and complications.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Review
Obstetrics & Gynecology
Marina Kvaskoff, Yahya Mahamat-Saleh, Leslie Farland, Nina Shigesi, Kathryn L. Terry, Holly R. Harris, Horace Roman, Christian M. Becker, Sawsan As-Sanie, Krina T. Zondervan, Andrew W. Horne, Stacey A. Missmer
Summary: This meta-analysis study shows a significant association between endometriosis and ovarian and thyroid cancer risk, a slight association with breast cancer risk, but a negative association with cervical cancer risk. There are risks of bias and heterogeneity in the studies, so caution is needed in interpreting these potential associations.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Obstetrics & Gynecology
Ido Feferkorn, Eva Suarthana, Hormoz Nassiri Kigloo, Ikram Abow-Mohamed, Yasna Golyari, Togas Tulandi
Summary: This study evaluates the combined effects of age and endometriosis on ovarian reserve in women with infertility. The results show that endometriosis is associated with lower anti-Mullerian hormone (AMH) and antral follicular count (AFC), and the impact is more significant in women aged 35 years or older.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Biochemistry & Molecular Biology
Menno ter Huurne, Hendrik G. Stunnenberg
Summary: During early embryonic development, the rapid increase in cell number and the expression of genes that control developmental decisions are tightly regulated and interconnected processes. Transcription factors and signaling pathways play a crucial role in maintaining pluripotency and cell cycle progression, while canonical cell cycle regulators impact molecular networks controlling pluripotency and lineage specification.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Carla Tomassetti, Neil P. Johnson, John Petrozza, Mauricio S. Abrao, Jon Einarsson, Andrew W. Horne, Ted T. M. Lee, Stacey Missmer, Nathalie Vermeulen, Krina T. Zondervan, Grigoris Grimbizis, Rudy Leon De Wilde
Summary: The study outlines a list of 49 terms and definitions related to endometriosis, aiming to facilitate standardization in disease description, classification, and research.
HUMAN REPRODUCTION OPEN
(2021)
Article
Cell Biology
I Banakh, Md M. Rahman, C. L. Arellano, D. C. Marks, S. Mukherjee, C. E. Gargett, H. Cleland, S. Akbarzadeh
Summary: This study found that platelet lysate (PL) can be used as a safe and effective serum alternative for bioengineering skin for cell therapies. PL supports the expansion of fibroblasts and directed epidermal stratification, and promotes better transplantation outcomes by regulating the expression of CD90 and FAP. Moreover, PL is rich in growth factors, including TGF-beta 1, which contributes to skin maturation. This research is of great importance for the development of bioengineered skin.
CELL AND TISSUE RESEARCH
(2023)
Article
Obstetrics & Gynecology
Chenyu Mao, Xishi Liu, Sun-Wei Guo
Summary: This study investigated the role of glycolysis in endometrial repair and heavy menstrual bleeding (HMB). Through mouse experiments and analysis of human endometrial samples, it was found that glycolysis plays an important role in endometrial repair, and its suppression delays the repair process and increases menstrual blood loss. Additionally, glycolysis suppression affects the proliferative and migratory capability of endometrial cells.
REPRODUCTIVE SCIENCES
(2023)
Review
Developmental Biology
Joanne Muter, Vincent J. Lynch, Rajiv C. McCoy, Jan J. Brosens
Summary: Embryo implantation in humans is a complex process involving the transformation of the endometrium into a placental bed and interactions between the embryo and the decidualising endometrium. This review examines the evolutionary context of implantation and discusses the remodeling of the uterus before and after conception. It highlights the precarious but adaptable nature of the implantation process.
Article
Obstetrics & Gynecology
Sun-Wei Guo
Summary: Currently, hormonal drugs are the main treatment for endometriosis or adenomyosis, but their lack of innovation and failure to target specific areas is concerning. The failure to understand the natural history of the ectopic endometrium has led to many unsuccessful nonhormonal drug research projects. This review aims to explore new concepts in the progression of ectopic endometrium and provide insights for better therapeutic options.
FERTILITY AND STERILITY
(2023)
Editorial Material
Obstetrics & Gynecology
Michel Canis, Sun-Wei Guo
Summary: Endometriosis-associated pain can be managed through either surgery or hormonal therapy, with the final decision dependent on efficacy, complications, recurrence risk, and patient preferences. However, choosing the right treatment involves weighing irrational fears against scientific evidence. Pros and cons of both treatment options should be thoroughly discussed with patients, considering the known irrationality of human beings.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Fiona L. Cousins, Brett D. McKinnon, Sally Mortlock, Harriet C. Fitzgerald, Chenyu Zhang, Grant W. Montgomery, Caroline E. Gargett
Summary: Endometriosis is a serious and chronic condition where tissue similar to the lining of the uterus grows outside of it, leading to severe pelvic pain and infertility. It affects 11% of women and has multiple causes, with retrograde menstruation being a major factor. There is a genetic component to endometriosis, with over 40 genetic risk factors identified, although their specific mechanisms are still being understood.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Sun-Wei Guo, Marwan Habiba, Giuseppe Benagiano
Summary: Practically unknown outside of China, the endometrial determinism theory proposes a causal and phylogenetic relationship between endometrial aberrations and endometriosis. However, all available evidence of endometrial defect is post hoc and may be secondary to induced endometriosis. While endometriosis is likely a consequence of retrograde menstruation, the case for molecular aberrations as a sole or necessary determinant remains unproven. Root treatment is currently a far-fetched ambition.
Review
Biochemistry & Molecular Biology
Marwan Habiba, Giuseppe Benagiano, Sun-Wei Guo
Summary: Due to the complex nature of endometriosis and adenomyosis, the understanding of their pathogenesis remains unclear. A tissue injury and repair theory suggests that both diseases originate from the same abnormalities within the uterus, but this theory has faced criticism for its lack of confirmatory evidence and epidemiological support. The theory also fails to explain why only a small percentage of women develop these conditions. Further research and evidence are necessary to validate this theory.
Article
Multidisciplinary Sciences
Laura Hume, Jessica C. Edge, Haidee Tinning, Dapeng Wang, Alysha S. Taylor, Vladimir Ovchinnikov, Annika Geijer-Simpson, Pavle Vrljicak, Jan J. Brosens, Emma S. Lucas, Nigel A. B. Simpson, Jayne Shillito, Karen Forbes, Mary J. O'Connell, Niamh Forde
Summary: We examined the role of conserved placental mammal-specific microRNAs and their targets in regulating endometrial receptivity to implantation. The expression of miR-340-5p, -542-3p, and -671-5p in endometrial epithelial cells was influenced by progesterone exposure. Proteomic analysis showed that these microRNAs altered the expression of numerous proteins, many of which were predicted targets and regulated by progesterone. Dysregulation of these microRNAs and their targets is implicated in recurrent pregnancy loss.
Review
Biochemistry & Molecular Biology
Giuseppe Benagiano, Salvatore Mancuso, Sun-Wei Guo, Gian Carlo Di Renzo
Summary: This article highlights the significant number of early embryo losses during the pre-implantation period and the importance of the maternal-embryonic dialogue in the formation of placenta and completion of pregnancy. Several factors and molecules have been identified to play a role in this process, including Chorionic Gonadotrophin, Early Pregnancy Factor, Pre-Implantation Factor, and Embryo-Derived Platelet-activating Factor. The implantation process is guided by signals from various types of cells in the decidualized endometrium, and immune cells also play a role. The distinction between the first two weeks after fertilization and the rest of gestation is proposed, with the former period being named gestation and the latter period being named pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xishi Liu, Ding Ding, Minhong Shen, Dingmin Yan, Sun-Wei Guo
Summary: This study investigated the association between anogenital distance (AGD) and adenomyosis, endometriosis, and uterine leiomyomas (UL). The results showed that women with ovarian endometrioma (OE) and adenomyosis had significantly shorter AGD from the posterior fourchette to the center of the anus (AGDAF), but not from the anterior clitoral surface or the tip of the clitoris. The findings suggest that reduced prenatal exposure to androgens may increase the risk of developing endometriosis and adenomyosis, but other factors may also contribute to the pathogenesis of these conditions.
Article
Obstetrics & Gynecology
Tasuku Harada, Fuminori Taniguchi, Sun-Wei Guo, Young Min Choi, Kutay Omer Biberoglu, Shaw-Jenq Sean Tsai, Saeed Alborzi, Moamar Al-Jefout, Amphan Chalermchokcharoenkit, Angela G. Sison-Aguilar, Yoke-Fai Fong, Hemantha Senanayake, Alexander Popov, Andon Hestiantoro, Yuval Kaufman
Summary: This is the first guideline for adenomyosis from the Asian Society of Endometriosis and Adenomyosis.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Hanxi Zheng, Xishi Liu, Sun-Wei Guo
Summary: This study aimed to screen Zn2+-dependent histone deacetylase 1-11 (HDAC) in endometriotic cells and evaluate their expression in ovarian endometrioma (OE) and deep endometriosis (DE) lesions. The therapeutic potential of HDAC8 inhibition was also assessed in mice.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Hanxi Zheng, Xishi Liu, Sun-Wei Guo
Summary: The study evaluated the staining changes of Class I HDACs and Hdac6 in serially harvested lesion samples in mice with induced endometriosis. The results showed a progressive increase in staining of Hdac1, Hdac8, and Hdac6 during the course of lesional progression, while Hdac2 staining gradually decreased and Hdac3 staining was consistently reduced. Hdac8 activation accelerated the progression and fibrogenesis of endometriotic lesions, while inhibition of Hdac8 or Hdac6 hindered lesional progression and fibrogenesis, especially Hdac8 inhibition. Further investigation of epigenetic aberrations of endometriosis and HDACs is warranted.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Chenyu Mao, Xishi Liu, Sun-Wei Guo
Summary: This study explores the role of histone deacetylase 3 (HDAC3) in adenomyosis-associated heavy menstrual bleeding (HMB). The researchers found that reduced expression of HDAC3 is associated with HMB in women with adenomyosis. Higher stiffness and fibrosis in the adenomyotic lesions and neighboring endometrial-myometrial interface were observed in women with excessive bleeding compared to those with moderate/heavy bleeding. Inhibition of HDAC3 resulted in disrupted NF-KB signaling, inflammation, and increased bleeding in mice with induced adenomyosis. Overall, this study highlights the importance of HDAC3 in the pathogenesis of adenomyosis-associated HMB.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
