Review
Obstetrics & Gynecology
Jianghong Cheng, Zizhuo Sha, Junyang Li, Bixuan Li, Xianyang Luo, Zhiming Zhang, Yi Zhou, Shuai Chen, Yang Wang
Summary: Embryo implantation and decidualization are vital for successful pregnancy, and defects in these processes can lead to adverse pregnancy outcomes. Around 75% of failed pregnancies are caused by implantation failure or defects. This article reviews recent advances in understanding the molecular mechanisms of estrogen and progesterone regulation in establishing uterine receptivity, blastocyst implantation, and decidualization, with the aim of developing strategies to prevent or treat implantation defects and improve pregnancy rates.
REPRODUCTIVE SCIENCES
(2023)
Article
Cell Biology
Yi Yang, Qiu-Yang Zhu, Ji-Long Liu
Summary: This study utilized single-cell RNA sequencing to investigate uterine receptivity in mice, revealing 19 distinct cell clusters and identifying global gene expression changes associated with uterine receptivity in each cell type. The data provide a valuable resource for understanding the molecular mechanisms underlying uterine receptivity.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Lin Lu, Yingni Chen, Zhenshan Yang, Shijin Liang, Songqi Zhu, Xiaohuan Liang
Summary: During decidualization in rodents, uterine stromal cells undergo reprogramming to differentiate into different cell types, forming primary and secondary decidual zones. Secondary decidual zones are accompanied by angiogenesis. Estrogen, both ovarian and locally synthesized, is essential for the progress of decidualization. Cystatin B (Cstb) is highly expressed in the decidual tissue of the uterus, but its regulation and mechanism in decidualization are not known.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact through Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of-function CTCF mutation in endometrial tumors indicates its importance in uterine homeostasis. Our study reveals that uterine Ctcf plays a key role in progesterone-dependent expression of uterine genes underlying optimal post-pubertal uterine development.
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact via Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of- function CTCF mutation indicates its importance in uterine homeostasis. Deleting Ctcf gene in female reproductive tissues of mice resulted in reduced uterine glands and hypoplastic uteri with decreased endometrial stroma. Ctcf deletion also altered the expression of progesterone-responsive genes, including Ihh, Fst, and Errfi1. Our findings highlight the key role of uterine Ctcf in progesterone-dependent expression and optimal post-pubertal uterine development.
Article
Immunology
Yue Li, Si-Ting Chen, Yu-Ying He, Bo Li, Chen Yang, Zhen-Shan Yang, Zeng-Ming Yang
Summary: In this study, the involvement of secreted HMGB1 in early mouse pregnancy was investigated. It was found that HMGB1 can be detected in the uterine lumen fluid and its secretion is influenced by the presence of blastocysts. The presence of trypsin in blastocysts and its ability to stimulate HB-EGF production was also demonstrated. Furthermore, the role of PAR2-HMGB1-ADAM17-HB-EGF signaling pathway in decidualization was identified.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Diana Monsivais, Takashi Nagashima, Renata Prunskaite-Hyyrylainen, Kaori Nozawa, Keisuke Shimada, Suni Tang, Clark Hamor, Julio E. Agno, Fengju Chen, Ramya P. Masand, Steven L. Young, Chad J. Creighton, Francesco J. DeMayo, Masahito Ikawa, Se-Jin Lee, Martin M. Matzuk
Summary: The study reveals that bone morphogenetic proteins control endometrial receptivity in mice through the ACVR2A and SMAD1/5 signaling pathway, with ACVR2B being dispensable during embryo implantation.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Zhifang Sun, Rufei Gao, Xuemei Chen, Xueqing Liu, Yubin Ding, Yanqing Geng, Xinyi Mu, Taihang Liu, Fangfang Li, Yingxiong Wang, Junlin He
Summary: This study found that gestational exposure to BHT inhibits decidualization of mouse endometrium during early pregnancy, resulting in a decrease in the number of implantation sites and uterine weight. Additionally, BHT suppressed the decidual morphology of endometrial stromal cells and significantly decreased the expression of decidual markers. Furthermore, BHT exposure led to upregulation of reproductive hormones and hormone receptor signals in early pregnancy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Reproductive Biology
Ryan M. Brown, Linda Wang, Anqi Fu, Athilakshmi Kannan, Michael Mussar, Indrani C. Bagchi, Joan S. Jorgensen
Summary: Irx3 promotes successful embryo-uterine interactions in mice.
BIOLOGY OF REPRODUCTION
(2022)
Review
Biochemistry & Molecular Biology
Min Chen, Zimeng Zheng, Jialu Shi, Jun Shao
Summary: Endometrial receptivity plays a crucial role in fertility and pregnancy outcomes. The role of lipids, particularly polyunsaturated fatty acids, has been recognized in influencing endometrial receptivity. They have a significant impact on cell proliferation, development, signaling, and function, and are involved in the production of hormones that affect the receptivity of the endometrium. They also play a role in immunity and regulating endometrial decidualization.
Article
Biochemistry & Molecular Biology
Zhuo Song, Bo Li, Mengyuan Li, Jiamei Luo, Yuqi Hong, Yuying He, Siting Chen, Zhenshan Yang, Chen Liang, Zengming Yang
Summary: This study investigated the expression, regulation, and function of Caveolin-1 during mouse early pregnancy and in vitro decidualization of both mice and humans. The results showed that Caveolin-1 expression is regulated by estrogen and progesterone during early pregnancy, and its levels are significantly increased during mouse in vitro decidualization but decreased during human in vitro decidualization. The study also found that Caveolin-1 is regulated by various factors, including tumor necrosis factor alpha and human Chorionic Gonadotropin. In conclusion, a low level of Caveolin-1 is beneficial for human decidualization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sohyeon Moon, Semi Hwang, Byeongseok Kim, Siyoung Lee, Hyoukjung Kim, Giwan Lee, Kwonho Hong, Hyuk Song, Youngsok Choi
Summary: In this review, the authors describe the association between the female reproductive system and the Hippo signaling pathway, as well as novel Hippo pathway genes and potential target genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Vineet K. Maurya, Francesco J. DeMayo, John P. Lydon
Summary: The synchrony between progesterone-driven endometrial receptivity and the arrival of a euploid blastocyst is crucial for successful embryo implantation and establishment of pregnancy. Aberrant progesterone molecular responses can lead to infertility, early embryo miscarriage, gestational complications, and endometrial pathologies. Further identification and functional analysis of key molecular mediators and modifiers of the endometrial response to progesterone may provide insight into early endometrial changes and lead to more effective diagnostics and therapies for female infertility and gynecological morbidities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Xiaoqian Di, Yanzhi Hao, Zibo Duan, Yucong Ma, Ying Cao, Zhanwang Tan, Cuimiao Song, Xiaohua Lin
Summary: Recurrent spontaneous abortion (RSA) is a common complication during pregnancy that affects women's physical and mental health. This study found that the expression levels of SGK1 and its signaling pathway-related proteins were decreased in the decidual tissue of URSA patients, and the expression levels of decidualization markers were downregulated. Estrogen and progesterone can induce decidualization by activating the SGK1/ENaC signaling pathway, and disruption of this pathway can lead to the development of URSA.
REPRODUCTIVE SCIENCES
(2023)
Article
Food Science & Technology
Tingting Song, Xuemei Zhou, Xiangming Ma, Yanping Jiang, Weiren Yang, Faxiao Liu, Mei Liu, Libo Huang, Shuzhen Jiang
Summary: The study found that ZEA can linearly increase nutrient digestibility and availability, promote the expression of estrogen/progesterone receptors in the uterus and endometrial cells.