Article
Computer Science, Interdisciplinary Applications
Nicola Altini, Michele Rossini, Sandor Turkevi-Nagy, Francesco Pesce, Paola Pontrelli, Berardino Prencipe, Francesco Berloco, Surya Seshan, Jean-Baptiste Gibier, Anibal Pedraza Dorado, Gloria Bueno, Licia Peruzzi, Mattia Rossi, Albino Eccher, Feifei Li, Adamantios Koumpis, Oya Beyan, Jonathan Barratt, Huy Quoc Vo, Chandra Mohan, Hien Van Nguyen, Pietro Antonio Cicalese, Angela Ernst, Loreto Gesualdo, Vitoantonio Bevilacqua, Jan Ulrich Becker
Summary: The study aimed to replicate the glomerular components of the Oxford Classification for IgA nephropathy using a deep learning pipeline. The results showed excellent performance in automatic glomerular segmentation and classification, with high correlation to expert labels, meeting the requirements of the Oxford Classification.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Immunology
Lin-Lin Xu, Di Zhang, Hao-Yi Weng, Li-Zhong Wang, Ruo-Yan Chen, Gang Chen, Su-Fang Shi, Li-Jun Liu, Xu-Hui Zhong, Shen-Da Hong, Li-Xin Duan, Ji-Cheng Lv, Xu-Jie Zhou, Hong Zhang
Summary: A pathology T-score prediction (T-pre) model was developed using routine clinical characteristics to evaluate the prognosis of patients with immunoglobulin A nephropathy (IgAN). This model can assist in predicting the pathological severity and prognosis for patients without kidney pathology scores.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Fang Yu, Xuejing Zhu, Shuguang Yuan, Xiaojun Chen, Zheng Li, Zhong Qu, Hong Liu, Lin Sun, Fuyou Liu
Summary: This study found that S lesion >= 25% is associated with a more rapid decline in glomerular filtration rate and a lower rate of complete remission of proteinuria, even when adjusted for multiple clinicopathological variables, compared to the S1a group (all p values <0.05). Patients with S lesion >= 25% also had a higher proportion of glomeruli with T lesion and crescents. This suggests that IgAN patients with S lesion >= 25% are at increased risk of poor renal outcomes, even with immunosuppressive therapy.
ANNALS OF MEDICINE
(2021)
Article
Urology & Nephrology
Shusaku Itami, Takahito Moriyama, Yoei Miyabe, Kazunori Karasawa, Kosaku Nitta
Summary: The study found that M1, E1, S1, and C1+2 scores in the Oxford classification showed positive response to steroid therapy, while patients with T1+2 scores exhibited resistance to steroid therapy. High SRS was a useful indicator for steroid therapy, while SNRS indicated resistance to steroid therapy.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Immunology
Dongqing Wang, Changwei Wu, Sipei Chen, Yi Li, Li Wang, Yong Zhang, Guisen Li
Summary: This study investigated the distribution of complement in the urine of IgA nephropathy (IgAN) patients using LC-MS/MS and analyzed its correlation with clinical and pathological characteristics. The results showed that urinary complement in IgAN patients was significantly correlated with renal function, proteinuria, and renal tissue damage. This could provide potential biomarkers for monitoring IgAN and insights for therapeutic choices targeting the complement system in IgAN patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Yun-Ting Juan, Wen-Chih Chiang, Wei-Chou Lin, Cheng-Wen Yang, San-Fang Chou, Ruo-Wei Hung, Yen-Ling Chiu
Summary: This study found that plasma levels of Gd-IgA1 antibody and biomarkers of alternative complement pathway activation are correlated with the Oxford classification of IgAN. These biomarkers may be helpful in guiding treatment decisions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Dana V. Rizk, Lea Novak, Stacy D. Hall, Zina Moldoveanu, Bruce A. Julian, Jan Novak, Mark Haas, Hiroshi Tanaka
Summary: This study used high-resolution confocal microscopy to examine kidney-biopsy samples from patients with IgA nephropathy, discovering components of glomerular immunodeposits not apparent on routine immunofluorescence microscopy and allowing colocalization of different components, which could potentially clarify the pathogenesis of the disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Nida Saleem, Humaira Nasir, Fatima Anwar, Maliha Aziz, Kiran Khurshid, Saima Bashir, Asrar Khan
Summary: This study retrospectively reviewed 93 cases of IgA nephropathy in the Pakistani population and found that T and C scores, as well as baseline renal function markers, significantly influenced the prognosis. The results supported the prognostic significance of the Oxford classification and recommended the inclusion of the total MESTC score in assessing IgAN prognosis.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Medical Laboratory Technology
Lingqiu Dong, Jiaxing Tan, Zhengxia Zhong, Yi Tang, Wei Qin
Summary: In this study, alterations in the serum metabolomic profile of IgA nephropathy (IgAN) patients were investigated using UPLC-MS. Differential metabolites associated with IgAN were identified, including glycerophospholipids, sphingolipids, and vitamins. These differential metabolites were found to be associated with the clinical and pathological features of IgAN, and some of them showed promising predictive ability for IgAN.
CLINICA CHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Andrzej Konieczny, Piotr Donizy, Tomasz Golebiowski, Andrzej Tukiendorf, Agnieszka Halon, Mariusz Kusztal, Hanna Augustyniak-Bartosik, Magdalena Krajewska
Summary: This study analyzed clinical and histopathological data from 80 patients with IgA nephropathy, and found that endocapillary hypercellularity and interstitial fibrosis were predictors of eGFR decline, while serum albumin concentration had a protective impact on eGFR deterioration. The presence of endocapillary hypercellularity and extent of interstitial fibrosis also negatively correlated with the reduction in proteinuria below 1.0 g/24 h.
Article
Medicine, General & Internal
Ying Chen, Yiya Yang, Yumei Liang, Manting Liu, Wei Xiao, Xiaofang Hu
Summary: By analyzing the clinicopathological data of 144 IgAN patients, it was found that Cs scoring is significantly correlated with renal pathological changes, increased proteinuria, and decreased glomerular filtration rate. A Cs proportion >= 11% is an independent risk factor for poor prognosis in IgAN patients.
Article
Urology & Nephrology
YuanFan Rui, ZiJun Yang, ZiHan Zhai, Cong Zhao, Lin Tang
Summary: The study retrospectively analyzed the efficacy of immunosuppressive therapy in IgA nephropathy patients, highlighting that M1 and T2 were negative predictive factors while eGFR was a protective factor for the treatment outcome. The analysis also revealed that stable eGFR and low proteinuria were associated with better renal outcomes after immunosuppressive therapy.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Xiachuan Qin, Linlin Xia, Xiaomin Hu, Weihan Xiao, Xian Huaming, Xie Xisheng, Chaoxue Zhang
Summary: A machine-learning model based on ultrasound radiomics was used to construct a nomogram for noninvasive evaluation of crescent status in IgA nephropathy. The combined model using clinical characteristics and the Rad score showed good discrimination in practical applications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Jing-Li Zhao, Jing-Jing Wang, Guo-Ping Huang, Chun-Yue Feng
Summary: This study investigated the clinicopathological features and outcomes of primary IgA nephropathy with nephrotic-range proteinuria in Chinese children. The results showed that a significant proportion of patients had decreased renal function at diagnosis, and remission of proteinuria was important for improving renal prognosis. The outcomes for pediatric patients appeared to be better than that reported in adults.
Article
Multidisciplinary Sciences
Taro Misaki, Shuhei Naka, Hitoshi Suzuki, Mingfeng Lee, Ryosuke Aoki, Yasuyuki Nagasawa, Daiki Matsuoka, Seigo Ito, Ryota Nomura, Michiyo Matsumoto-Nakano, Yusuke Suzuki, Kazuhiko Nakano
Summary: The presence of cnm-positive S. mutans is associated with IgAN, but the exact mechanism is unclear. This study found a significant association between the glomerular staining intensity of IgA and the positive rate of cnm-positive S. mutans. There was also a significant association between the glomerular staining intensity of Gd-IgA1 and the positive rate of cnm-positive S. mutans.
Article
Urology & Nephrology
Vikraman Gopalakrishnan, Sanjay K. Agarwal, Sandeep Aggarwal, Sandeep Mahajan, Dipankar Bhowmik, Soumita Bagchi
Article
Urology & Nephrology
Parmod Mittal, Sanjay K. Agarwal, Geetika Singh, Dipankar Bhowmik, Sandeep Mahajan, Amit Dinda, Soumita Bagchi
Article
Surgery
Shreepriya Mangalgi, Karan Madan, Chandan J. Das, Gagandeep Singh, Hemchandra Sati, Raj Kanwar Yadav, Immaculata Xess, Sarman Singh, Dipankar Bhowmik, Sanjay Kumar Agarwal, Soumita Bagchi
Summary: Pulmonary infections are a major cause of morbidity and mortality in renal transplant recipients, with fungal infections, bacterial infections, and patients requiring mechanical ventilation having higher mortality rates. Infections often occur in the first year post-transplantation and beyond 5 years, with some cases requiring computed tomography imaging for diagnosis.
TRANSPLANT INTERNATIONAL
(2021)
Article
Urology & Nephrology
Soumita Bagchi, Kalaivani Mani, Anitha Swamy, Adarsh Barwad, Geetika Singh, Dipankar Bhowmik, Sanjay Kumar Agarwal
Summary: This study demonstrates that half of IgA nephropathy patients achieved remission after 6 months of ACEi/ARB treatment. Patients who were older, had lower eGFR, and showed worse histological presentations were less likely to tolerate and respond to the treatment.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Kristin George, Ashish Datt Upadhyay, Arun Kumar Subbiah, Raj Kanwar Yadav, Sandeep Mahajan, Dipankar Bhowmik, Sanjay Kumar Agarwal, Soumita Bagchi
Summary: There is a high incidence of metabolic acidosis (MA) in the first 6 months post-transplant, with serum creatinine and high tacrolimus C0 levels being independent risk factors.
Article
Urology & Nephrology
Sana Shadab, Parmod Mittal, Adarsh Barwad, Geetika Singh, Arun Kumar Subbiah, Raj Kanwar Yadav, Sandeep Mahajan, Dipankar Bhowmik, Amit Dinda, Sanjay Kumar Agarwal, Soumita Bagchi
Summary: Diabetic kidney disease (DKD) is the main cause of renal involvement in diabetic patients, but non-diabetic kidney disease (NDKD) can be missed without biopsy. This study found that over half of diabetic patients undergoing kidney biopsy had NDKD, with membranous nephropathy, IgA nephropathy, and focal segmental glomerulosclerosis being the main pathologies identified. Female gender, absence of diabetic retinopathy, absence of hypertension, and duration of diabetes <= 24 months were independent predictors for NDKD.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Letter
Urology & Nephrology
Arunkumar Subbiah, Dipankar Bhowmik
KIDNEY INTERNATIONAL
(2022)
Letter
Urology & Nephrology
Soumita Bagchi, Dipankar Bhowmik, Geetika Singh, Sanjay Kumar Agarwal
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Soumita Bagchi, Ashish Datt Upadhyay, Adarsh Barwad, Geetika Singh, Arunkumar Subbiah, Raj Kanwar Yadav, Sandeep Mahajan, Dipankar Bhowmik, Sanjay Kumar Agarwal
Summary: The IIgANN prediction tool showed reasonable discrimination of risk in Indian patients but underestimated the trajectory of disease progression across all risk groups.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Naba Farooqui, Arunkumar Subbiah, Pradeep Chaturvedi, Hem Sati, Geetika Singh, Dipankar Bhowmik, Sanjay K. Agarwal, Soumita Bagchi
Summary: A retrospective cohort study found no association between vitamin D deficiency and disease profile as well as renal outcome in Indian patients with IgA nephropathy.
Article
Urology & Nephrology
Vijoy Kumar Jha, D. Bhowmik, Sanjay Kumar Agarwal, Manpreet Kaur, Ashok Jaryal
Summary: The most common cause of mortality in chronic kidney disease patients is cardiovascular events. Renal transplantation (RT) has been shown to improve cardiovascular function, including heart rate variability (HRV) and blood pressure variability (BPV), with positive effects on decreasing BPV and improving baroreflex sensitivity.
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Vijoy Kumar Jha, D. Bhowmik, Sanjay Kumar Agarwal, Manpreet Kaur, Ashok Jaryal
Summary: Cardiovascular diseases are a significant cause of mortality in ESRD patients, with increased arterial stiffness and autonomic dysfunction contributing to the excess cardiovascular risk. This study aimed to assess noninvasively the vascular function in ESRD patients before and after renal transplantation, showing significant improvement in BRS at three months posttransplant. There was a negative correlation between changes in PWV and baseline PWV, but no correlation was observed between changes in PWV and BRS postrenal transplant.
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2021)
Meeting Abstract
Urology & Nephrology
Dipankar Bhowmik, Mohammed Aslam, Gurdeep Kaur
AMERICAN JOURNAL OF KIDNEY DISEASES
(2019)
Article
Urology & Nephrology
Pavitra Manu Dogra, Anil Kumar Bhatt, Sanjay Kumar Agarwal, Dipankar Bhowmik
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2018)
Article
Oncology
Aruna Nambirajan, Abhishek Kumar Shukla, Sandeep R. Mathur, Hemanth Kumar, Rajeev Kumar, Dipankar M. Bhowmik, Ashok Singh, Deepali Jain, Mehar Chand Sharma, Seema Kaushal
CLINICAL GENITOURINARY CANCER
(2017)