Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Sreevani Katabathula, Pamela B. Davis, Rong Xu
Summary: This study investigated the heterogeneity of mild cognitive impairment (MCI) in the context of Alzheimer's disease (AD)-related comorbidities and other relevant features and biomarkers. The results showed that MCI subtypes driven by comorbidities differed from those identified without comorbidity information. The comorbidity-driven MCI subtypes demonstrated clinical relevance in terms of MCI to AD prognosis, cognitive test-related means, and plasma features.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Vanessa J. Lissek, Heithem Ben Abdallah, Arthur Praetorius, Tobias Ohmann, Boris Suchan
Summary: This study evaluated two group interventions combining physical and cognitive training in individuals with MCI, and found that both interventions were effective in improving cognitive function for a period of three months.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biology
Zoya O. Serebrovska, Lei Xi, Lesya Tumanovska, Angela M. Shysh, Sergii Goncharov, Michael Khetsuriani, Taisia O. Kozak, Denis A. Pashevin, Victor E. Dosenko, Sergii V. Virko, Viktor A. Kholin, Oksana N. Grib, Natalie A. Utko, Egor Egorov, Anna O. Polischuk, Tetiana Serebrovska
Summary: The study investigated the effects of intermittent hypoxia-hyperoxia training (IHHT) on pro-inflammatory factors in healthy elderly individuals and patients with early signs of Alzheimer's disease (AD). IHHT was found to improve cognitive function, potentially through upregulating circulating levels of inflammatory markers and triggering cellular adaptive reprogramming.
Article
Neurosciences
Li-Yang Liu, Yi Xing, Zi-Heng Zhang, Qing-Ge Zhang, Ming Dong, Haibo Wang, Longjun Cai, Xiaoyi Wang, Yi Tang
Summary: Computerized cognitive training (CCT) can reliably assess cognitive status and distinguish patients with dementia from patients with mild cognitive impairment (MCI).
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Rui Tian, Yujuan Jiang, Yanchun Zhang, Xinyue Yan, Yingwen Zhou, Deqiang Chen
Summary: Cognitive function training interventions in elderly patients with MCI led to significant improvements in MMSE and MoCA scores, with the intervention group showing higher scores. Both groups saw increased ADL and BI scores in the intervention group, as well as significantly lower serum levels of NSE and S100 beta. Overall, the cognitive training program improved cognitive and daily living abilities in elderly patients with MCI.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Neurosciences
Julius S. Ngwa, Evaristus Nwulia, Oyonumo Ntekim, Fikru B. Bedada, Bernard Kwabi-Addo, Sheeba Nadarajah, Steven Johnson, William M. Southerland, John Kwagyan, Thomas O. Obisesan
Summary: This study investigates the effects of aerobic exercise on DNA methylation in older African American individuals with mild cognitive impairment. The results show that aerobic exercise training is associated with changes in global methylation levels and identifies specific genes related to amyloid biology, protein trafficking, and lipoprotein regulation that are affected by exercise-induced methylation changes.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jacqueline Chua, Chi Li, Lucius Kang Hua Ho, Damon Wong, Bingyao Tan, Xinwen Yao, Alfred Gan, Florian Schwarzhans, Gerhard Garhoefer, Chelvin C. A. Sng, Saima Hilal, Narayanaswamy Venketasubramanian, Carol Y. Cheung, Georg Fischer, Clemens Vass, Tien Yin Wong, Christopher Li-Hsian Chen, Leopold Schmetterer
Summary: Compensating for various factors and combining information from the macular layer can improve the detection of early cognitive impairment in high-risk individuals.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Medicine, General & Internal
Jing Cheng, Xiaoqi Ji, Lu He, Yutong Zhang, Tongtong Xiao, Qiang Geng, Zhihui Wang, Shige Qi, Fang Zhou, Jianbo Zhan
Summary: By studying the prevalence, associated factors, and population distribution of Alzheimer's disease (AD) and mild cognitive impairment (MCI) among elderly residents in Hubei province, it was proven that studying, socializing, regular physical exercise, and a healthy lifestyle can prevent or slow down cognitive decline. A cross-sectional study was conducted, recruiting 4314 subjects and finding a prevalence of 1.44% for AD and 10.04% for MCI. Factors influencing the occurrence of AD and MCI included marriage, education, social activities, and communication with children. The prevalence of AD in Hubei province was lower than the national average, while the prevalence of MCI was within the national range.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Sreevani Katabathula, Pamela B. Davis, Rong Xu
Summary: This study identified sex-specific heterogeneity in mild cognitive impairment (MCI) using multi-modality data. There were significant differences in prognosis and risk of MCI to Alzheimer's disease (AD) conversion between male and female MCI subtypes. Analyzing sex-specific heterogeneity of MCI provides insights into the pathophysiology of MCI and AD, allows risk stratification in clinical trials, and suggests gender-based early intervention for patients at risk of developing AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Ilju Lee, Dohyun Kim, Sehwan Kim, Hee Jung Kim, Un Sun Chung, Jung Jae Lee
Summary: Mild cognitive impairment (MCI) is an intermediate stage of normal cognitive decline and there is increasing interest in non-pharmacological interventions for MCI. In this preliminary study, neurofeedback was applied during cognitive training to enhance working memory in MCI patients. The results suggest that this approach can significantly improve working memory in MCI patients.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Ruben Sanz-Blasco, Jose M. Ruiz-Sanchez de Leon, Marina Avila-Villanueva, Meritxel Valenti-Soler, Jaime Gomez-Ramirez, Miguel A. Fernandez-Blazquez
Summary: The study examined the rate of reversion from mild cognitive impairment to normal cognition in a unidirectional manner within the Alzheimer's disease continuum. There were both non-modifiable factors (age, socioeconomic status, apolipoprotein E) and modifiable factors (cognitive training, absence of affective symptoms) associated with reversion. The likelihood of progression from MCI to dementia was found to be similar to that of reversion from MCI to NC.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Geriatrics & Gerontology
Marco Socci, Andrea Principi, Mirko Di Rosa, Patricia Carney, Carlos Chiatti, Fabrizia Lattanzio, Diletta Baldassarri, Luigina Bitti, Aurora Carosi, Maila Sabbatini, Elisabetta Paolasini, Tania Fiori, Cinzia Fronzi, Simona Giacchetta, Valeria Giacomini, Laura Giovagnoli, Giuli Lattanzi, Anna Maria Manca, Ida Marinelli, Valeria Pigini, Marina Pignotti, Maria Chiara Proietti, Antonia Quarticelli, Martina Rovedi, Letizia Tasso, Valentina Valeri, Andrea Antonioli, Mariella Barabucci, Mara Bassani, Paola Bollettini, M. Cristina Bruttapasta, Carla Buccolini, Rosa Carangella, Franca Carboni, Daniela Ceccolini, Patrizia D'Incecco, Mariangela Di Felice, Lara Dini, Giordano Gioia, Giuseppe Di Prima, Giancarlo Giusepponi, Cesarina Lanciotti, Alessia Loffreda, Oriana Luciani, Laura Mariani, Francesco Mastrorilli, Roberto Moroni, Izabela Piatkowska, Roberta Rucoli, Giampaola Scoccia, Nives Teodori, Tiziana Tonelli, Rossano Angeloni, Rosa Anna Bratti, Giuseppe Bonafede, Severino Lorenzetti, Cristina Paci, Giovanna Picciotti, Donella Pezzola, Vincenzo Rea, Vittorio Sciale, Mario Signorino, Francesca Sorvillo, Pia Francesca Tomassini, Alessia Ciccola, Loena Cionfrini, Daniela Alessandrini, Antonio De Santis, Brunetta Formica, Giuliano Tacchi, Silvia Tortorelli, Gemma Marchegiani, Giovanni Pozzari, Giovanni Santarelli, Dario Bartolucci, Giorgio Caraffa, Filippo Cavallo, Lucia Di Furia, Antonio Lacetera, Claudio M. Maffei, Lamberto Manzoli, Demetrio Postacchini, Roberta Bevilacqua, Anna Rita Bonfigli, Franco Bonfranceschi, Silvia Bustacchini, Marina Capasso, Laura Cassetta, Patrizia Civerchia, Federica Demma, Mirko Di Rosa, Gianluca Furneri, Cinzia Giuli, Marzio Marcellini, Paolo Marinelli, Maria Gabriella Melchiorre, Maria Elena Moraca, Andrea Principi, Cristina Rocchetti, Liana Spazzafumo, Daniela Vincitorio
Summary: The study found that caregivers who were forced to reduce working hours or were unemployed had worse physical health compared to working caregivers. This result was confirmed in the adjusted model. Additionally, factors such as caregiving hours, the cared-for individual's ADL/IADL scores, and informal support network also played important roles in caregivers' mental health.
AGING & MENTAL HEALTH
(2021)
Article
Clinical Neurology
Roberta Bevilacqua, Elvira Maranesi, Mirko Di Rosa, Riccardo Luzi, Elisa Casoni, Nadia Rinaldi, Renato Baldoni, Fabrizia Lattanzio, Valentina Di Donna, Giuseppe Pelliccioni, Giovanni Renato Riccardi
Article
Geriatrics & Gerontology
Sonia D'Alia, Francesco Guarasci, Luca Bartucci, Ramona Caloiero, Maurizio Leonardo Guerrieri, Luca Soraci, Daniele Colombo, Lucia Crescibene, Graziano Onder, Stefano Volpato, Antonio Cherubini, Carmelinda Ruggiero, Andrea Corsonello, Fabrizia Lattanzio, Paolo Fabbietti
Article
Infectious Diseases
Alessia Fumagalli, Clementina Misuraca, Achille Bianchi, Noemi Borsa, Simone Limonta, Sveva Maggiolini, Daniela Rita Bonardi, Andrea Corsonello, Mirko Di Rosa, Luca Soraci, Fabrizia Lattanzio, Daniele Colombo
Summary: This study aimed to assess respiratory function in patients surviving COVID-19 pneumonia. The findings suggest that patients may experience clinically relevant alterations in pulmonary function, characterized by a mainly restrictive pattern, even 6 weeks after discharge.
Article
Biochemistry & Molecular Biology
Tiziana Casoli, Cinzia Giuli, Marta Balietti, Paolo Fabbietti, Fiorenzo Conti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Geriatrics & Gerontology
Marta Balietti, Tiziana Casoli, Robertina Giacconi, Cinzia Giuli
Summary: Early diagnosis of Alzheimer's disease is essential, and the activity of phospholipases A(2) (PLA(2)) may serve as a potential biomarker for diagnosis and prognosis of the disease.
REJUVENATION RESEARCH
(2022)
Article
Geriatrics & Gerontology
Francesc Formiga, Rafael Moreno-Gonzalez, Andrea Corsonello, Axel Carlsson, Johan Arnlov, Francesco Mattace-Raso, Tomasz Kostka, Christian Weingart, Regina Roller-Wirnsberger, Lisanne Tap, Agnieszka Guligowska, Cornel Sieber, Gerhard Wirnsberger, Rada Artzi-Medvedik, Ilan Yehoshua, Cinzia Giuli, Fabrizia Lattanzio, Xavier Corbella
Summary: This study evaluated the prevalence of sarcopenia and its associated risk factors among community-dwelling older adults with diabetes. The results showed that older age and being thinner were associated with a higher prevalence of sarcopenia in older adults with diabetes, while worse renal function did not have a significant association with sarcopenia.
Article
Biochemistry & Molecular Biology
Robertina Giacconi, Patrizia D'Aquila, Marta Balietti, Cinzia Giuli, Marco Malavolta, Francesco Piacenza, Laura Costarelli, Demetrio Postacchini, Giuseppe Passarino, Dina Bellizzi, Mauro Provinciali
Summary: Microbial dysbiosis leads to alterations in gut barrier and bacterial translocation, resulting in increased blood bacterial DNA that promotes peripheral and neuro inflammation and contributes to cognitive impairment. It also affects the production of brain-derived neurotrophic factor, which plays a role in the etiopathogenesis of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Education & Educational Research
Roberta Papa, Jane Sixsmith, Cinzia Giammarchi, Sonia Lippke, Verna Mckenna, Lucia Di Furia, Maria Gabriella Ceravolo, Andrea De Winter
Summary: This study describes the piloting process of a pan-European health literacy educational programme and shows how the educational material is being used during the COVID-19 pandemic. The evaluation results indicate that the programme received positive feedback from students and educators, with significant improvement in students' health literacy awareness after the training.
BMC MEDICAL EDUCATION
(2023)
Article
Geriatrics & Gerontology
Andrea Corsonello, Francesco Mattace-Raso, Lisanne Tap, Marcello Maggio, Luna Zerbinati, Francesco Guarasci, Annalisa Cozza, Sonia D'Alia, Luca Soraci, Valentina Corigliano, Mirko Di Rosa, Paolo Fabbietti, Fabrizia Lattanzio
Summary: The CKD-3D project aims to conduct an observational study in elderly patients to expand the understanding of the relationship between CKD and disability, as well as investigate the use of novel biomarkers of kidney function.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Emanuele Rocco Villani, Davide Liborio Vetrano, Laura Franza, Angelo Carfi, Vincenzo Brandi, Stefano Volpato, Andrea Corsonello, Fabrizia Lattanzio, Carmelinda Ruggiero, Graziano Onder, Katie Palmer
Summary: Walking speed (WS) and grip strength (GS) are predictors of hospital length-of-stay, in-hospital mortality, and 1-year mortality and rehospitalisation among older adults admitted to acute care wards.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Alessia Fumagalli, Clementina Misuraca, Sonia Riva, Luca Soraci, Paolo Fabbietti, Mirko Di Rosa, Andrea Corsonello, Fabrizia Lattanzio, Daniele Colombo
Summary: This study found that executive abilities in COPD patients may be associated with long-term mortality. Deficits in TMT-B were significantly linked to mortality in stable COPD patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Geriatrics & Gerontology
Alessia Gallucci, Pietro Davide Trimarchi, Carlo Abbate, Cosimo Tuena, Elisa Pedroli, Fabrizia Lattanzio, Marco Stramba-Badiale, Matteo Cesari, Fabrizio Giunco
Summary: Research on the use of ICT in the context of frailty is still in its early stages, with few studies focusing strictly on frailty assessment and rare reports of ICT interventions for frailty. The lack of proper characterization of frailty condition and methodological limitations have hindered the investigation of ICT within complex care models. Future studies are needed to effectively integrate ICT in the care of frailty in older persons.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Elisa Pierpaoli, Katia Fabi, Federica Francesca Lenci, Maddalena Ricci, Mirko Di Rosa, Graziano Onder, Stefano Volpato, Carmelinda Ruggiero, Antonio Cherubini, Andrea Corsonello, Fabrizia Lattanzio
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2020)