Article
Medicine, General & Internal
Paul Morris, Simon McDermott, Fiona Chapman, Thomas Verron, Xavier Cahours, Matthew Stevenson, Joseph Thompson, Nveed Chaudhary, Grant O'Connell
Summary: This study confirms that exclusive use of electronic nicotine delivery systems (ENDS) can substantially reduce smokers' exposure to harmful constituents while providing satisfying levels of nicotine delivery. For adult smokers unwilling or uninterested in quitting smoking, ENDS may be an important tool in reducing smoking-related harm.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Nathan Gale, Michael McEwan, Oscar M. Camacho, George Hardie, Christopher J. Proctor, James Murphy
Summary: The study found that switching from smoking cigarettes to using a tobacco heating product resulted in reduced biomarkers of exposure and potential harm, indicating that completely switching to THPs may reduce the adverse health impacts of smoking.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Medicine, Legal
Selvin H. Edwards, Matthew D. Hassink, Kenneth M. Taylor, An T. Vu
Summary: Smokeless tobacco products contain addictive and carcinogenic substances that can cause nicotine dependence and oral cancers. This study measured the levels of various substances in 16 smokeless tobacco products and found significant variations. Additionally, the study observed that the analytical variability stabilized after seven replicate measurements.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Nathan Gale, Michael McEwan, George Hardie, Christopher J. Proctor, James Murphy
Summary: This study investigated whether biomarkers of exposure and potential harm are modified when smokers continue to smoke or switch to a tobacco heating product (THP) over a year. It found that switching to THP or quitting smoking led to significant reductions in biomarker levels associated with tobacco smoke and improvements in certain biomarkers of potential harm.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Tianrong Cheng, Samantha M. Reilly, Charles Feng, Matthew J. Walters, Matthew R. Holman
Summary: This study addresses the knowledge gaps regarding the presence of harmful constituents in tobacco products by measuring the quantity of these constituents in different types and matrices of tobacco products. The findings show that some harmful constituents are quantifiable in all brands and products, while others are not quantifiable.
Article
Chemistry, Multidisciplinary
Susanne Back, Anna E. Masser, Lars E. Rutqvist, Johan Lindholm
Summary: Tobacco-free nicotine pouches are a new type of oral nicotine delivery products that may serve as a low-risk alternative to traditional tobacco-based products. The market leading brand in the US is ZYN, but no data on its chemical characteristics have been published.
Article
Health Care Sciences & Services
Yukie Oya, Koji Inagaki, Keiji Tokumaru, Toshiyuki Watanabe, Nobuhiro Segawa, Yohei Yamamoto, Shinsuke Takaki, Takahiro Nimi, Makoto Okai, Noriyasu Uchibori, Takahiro Tabuchi, Akio Mitani, Toru Nagao
Summary: This study investigated the awareness of smoking risks and HTP use risks among dentists in Japan, finding that some HTP users are more attentive to the risks. Therefore, it is necessary to strengthen the education on smoking and HTP use risks for dentists and the general population.
Article
Public, Environmental & Occupational Health
D. -h. Koh
Summary: This study aimed to examine the relationship between heated cigarette smoking and white blood cell (WBC) counts using nationally representative health data. The results showed that conventional cigarette smoking increases WBC counts, while there was no significant difference in WBC counts between heated cigarette smokers and non-smokers. There was a positive dose-response relationship between smoking amount and WBC count for both conventional and heated cigarette smokers.
Article
Energy & Fuels
Hao Wei, Jiangkuan Xing, Kun Luo, Yuhan Peng, Jianren Fan, Ke Zhang, Hui Wang
Summary: A tobacco pyrolysis model based on complex chemical constituents and heating conditions was developed using machine learning approaches. A database containing 49 samples was constructed from chemical analysis and thermogravimetric analysis. The model was trained and evaluated using this database, and it showed accurate prediction of tobacco pyrolysis behavior.
Article
Substance Abuse
Rosemarie A. Martin, L. A. R. Stein, Augustine Kang, Damaris J. Rohsenow, Beth Bock, Stephen A. Martin, Jennifer G. Clarke
Summary: This study explores the situational, affective, and motivational factors that contribute to the high rate of relapse in smoking after release from tobacco-free prisons. It found that proximity to other smokers, the use of other substances, and positive moods were significant triggers for relapse. The study suggests that interventions targeting these specific factors and accessible immediately upon release are necessary to support individuals in maintaining their desired abstinence.
JOURNAL OF ADDICTION MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Loren S. Kock, Tyler G. Erath, Sulamunn R. M. Coleman, Stephen T. Higgins, Sarah H. Heil
Summary: Contingency management with financial incentives is an effective intervention for promoting smoking cessation in pregnant women. It increases the likelihood of smoking abstinence during pregnancy and continues to have a positive impact in the postpartum period. However, more research is needed to further validate these findings.
PREVENTIVE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Dai Yuki, Akira Kikuchi, Takuya Suzuki, Chikako Sakaguchi, Danting Huangfu, Yasufumi Nagata, Aoi Kakehi
Summary: The objective of this clinical study was to demonstrate a reduction in exposure to harmful and potentially harmful constituents in Japanese adult smokers who switched to heated tobacco products. The results showed that after using these products, the reduction in exposure to selected harmful constituents was comparable to that observed in smokers who quit.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Daisuke Nishihara, Dai Yuki, Takuya Suzuki, Chikako Sakaguchi, Yasufumi Nagata, Aoi Kakehi
Summary: This was a randomized, controlled, open-label, confinement study that aimed to assess the change in exposure to cigarette smoke constituents in healthy adult smokers who switched to a novel heated tobacco product. Results showed that switching to the new product significantly reduced exposure to harmful constituents, similar to the reductions observed with smoking cessation. Overall, the study suggests the potential benefits of switching to heated tobacco products.Rating: 8/10.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2023)
Review
Cell Biology
Amelie H. Ohlrogge, Lars Frost, Renate B. Schnabel
Summary: Tobacco smoking and alcohol consumption are common and socially accepted, but they are also important risk factors for cardiovascular diseases, particularly atrial fibrillation and stroke. The alterations in atrial myocardium associated with smoking and alcohol involve complex mechanisms and factors, including pathophysiology, environment, and society.
Article
Medicine, General & Internal
Hyo-Sun You, Jae-woo Lee, Ye-seul Kim, Yonghwan Kim, Hyeong-Cheol Lee, Jin Young Hwang, Woojung Yang, Hee-Taik Kang
Summary: The study found a significant association between second-hand smoke exposure and elevated urine NNAL levels in Korean adolescents, especially in female adolescents and those exposed to SHS at home.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Oncology
Emily Chan, Eunice L. Kwak, Jimmy Hwang, Marja Heiskala, Guillaume de La Bourdonnaye, Monica Mita
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2015)
Article
Medicine, Legal
Christelle Haziza, Guillaume de La Bourdonnaye, Dimitra Skiada, Jacek Ancerewicz, Gizelle Baker, Patrick Picavet, Frank Ludicke
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2016)
Article
Rheumatology
M. C. Genovese, N. Kinnman, G. de La Bourdonnaye, C. Pena Rossi, P. P. Tak
ARTHRITIS AND RHEUMATISM
(2011)
Article
Oncology
David A. Smith, Paul Conkling, Donald A. Richards, John J. Nemunaitis, Thomas E. Boyd, Alain C. Mita, Guillaume de La Bourdonnaye, David Wages, Alice S. Bexon
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2014)
Article
Toxicology
Angela van der Plas, Sandrine Pouly, Guillaume de La Bourdonnaye, Gizelle Baker, Frank Luedicke
TOXICOLOGY REPORTS
(2019)
Article
Multidisciplinary Sciences
Christelle Haziza, Guillaume de La Bourdonnaye, Dimitra Skiada, Jacek Ancerewicz, Gizelle Baker, Patrick Picavet, Frank Ludicke
Review
Toxicology
Angela van der Plas, Sandrine Pouly, Guillaume de la Bourdonnaye, Wee Teck Ng, Gizelle Baker, Frank Ludicke
TOXICOLOGY REPORTS
(2018)
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)