Developing an automated robotic factory for novel stem cell therapy production
REGENERATIVE MEDICINE (2016)
Journal
REGENERATIVE MEDICINE
Volume 11, Issue 4, Pages 351-354Publisher
FUTURE MEDICINE LTD
Keywords
Categories
Ask authors/readers for more resources
Authors
I am an author on this paper
Reviews
Recommended
Umbilical cord derived mesenchymal stromal cells in microcarrier based industrial scale culture sustain the immune regulatory functions
Hikari Kurogi, Atsuko Takahashi, Maya Isogai, Marimu Sakumoto, Takashi Takijiri, Akiko Hori, Tetsuo Furuno, Tetsuo Koike, Tetsumasa Yamada, Tokiko Nagamura-Inoue, Masayo Sakaki-Yumoto
BIOTECHNOLOGY JOURNAL (2021)
Development of bioreactor protocols for stem cell-based therapies
Krishna Panchalingam, Tony Wang, Sunghoon Jung, Behnam Ahmadian Baghbaderani
CANADIAN JOURNAL OF CHEMICAL ENGINEERING (2021)
Design and development of a new ambr250® bioreactor vessel for improved cell and gene therapy applications
Marco Rotondi, Ned Grace, John Betts, Neil Bargh, Elena Costariol, Barney Zoro, Christopher J. Hewitt, Alvin W. Nienow, Qasim A. Rafiq
BIOTECHNOLOGY LETTERS (2021)
A 3D Platform to Investigate Dynamic Cell-to-Cell Interactions Between Tumor Cells and Mesenchymal Progenitors
Giulia Golinelli, Rebecca Talami, Stella Frabetti, Olivia Candini, Giulia Grisendi, Carlotta Spano, Chiara Chiavelli, Gaelle F. Arnaud, Giorgio Mari, Massimo Dominici
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
A scalable culture system incorporating microcarrier for specialised mesenchymal stem cells from human embryonic stem cells
Tingting Gao, Xiyuan Zhao, Jie Hao, Yao Tian, Huike Ma, Wenjing Liu, Bin An, Faguo Sun, Shasha Liu, Baojie Guo, Shuaishuai Niu, Zhongwen Li, Chenxin Wang, Yukai Wang, Guihai Feng, Liu Wang, Wei Li, Jun Wu, Meijin Guo, Qi Zhou, Qi Gu
MATERIALS TODAY BIO (2023)
Advances in automated cell washing and concentration
Anqi Li, Gina D. Kusuma, Dawn Driscoll, Nathan Smith, Dominic M. Wall, Bruce L. Levine, David James, Rebecca Lim
CYTOTHERAPY (2021)
GMP-Compliant Production of Autologous Adipose-Derived Stromal Cells in the NANT 001 Closed Automated Bioreactor
Joan C. Fitzgerald, Niamh Duffy, Giacomo Cattaruzzi, Francesco Vitrani, Alice Paulitti, Flavia Mazzarol, Prisca Mauro, Antonio Sfiligoj, Francesco Curcio, Deirdre M. Jones, Veronica McInerney, Janusz Krawczyk, Jack Kelly, Andrew Finnerty, Katya McDonagh, Una McCabe, Matthew Duggan, Lauren Connolly, Georgina Shaw, Mary Murphy, Frank Barry
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)
A scalable system for generation of mesenchymal stem cells derived from induced pluripotent cells employing bioreactors and degradable microcarriers
Robert E. Rogers, Andrew Haskell, Berkley P. White, Sujata Dalal, Megan Lopez, Daniel Tahan, Simin Pan, Gagandeep Kaur, Hyemee Kim, Heather Barreda, Susan L. Woodard, Oscar R. Benavides, Jing Dai, Qingguo Zhao, Kristen C. Maitland, Arum Han, Zivko L. Nikolov, Fei Liu, Ryang Hwa Lee, Carl A. Gregory, Roland Kaunas
STEM CELLS TRANSLATIONAL MEDICINE (2021)
Enhanced chondrogenic differentiation of iPS cell-derived mesenchymal stem/stromal cells via neural crest cell induction for hyaline cartilage repair
Denise Zujur, Ziadoon Al-Akashi, Anna Nakamura, Chengzhu Zhao, Kazuma Takahashi, Shizuka Aritomi, William Theoputra, Daisuke Kamiya, Koichi Nakayama, Makoto Ikeya
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
Mesenchymal stem cells in glioblastoma therapy and progression: How one cell does it all
Blazej Nowak, Piotr Rogujski, Miroslaw Janowski, Barbara Lukomska, Anna Andrzejewska
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)
Hypoxic ucMSC-secreted exosomal miR-125b promotes endothelial cell survival and migration during wound healing by targeting TP53INP1
Xiao-Fei Zhang, Ting Wang, Zi-Xuan Wang, Kun-Peng Huang, Yun-Wei Zhang, Guo-Liang Wang, Hong-Ji Zhang, Zi-Han Chen, Chang-Yan Wang, Jin-Xiang Zhang, Hui Wang
MOLECULAR THERAPY-NUCLEIC ACIDS (2021)
Gap junction-mediated cell-cell interaction between transplanted mesenchymal stem cells and vascular endothelium in stroke
Akie Kikuchi-Taura, Yuka Okinaka, Orie Saino, Yukiko Takeuchi, Yuko Ogawa, Takafumi Kimura, Sheraz Gul, Carsten Claussen, Johannes Boltze, Akihiko Taguchi
STEM CELLS (2021)
Production of Mesenchymal Progenitor Cell-Derived Extracellular Vesicles in Suspension Bioreactors for Use in Articular Cartilage Repair
Jolene Phelps, Catherine Leonard, Sophia Shah, Roman Krawetz, David A. Hart, Neil A. Duncan, Arindom Sen
STEM CELLS TRANSLATIONAL MEDICINE (2022)
Enhancing Mesenchymal Stromal Cell Potency: Inflammatory Licensing via Mechanotransduction
Max A. Skibber, Scott D. Olson, Karthik S. Prabhakara, Brijesh S. Gill, Charles S. Cox
FRONTIERS IN IMMUNOLOGY (2022)
A modular 3D printed microfluidic system: a potential solution for continuous cell harvesting in large-scale bioprocessing
Lin Ding, Sajad Razavi Bazaz, Mahsa Asadniaye Fardjahromi, Flyn McKinnirey, Brian Saputro, Balarka Banerjee, Graham Vesey, Majid Ebrahimi Warkiani
BIORESOURCES AND BIOPROCESSING (2022)
Development of a process control strategy for the serum-free microcarrier expansion of human mesenchymal stem cells towards cost-effective and commercially viable manufacturing
Thomas R. J. Heathman, Alvin W. Nienow, Qasim A. Rafiq, Karen Coopman, Bo Kara, Christopher J. Hewitt
BIOCHEMICAL ENGINEERING JOURNAL (2019)
A scaled-down model for the translation of bacteriophage culture to manufacturing scale
Junaid Ali, Qasim Rafiq, Elizabeth Ratcliffe
BIOTECHNOLOGY AND BIOENGINEERING (2019)
Beta-tricalcium phosphate ceramic triggers fast and robust bone formation by human mesenchymal stem cells
Rui C. Pereira, Roberto Benelli, Barbara Canciani, Monica Scaranari, Guy Daculsi, Ranieri Cancedda, Chiara Gentili
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)
CAR-T immunotherapies: Biotechnological strategies to improve safety, efficacy and clinical outcome through CAR engineering
Theano I. Panagopoulou, Qasim A. Rafiq
BIOTECHNOLOGY ADVANCES (2019)
Progenitor Cells Activated by Platelet Lysate in Human Articular Cartilage as a Tool for Future Cartilage Engineering and Reparative Strategies
Simonetta Carluccio, Daniela Martinelli, Maria Elisabetta Federica Palama, Rui Cruz Pereira, Roberto Benelli, Ana Guijarro, Ranieri Cancedda, Chiara Gentili
CELLS (2020)
Demonstrating the Manufacture of Human CAR-T Cells in an Automated Stirred-Tank Bioreactor
Elena Costariol, Marco C. Rotondi, Arman Amini, Christopher J. Hewitt, Alvin W. Nienow, Thomas R. J. Heathman, Qasim A. Rafiq
BIOTECHNOLOGY JOURNAL (2020)
Expansion of human mesenchymal stem/stromal cells (hMSCs) in bioreactors using microcarriers: lessons learnt and what the future holds
P. Silva Couto, M. C. Rotondi, A. Bersenev, C. J. Hewitt, A. W. Nienow, F. Verter, Q. A. Rafiq
BIOTECHNOLOGY ADVANCES (2020)
Design and development of a new ambr250® bioreactor vessel for improved cell and gene therapy applications
Marco Rotondi, Ned Grace, John Betts, Neil Bargh, Elena Costariol, Barney Zoro, Christopher J. Hewitt, Alvin W. Nienow, Qasim A. Rafiq
BIOTECHNOLOGY LETTERS (2021)
Role of extracellular vesicles from adipose tissue- and bone marrow-mesenchymal stromal cells in endothelial proliferation and chondrogenesis
Cansu Gorgun, Maria Elisabetta Federica Palama, Daniele Reverberi, Maria Cristina Gagliani, Katia Cortese, Roberta Tasso, Chiara Gentili
STEM CELLS TRANSLATIONAL MEDICINE (2021)
Needle to needle robot-assisted manufacture of cell therapy products
Jelena Ochs, Mariana P. Hanga, Georgina Shaw, Niamh Duffy, Michael Kulik, Nokilaj Tissin, Daniel Reibert, Ferdinand Biermann, Panagiota Moutsatsou, Shibani Ratnayake, Alvin Nienow, Niels Koenig, Robert Schmitt, Qasim Rafiq, Christopher J. Hewitt, Frank Barry, J. Mary Murphy
BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)
Regenerative and Anti-Inflammatory Potential of Regularly Fed, Starved Cells and Extracellular Vesicles In Vivo
Federico Ferro, Renza Spelat, Georgina Shaw, Cynthia M. Coleman, Xi Zhe Chen, David Connolly, Elisabetta M. F. Palama, Chiara Gentili, Paolo Contessotto, Mary J. Murphy
CELLS (2022)
Prognostic Role of Soluble and Extracellular Vesicle-Associated PD-L1, B7-H3 and B7-H4 in Non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors
Carlo Genova, Roberta Tasso, Alessandra Rosa, Giovanni Rossi, Daniele Reverberi, Vincenzo Fontana, Silvia Marconi, Michela Croce, Maria Giovanna Dal Bello, Chiara Dellepiane, Marco Tagliamento, Maria Chiara Ciferri, Lodovica Zullo, Alessandro Fedeli, Angela Alama, Katia Cortese, Chiara Gentili, Eugenia Cella, Giorgia Anselmi, Marco Mora, Giulia Barletta, Erika Rijavec, Francesco Grossi, Paolo Pronzato, Simona Coco
CELLS (2023)
Scalable manufacturing of gene-modified human mesenchymal stromal cells with microcarriers in spinner flasks
Pedro Silva Couto, Dale J. J. Stibbs, Marco C. C. Rotondi, Yasuhiro Takeuchi, Qasim A. A. Rafiq
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2023)
Optimizing and developing a scalable, chemically defined, animal component-free lentiviral vector production process in a fixed-bed bioreactor
Carme Ripoll Fiol, Marie-Laure Collignon, John Welsh, Qasim A. Rafiq
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2023)
Pilot study investigating BP-180 in extracellular vesicles derived from blister fluid of bullous pemphigoid patients
Giulia Gasparini, Roberta Tasso, Maria Elisabetta Federica Palama, Maria Chiara Ciferri, Chiara Gentili, Giovanni Di Zenzo, Alessia Provini, Adele Salemme, Rodolfo Quarto, Aurora Parodi, Emanuele Cozzani
ARCHIVES OF DERMATOLOGICAL RESEARCH (2023)