Beneath the sword of Damocles: regenerative medicine and the shadow of immunogenicity

Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm

(2015) Gregory L. Szot et al.   Cell Stem Cell

Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells

(2015) Tongbiao Zhao et al.   Cell Stem Cell

Stem Cell Therapies in Clinical Trials: Progress and Challenges

(2015) Alan Trounson et al.   Cell Stem Cell

Pluripotent stem cells and tolerance induction in organ transplantation

(2015) Barbara Imberti et al.   Current Opinion in Organ Transplantation

Inhibition of T-Cell Activation by Retinal Pigment Epithelial Cells Derived From Induced Pluripotent Stem Cells

(2015) S. Sugita et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

(2015) Steven D Schwartz et al.   LANCET

Avoiding immunological rejection in regenerative medicine

(2015) Eleanor M Bolton et al.   Regenerative Medicine

Development of a global network of induced pluripotent stem cell haplobanks

(2015) Ian Wilmut et al.   Regenerative Medicine

Engraftment of Embryonic Stem Cells and Differentiated Progeny by Host Conditioning with Total Lymphoid Irradiation and Regulatory T Cells

(2015) Yuqiong Pan et al.   Cell Reports

Immunogenicity and functional evaluation of iPSC-derived organs for transplantation

(2015) Libin Wang et al.   Cell Discovery

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

An Effective Approach to Prevent Immune Rejection of Human ESC-Derived Allografts

(2014) Zhili Rong et al.   Cell Stem Cell

Potentially immunogenic proteins expressed similarly in human embryonic stem cells and induced pluripotent stem cells

(2014) Kristen M Maynard et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Japan stem-cell trial stirs envy

(2014) Sara Reardon et al.   NATURE

Reduced Immunogenicity of Induced Pluripotent Stem Cells Derived from Sertoli Cells

(2014) Xiaoying Wang et al.   PLoS One

Negligible Immunogenicity of Induced Pluripotent Stem Cells Derived from Human Skin Fibroblasts

(2014) Qiao Lu et al.   PLoS One

Banking on iPSC- Is it Doable and is it Worthwhile

(2014) Susan Solomon et al.   Stem Cell Reviews and Reports

Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance

(2014) Patricia .E de Almeida et al.   Nature Communications

Tolerance induction to human stem cell transplants with extension to their differentiated progeny

(2014) Kathy O. Lui et al.   Nature Communications

Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application

(2014) Hiroyuki Kamao et al.   Stem Cell Reports

Toward the Development of a Global Induced Pluripotent Stem Cell Library

(2013) Marc Turner et al.   Cell Stem Cell

Lack of Immune Response to Differentiated Cells Derived from Syngeneic Induced Pluripotent Stem Cells

(2013) Prajna Guha et al.   Cell Stem Cell

Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

(2013) Ryoko Araki et al.   NATURE

Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies

(2013) Andrew S Lee et al.   NATURE MEDICINE

Low Immunogenicity of Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Derived from Less Immunogenic Somatic Cells

(2013) Pengfei Liu et al.   PLoS One

Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

(2013) Asuka Morizane et al.   Stem Cell Reports

Biological significance of HORMA domain containing protein 1 (HORMAD1) in epithelial ovarian carcinoma

(2012) Mian M.K. Shahzad et al.   CANCER LETTERS

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

(2012) Robert M. Samstein et al.   CELL

Embryonic stem cell trials for macular degeneration: a preliminary report

(2012) Steven D Schwartz et al.   LANCET

Short-Term Immunosuppression Promotes Engraftment of Embryonic and Induced Pluripotent Stem Cells

(2011) Jeremy I. Pearl et al.   Cell Stem Cell

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

(2011) Yongfang Zhao et al.   NATURE

Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1

(2011) Katrin Daniel et al.   NATURE CELL BIOLOGY

Long-Term Renal Allograft Survival in the United States: A Critical Reappraisal

(2010) K. E. Lamb et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Epigenetic memory in induced pluripotent stem cells

(2010) K. Kim et al.   NATURE

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

(2010) Jose M Polo et al.   NATURE BIOTECHNOLOGY

A Role for Regulatory T Cells in Acceptance of ESC-Derived Tissues Transplanted Across an Major Histocompatibility Complex Barrier

(2010) Kathy O. Lui et al.   STEM CELLS

Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions

(2010) Andrzej Swistowski et al.   STEM CELLS

HLA-Matching Potential of an Established Human Embryonic Stem Cell Bank in China

(2009) Ge Lin et al.   Cell Stem Cell

Directed Differentiation of Human Embryonic Stem Cells into Functional Retinal Pigment Epithelium Cells

(2009) Maria Idelson et al.   Cell Stem Cell

Human Embryonic Stem Cells Suppress T Cell Responses via Arginase I-Dependent Mechanism

(2009) N. Yachimovich-Cohen et al.   JOURNAL OF IMMUNOLOGY

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

HLA-haplotype banking and iPS cells

(2008) Norio Nakatsuji et al.   NATURE BIOTECHNOLOGY

Costimulation Blockade Induces Tolerance to HESC Transplanted to the Testis and Induces Regulatory T-Cells to HESC Transplanted into the Heart

(2008) Karl-Henrik Grinnemo et al.   STEM CELLS

Embryonic Stem Cells and Their Differentiated Derivatives Have a Fragile Immune Privilege but Still Represent Novel Targets of Immune Attack

(2008) Douglas C. Wu et al.   STEM CELLS