Review
Oncology
Jana M. Kobeissi, Charles B. Simone, Haibo Lin, Lara Hilal, Carla Hajj
Summary: Radiation therapy plays a central role in the management of pancreatic cancer, and proton therapy is an emerging treatment modality. Proton irradiation remains a challenge in radiation therapy, but no significant differences in oncologic outcomes and toxicity rates have been shown compared to photon radiation treatment.
Article
Oncology
Avani Dholakia Rao, Kai Sun, Mingyao Zhu, Sina Mossahebi, Pouya Sabouri, Thomas Houser, Jenna Jatczak, Mark Zakhary, William F. Regine, Robert C. Miller, Soren Bentzen, Mark Mishra
Summary: This study evaluated the impact of maximum MU weighting per spot restrictions on pencil beam scanning proton therapy plan quality, and found that within the evaluated thresholds, these restrictions did not degrade overall plan quality metrics and did not increase treatment delivery time. Further studies are needed to evaluate spot weighting manipulation on clinical outcomes and toxicity mitigation.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Reinhardt Krcek, Dominic Leiser, Marta Garcia-Marqueta, Alessandra Bolsi, Damien Charles Weber
Summary: In this retrospective study, the clinical outcomes and quality of life (QoL) of patients with intracranial meningiomas treated with Pencil Beam Scanning Proton Therapy (PBS PT) were evaluated. The results showed high local control and survival rates, particularly in patients with grade 1 tumors, as well as stable QoL after treatment. These findings suggest that PBS PT is a suitable alternative to conventional radiotherapy for the treatment of meningiomas.
Article
Oncology
Christian Baeumer, Sandija Plaude, Dalia Ahmad Khalil, Dirk Geismar, Paul-Heinz Kramer, Kevin Kroninger, Christian Nitsch, Joerg Wulff, Beate Timmermann
Summary: Proton therapy utilizes the Bragg peak and dose distribution advantage to spare normal tissue, and improves lateral dose gradient with apertures to reduce damage to organs-at-risk. The study demonstrates that apertures can enhance conformity index, decrease volume of dose gradient surrounding PTV, and lower average dose to certain organs-at-risk.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Susu Yan, Nicolas Depauw, Judith Adams, Bram L. Gorissen, Helen A. Shih, Jay Flanz, Thomas Bortfeld, Hsiao-Ming Lu
Summary: This study investigates the possibility of obtaining high-quality treatment plans without the use of a gantry. The results show that gantry-less treatment plans using pencil beam scanning (PBS) have similar target homogeneity and organs-at-risk mean dose as compared to plans with a gantry, and they also demonstrate similar robustness to range uncertainties and setup errors.
Article
Engineering, Biomedical
A. M. M. Leite, M. G. Ronga, M. Giorgi, Y. Ristic, Y. Perrot, F. Trompier, Y. Prezado, G. Crehange, L. De Marzi
Summary: The study compares organ-specific secondary neutron doses from different proton therapy modalities at the Orsay Proton therapy Center, showing that proton minibeams therapy results in higher neutron doses for organs closer to the target volume, while organs further from the target receive more neutrons from the passive scattering beam line.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Biomedical
Yaoying Liu, Xuying Shang, Wei Zhao, Nan Li, Baolin Qu, Yue Zou, Xiaoyun Le, Gaolong Zhang, Shouping Xu
Summary: This study proposes a commissioning method for the proton source model using convolutional neural networks (CNNs), which efficiently and accurately determines the nominal energy and energy spread parameters in the proton source model. Experimental results show that commissioning using this method significantly improves the accuracy of dose calculation.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Shouyi Wei, Haibo Lin, Sheng Huang, Chengyu Shi, Weijun Xiong, Huifang Zhai, Lei Hu, Gang Yu, Robert H. Press, Shaakir Hasan, Arpit M. Chhabra, J. Isabelle Choi, Charles B. Simone, Minglei Kang
Summary: This study evaluated the plan quality and robustness of proton pencil beam scanning transmission FLASH delivery in lung cancer treatment. The results showed that transmission plans had slightly inferior plan quality compared to conventional proton radiation plans, but provided improved robustness and the potential for reducing toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Jiri Kubes, Vladimir Vondracek, Michal Andrlik, Matej Navratil, Silvia Slavikova, Pavel Vitek, Katerina Dedeckova, Jana Prausova, Barbora Ondrova, Eliska Rotnaglova, Petr Lukes, Matej Patzelt, Alexander Grebenyuk, Jozef Rosina
Summary: Patients with nasopharyngeal cancer treated with proton pencil-beam scanning radiotherapy showed promising treatment outcomes and mild acute toxicity. The study highlighted the feasibility of proton therapy in this group of patients with advanced disease.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Oncology
Nalee Kim, Jae Myoung Noh, Woojin Lee, Byoungsuk Park, Hongryull Pyo
Summary: This study compared oncologic outcomes and toxicities of pencil beam scanning proton therapy (PBSPT) versus intensity-modulated (photon) radiotherapy (IMRT) in patients with locally advanced non-small cell lung cancer (NSCLC). PBSPT showed superior sparing of normal tissues compared to IMRT, but had higher rates of severe dermatitis and esophagitis. Despite baseline lung function decline, PBSPT had comparable rates of symptomatic radiation pneumonitis to IMRT.
Article
Engineering, Biomedical
Racell Nabha, Marijke De Saint-Hubert, Joachim Marichal, Johannes Esser, Olivier Van Hoey, Christian Baeumer, Nico Verbeek, Lara Struelens, Edmond Sterpin, Kevin Tabury, Lukas Marek, Carlos Granja, Beate Timmermann, Filip Vanhavere
Summary: This study characterized the radiation fields produced by collimated and uncollimated proton beams. The results showed that combining proton beam scanning with an aperture can reduce the absorbed dose in the lateral fall-off and out-of-field by 60%. However, the increase in linear energy transfer (LET) caused by collimated fields did not result in higher DNA damage yields due to the large dose reduction.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jufri Setianegara, Thomas R. Mazur, Yao Hao, Deshan Yang, H. Harold Li
Summary: The study aimed to establish an independent dosimetry system for accurate 2D proton spot measurements using an in-house optical scanner and BaFBrI:Eu2+ storage phosphor dosimeter. The research determined the optimal settings for the optical scanner, as well as the linear range and dosimetric accuracy of the storage phosphor dosimeters.
Article
Oncology
Pingfang Tsai, Yu-Lun Tseng, Brian Shen, Christopher Ackerman, Huifang A. Zhai, Francis Yu, Charles B. Simone II, J. Isabelle Choi, Nancy Y. Lee, Rafi Kabarriti, Stanislav Lazarev, Casey L. Johnson, Jiayi Liu, Chin-Cheng Chen, Haibo Lin
Summary: This study evaluates the potential of cone-beam computed tomography (CBCT)-based synthetic CT (sCT) as an alternative to verification CT (vCT) in proton therapy for enhanced treatment monitoring and early adaptation. The study found that sCT agreed with vCT in regions of homogeneous tissues, but discrepancies were observed in the thorax and abdomen. The study also observed outliers in sCT plans when there was an anatomy change or in low-density regions. The target coverage variance in most sCT cases compared to vCT was less than 5%. The study concludes that the use of sCT allows for precise treatment and prompt early adaptation in proton therapy, but quality assurance of sCT is crucial in the early stages of clinical implementation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Carina Behrends, Christian Baeumer, Nico Gerd Verbeek, Joerg Wulff, Beate Timmermann
Summary: The study investigates the relationship between spot position and collimating aperture edge in proton therapy, finding that overscanning the spot position beyond the edge can reduce the lateral penumbra. The results show that overscanning by 5mm can reduce the lateral penumbra by an average of 20%. This study has important implications for optimizing proton therapy techniques.
Article
Oncology
Jonas Willmann, Dominic Leiser, Damien Charles Weber
Summary: Proton therapy for patients with low-grade glioma results in favorable oncological outcomes and patient-reported results, with low rates of treatment-related side effects. Overall quality of life and sexual satisfaction remain stable during and after proton therapy.
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
