Article
Biochemistry & Molecular Biology
Maria Elena Ainora, Lucia Cerrito, Antonio Liguori, Irene Mignini, Angela De Luca, Linda Galasso, Matteo Garcovich, Laura Riccardi, Francesca Ponziani, Francesco Santopaolo, Maurizio Pompili, Antonio Gasbarrini, Maria Assunta Zocco
Summary: A correct differentiation between hepatocellular carcinoma (HCC) and intracellular cholangiocarcinoma (ICC) is essential but challenging. Dynamic contrast-enhanced ultrasound (D-CEUS) and shear wave elastography (SWE) can provide valuable information for accurate diagnosis. A multiparametric ultrasound (MP-US) score based on D-CEUS and SWE parameters showed high accuracy in distinguishing ICC from HCC, potentially reducing the need for liver biopsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Li Xu, Zhanying Ren, Guolin Li, Danni Xu, Jiaqian Miao, Jingxuan Ju, Xuan Mo, Xianghui Wang, Hongping Deng, Min Xu
Summary: A liver-targeting gadolinium-based MRI contrast agent was developed using galactose functionalized o-carboxymethyl chitosan, which exhibited higher hepatocyte uptake, excellent biocompatibility, and better T1-weighted signal enhancement in the liver. The agent showed good safety in vivo at a specific dose.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuan Xue, Bin Xiao, Zhiyang Xia, Lixiong Dai, Qian Xia, Lei Zhong, Chunrong Zhu, Jiang Zhu
Summary: This study evaluated the ability of Mn-BnO-TyEDTA MRI contrast agent to detect hepatocellular carcinoma in a mouse model. Results showed that it provides comparable hepatobiliary tumor contrast enhancement to Gd-EOB-DTPA.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Medicine, General & Internal
Thomas Geyer, Dirk-Andre Clevert, Sonja Schwarz, Paul Reidler, Sebastian Gassenmaier, Thomas Knoeel, Johannes Ruebenthaler, Vincent Schwarze, Marco Armbruster
Summary: CEUS shows high diagnostic performance in characterizing suspicious liver lesions, with a high sensitivity and true positive rate compared to histopathological results. It is a safe imaging modality for evaluating both benign and malignant liver lesions.
Article
Clinical Neurology
Francois Lersy, Julie Royer-Leblond, Benoit Lhermitte, Agathe Chammas, Francis Schneider, Yves Hansmann, Nicolas Lefebvre, Julie Denis, Marcela Sabou, Francois Lafitte, Francois Cotton, Marie-Paule Boncoeur-Martel, Thomas Tourdias, Jean-Pierre Pruvo, Jean-Philippe Cottier, Raoul Herbrecht, Stephane Kremer
Summary: The study describes common radiographic patterns of cerebral mucormycosis and histopathological correlations, all patients were immunocompromised and/or diabetic. The type of lesions depended on the infection's dissemination pathway, with MRI being critical for diagnosis.
JOURNAL OF NEUROLOGY
(2022)
Article
Engineering, Biomedical
Shuai Guo, Wei Xiong, Jiaoyang Zhu, Jie Feng, Ruilong Zhou, Qingdeng Fan, Qianqian Zhang, Zongheng Li, Jing Yang, Huimin Zhou, Peiwei Yi, Yanqiu Feng, Sugeun Yang, Xiaozhong Qiu, Yikai Xu, Zheyu Shen
Summary: In this study, a STING pathway-activatable contrast agent was developed for magnetic resonance imaging (MRI)-guided tumor immunoferroptosis synergistic therapy. The effectiveness and biosafety of this therapy were demonstrated by in vivo investigations, and the mechanisms of action were studied using various indicators.
Article
Gastroenterology & Hepatology
Matteo Ravaioli, Quirino Lai, Maurizio Sessa, Davide Ghinolfi, Guido Fallani, Damiano Patrono, Stefano Di Sandro, Alfonso Avolio, Federica Odaldi, Jessica Bronzoni, Francesco Tandoi, Riccardo De Carlis, Marco Maria Pascale, Gianluca Mennini, Giuliana Germinario, Massimo Rossi, Salvatore Agnes, Luciano De Carlis, Matteo Cescon, Renato Romagnoli, Paolo De Simone
Summary: Italy's policy of giving national allocation priority to patients with a model for end-stage liver disease (MELD) score ≥30 has resulted in more liver transplants, fewer dropouts, and shorter waiting times for patients with MELD ≥30. However, there is still a higher risk of graft loss in these cases. The size of transplant centers and competition among centers may play a role in recipient prioritization and outcomes.
JOURNAL OF HEPATOLOGY
(2022)
Article
Chemistry, Medicinal
Koen G. A. M. Hussaarts, Leni van Doorn, Sander Bins, Dave Sprengers, Peter de Bruijn, Roelof W. F. van Leeuwen, Stijn L. W. Koolen, Teun van Gelder, Ron H. J. Mathijssen
Summary: The study found that sorafenib exposure decreased over time during combined treatment with immunosuppressants, and two patients also experienced declining tacrolimus plasma levels. Patients were unable to increase the sorafenib dose higher than 200 mg b.i.d. without experiencing significant toxicity.
Review
Radiology, Nuclear Medicine & Medical Imaging
Faraz Ahmad, Lee Treanor, Trevor A. McGrath, Daniel Walker, Matthew D. F. McInnes, Nicola Schieda
Summary: The study found that the adverse event rate of ferumoxytol as an MRI contrast agent is 2%, with a mix of mild, moderate, and severe adverse events reported. There were no deaths related to ferumoxytol administration, but the safety of ferumoxytol as an alternative to gadolinium-based contrast agents in patients with prior hypersensitivity reactions remains unexplored.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuhang Sun, Qiaoyun Zhu, Meiyan Huang, Dinggang Shen, Yujia Zhou, Qianjin Feng
Summary: Dynamic contrast-enhanced MRI (DCE-MRI) registration is challenging due to intensity changes from contrast agent injections. An innovative strategy involving sparse representation and alignment methods was proposed for liver DCE-MRI registration, yielding comparable results to advanced methods.
Article
Chemistry, Multidisciplinary
Yijie Qiu, Zhihua Wu, Yanling Chen, Jinghan Liao, Qi Zhang, Quan Wang, Yi Duan, Ke Gong, Sheng Chen, Liting Wang, Peili Fan, Yourong Duan, Wenping Wang, Yi Dong
Summary: This study introduces a nano ultrasound contrast agent (ATO/PFH NPs@Au-cRGD) that integrates diagnosis and treatment for efficient ultrasound imaging and liver cancer therapy. The nanodrug delivery system promotes the release of tumor-associated antigens, enhances the synergistic effects of ATO and photothermal therapy, and activates the antitumor immune response. Additionally, when combined with anti-PD-L1 immunotherapy, the system inhibits tumor metastasis and establishes long-term immunological memory.
Article
Materials Science, Multidisciplinary
Lu An, Yu Cai, Qiwei Tian, Jiaomin Lin, Shiping Yang
Summary: The research demonstrates the potential of using Fe(III) complexes constructed with tannic acid and bovine serum albumin as an alternative T-1 MRI contrast agent and tumor theranostics agent.
SCIENCE CHINA-MATERIALS
(2021)
Review
Gastroenterology & Hepatology
Emily Harding-Theobald, Jeremy Louissaint, Bharat Maraj, Edward Cuaresma, Whitney Townsend, Mishal Mendiratta-Lala, Amit G. Singal, Grace L. Su, Anna S. Lok, Neehar D. Parikh
Summary: Studies have shown that radiomic features have good discriminatory performance in differentiating HCC from other solid lesions, predicting microvascular invasion, early recurrence after hepatectomy, and prognosis after therapies. However, the overall quality of the included studies was low due to common deficiencies in internal and external validation, standardized imaging segmentation, and comparison to a gold standard. Therefore, standardization of protocols and outcome measurements, sharing of algorithms and analytic methods, and external validation are necessary before widespread application of radiomics in HCC diagnosis and prognosis in clinical practice.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Oncology
Matthias Ilmer, Markus Otto Guba
Summary: Liver transplantation is now being considered for non-resectable colorectal liver metastases, with good oncologic outcomes; however, due to organ shortage, strict selection of suitable candidates is necessary. Dynamic criteria based on tumor biology provide a better prediction of individual oncological outcomes.
Article
Clinical Neurology
Fana Alemseged, Felix C. Ng, Cameron Williams, Volker Puetz, Gregoire Boulouis, Timothy John Kleinig, Alessandro Rocco, Teddy Y. Wu, Darshan Shah, Francesco Arba, Daniel Kaiser, Francesca Di Giuliano, Andrea Morotti, Fabrizio Sallustio, Helen M. Dewey, Peter Bailey, Billy O'Brien, Gagan Sharma, Steven Bush, Richard Dowling, Marina Diomedi, Leonid Churilov, Bernard Yan, Mark William Parsons, Stephen M. Davis, Peter J. Mitchell, Nawaf Yassi, Bruce C. V. Campbell
Summary: The study showed that the use of TNK prior to EVT in patients with BAO may lead to higher rates of reperfusion compared to alteplase. Randomized controlled trials comparing TNK with alteplase in BAO patients are needed to further validate these findings.
Review
Biochemistry & Molecular Biology
Susana Lopez-Ortiz, Jose Pinto-Fraga, Pedro L. Valenzuela, Juan Martin-Hernandez, Maria M. Seisdedos, Oscar Garcia-Lopez, Nicola Toschi, Francesca Di Giuliano, Francesco Garaci, Nicola Biagio Mercuri, Robert Nistico, Enzo Emanuele, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: Regular physical exercise plays a protective role against Alzheimer's disease by inhibiting crucial pathophysiological molecular pathways related to the disease. Advanced neuroimaging technologies have become increasingly important in exploring the link between AD and physical exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Silvia Minosse, Eliseo Picchi, Francesca Di Giuliano, Loredana Sarmati, Elisabetta Teti, Chiara Adriana Pistolese, Simona Lanzafame, Francesco Di Cio, Maria Guerrisi, Massimo Andreoni, Roberto Floris, Nicola Toschi, Francesco Garaci
Summary: Our study using rs-fMRI combined with advanced graph theoretical analysis and disruption indices revealed profound reorganization of brain function in HIV patients compared to healthy controls. The disruption index showed significant negative association with relative CD4 values, and a positive significant association between plasmatic HIV-RNA and local graph-theoretical metrics. Additionally, differential distribution of HIV clinical biomarkers and brain metrics was observed across different cART duration groups.
JOURNAL OF NEUROIMAGING
(2021)
Review
Clinical Neurology
Eliseo Picchi, Valentina Ferrazzoli, Giulia Pizzicannella, Noemi Pucci, Francesca Pitocchi, Fabrizio Valente, Silvia Minosse, Francesca Izzi, Tommaso Schirinzi, Chiara Bonomi, Chiara Aiello, Roberto Floris, Francesco Garaci, Francesca Di Giuliano
Summary: Leukoencephalopathy with cerebral calcifications and cysts (LCC) is a neurological disorder characterized by white matter abnormalities, intracranial calcifications, and variable cystic lesions resulting from diffuse cerebral microangiopathy. Clinical manifestations include focal neurological deficits and seizures, severity depends on cyst size and location. Diffuse microangiopathy is a common histopathological finding, associated with pathogenic mutations in SNORD118 gene causing Labrune syndrome.
NEUROLOGICAL SCIENCES
(2021)
Article
Biophysics
Silvia Minosse, Francesco Garaci, Federica Martino, Roberta Di Mauro, Milena Melis, Francesca Di Giuliano, Eliseo Picchi, Maria Guerrisi, Roberto Floris, Stefano Di Girolamo, Nicola Toschi
Summary: Recent study used rs-fMRI, graph-theoretical analysis, and a functional disruption index to investigate whole-brain functional changes in patients with sudden sensorineural hearing loss (SSNHL). The findings demonstrated a brain-wide functional network reorganization in SSNHL patients, which correlated with clinical impairment.
NMR IN BIOMEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Di Giuliano Francesca, Minosse Silvia, Picchi Eliseo, Ferrazzoli Valentina, Da Ros Valerio, Muto Massimo, Pistolese Chiara Adriana, Garaci Francesco, Floris Roberto
Summary: The study compared brain MRI using different sequences and found that while BRAVO had higher image quality scores than Silent qualitatively, the diagnostic use of Silent images was similar to BRAVO. Quantitatively, the contrast-to-noise ratio for grey matter and cerebrospinal fluid was comparable in the two sequences, with the signal-to-noise ratio in cerebrospinal fluid being higher in Silent than BRAVO. The acoustic noise of the Silent sequence was significantly lower compared to BRAVO.
Article
Pharmacology & Pharmacy
Alessio Martucci, Eliseo Picchi, Francesca Di Giuliano, Giulio Pocobelli, Raffaele Mancino, Nicola Toschi, Rossella Russo, Roberto Floris, Francesco Garaci, Carlo Nucci
Summary: Glaucoma is a leading cause of blindness globally, with intraocular pressure being the main risk factor. Diagnosis relies on clinical features of the optic nerve, visual field test, and optical coherence tomography, but novel imaging techniques may also play a significant role in supporting diagnosis.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Fana Alemseged, Alessandro Rocco, Francesco Arba, Jaroslava Paulasova Schwabova, Teddy Wu, Leone Cavicchia, Felix Ng, Jo Lyn Ng, Henry Zhao, Cameron Williams, Fabrizio Sallustio, Anna H. Balabanski, Ales Tomek, Mark W. Parson, Peter J. Mitchell, Marina Diomedi, Nawaf Yassi, Leonid Churilov, Stephen M. Davis, Bruce C. Campbell
Summary: By developing the POST-NIHSS, the prognostic accuracy for posterior circulation stroke patients with mild-moderate symptoms can be improved, and it can help identify patients with NIHSS<10 who are at higher risk of poor outcome.
Article
Pharmacology & Pharmacy
Valerio Da Ros, Letizia Oddo, Yosra Toumia, Eugenia Guida, Silvia Minosse, Lidia Strigari, Silvia Strolin, Giulia Paolani, Francesca Di Giuliano, Roberto Floris, Francesco Garaci, Susanna Dolci, Gaio Paradossi, Fabio Domenici
Summary: This proof-of-concept study establishes a delivery strategy for radioactive lanthanides against recurrent glioblastoma using biocompatible PVA microbubbles and endovascular radiopharmaceutical infusion. The successful formulation turns PVA microbubbles into a microdevice with efficient Yttrium cargo loading. The selective targeting of Yttrium-loaded microbubbles on glioblastoma-associated tumor endothelial cells is achieved through biorecognition between overexpressed alpha(V)beta(3) integrin and the ligand Cyclo(Arg-Gly-Asp-D-Phe-Lys) on the microbubble surface.
Review
Biochemistry & Molecular Biology
Alessio Martucci, Francesca Di Giuliano, Silvia Minosse, Giulio Pocobelli, Carlo Nucci, Francesco Garaci
Summary: This article summarizes the current research status of the use of advanced neuroimaging techniques in glaucoma and Alzheimer's disease, and explores the shared biomarkers between the two diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Cartesio D'Agostini, Jacopo M. Legramante, Marilena Minieri, Vito N. Di Lecce, Maria Stella Lia, Massimo Maurici, Ilaria Simonelli, Marco Ciotti, Carla Paganelli, Alessandro Terrinoni, Alfredo Giovannelli, Massimo Pieri, Mariacarla Gallu, Vito Dell'Olio, Carla Prezioso, Dolores Limongi, Sergio Bernardini, Antonio Orlacchio, Aw Tar-Choon
Summary: The study aimed to assess the association between CT scan results and MR-proADM levels in order to improve the prediction of in-hospital mortality of COVID-19 patients at the triage. The key role of CT score and MR-proADM levels in determining the correct clinical setting for these patients was also evaluated. The results showed that using CT score in combination with MR-proADM levels was particularly effective in risk stratification and decision-making in the emergency department, optimizing hospital resources.
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Orlacchio, Carlo Guastoni, Giordano Domenico Beretta, Laura Cosmai, Michele Galluzzo, Stefania Gori, Emanuele Grassedonio, Lorena Incorvaia, Carmelita Marcantoni, Giuseppe Stefano Netti, Matteo Passamonti, Camillo Porta, Giuseppe Procopio, Mimma Rizzo, Silvia Roma, Laura Romanini, Fulvio Stacul, Alice Casinelli
Summary: The increasing number of examinations and interventional radiological procedures requiring contrast medium administration highlights the problem of CM-induced renal toxicity in patients at risk. This position paper provides guidelines for clinicians to manage CM-related renal dysfunction, emphasizing the importance of assessing renal function through eGFR measurement and defining cutoff values for renal risk. Intravenous hydration and preventive measures are recommended for patients at risk.
Proceedings Paper
Engineering, Biomedical
Silvia Minosse, Eliseo Picchi, Francesca Di Giuliano, Francesco di Cio, Chiara Adriana Pistolese, Loredana Sarmati, Elisabetta Teti, Massimo Andreoni, Roberto Floris, Maria Guerrisi, Francesco Garaci, Nicola Toschi
Summary: Diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) models were used to evaluate microstructural differences between 35 HIV-positive patients and 20 healthy controls. The study revealed that NODDI analysis uncovered a much wider involvement of brain tissue in HIV infection as compared to DTI.
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
(2021)
Proceedings Paper
Engineering, Biomedical
F. Di Cio, S. Minosse, E. Picchi, F. Di Giuliano, L. Sarmati, E. Teti, M. Andreoni, R. Floris, M. Guerrisi, F. Garaci, N. Toschi
Summary: In this study, potential structural brain network changes in HIV-infected patients were examined using diffusion-imaging-related biomarkers. Significant effects were found in both local and global graph-theoretical measures, highlighting a reorganization of the structural connectome in HIV patients and the potential application of graph theory to detect subtle alterations in brain regions.
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Valerio Da Ros, Eliseo Picchi, Valentina Ferrazzoli, Tommaso Schirinzi, Federico Sabuzi, Piergiorgio Grillo, Massimo Muto, Francesco Garaci, Mario Muto, Francesca Di Giuliano
Summary: This article provides a comprehensive review on the radiological features of the most common vascular myelopathies, emphasizing the importance of understanding vascular spinal anatomy and the clinical aspects of different etiologies in promptly addressing diagnosis and radiological assessment.
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2021)