Methotrexate up-regulates ecto-5′-nucleotidase/CD73 and reduces the frequency of T lymphocytes in the glioblastoma microenvironment

Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

(2015) Elias J. Sayour et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pharmacological Improvement and Preclinical Evaluation of Methotrexate-Loaded Lipid-Core Nanocapsules in a Glioblastoma Model

(2015) Fabrício Figueiró et al.   Journal of Biomedical Nanotechnology

Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Immunoregulatory activity of adenosine and its role in human cancer progression

(2014) Sylvia Muller-Haegele et al.   Expert Review of Clinical Immunology

Glioblastoma cancer stem cells: Biomarker and therapeutic advances

(2014) Kelli B. Pointer et al.   NEUROCHEMISTRY INTERNATIONAL

Activation of adenosine A2Areceptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation

(2013) Aránzazu Mediero et al.   BRITISH JOURNAL OF PHARMACOLOGY

A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis

(2013) Samira Sadat Abolmaali et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes

(2013) Alessia Parodi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Resveratrol-Loaded Lipid-Core Nanocapsules Treatment Reduces In Vitro and In Vivo Glioma Growth

(2013) Fabrício Figueiró et al.   Journal of Biomedical Nanotechnology

Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas

(2013) Shuo Xu et al.   NEURO-ONCOLOGY

Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma

(2012) Roniel Cabrera et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Curcumin inhibits suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro

(2012) Guang-ju Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Influence of anticancer agents on cell survival, proliferation, and CD4+CD25+Foxp3+ regulatory T cell-frequency in human peripheral-blood mononuclear cells activated by T cell-mitogen

(2012) Naoya Tohyama et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Adenosine A3 Receptor Agonist Cl-IB-MECA Induces Cell Death Through Ca2+/ROS-Dependent Down Regulation of ERK and Akt in A172 Human Glioma Cells

(2012) Thae Hyun Kim et al.   NEUROCHEMICAL RESEARCH

Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?

(2012) V. Kumar   Purinergic Signalling

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

(2011) Sebastian F. M. Häusler et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD73 Expression as a Potential Marker of Good Prognosis in Breast Carcinoma

(2011) Anna Supernat et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Exciting New Advances in Neuro-Oncology: The Avenue to a Cure for Malignant Glioma

(2010) E. G. Van Meir et al.   CA-A CANCER JOURNAL FOR CLINICIANS

High dose methotrexate for pediatric high grade glioma: results of the HIT-GBM-D Pilot study

(2010) Johannes E. Wolff et al.   JOURNAL OF NEURO-ONCOLOGY

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

(2009) M. Mandapathil et al.   CLINICAL CANCER RESEARCH

Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression

(2009) Magis Mandapathil et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Mechanisms of Local Immunoresistance in Glioma

(2009) Emilia Albesiano et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

(2009) Michail V. Sitkovsky   TRENDS IN IMMUNOLOGY

Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP–PKA signaling and immunosuppression

(2008) Yunyun Su et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY