Article
Endocrinology & Metabolism
Skand Shekhar, Raven McGlotten, Sunyoung Auh, Kristina Rother, Lynnette K. Nieman
Summary: The study revealed that abnormal thyroid function, likely mediated by subnormal nocturnal TSH levels, is prevalent in patients with Cushing syndrome. This abnormality can be reversed after cure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Sibel Nayman, Isabelle Florence Schricker, Iris Reinhard, Christine Kuehner
Summary: This study investigated the impact of childhood adversity on mood and stress appraisal in women with Premenstrual Dysphoric Disorder (PMDD), finding that childhood adversity may have independent deteriorating effects on mood worsening and stress appraisal in PMDD patients. The observed cortisol cyclicity in women with higher childhood adversity may suggest different neuroendocrine subtypes of PMDD related to childhood trauma and warrants further research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Psychiatry
Anastasiya Slyepchenko, Luciano Minuzzi, Benicio N. Frey
Summary: Bipolar disorder presents differently in females compared to males, with characteristics such as more depressive episodes and rapid cycling. Comorbid PMDD with BD in females may lead to a more complex illness course and unique neurobiological correlates, posing challenges in treatment.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Obstetrics & Gynecology
Donghao Lu, Jurate Aleknaviciute, Ragnar Bjarnason, Rulla M. Tamimi, Unnur A. Valdimarsdottir, Elizabeth R. Bertone-Johnson
Summary: Rodents are omnivorous animals that primarily feed on plants, including various species such as rabbits, hamsters, and mice. They usually live on the ground, but there are also species that live in trees. Their characteristics include sharp incisors and lateral movement of the jaw.
HUMAN REPRODUCTION
(2021)
Article
Psychology, Clinical
Sibel Nayman, Theresa Beddig, Iris Reinhard, Christine Kuehner
Summary: In women with premenstrual dysphoric disorder (PMDD), habitual mindfulness and reappraisal have a positive effect on momentary mood, but do not protect against premenstrual mood deterioration. Additionally, habitual mindfulness seems to buffer blunted cortisol activity in women with PMDD, especially during the menstrual phase.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Mingzhou Gao, Hao Zhang, Zhan Gao, Xunshu Cheng, Ya Sun, Mingqi Qiao, Dongmei Gao
Summary: This study aims to estimate the prevalence and risk factors of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) globally and regionally, with the goal of providing scientific basis for prevention and management of these disorders.
Article
Biology
Andrzej Sliwerski, Karolina Koszalkowska
Summary: The study found that fatigue, depressed mood, feeling overwhelmed, anxiety/tension, and decreased interest in everyday activities were the best predictors of PMS. However, PSST over-diagnosed PMS/PMDD in the depressed group but not in the group of women without PMS/PMDD. Clinicians should be aware that a retrospective diagnosis with PSST can be more sensitive to mood disorders and cycle phases than a prospective diagnosis with a daily symptoms calendar.
Review
Psychiatry
Jingyi Long, Yuejie Wang, Lianzhong Liu, Juan Zhang
Summary: Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are related to the menstrual cycle and can affect patients' psychological, physical, and behavioral well-being. The detailed pathogenesis of these conditions is still unclear, and research on brain structure and function may provide insights into disease development.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Computer Science, Cybernetics
Soyoung Ahn, Yongsoon Choi
Summary: This study developed a smart mirror called Smiley, which can only be seen when users smile, and evaluated its effects on women suffering from PMS. The results showed that smiling can change negative emotions caused by PMS and positively influence users' psychological stability and daily life.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Review
Public, Environmental & Occupational Health
Divya Prasad, Bianca Wollenhaupt-Aguiar, Katrina N. Kidd, Taiane de Azevedo Cardoso, Benicio N. Frey
Summary: This study found that women with PMDD and PMS are more likely to have suicidal ideation and risk of suicide. Routine suicidal risk assessments are recommended for women with moderate-to-severe premenstrual disturbances, and psychosocial treatments for PMS/PMDD should target suicidality to minimize risk and improve well-being.
JOURNAL OF WOMENS HEALTH
(2021)
Review
Obstetrics & Gynecology
Sara Carlini, Teresa Lanza di Scalea, Stephanie Trentacoste McNally, Janice Lester, Kristina M. Deligiannidis
Summary: This article provides a clinically focused review of the last twenty years of research on the treatment of premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS). The review evaluates 194 studies and finds that selective serotonin reuptake inhibitors (SSRIs) and combined oral contraceptives (COCs) have the highest quality evidence, while gonadotropin releasing hormone (GnRH) agonists and surgical interventions show efficacy for refractory cases. Alternative and complementary medicine treatments such as nutraceuticals, acupuncture, and yoga also show some evidence of efficacy, but the variability in study quality and methods must be considered.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Pediatrics
Cynthia R. Rovnaghi, Joseph Rigdon, Jean-Michel Roue, Monica O. Ruiz, Victor G. Carrion, Kanwaljeet J. S. Anand
Summary: This study aimed to identify children at risk for altered HPA-axis function due to early life stress by examining longitudinal trajectories of hair cortisol concentrations. The results revealed different classes of children with distinct HCC profiles, suggesting varying impacts of ELS on HPA-axis function.
FRONTIERS IN PEDIATRICS
(2021)
Article
Psychiatry
Tory Eisenlohr-Moul, Madeline Divine, Katja Schmalenberger, Laura Murphy, Brett Buchert, Melissa Wagner-Schuman, Alyssa Kania, Sabina Raja, Adam Bryant Miller, Jordan Barone, Jaclyn Ross
Summary: This study found high rates of self-injurious thoughts and behaviors in individuals reporting a diagnosis of PMDD, emphasizing the need for further research on understanding and preventing STBs in PMDD. Clinical practice guidelines for PMDD should address comorbidities and include frequent screenings for suicide risk. STBs should be considered for inclusion in future updates of the DSM PMDD diagnostic criteria.
Article
Psychiatry
Xiaolin Liang, Ting Yang, Yingtao Liao, Zhihua Yang, Youzhen Lin, Xiuhua Wu, Jiong Tao, Zhaoyu Gan
Summary: This study aimed to assess the impact of comorbid premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD) on the clinical characteristics of bipolar disorder (BD). The results showed that compared to BD patients without PMS or PMDD, patients with comorbid BD and PMS or PMDD were younger, more educated, had a higher risk of obsessive-compulsive disorder (OCD), had an earlier age of onset, and scored higher on depression scales and its sub-scales. In addition, patients with comorbid BD and PMDD were less likely to experience traumatic life events, more likely to have a family history of mental disorders and have inflammatory or autoimmune disease, and scored higher on the depression scale, particularly in its sub-scales related to anxiety and somatization, cognitive deficit, psychomotor retardation, and sleep disturbance. These findings suggest that BD with PMS or PMDD may be a specific subtype of BD characterized by earlier onset age, heavier genetic load, increased symptom severity, and atypical features.
ARCHIVES OF WOMENS MENTAL HEALTH
(2023)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)