Article
Psychology, Clinical
Wael K. Karameh, Ines Kortebi, Sanjeev Kumar, Damien Gallagher, Angela Golas, Krista L. Lanctot, Meryl A. Butters, Christopher R. Bowie, Alastair Flint, Tarek Rajji, Nathan Herrmann, Bruce G. Pollock, Benoit Mulsant, Linda Mah, David G. Munoz, Tom A. Schweizer, Corinne E. Fischer
Summary: This study compared the prevalence of cardiovascular risk factors in patients with mild cognitive impairment, major depression disorder, and a normal comparison group. The results showed an association between hypertension and cognitive performance in patients with MCI or MDD, highlighting the importance of treating modifiable CVRFs to mitigate cognitive decline.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Geriatrics & Gerontology
Juan Francisco Flores-Vazquez, Gabriel Ramirez-Garcia, Oscar Rene Marrufo-Melendez, Ruth Alcala-Lozano, Morten Peter Lietz, Yaneth Rodriguez-Agudelo, Gilberto Isaac Acosta-Castillo, Remco J. Renken, Andre Aleman, Stefanie Enriquez-Geppert, Ana Luisa Sosa-Ortiz
Summary: Individuals with aMCI and anosognosia showed significantly lower gray matter density in the bilateral hippocampus, with similar hippocampal density to AD patients, suggesting that anosognosia in aMCI could be an important clinical marker for predicting brain changes associated with AD neuropathology.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Alessandro Galgani, Francesco Lombardo, Nicola Martini, Andrea Vergallo, Luca Bastiani, Harald Hampel, Hana Hlavata, Filippo Baldacci, Gloria Tognoni, Daniele De Marchi, Irene Ghicopulos, Sara De Cori, Francesca Biagioni, Carla Letizia Busceti, Roberto Ceravolo, Ubaldo Bonuccelli, Dante Chiappino, Gabriele Siciliano, Francesco Fornai, Nicola Pavese, Filippo Sean Giorgi
Summary: This study used LC-MRI to investigate the involvement of the pontine nucleus Locus Coeruleus (LC) in Alzheimer's disease progression and its association with prognosis and cognitive performance in amnestic Mild Cognitive Impairment. The findings suggest that reductions in LC-MRI parameters may be predictive of clinical progression in Mild Cognitive Impairment and support the role of LC degeneration in the continuum of Alzheimer's disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Neuroimaging
Jinhuan Zhang, Linlin Xie, Changjiang Cheng, Yongfeng Liu, Xiaodong Zhang, Haoyu Wang, Jingting Hu, Haibo Yu, Jinping Xu
Summary: The hippocampus is a complex structure consisting of several subfields with different functions. Studies on hippocampal subfield atrophy in MCI and AD have yielded inconsistent results regarding potential biomarkers. This meta-analysis synthesized existing literature and found that hippocampal subfield volume reductions were not limited to specific subfields in MCI and AD. The subiculum and presubiculum showed the largest z-scores across comparisons. However, none of the subfields performed significantly better than whole hippocampus volume in distinguishing between MCI and HC, AD and MCI, and AD and HC.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Geriatrics & Gerontology
Jordan Williamson, Andriy Yabluchanskiy, Peter Mukli, Dee H. Wu, William Sonntag, Carrie Ciro, Yuan Yang
Summary: Research shows that females are more impacted by mild cognitive impairment (MCI) and experience greater cognitive deterioration than males in the same disease stage. These sex differences are linked to neuroimaging markers of brain pathology, such as hippocampal volumes. This study found that males have stronger connectivity between the hippocampus and the precuneus cortex and brain stem compared to females.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Sneha Chenji, Emily Cox, Natalia Jaworska, Rose M. Swansburg, Frank P. MacMaster
Summary: The study explored the relationship between body mass index (BMI) and hippocampal volume in youth with major depressive disorder (MDD). Results showed a reduction in right hippocampal volume in MDD youth with normal BMI, and a negative association between left hippocampal volume and BMI in MDD youth with high BMI. The findings suggest that BMI may play a role in the variability of hippocampal volume in MDD, highlighting the importance of considering BMI effects in future analyses.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Shunkai Lai, Shuming Zhong, Ying Wang, Yiliang Zhang, Ying Xue, Hui Zhao, Hanglin Ran, Shuya Yan, Yange Luo, Jiali He, Yunxia Zhu, Sihui Lv, Zijing Song, Haofei Miao, Yilei Hu, Xiaosi Huang, Xiaodan Lu, Jiansong Zhou, Yanbin Jia
Summary: This study investigated the prevalence and characteristics of cognitive impairment in patients with bipolar disorder and major depressive disorder. The results showed that both groups had significantly reduced cognitive performance compared to the healthy control group. The cognitive impairments in both groups were clinically significant, but more common in patients with bipolar disorder. These findings suggest the importance of cognitive screening and intervention strategies for patients with mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Meisheng Wang, Deju Yin, Lijun Liu, Shuzhe Zhou, Qi Liu, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Tianmei Si, Xin Yu, Xiaozhen Lv, Nan Zhang
Summary: This study found that cognitive impairment is common in patients with major depressive disorder, and it is associated with male sex and younger age of first onset, while comorbid anxiety disorders are protective against cognitive impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Anatomy & Morphology
Yuan Jiang, Pan Wang, Jiaping Wen, Jianlin Wang, Hongyi Li, Bharat B. Biswal
Summary: This study utilized functional connectivity analysis to investigate abnormal brain connections between white matter and gray matter in patients with MCI. The results showed that compared to healthy controls, MCI patients exhibited specific dysconnectivity in certain brain regions, particularly in the connections between the hippocampus and the temporal pole. These findings are important for understanding the mechanisms of memory decline in MCI and the progression of Alzheimer's disease.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Sydney Y. Schaefer, Michael Malek-Ahmadi, Andrew Hooyman, Jace B. King, Kevin Duff
Summary: Hippocampal atrophy is a common biomarker for Alzheimer's disease, but its use is limited by the cost and contraindications of magnetic resonance imaging (MRI). Recent research has found that a low-cost upper extremity motor task has the potential to identify Alzheimer's disease risk. The study shows that measures of motor task performance can predict hippocampal volume, offering a cost-effective and non-invasive screening method for Alzheimer's disease risk and progression.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Beatriz Pozuelo Moyano, Marie-Pierre F. Strippoli, Setareh Ranjbar, Caroline L. Vandeleur, Julien Vaucher, Martin Preisig, Armin von Gunten
Summary: The stability of different subtypes of MDD in older adults was assessed, with a specific focus on the atypical subtype. It was found that the atypical subtype showed strong stability, while there was overlap between the subtypes. Mild cognitive impairment did not impact the stability of the subtypes.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Neurosciences
Lingyu Zhang, Yu Fu, Ziyang Zhao, Zhaoyang Cong, Weihao Zheng, Qin Zhang, Zhijun Yao, Bin Hu
Summary: This study investigated the temporal evolution pattern of MCI and the conversion to AD using multivariate morphometry statistics as features. The atrophy of hippocampus in MCI patients showed a specific distribution pattern, with the introduction of longitudinal information significantly improving the accuracy of conversion prediction.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Feng Feng, Weijie Huang, Qingqing Meng, Weijun Hao, Hongxiang Yao, Bo Zhou, Yan'e Guo, Cui Zhao, Ningyu An, Luning Wang, Xusheng Huang, Xi Zhang, Ni Shu
Summary: The combination of hippocampal volume and structural connectivity (number of connecting fibers) is a new perspective for the discrimination of Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). Despite decreases in volume and structural connectivity of the bilateral hippocampi in patients with AD and aMCI, only hippocampal volume correlated with neuropsychological test scores.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Eun Jin Yoon, Jun-Young Lee, Seyul Kwak, Yu Kyeong Kim
Summary: Mild behavioral impairment (MBI) is a neurobehavioral syndrome associated with a higher risk of progression to Alzheimer's disease (AD) in individuals with amnestic mild cognitive impairment (MCI). The presence of multiple MBI domains is also associated with cortical thinning in specific brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Toshinori Nakamura, Daimei Sasayama, Tetsuya Hagiwara, Hisashi Kito, Shinsuke Washizuka
Summary: Using functional near-infrared spectroscopy (fNIRS) to evaluate the hemodynamic activities in the brain of catatonic patients, it was found that the resting state functional connectivity (RSFC) in the prefrontal cortex was significantly lower in the catatonic state compared to the non-catatonic state.
NEUROSCIENCE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Shinsuke Hidese, Kotaro Hattori, Daimei Sasayama, Takuya Tsumagari, Tomoko Miyakawa, Ryo Matsumura, Yuuki Yokota, Ikki Ishida, Junko Matsuo, Sumiko Yoshida, Miho Ota, Hiroshi Kunugi
Summary: Neural inflammation is believed to play a crucial role in psychiatric disorders. Through quantifying inflammatory cytokine levels in cerebrospinal fluid samples, this study aimed to identify the involvement of these cytokines in the pathophysiology of major psychiatric disorders. The findings suggest that interferon-beta may be a key player in the inflammation-related pathophysiology of these disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Psychiatry
Kazuhito Takahashi, Toshinori Nakamura, Daimei Sasayama, Shinsuke Washizukac
PSYCHIATRIA DANUBINA
(2021)
Article
Biochemistry & Molecular Biology
Kosuke Saito, Kotaro Hattori, Shinsuke Hidese, Daimei Sasayama, Tomoko Miyakawa, Ryo Matsumura, Megumi Tatsumi, Yuuki Yokota, Miho Ota, Hiroaki Hori, Hiroshi Kunugi
Summary: Lipidomics study on CSF and plasma samples from healthy Japanese individuals revealed significant differences in global lipid profiles between CSF and plasma, with only a small number of lipids showing correlation between the two matrices. CSF total protein content was identified as the primary factor associated with CSF lipids.
Letter
Medicine, General & Internal
Daimei Sasayama, Rie Kuge, Yuki Toibana, Hideo Honda
Letter
Clinical Neurology
Kazuhito Takahashi, Saeko Yokotsuka-Ishida, Toshinori Nakamura, Daimei Sasayama, Shinsuke Washizuka
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Daimei Sasayama, Miyuki Chijiiwa, Shun Nogawa, Kenji Saito, Hiroshi Kunugi
Summary: This study found that adults with biromantic and homoromantic orientations in Japan are more likely to experience psychological distress compared to heterosexual individuals, and these mental health disparities are unrelated to personality profiles.
Article
Psychology, Developmental
Mitsuaki Iwasa, Yasuo Shimizu, Daimei Sasayama, Miho Imai, Hiroko Ohzono, Miori Ueda, Ikuko Hara, Hideo Honda
Summary: This long-term follow-up study found that psychosocial outcomes for autistic adults are generally limited, but many individuals still engage in important areas of life such as work, education, and sports. The study also revealed that individuals with lower IQ at age five had worse outcomes, while outcomes were not significantly associated with IQ for those with IQ above 50.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Sumie Yui, Daimei Sasayama, Masaki Yamaguchi, Shinsuke Washizuka
Summary: This study found that patients with major depressive disorder had significantly higher levels of several cytokines in their saliva, which is consistent with previous studies showing elevated levels of cytokines in peripheral blood. These findings provide preliminary support for elucidating the pathophysiology underlying major depressive disorder by examining salivary cytokine levels.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Letter
Medicine, General & Internal
Daimei Sasayama, Rie Kuge, Yuki Toibana, Hideo Honda
Article
Psychiatry
Toshinori Nakamura, Misaki Shimizu-Ichikawa, Kazuhito Takahashi, Sari Shimizu, Takashi Ichiyama, Keisuke Todoroki, Masataka Konno, Daisuke Amada, Daimei Sasayama, Shinsuke Washizuka
Summary: This article describes a case of sudden respiratory failure during the treatment of catatonia, which required intensive care. Electroconvulsive therapy (ECT) was successfully administered in the intensive care unit, relieving the catatonia symptoms and improving the respiratory failure. It highlights the importance of monitoring the patient's physical and psychological symptoms, as respiratory status may deteriorate rapidly in a catatonic state.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Yusuke Arai, Daimei Sasayama, Kazuaki Kuraishi, Shiho Murata, Nobuteru Usuda, Mika Tsuchida, Yuka Nakajima, Shinsuke Washizuka
Summary: This study aimed to investigate the effects of brexpiprazole on sleep architecture in patients with schizophrenia. The results showed that add-on brexpiprazole could alter the sleep architecture of patients with schizophrenia. Future studies are needed to replicate these findings and further explore the beneficial influence of brexpiprazole on sleep.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Psychology, Developmental
Hideo Honda, Daimei Sasayama, Taemi Niimi, Ayako Shimizu, Yuki Toibana, Rie Kuge, Hidetoshi Takagi, Aya Nakajima, Reiko Sakatsume, Michiko Takahashi, Takuma Heda, Yukari Nitto, Shota Tsukada, Akiko Nishigaki
Summary: This study investigates the awareness of developmental problems among preschool teachers and childcare workers, as well as their communication with parents regarding concerns about a child's development or diagnosis of NDDs. Data from 10,354 children in 206 preschools and childcare centers were collected, showing that a considerable number of children had concerns about their development but the teachers did not share this information with their parents. The findings highlight challenges in information-sharing between teachers/childcare workers and parents.
CHILD CARE HEALTH AND DEVELOPMENT
(2023)
Article
Medicine, General & Internal
Yusuke Arai, Daimei Sasayama, Akira Kuraishi, Reiko Sahara, Shiho Murata, Akira Tanaka, Kotaro Amemiya, Nobuteru Usuda, Kazuaki Kuraishi, Shinsuke Washizuka
Summary: This study retrospectively examined the association between mood stabilizers, specifically sodium valproate, and the risk of pneumonia development in COVID-19 infected patients with schizophrenia. The study found that patients using sodium valproate were more likely to develop pneumonia, suggesting it as a risk factor for pneumonia in COVID-19 infected patients with chronic schizophrenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Correction
Medicine, General & Internal
Daimei Sasayama, Rie Kuge, Yuki Toibana, Hideo Honda
