Article
Multidisciplinary Sciences
Tomasz Nowikiewicz, Andrzej Kurylcio, Iwona Glowacka-Mrotek, Maria Szymankiewicz, Magdalena Nowikiewicz, Wojciech Zegarski
Summary: The study evaluated the clinical relevance of ECE in BC patients, finding that its presence is associated with a higher stage of metastatic lesions in the lymphatic system. However, ECE does not impact treatment outcomes, and supplementary ALND and equivalent cancer treatment procedures are still indicated regardless of ECE size.
SCIENTIFIC REPORTS
(2021)
Review
Psychology, Multidisciplinary
Louise O'Rourke, Peter L. L. Fisher, Sophie Campbell, Amelia Wright, Mary Gemma Cherry
Summary: Research on factors associated with fear of cancer recurrence (FCR) in family caregivers of cancer survivors identified age, treatment modality, and illness perceptions as influencing FCR. However, studies primarily focused on clinical and demographic factors, with limited exploration of psychological mechanisms. Future research should investigate theoretical underpinnings of FCR in caregivers to support the development of psychological interventions for this population.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Surgery
Nicholas D. A. Blefari, Christopher W. Rowe, Elvina Wiadji, David Lambkin, Rosemary Carroll, Elizabeth A. Fradgley, Christine J. O'Neill
Summary: This study compares long-term health-related quality of life (HRQoL) between patients with thyroid cancer or benign disease, following thyroid surgery. The results show no significant differences in overall HRQoL scores between groups, but cancer patients experience a significant detriment in the social subdomain score. Female gender, increasing BMI, and cancer recurrence are associated with decreased overall HRQoL.
WORLD JOURNAL OF SURGERY
(2022)
Review
Behavioral Sciences
Kenji J. Nishimura, Andrew M. Poulos, Michael R. Drew, Abha K. Rajbhandari
Summary: Extreme stress can lead to long-lasting changes in affective behavior, which can be seen in conditions like post-traumatic stress disorder (PTSD). To understand the biological mechanisms behind trauma-induced behavioral dysregulation, reliable and rigorous pre-clinical models are needed. Pavlovian fear conditioning has been widely used to study the effects of trauma, but often overlooks the long-lasting nonassociative fear sensitization caused by severe stress. This paper reviews recent research on stress-enhanced fear learning (SEFL), a valuable rodent model that can distinguish between associative and nonassociative effects of stress.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Cell Biology
Alicja Rajtak, Arkadiusz Czerwonka, Michael Pitter, Jan Kotarski, Karolina Okla
Summary: This study found that local levels of mortalin protein were upregulated in ovarian cancer patients and were associated with cancer-related signaling pathways and worse clinical outcomes. High levels of local mortalin predicted worse patient prognosis. These findings could be useful in the development of biomarker-based targeted therapies and immunotherapies.
Review
Psychology, Multidisciplinary
Chuan Pang, Gerry Humphris
Summary: This systematic review clarified that women report higher levels of FCR than men. However, there is moderate variation in effect sizes, indicating that there may be factors beyond gender influencing FCR levels that warrant further investigation.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Oncology
Yvonne L. Luigjes-Huizer, Nina M. Tauber, Gerry Humphris, Nadine A. Kasparian, Wendy W. T. Lam, Sophie Lebel, Sebastien Simard, Allan Ben Smith, Robert Zachariae, Yati Afiyanti, Katy J. L. Bell, Jose A. E. Custers, Niek J. de Wit, Peter L. Fisher, Jacqueline Galica, Sheila N. Garland, Charles W. Helsper, Mette M. Jeppesen, Jianlin Liu, Roxana Mititelu, Evelyn M. Monninkhof, Lahiru Russell, Josee Savard, Anne E. M. Speckens, Sanne J. van Helmondt, Sina Vatandoust, Nicholas Zdenkowski, Marije L. van der Lee
Summary: Objective Care for fear of cancer recurrence (FCR) is the most common unmet need among cancer survivors. This study provides a comprehensive overview of the prevalence and severity of FCR among cancer survivors and patients, and reveals the associations between FCR and clinical and demographic characteristics. The findings emphasize the importance of addressing FCR and providing treatment to those in need.
Review
Psychology, Multidisciplinary
Kate Anderson, Allan 'Ben' Smith, Abbey Diaz, Joanne Shaw, Phyllis Butow, Louise Sharpe, Afaf Girgis, Sophie Lebel, Haryana Dhillon, Linda Burhansstipanov, Boden Tighe, Gail Garvey
Summary: While cancer survivors commonly experience fear and anxiety, there is limited understanding of fear of cancer recurrence (FCR) among people from Indigenous or other ethnic and racial minority populations; the review found differences in FCR across cultures and contexts, highlighting the necessity of culturally-specific approaches; the lack of research on FCR among Indigenous and minority populations is concerning given the significant burden of cancer in these groups.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Oncology
J. J. Adashek, A. Jordan, L. S. Redwine, D. Martinez Tyson, Z. Thompson, S. Pabbathi
Summary: The study indicates that most cancer survivors had clinical needs relating to Fear of Cancer Recurrence (FCR) at the time of survey, but these needs were met. Patients with higher distress scores were more likely to report FCR as an unmet need.
Article
Pharmacology & Pharmacy
Sanjay Kumar, Manita Raina, Kalpana Tankay, Gaurav Milind Ingle
Summary: Despite recent advances in cancer treatment, ovarian cancer patients continue to face challenges such as late-stage diagnosis, disease recurrence, and the lack of early biomarkers, resulting in a relatively low survival rate. The development of the patient-derived organoid model provides a unique platform for identifying tumor origin, drug screening, and precision medicine development, offering a promising approach in advancing ovarian cancer research. This review summarizes the progress in patient-derived organoids and their clinical relevance, highlighting their uses in transcriptomics, genomics profiling, drug screening, translational study, and their potential impact on precision medicine development in ovarian cancer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Jinyoung Shin, Dong Wook Shin, Jungkwon Lee, Jihye Hwang, Ji Eun Lee, Belong Cho, Yun-Mi Song
Summary: This study evaluated fear of cancer recurrence (FCR) and factors related to FCR in Korean stomach cancer survivors. The results showed that FCR was associated with social, psychological, and health-related quality of life factors, rather than demographic, socioeconomic, or cancer-related factors. This suggests the importance of addressing FCR and providing comprehensive survivorship care for stomach cancer survivors.
Article
Biochemistry & Molecular Biology
Sisi Chen, Michael J. Seckl, Marc P. G. Lorentzen, Olivier E. Pardo
Summary: The role of RSK4 in different types of cancers remains controversial, possibly due to differential expression of its isoforms. Our study found that expression of RSK4 isoforms 1 and 2 is associated with patient survival, pathological stage, cancer metastasis, recurrence, and immune infiltration in brain, stomach, cervical, and kidney cancers. However, upregulation of either isoform can be associated with both good and bad prognosis depending on the cancer type, and changes in isoform expression ratio do not predict clinical outcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Maurade Gormley, Lauren Ghazal, Mei R. Fu, Janet H. Van Cleave, Tish Knobf, Marilyn Hammer
Summary: Fear of cancer recurrence is a prevalent concern among young adult breast cancer survivors, with age being a consistent predictor of higher levels of fear. Factors such as motherhood status, health behaviors, psychological morbidity, and social support contribute to higher levels of fear in this population. More research and tailored interventions are needed to address the unique construct of fear of cancer recurrence among young adult breast cancer survivors.
Review
Oncology
So-Young Park, Jung-Won Lim
Summary: This study systematically reviewed the evidence from randomized controlled trials (RCTs) of cognitive behavioral therapy (CBT) designed to reduce fear of cancer recurrence (FCR) among breast cancer survivors (BCSs). The findings suggest that face-to-face interventions lasting at least 1 month were more effective and better complied with the CONSORT 2010 criteria than brief online or telephone interventions. Overall, most interventions appeared to be effective.
Review
Oncology
Callum James, Oliver Brunckhorst, Omar Eymech, Robert Stewart, Prokar Dasgupta, Kamran Ahmed
Summary: The impact of prostate cancer on the mental wellbeing of patients is increasingly being appreciated. Fear of cancer recurrence (FCR) and prostate-specific antigen (PSA) anxiety are common in prostate cancer patients and are associated with poorer quality of life and mental health symptoms.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Psychology, Clinical
Emily C. Soriano, Elizabeth C. Pasipanodya, Stefanie T. LoSavio, Amy K. Otto, Christine Perndorfer, Scott D. Siegel, Jean-Philippe Laurenceau
Article
Oncology
Christine Perndorfer, Emily C. Soriano, Scott D. Siegel, Jean-Philippe Laurenceau
Article
Public, Environmental & Occupational Health
Scott D. Siegel, Madeline M. Brooks, Bayo M. Gbadebo, James T. Laughery
PREVENTING CHRONIC DISEASE
(2019)
Review
Oncology
Scott D. Siegel, Caryn Lerman, Alex Flitter, Robert A. Schnoll
CANCER PREVENTION RESEARCH
(2020)
Article
Health Care Sciences & Services
Scott D. Siegel, Madeline Brooks, Frank C. Curriero
Summary: This study proposed a new approach to operationalize population health in clinical settings using the example of tobacco use, analyzing the characteristics of a hospital-based population of current smokers and assessing the impact of social factors and the built environment. By defining populations around modifiable medical determinants of health and considering sociodemographic factors, health systems can invest in comprehensive programs to generate the greatest population health returns.
POPULATION HEALTH MANAGEMENT
(2021)
Article
Psychology, Clinical
Scott D. Siegel, J. P. Laurenceau, Naja Hill, Anna-Marika Bauer, Alex Flitter, Douglas Ziedonis, Nathaniel Stevens, Mackenzie Hosie Quinn, Frank Leone, Rinad Beidas, John Kimberly, Robert A. Schnoll
Summary: The study found that clinicians' general ethical commitment to providing TUD services and perceptions of their skills were significantly associated with providing TUD treatment, while patient motivation, anticipated quit rates, or available resources were not significant factors. Enhancing community mental health clinician TUD treatment skills and commitment to providing such services may reduce TUD rates among people with SMI.
ADDICTIVE BEHAVIORS
(2021)
Article
Public, Environmental & Occupational Health
Madeline M. Brooks, Scott D. Siegel, Frank C. Curriero
Summary: The study found that in New Castle County, current smokers are more likely to be exposed to tobacco retail and cluster together compared to former smokers. Analysis at different geographic scales can provide complementary insights for tobacco control policy.
Article
Psychology, Clinical
Scott D. Siegel, Madeline Brooks, Heather E. Ragozine-Bush, Robert A. Schnoll, Frank C. Curriero
Summary: A study on patients who concurrently smoke and have an Alcohol Use Disorder (AUD) found that they are typically younger, more likely to be male, and have higher rates of other substance use disorders, depression, HIV/AIDS, and liver disease compared to non-smokers without an AUD. These patients also tend to reside in areas with higher counts of tobacco and alcohol retailers.
ADDICTIVE BEHAVIORS
(2021)
Article
Oncology
Scott D. Siegel, Madeline M. Brooks, Jennifer Sims-Mourtada, Zachary T. Schug, Dawn J. Leonard, Nicholas Petrelli, Frank C. Curriero
Summary: This study used geocoding and electronic health records to identify hot spots of triple-negative breast cancer (TNBC) and found a correlation between these hot spots and higher rates of unhealthy alcohol use and obesity. This provides guidance for cancer control and prevention efforts in community cancer centers.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Scott D. Siegel, Madeline M. Brooks, Jesse D. Berman, Shannon M. Lynch, Jennifer Sims-Mourtada, Zachary T. Schug, Frank C. Curriero
Summary: This study investigated the relationship between neighborhood-level exposures and the risk of triple negative breast cancer (TNBC). The results showed that cumulative exposure to neighborhood-level risk factors was associated with a higher risk of TNBC. Census tracts with a higher proportion of Black residents had higher cumulative exposure risk scores, suggesting that neighborhood conditions may contribute to the risk of TNBC in Black communities.
Article
Health Care Sciences & Services
Scott D. Siegel, Jennifer P. Rowland, Dawn J. Leonard, Nora Katurakes, Heather Bittner-Fagan, Matthew Hoffman, Robert Hall-McBride, LeRoi S. Hicks, Nicholas J. Petrelli
POPULATION HEALTH MANAGEMENT
(2023)
Article
Psychology, Multidisciplinary
Emily C. Soriano, James M. Lenhard, Jeffrey S. Gonzalez, Howard Tennen, Sy-Miin Chow, Amy K. Otto, Christine Perndorfer, Biing-Jiun Shen, Scott D. Siegel, Jean-Philippe Laurenceau
Summary: This study aimed to clarify the conditions under which spousal influence impedes glycemic control in patients with type 2 diabetes. Results indicated that in patients with high diabetes distress and low relationship quality, spousal influence may lead to increased glucose variability.
ANNALS OF BEHAVIORAL MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Emily C. Soriano, Amy K. Otto, Stefanie T. LoSavio, Christine Perndorfer, Scott D. Siegel, Jean-Philippe Laurenceau
Summary: The study shows that both social constraints and protective buffering are independently associated with higher fear of cancer recurrence in both survivors and spouses, highlighting the importance of social interactions in cancer survivors' adjustment.
ANNALS OF BEHAVIORAL MEDICINE
(2021)
Article
Psychology, Social
Emily C. Soriano, Christine Perndorfer, Scott D. Siegel, Jean-Philippe Laurenceau
JOURNAL OF PSYCHOSOCIAL ONCOLOGY
(2019)
Article
Psychology, Multidisciplinary
Emily C. Soriano, Rosmeiry Valera, Elizabeth C. Pasipanodya, Amy K. Otto, Scott D. Siegel, Jean-Philippe Laurenceau
ANNALS OF BEHAVIORAL MEDICINE
(2019)
Article
Oncology
Christine J. McPherson, Alanna Devereaux
Summary: This study examines the dyadic effects of patient and caregiver attachment orientations on mutually supportive care in cancer treatment. It highlights the interdependence within the cancer caregiving relationship and emphasizes the importance of considering individual and relational ways of responding in providing support. Attachment theory provides a framework for understanding and therapeutic intervention.