Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 255, Issue -, Pages 50-59Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2016.07.007
Keywords
Neuroimaging; fMRI; Stroop; Go/No-go; Conflict monitoring; Response inhibition; Hoarding disorder
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Funding
- NIMH [R21 MH087748, K08 MH081065, R01 0977669]
- Fogarty International Training Program in Chronic Non-Communicable Diseases and Disorders at the University of Florida [1D43TW009120]
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We examined differences in regional brain activation during tests of executive function in individuals with Hoarding Disorder (HD), Obsessive Compulsive Disorder (OCD), and healthy controls (HC) using functional magnetic resonance imaging (fMRI). Participants completed computerized versions of the Stroop and Go/No-Go task. We found that during the conflict monitoring and response inhibition condition in the Go/No-Go task, individuals with HD had significantly greater activity than controls in the anterior cingulate cortex (ACC) and right dorsolateral prefrontal cortex (DLPFC). HD also exhibited significantly greater right DLPFC activity than OCD. We also observed significant differences in activity between HD and HC and between HD and OCD in regions (ACC, anterior insula, orbitofrontal cortex, and striatum) involved in evaluating stimulus-response-reward associations, or the personal and task-relevant value of stimuli and behavioral responses to stimuli. These results support the hypothesis that individuals with HD have difficulty deciding on the value or task relevance of stimuli, and may perceive an abnormally high risk of negative feedback for difficult or erroneous cognitive behavior. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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