Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 255, Issue -, Pages 81-86Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2016.08.002
Keywords
Serotonin; Serotonin transporter; Serotonin 1A receptor; PET
Categories
Funding
- National Institutes of Mental Health [MH040695, MH062185]
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The serotonin neurotransmitter system is modulated in part by the uptake of synaptically released serotonin (5-HT) by the serotonin transporter (5-HTT), and by specific serotonin autoreceptors such as the somatodendritic 5-HT1A receptor, which can limit serotonin neuron depolarization. However, little is known about how 5-HTT and 5-HT1A are related in vivo. To study this question, we reanalyzed positron emission tomography (PET) data obtained earlier in 40 healthy participants (21 females) using [C-11]WAY-100635 for quantification of 5-HT1A binding and [C-11](+)-McN-5652 for quantification of 5-HTT binding. We hypothesized negative correlations between 5-HT1A binding in the raphe nuclei (RN) and 5-HTT binding in RN terminal field regions. Controlling for sex, no significant correlations were found (all p > 0.05). Similarly, an exploratory analysis correlating whole-brain voxel-wise 5-HTT binding with 5-HT1A binding in RN identified no significant clusters meeting our a priori statistical threshold. The lack of correlation between 5-HT1A and 5-HTT binding observed in the current study may be due to the different temporal responsiveness of regulatory processes controlling the somatodendritic 5-HT1A receptor and 5-HTT in response to changing availability of intrasynaptic serotonin. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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