Article
Clinical Neurology
Victor M. Tang, Dengdeng Yu, Cory R. Weissman, Brett D. M. Jones, Guan Wang, Matthew E. Sloan, Daniel M. Blumberger, Zafiris J. Daskalakis, Bernard Le Foll, Daphne Voineskos
Summary: This study examined the treatment outcomes of patients with major depressive disorder (MDD) and comorbid alcohol use disorder (AUD). The results showed that patients with comorbid AUD had poorer response to antidepressant treatment. Addressing this comorbidity requires unique assessment and treatment approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Marsal Sanches, Joao Quevedo, Jair C. Soares
Summary: Despite significant advances in understanding the pathophysiology of MDD, many depressed patients do not respond well to traditional pharmacological agents. Researchers are exploring new targets and directions in pharmacological treatment for MDD. In addition to traditional antidepressants, many novel compounds are currently under investigation, with promising preliminary results.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Microbiology
Yaping Wang, Jingjing Zhou, Junbin Ye, Zuoli Sun, Yi He, Yingxin Zhao, Siyu Ren, Guofu Zhang, Min Liu, Peng Zheng, Gang Wang, Jian Yang
Summary: This study reveals that antidepressants can improve abnormal blood metabolism and have a weak inhibitory effect on the gut microbiota. The gut microbiota is associated with changes in plasma metabolites and clinical remission in patients with major depressive disorder (MDD). Furthermore, the presence of sporulation genes can predict the efficacy of antidepressant treatment.
Article
Clinical Neurology
Frederikke Hordam Gronemann, Janne Petersen, Sarah Alulis, Kristoffer Jarlov Jensen, Jesper Riise, Mikkel Zollner Ankarfeldt, Espen Jimenez Solem, Nikolaj Bodker, Merete Osler
Summary: This study found that the majority of MDD patients in Denmark initially received treatment with antidepressants or ECT, and often changed medications during the course of treatment. TRD patients were more likely to use SNRIs, and a significant proportion initiated new treatments in the following year.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Joana Gomes, Miguel Farinha-Ferreira, Nadia Rei, Joana Goncalves-Ribeiro, Joaquim A. Ribeiro, Ana M. Sebastiao, Sandra H. Vaz
Summary: The review highlights the potential role of the adenosinergic system in the pathophysiology and treatment of MDD, with evidence suggesting alterations in this system in both MDD patients and animal models. Further research is needed to fully understand the impact of adenosine signaling in antidepressant treatments.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Clinical Neurology
Yuncheng Zhu, Zhiguo Wu, Dongmei Zhao, Xiaohui Wu, Ruoqiao He, Zuowei Wang, Daihui Peng, Yiru Fang
Summary: This study investigated the medical treatment of major depressive disorder (MDD) in China and compared it with the Canadian Network for Mood and Anxiety Treatments (CANMAT). A total of 3275 patients from 16 mental health centers and 16 general hospitals in China were surveyed. The results showed that selective serotonin reuptake inhibitors (SSRIs) were the most commonly used drugs in the initial therapy, but their proportion decreased in the follow-up therapy and were replaced by serotonin-noradrenaline reuptake inhibitors (SNRIs). Many patients directly opted for combined pharmacotherapies as the first treatment, which deviated from guideline recommendations.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Biochemistry & Molecular Biology
Gregory C. Wilson, Simone Keitsch, Matthias Soddemann, Barbara Wilker, Michael J. Edwards, Erich Gulbins
Summary: This study investigates the role of tyrosine nitrosylation in the pathogenesis of Major Depressive Disorder (MDD). The results show that tyrosine nitrosylation is induced by stress and can be prevented by antidepressant treatment. Inhibition of tyrosine nitrosylation can partly restore normal behavior in stressed mice. These findings suggest that targeting tyrosine nitrosylation may contribute to the treatment of MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Tianyu Wang, Lei Li, Yingying Yue, Xiaoyun Liu, Suzhen Chen, Tian Shen, Zhi Xu, Yonggui Yuan
Summary: This study investigates the influence of P11 gene DNA methylation and life stress on the response to antidepressants in patients with major depressive disorder. The results show that the methylation of the P11 gene is significantly higher in patients with major depressive disorder, and the interaction between P11 DNA methylation and early-life stress may affect the response to short-term antidepressant treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Le Li, Yun-Ai Su, Yan-Kun Wu, Francisco Xavier Castellanos, Ke Li, Ji-Tao Li, Tian-Mei Si, Chao-Gan Yan
Summary: This study found significant intrinsic functional connectivity decreases in extensive brain networks after antidepressant treatment, indicating considerable antidepressant effects. There were no significant differences in resting-state functional connectivity between treatment-naive MDD patients and healthy controls.
HUMAN BRAIN MAPPING
(2021)
Article
Psychiatry
Marie Moulard, Eve Cosker, Karine Angioi-Duprez, Vincent Laprevote, Raymund Schwan, Thomas Schwitzer
Summary: This study revealed specific effects of various antidepressants on retinal function in MDD patients, as evaluated by electroretinogram, highlighting the importance of further research to isolate reliable markers for predicting and monitoring response to antidepressants.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Tariku Sisay, Roza Wami
Summary: This study aimed to estimate the prevalence rate of adverse drug reactions (ADRs) among major depressive disorder (MDD) patients by age and gender at the outpatient department of Amanuel Mental Specialized Hospital (AMSH) in Addis Ababa, Ethiopia. The overall prevalence of antidepressant-related adverse reactions was 69%, with females showing a higher prevalence rate. Young study subjects had significantly higher ADR rates compared to the elderly, and ADRs were more common in patients taking polypharmacy than monopharmacy.
Article
Clinical Neurology
Gernot Fugger, Lucie Bartova, Markus Dold, Chiara Fabbri, Giuseppe Fanelli, Raffaella Zanardi, Alexander Kautzky, Joseph Zohar, Daniel Souery, Julien Mendlewicz, Stuart Montgomery, Dan Rujescu, Alessandro Serretti, Siegfried Kasper
Summary: The study found an association between SGA augmentation and the presence of psychotic symptoms, longer lifetime psychiatric hospitalizations, employment of further augmentation strategies with mood-stabilizers and benzodiazepines, and a trend towards higher current suicidal risk in patients with major depressive disorder. However, there was no significant difference in treatment outcome between patients receiving SGA augmentation or AD combination.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Psychiatry
Hongzhe Ma, Min Cai, Huaning Wang
Summary: Emotional blunting is commonly reported by patients with major depressive disorder as a side effect of antidepressants, but there is still a lack of clinical definition and consensus on its etiology. Research suggests that higher antidepressant doses may be associated with a higher likelihood of inducing emotional blunting, leading clinicians to adjust dosage or try different medications. There is a need for more comprehensive clinical assessments to understand the neuropsychological mechanisms behind this symptom.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Clinical Neurology
Giampaolo Perna, Silvia Dacco, Alessandra Alciati, Francesco Cuniberti, Domenico De Berardis, Daniela Caldirola
Summary: This systematic review examined pharmacological studies comparing antidepressant treatments among MDD patients with or without a history of childhood maltreatment. Preliminary findings suggest that childhood maltreatment history may influence the choice of antidepressants for successful outcomes, but further large-sample studies are needed to confirm these results.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
V. Vadim Tarasov, N. Nikolay Ivanets, A. Andrey Svistunov, N. Vladimir Chubarev, A. Marina Kinkulkina, G. Yuliya Tikhonova, S. Nikita Syzrantsev, V. Ivan Chubarev, Cristian Muresanu, G. Siva Somasundaram, E. Cecil Kirkland, Gjumrakch Aliev
Summary: This review summarizes recent findings in molecular biology and neuroimaging for the classification and identification of depression. While there are currently no reliable biomarkers for the diagnosis of depression types, further research into the molecular mechanisms of different types of depression is promising.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Claudia Koch, Diana-Maria Dreava, Anamaria Todea, Francisc Peter, Mihai Medeleanu, Iulia Pausescu, Corina Samoila, Ioan Ovidiu Sirbu
Summary: Xanthylium derivatives with photochromic properties were synthesized and their biological properties were investigated. The halochromic properties and different molecular species were confirmed using UV-Vis spectroscopy and pH-jumps studies. Both compounds showed significant antiproliferative effects on P19 cells by modifying the cell cycle progression.
Article
Medicine, General & Internal
Tamara Mirela Porosnicu, Dorel Sandesc, Daniel Jipa, Ciprian Gindac, Cristian Oancea, Felix Bratosin, Roxana Manuela Fericean, Shiva Charana Kodimala, Ciprian Nicolae Pilut, Laura Alexandra Nussbaum, Ioan Ovidiu Sirbu
Summary: The high mortality risk in severe SARS-CoV-2 infections is closely related to the extreme elevation of inflammatory markers. This study examined the efficacy and outcomes of plasma exchange (TPE) based on different treatment methods in COVID-19 patients. It was found that TPE significantly reduced IL-6, CRP, and ESR levels, but had no significant impact on survival rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Alexandra Ioana Moatar, Aimee Rodica Chis, Mirabela Romanescu, Paula-Diana Ciordas, Diana Nitusca, Catalin Marian, Cristian Oancea, Ioan-Ovidiu Sirbu
Summary: This study evaluated the early level of circulating miR-195 in Covid-19 patients and found it to be a potential biomarker of disease severity. miR-195 is associated with several clinical and paraclinical parameters and can effectively discriminate between severe and mild forms of the disease. The study also suggests a possible role of miR-195 in long Covid and chronic fatigue syndrome.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Ana-Maria Marin, Dan-Cornel Popovici, Gheorghe Darabus, Catalin Marian, Diana Nitusca, Narcisa Mederle
Summary: This study confirms the presence of Trichinella britovi in raccoon dogs for the first time by detecting the parasite larvae in muscle samples from Romania.
Article
Biochemistry & Molecular Biology
Liana Maries, Alexandra Ioana Moatar, Maria Sala-Cirtog, Laurentiu Sima, Andrei Anghel, Catalin Marian, Aimee Rodica Chis, Ioan-Ovidiu Sirbu
Summary: Left ventricle remodeling after acute myocardial infarction is a significant contributor to heart failure, but predicting it remains challenging. This study found that certain circulant microRNAs may not be effective in distinguishing patients with left ventricle remodeling from those without.
Article
Biochemistry & Molecular Biology
Liana Maries, Alexandra Ioana Moatar, Aimee Rodica Chis, Catalin Marian, Constantin Tudor Luca, Ioan-Ovidiu Sirbu, Dan Gaita
Summary: Left ventricle remodeling after acute myocardial infarction leads to heart failure, but predicting this remodeling is challenging. This study found that the microRNA miR-22 can accurately distinguish between patients with and without left ventricle remodeling. The predictive power of miR-22 is even better when combined with other clinical variables. miR-22 may be a useful predictor of ventricular function recovery in STEMI patients.
Article
Health Care Sciences & Services
Simona-Alina Abu-Awwad, Marius Craina, Lioara Boscu, Elena Bernad, Paula Diana Ciordas, Catalin Marian, Mircea Iurciuc, Ahmed Abu-Awwad, Stela Iurciuc, Brenda Bernad, Diana Maria Anastasiu Popov, Anca Laura Maghiari
Summary: This research investigates the association between altered lipid profiles and hypertensive disorders of pregnancy (HDP). The study finds significant elevations in Apolipoprotein B (ApoB) and Lipoprotein(a) (Lp(a)) levels in pregnant women with HDP, emphasizing the importance of early detection and specialized handling of cardiovascular risks in expectant mothers.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pediatrics
Simona-Alina Abu-Awwad, Marius Craina, Lioara Boscu, Elena Bernad, Paula Diana Ciordas, Catalin Marian, Mircea Iurciuc, Ahmed Abu-Awwad, Stela Iurciuc, Brenda Bernad, Diana Maria Anastasiu Popov, Anca Laura Maghiari
Summary: This study compares the lipid profiles of pregnant women with and without cardiovascular risk factors, revealing that women with cardiovascular risk factors have higher rates of adverse neonatal outcomes and abnormal lipid and inflammatory profiles. These findings highlight the need for effective risk stratification and management strategies in this population.
Article
Biochemistry & Molecular Biology
Diana Nitusca, Carmen Socaciu, Andreea Iulia Socaciu, Ioan Ovidiu Sirbu, Razvan Bardan, Alin Adrian Cumpanas, Edward Seclaman, Catalin Marian
Summary: Prostate cancer is a leading cause of cancer mortality in men worldwide, with a lack of specific early detection and staging biomarkers. This study identified five potential biomarkers for prostate cancer using metabolomics, with all the molecules displaying decreased levels in prostate cancer plasma samples. The high diagnostic accuracy of these metabolites suggests their potential as non-invasive biomarkers for prostate cancer detection.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Simona-Alina Abu-Awwad, Marius Craina, Adrian Gluhovschi, Paula Diana Ciordas, Catalin Marian, Lioara Boscu, Elena Bernad, Mircea Iurciuc, Ahmed Abu-Awwad, Stela Iurciuc, Anca Laura Maghiari
Summary: This study investigated whether pregnant women with cardiovascular risk have shorter telomeres compared to those without cardiovascular risk. The results showed that pregnant women with cardiovascular risk had significantly shorter telomeres, which may have implications for the long-term health of both the mother and the child.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Ionut Dragos Capraru, Dan Dumitru Vulcanescu, Iulia Cristina Bagiu, Florin George Horhat, Irina Maria Popescu, Luminita Mirela Baditoiu, Delia Muntean, Monica Licker, Matilda Radulescu, Ion Cristian Mot, Mircea Mihai Diaconu, Catalin Marian
Summary: This study aimed to investigate the associations between biomarkers CRP, LDH, CK, 25-OHD, ferritin, HDL cholesterol, and clinical severity in COVID-19 patients in Romania, and their potential use in predicting ICU admission and death. The results showed that CRP, LDH, 25-OHD, ferritin, and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges.
MEDICINA-LITHUANIA
(2023)
Review
Medicine, General & Internal
Tamara Mirela Porosnicu, Ioan Ovidiu Sirbu, Cristian Oancea, Dorel Sandesc, Felix Bratosin, Ovidiu Rosca, Daniel Jipa, Estera Boeriu, Satya Sai Sri Bandi, Marius Pricop
Summary: This review analyzed the effects of therapeutic plasma exchange (TPE) on inflammatory markers in critically ill COVID-19 patients. The results showed that TPE significantly reduced inflammation and improved clinical status and hospitalization duration in these patients.
MEDICINA-LITHUANIA
(2023)
Article
Pharmacology & Pharmacy
Iosif Ilia, Doina Chioran, Daniela Radu, Raul Chioiba, Ioana Ionita, Catalin Marian, Alexandra Semenescu, Robert Cosmin Racea, Ramona Popovici, Stefania Dinu, Mircea Rivis, Andrada Iftode
Summary: Hyaluronic acid has the potential to be an effective candidate for the treatment of osteosarcoma, as it can induce cell apoptosis and alter gene expression. However, further research is needed to elucidate the molecular mechanisms involved.