Article
Medicine, Research & Experimental
Youji Jia, Guodong Wang, Wei Yan, Bo Kong, Yong Xu, Chenglong Wang, Dezhi Tang, Xiaobing Xi
Summary: This study aimed to investigate the effect of Psoralen on myelosuppression and elucidate the underlying mechanism. Both cell and animal models were used to observe the impacts of Psoralen on hematopoietic stem cells and bone growth factors. The results showed that Psoralen treatment inhibited cell apoptosis and regulated the expression of bone growth factors and hematopoietic growth factors.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Qing Xia, XinYu Yang, JiaBin Shi, ZiJie Liu, YaHui Peng, WenJing Wang, BoWen Li, Yu Zhao, JiaYing Xiao, Lei Huang, DaYong Wang, Xu Gao
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by abnormal accumulation of amyloid beta peptides and Tau protein in the brain. Mutations in amyloid precursor protein gene can cause familial Alzheimer's disease, but the A673T mutation shows protective effects against it.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Han Na Lee, Mi Suk Jeong, Se Bok Jang
Summary: Amyloid precursor protein (APP) and its homologs play important roles in the nervous system and are overexpressed in cancer cells. Research indicates their involvement in several cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jowita Nowakowska-Golacka, Justyna Czapiewska, Hanna Sominka, Natalia Sowa-Rogozinska, Monika Slominska-Wojewodzka
Summary: EDEM1 is an important regulatory factor involved in APP metabolism, as it recognizes misfolded APP proteins and directs them to cytosol for degradation, leading to decreased secretion of Aβ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Youjia Zhang, Xiaxin Yang, Yongrui Liu, Liang Ge, Jiarong Wang, Xiulian Sun, Bo Wu, Junfeng Wang
Summary: Amyloid precursor protein (APP) plays critical roles in Alzheimer's disease and cancers. The Y682 phosphorylation site in the intracellular tail of APP is crucial for its function. This study identifies Vav2 as a novel interaction partner of APP and demonstrates its regulatory role in APP.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Yusuke Fukuda, Maria F. Pazyra-Murphy, Elizabeth S. Silagi, Ozge E. Tasdemir-Yilmaz, Yihang Li, Lillian Rose, Zoe C. Yeoh, Nicholas E. Vangos, Ezekiel A. Geffken, Hyuk-Soo Seo, Guillaume Adelmant, Gregory H. Bird, Loren D. Walensky, Jarrod A. Marto, Sirano Dhe-Paganon, Rosalind A. Segal
Summary: A complex involving RNA and the RNA-binding protein SFPQ interacts with a kinesin complex crucial for axon survival. Therapeutic approaches bypassing local translation have shown potential in preventing axon degeneration.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Cell Biology
Grant Pfundstein, Alexander G. Nikonenko, Vladimir Sytnyk
Summary: This review examines the interactions of cell adhesion molecules with APP and Aβ, and analyzes the critical role these proteins play in regulating APP metabolism and physiological function, as well as Aβ toxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, Christian Koch, Lea Bertgen, Edward H. Koo, Gunnar Brinkmalm, Henrik Zetterberg, Stefan Kins, Simone Eggert
Summary: This study compares the effects of different APP genetic mutations on their processing and pathogenic mechanisms in Alzheimer's disease. The results show significant differences in the underlying mechanisms for familial AD mutations located at the alpha-, beta-, and gamma-secretase cleavage sites. Different mutations have different effects on APP processing and the generation of A β peptides.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Stefania Kalampokini, Despoina Georgouli, Eleni Patrikiou, Antonios Provatas, Varvara Valotassiou, Panagiotis Georgoulias, Cleanthe Spanaki, Georgios M. Hadjigeorgiou, Georgia Xiromerisiou
Summary: Mutations in the APP gene can cause autosomal dominant Alzheimer's disease, with mutations most commonly found in exons 17 and 16. Patients present with a variety of symptoms including dementia, visuospatial symptoms, aphasia, epilepsy, and psychiatric symptoms. Mutations in exon 17 are associated with high pathogenicity and a younger age of disease onset.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Raquel Coronel, Adela Bernabeu-Zornoza, Charlotte Palmer, Rosa Gonzalez-Sastre, Andreea Rosca, Patricia Mateos-Martinez, Victoria Lopez-Alonso, Isabel Liste
Summary: This study investigates the effects of amyloid precursor protein (APP) overexpression on human neural stem cells (hNSCs) and identifies differentially expressed genes related to neuronal and glial differentiation processes, as well as signaling pathways such as Notch, Wnt, PI3K-AKT, and JAK-STAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Neda Ojaghlou, Justin Airas, Lauren M. McRae, Cooper A. Taylor, Bill R. Miller, Carol A. Parish
Summary: Recent experiments have shown that JIP1 activates JNK, which is involved in cell apoptosis and diseases like Alzheimer's disease, obesity, and cancer. The structure and dynamics of JIP1, particularly a functionally active 10mer fragment, were studied using MD simulations. A Markov state model identified four metastable states with dominant pathways of conformational interconversions.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Biochemistry & Molecular Biology
Raquel Coronel, Victoria Lopez-Alonso, Marta I. Gallego, Isabel Liste
Summary: This article investigates the biological role of APP in hNSCs cells, revealing its association with cell proliferation and cell fate specification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jinsu Park, Meenu Madan, Srinivasulu Chigurupati, Seung Hyun Baek, Yoonsuk Cho, Mohamed R. Mughal, Amin Yu, Sic L. Chan, Jogi Pattisapu, Mark P. Mattson, Dong-Gyu Jo
Summary: AQP1 levels are elevated in the cerebral cortex during the early stages of AD, particularly in vulnerable neurons, and increase as aging progresses in AD mouse models. AQP1 appears to reduce A beta production by inhibiting the binding between BACE1 and APP.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Physiology
Bradley J. Baranowski, Ahmad Mohammad, Michael S. Finch, Alex Brown, Roopan Dhaliwal, Daniel M. Marko, Paul J. LeBlanc, Cheryl M. McCormick, Val A. Fajardo, Rebecca E. K. MacPherson
Summary: Exercise reduces cognitive aging, neurodegeneration, and Alzheimer's disease risk. BDNF, an exercise-induced neurotrophin, plays a role in APP processing and is associated with improved cognition. This study shows that BDNF treatments have similar effects on APP processing as exercise training.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Neurosciences
Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou Wikberg, Gloria Lau, Sue Noy, Karen Cleverley, Takashi Saito, Takaomi C. Saido, Eugene Yu, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Victor Tybulewicz, Elizabeth M. C. Fisher, Frances K. Wiseman
Summary: This study found that in individuals with Down syndrome (DS), early onset Alzheimer's disease (AD) is associated with multiple copies of the APP gene on chromosome 21, while three copies of other genes on chromosome 21 can partially alleviate the accumulation of AP in the brain. This provides critical mechanistic insight into disease development and explains the typically later age of onset of dementia in DS individuals compared to those with familial AD caused by triplication of APP.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Soleil S. Shah, Lakshika Tennakoon, Edward O'Beirne, Kristan L. Staudenmayer, Nishita Kothary
Summary: Interventional radiology plays a significant role in inpatient care in the United States, with around 10% of hospitalized patients receiving such services. Patients requiring interventional radiology are typically older, sicker, and account for a large portion of healthcare costs.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Robert P. Kocher, Soleil Shah, Amol S. Navathe
Summary: This Viewpoint examines the conditions that drive consolidation in healthcare, and suggests policy solutions to protect patients from the potential negative effects of this trend.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Health Care Sciences & Services
Rebecca Forman, Soleil Shah, Patrick Jeurissen, Mark Jit, Elias Mossialos
Summary: The development and distribution of a safe and effective SARS-CoV-2 (COVID-19) vaccine has attracted global interest. Despite emergency use authorization for several vaccine candidates within a year of the pandemic, there are still significant policy challenges that require a collaborative global response.
Letter
Medicine, General & Internal
Soleil Shah, Amol S. Navathe, Robert P. Kocher
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Public, Environmental & Occupational Health
Anant Jani, Sindhu Ravishankar, Naresh Kumar, J. Vimitha, Soleil Shah, Anees Pari, C. Ramasubramaniam
Summary: This qualitative study in Tamil Nadu, India, identified three key areas influencing care-seeking behavior for mental illness: views on causes of mental illness, stigma and discrimination, and broader factors influencing decision-making. These contextual factors can be used to design and implement approaches to address treatment gaps in India.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Joseph T. T. Kannarkat, Soleil Shah, Natasha Parekh, Francis J. J. Crosson
Summary: The Center for Medicare and Medicaid Innovation (CMMI) aims to develop evidence-based alternative payment models (APM) to enhance healthcare quality and decrease costs, but its achievement in these goals has been inconsistent. In October 2021, CMMI released its Innovation Strategy Refresh to address challenges in payment models and propose new strategies. However, there are still unresolved issues, including engaging physicians and patients in APMs, minimizing conflicting incentives, reducing selection bias, and transitioning from fee-for-service framework. This article offers guidance and solutions to improve CMMI's vision and tackle these challenges.
Editorial Material
Medicine, General & Internal
Soleil Shah, Hayden Rooke-ley, Erin C. Fuse Brown
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Pediatrics
Shilpa G. Jani, Jasmin Ma, Uma Pulendran, Julianna C. Hsing, Jonathan Altamirano, Soleil Shah, Elizabeth Y. Toomarian, Yvonne Maldonado, Chih-Hung Jason Wang
Summary: This prospective study conducted in a K-8 school over a 22-week period demonstrates that secondary transmission of COVID-19 can be limited with comprehensive preventive measures. Surveillance testing and adherence to key mitigation measures, such as masking, were found to be effective in preventing in-school transmission.
ACADEMIC PEDIATRICS
(2022)
Meeting Abstract
Anesthesiology
Chris A. Rishel, Soleil Shah, Yuting Zhang, Beth Darnall, Eric Sun
ANESTHESIA AND ANALGESIA
(2021)