Journal
PROTEIN SCIENCE
Volume 25, Issue 7, Pages 1363-1365Publisher
WILEY-BLACKWELL
DOI: 10.1002/pro.2919
Keywords
presenilin; ClC channel; protein fold; calcium leak channel
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Funding
- NIGMS NIH HHS [R01 GM096053] Funding Source: Medline
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Presenilin is an integral membrane aspartate protease that regulates cellular processes by cleaving proteins within the cell membrane. The recent crystal structure of presenilin reveals a conspicuous pore in a bundle of nine alpha-helices, which was originally thought to adopt a novel protein fold. However, here I show that the presenilin fold is a variant of the ClC chloride channel/transporter fold. This observation may have important implications for presenilin's postulated biological role as a calcium leak channel.
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