5′-N -ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor

Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright Future

(2016) Daniel T. Gewirth   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Crowding Activates Heat Shock Protein 90

(2016) Jackson C. Halpin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94

(2015) Hardik J. Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Using ancient protein kinases to unravel a modern cancer drug's mechanism

(2015) C. Wilson et al.   SCIENCE

Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source

(2013) Scott Classen et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

(2013) Pallav D Patel et al.   Nature Chemical Biology

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

New developments in theATSASprogram package for small-angle scattering data analysis

(2012) Maxim V. Petoukhov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Development of a Grp94 inhibitor

(2012) Adam S. Duerfeldt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

(2011) Michal Marzec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HSP90 inhibition: two-pronged exploitation of cancer dependencies

(2011) Jon Travers et al.   DRUG DISCOVERY TODAY

An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells

(2009) Olga Ostrovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide

(2009) Kristin A. Krukenberg et al.   PROTEIN SCIENCE

The ATPase Cycle of the Mitochondrial Hsp90 Analog Trap1

(2008) Adriane Leskovar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90

(2008) Christian N. Cunningham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Species-Dependent Ensembles of Conserved Conformational States Define the Hsp90 Chaperone ATPase Cycle

(2008) Daniel R. Southworth et al.   MOLECULAR CELL

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum

(2008) R. A. Spooner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Conformations of E. coli Hsp90 in Solution: Insights into the Conformational Dynamics of Hsp90

(2008) Kristin A. Krukenberg et al.   STRUCTURE